Presbycusis

Gradual bilateral hearing loss associated with aging that is due to progressive degeneration of cochlear structures and central auditory pathways. Hearing loss usually begins with the high frequencies then progresses to sounds of middle and low frequencies.

Also Known As:

Networked: 129 relevant articles (6 outcomes, 28 trials/studies)

Relationship Network

Disease Context: Research Results

Related Diseases

1.	Sensorineural Hearing Loss
2.	Tinnitus
3.	Seizures (Seizure)
4.	Hearing Loss (Hearing Impairment)
5.	Noise-Induced Hearing Loss (Acoustic Trauma)

Experts

1.	Sun, Yu: 5 articles (07/2015 - 07/2010)
2.	Zhong, Yi: 4 articles (07/2015 - 07/2010)
3.	Kong, Wei-Jia: 3 articles (07/2015 - 07/2010)
4.	Yang, Yang: 3 articles (01/2014 - 08/2011)
5.	Peng, Wei: 3 articles (02/2013 - 07/2010)
6.	Markaryan, Adam: 3 articles (07/2011 - 06/2009)
7.	Hinojosa, Raul: 3 articles (07/2011 - 06/2009)
8.	Nelson, Erik G: 3 articles (07/2011 - 06/2009)
9.	Yamashita, Toshio: 3 articles (05/2008 - 03/2003)
10.	Baba, Susumu: 3 articles (05/2008 - 03/2003)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Presbycusis:

1.	gamma-Aminobutyric Acid (GABA)IBA 02/01/2015 - "However, to date there has been a paucity of studies exploring changes to the GABA concentrations in the auditory region of patients with presbycusis. " 10/01/2012 - "In comparison to the aged group and the youth group, the changes of NAA, GABA, Cho and Glu is found in auditory cortex in patients with presbycusis." 10/01/2012 - "GABA/Cr ratio and Glu/Cr ratio were significant difference between presbycusis group and youth group (P < 0.05). " 07/01/1990 - "Immunocytochemical and neurochemical evidence for age-related loss of GABA in the inferior colliculus: implications for neural presbycusis." 11/01/1999 - "Normal GABAergic function in IC has been shown to be important in acoustic coding, and reduced efficacy of GABA function in IC neurons is critical in IC pathophysiology in presbycusis, tinnitus and audiogenic seizures."
2.	Dexamethasone (Maxidex)FDA LinkGeneric 10/01/2011 - "To determine whether intratympanic (i.t.) dexamethasone ameliorates cisplatin-induced ototoxicity in a mouse model of presbycusis. "
3.	Cisplatin (Platino)FDA LinkGeneric 10/01/2011 - "To determine whether intratympanic (i.t.) dexamethasone ameliorates cisplatin-induced ototoxicity in a mouse model of presbycusis. "
4.	Mitochondrial DNA (mtDNA)IBA 07/01/1997 - "The current study demonstrates the presence of a 4,977 bp deletion in human mitochondrial DNA genome that is associated with aging and with some forms of presbycusis. " 07/01/1997 - "The current study examined mitochondrial DNA (mtDNA) from cochlear sections of 34 human temporal bones: 17 with normal hearing and 17 with presbycusis. " 07/01/1997 - "Mitochondrial DNA deletions associated with aging and possibly presbycusis: a human archival temporal bone study." 06/01/1996 - "Additionally, preliminary results in human archival temporal bone studies reveal the presence of the 4977-bp mtDNA deletion in two out of three patients with presbycusis. " 02/01/2013 - "Several investigations indicated the association between a mitochondrial common deletion (CD) (mtDNA 4977-bp deletion in humans, corresponding to 4834-bp deletion in rats) and presbycusis. "
5.	Galactose (Galactopyranose)FDA LinkGeneric 07/01/2015 - "The purpose of this study was to explore the association between Trx2 and the phenotype of central presbycusis using a mimetic aging animal model induced by long-term exposure to d-galactose (d-Gal). " 01/01/2014 - "In this study, the mechanisms of central presbycusis were investigated using a mimetic aging rat model induced by chronic injection of D-galactose (D-Gal). " 08/01/2011 - "The current study was designed to investigate potential causative mechanisms of central presbycusis by using a rat mimetic aging model induced by subcutaneous administration of D-galactose (D-gal). " 07/16/2010 - "The current study was designed to investigate potential causative mechanisms of this impairment by using a rat model in which presbycusis is inducible by administration of D-galactose (D-gal). "
6.	Neurotransmitter Agents (Neurotransmitter)IBA 01/01/2012 - "Despite the importance of understanding changes in neurotransmitters during presbycusis, only a few studies have assessed age-associated changes in neurotransmitter at each level of the CAS. " 04/21/2009 - "Previous studies suggest that certain deficits seen in presbycusis may partially result from functional loss of the inhibitory neurotransmitter glycine in dorsal cochlear nucleus (DCN). " 01/01/1999 - "Presbycusis may result, in part, from functional loss of the inhibitory neurotransmitter GABA. "
7.	coenzyme Q10 (CoQ10)IBA 05/01/2011 - "The aim of this study was to evaluate the long-term effects of a water-soluble formulation of CoQ10 (Q-TER) in subjects with presbycusis. " 10/01/2010 - "The purpose of this study was to evaluate the efficiency and applicability of a water-soluble formulation of CoQ10 (Q-TER(®)) in subjects with presbycusis. " 05/01/2011 - "Water-soluble coenzyme Q10 formulation in presbycusis: long-term effects." 10/01/2010 - "Water-soluble coenzyme Q10 formulation (Q-TER(®)) in the treatment of presbycusis." 05/01/2011 - "These findings provide the basis for understanding the duration of the effect after the last use of the drug and encourage a larger clinical trial to collect additional evidence on the effect of coenzyme Q10 (CoQ10) in preventing the development of hearing loss in subjects with presbycusis. "
8.	DNA (Deoxyribonucleic Acid)IBA 02/01/2015 - "The aim of the present study was to examine the role of the mitochondrial (mt) DNA common deletion (CD) 4977 (mtDNACD4977) in the hair shaft in patients with presbycusis. " 08/01/2010 - "Clinical, audiometric, and DNA testing of 55 adults with presbycusis and 79 control patients with normal hearing. " 09/01/2013 - "Factors contributing to presbycusis include mitochondria DNA mutation, genetic disorders including Ahl, hypertension, diabetes, metabolic disease and other systemic diseases in the intrinsic aspects. " 11/01/2003 - "By observing the relationship between the fragment deletion of mitochondrial DNA (mt DNA) of inner ear in rat and the hearing loss to investigate the possible role of mt DNA deletion in presbycusis. "
9.	Gonadal Steroid Hormones (Sex Hormones)IBA 04/01/1958 - "[Additional studies on the effects of sex hormones on presbycusis]." 08/01/1967 - "[On the treatment of presbycusis with sex hormones]." 06/01/1956 - "[Presbycusis and its treatment with Bogomoletz serum or sex hormones]."
10.	Brain-Derived Neurotrophic Factor (BDNF)IBA 04/01/2007 - "Our results suggest that reduced BDNF protein levels in auditory nerves over age may be a crucial factor in the altered brainstem plasticity observed during presbycusis." 10/01/2006 - "The expression of BDNF is closely correlated to presbycusis in the aged rats." 10/01/2006 - "The expression of BDNF in the cochleas of the aged rats with presbycusis was obviously less than that in the control group. " 10/01/2006 - "To explore the correlation between the expression of brain derived neurotrophic factor (BDNF) and presbycusis in the cochleae of the aged rats. " 04/01/2007 - "Alteration of plasticity is also correlated with age-related hearing loss (presbycusis), but to date no detailed studies of BDNF expression have been performed in the young or aging mature cochlea. "

Therapies and Procedures

1.	Hearing Aids (Hearing Aid) 05/01/2011 - "In conclusion, for the elderly people with the effects of hearing aids in presbycusis and due to the significant improvement in psychological state and mental functions, using and being adaptable to hearing aids is a good solution." 07/01/2009 - "In conclusion, with respect to the beneficial effects of hearing aids in presbycusis and due to the significant improvement in the quality of life, hearing aids are recommended for this group of population." 05/01/2015 - "While the benefits of hearing aids among older adults with presbycusis have been well documented, there is limited research on hearing-aid usage. " 02/01/2011 - "Through face to face way to investigate and analyse patients with hearing aids fitting, totally 30 subjects accepted the analysis, preliminary assessment of the use of hearing aids in patient with presbycusis results and solve problems encountered in its use by using SPSS software to analyze the collecting data. " 02/01/2011 - "By matching patients with presbycusis hearing aids,hearing aid performance assessment questionnaire to fill out to assess the effect of its use and targeted to solve problems encountered in its use and improve the quality of life of older persons. "
2.	Transplantation (Transplant Recipients) 01/01/2013 - "Intracerebral neural stem cell transplantation improved the auditory of mice with presbycusis." 01/01/2013 - "Together, our results demonstrate that NSCs transplantation improve the auditory of C57BL/6J mice with presbycusis." 01/01/2013 - "Here, we assess the capability of intracerebral embryonic NSCs transplantation for C57BL/6J mice with presbycusis in vivo. " 11/20/2006 - "Transfer of accelerated presbycusis by transplantation of bone marrow cells from senescence-accelerated mice."
3.	Cochlear Implants (Cochlear Implant) 11/01/2013 - "Further studies and more experience with more patients and pathological conditions such as plasticity of the auditory system, cochlear implants, hearing aids, presbycusis, or acoustic neuropathy are necessary until this type of testing is ready for clinical application." 01/01/2010 - "Hearing aids and cochlear implants (CIs) are the most commonly used devices for treating mild-severe presbycusis. " 06/01/2011 - "The further technical development of cochlear implants has now widened their indications to include severe congenital deafness and presbycusis." 01/01/2010 - "A PubMed literature search was conducted using the keywords 'presbycusis/presbyacusis/geriatric AND hearing aids/cochlear implants/electric acoustic stimulation/middle ear implants' and 'elderly AND cochlear implants'. " 04/01/2013 - "The prevailing otolaryngologic approach to treatment of age-related hearing loss (ARHL), presbycusis, emphasizes compensation of peripheral functional deficits (ie, hearing aids and cochlear implants). "
4.	Bone Marrow Transplantation (Transplantation, Bone Marrow) 05/07/2008 - "In the present study, we show that the age-related dysfunctions of the systemic immune system in an animal model of accelerated presbycusis (SAMP1, senescence-accelerated mouse P1) can be corrected by allogeneic bone marrow transplantation (BMT). " 11/20/2006 - "These results indicated that accelerated presbycusis, cochlear pathology, and immune dysfunction of SAMP1 mice can be transferred to BALB/c recipient mice using allogeneic bone marrow transplantation (BMT). " 08/01/2001 - "Prevention of accelerated presbycusis by bone marrow transplantation in senescence-accelerated mice."
5.	Caloric Restriction 07/01/2002 - "The purpose of the present study was to document presbycusis and the effect of caloric restriction on presbycusis in monkeys. " 10/01/2007 - "Here we show that caloric restriction suppresses apoptotic cell death in the mouse cochlea and prevents late onset of presbycusis. " 10/01/2007 - "Caloric restriction suppresses apoptotic cell death in the mammalian cochlea and leads to prevention of presbycusis."