Prephenate Dehydratase

An enzyme that catalyzes the conversion of prephenate to phenylpyruvate with the elimination of water and carbon dioxide. In the enteric bacteria this enzyme also possesses chorismate mutase activity, thereby catalyzing the first two steps in the biosynthesis of phenylalanine. EC 4.2.1.51.

Also Known As:

Chorismate Mutase Prephenate Dehydratase; Dehydratase, Chorismate Mutase-Prephenate; Dehydratase, Prephenate; Hydro-lyase, Prephenate; Mutase-Prephenate Dehydratase, Chorismate; Prephenate Hydro lyase; Chorismate Mutase-Prephenate Dehydratase; Prephenate Hydro-lyase; Prephenate hydro-lyase (decarboxylating)

Networked: 2 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Enzymes and Coenzymes: 1
- Enzymes: 152586
  - Lyases: 637
    - Carbon-Oxygen Lyases
      - Hydro-Lyases: 266
        Prephenate Dehydratase: 2
        cyclohexadienyl dehydratase
        E coli P-protein
  - Isomerases: 463
    - Intramolecular Transferases: 3
      - Chorismate Mutase: 18
        Prephenate Dehydratase: 2
        cyclohexadienyl dehydratase
        E coli P-protein

Experts

1.	Gatenby, Anthony A: 1 article (04/2007)
2.	Olson, Monica M: 1 article (04/2007)
3.	Sariaslani, F Sima: 1 article (04/2007)
4.	Suh, Wonchul: 1 article (04/2007)
5.	Templeton, Lori J: 1 article (04/2007)
6.	Van Dyk, Tina K: 1 article (04/2007)
7.	Youderian, Philip: 1 article (04/2007)
8.	Basso, Luiz Augusto: 1 article (04/2006)
9.	Dias, Márcio Vinícius Bertacini: 1 article (04/2006)
10.	Santos, Diógenes Santiago: 1 article (04/2006)

Related Diseases

1.	Tuberculosis (Tuberculoses) 04/01/2006 - "tuberculosis prephenate dehydratase has been cloned, expressed, purified and crystallized by the hanging-drop vapour-diffusion method using PEG 400 as a precipitant. "
2.	Cicatrix (Scar) 04/01/2007 - "coli K12 chromosome including the pheA gene encoding chorismate mutase/prephenate dehydratase, its leader peptide (pheL), and its promoter using a new polymerase chain reaction-based method that does not leave a chromosomal scar. "

Related Drugs and Biologics

1.	Protein Sorting Signals (Signal Peptide)
2.	poly(2-hydroxyethyl acrylate) (PHEA)
3.	polyethylene glycol 400