Pregnenolone

A 21-carbon steroid, derived from CHOLESTEROL and found in steroid hormone-producing tissues. Pregnenolone is the precursor to GONADAL STEROID HORMONES and the adrenal CORTICOSTEROIDS.

Also Known As:

Networked: 356 relevant articles (14 outcomes, 51 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Marx, Christine E: 10 articles (01/2020 - 06/2006)
2.	Shampine, Lawrence J: 6 articles (01/2020 - 06/2006)
3.	Kilts, Jason D: 5 articles (01/2020 - 07/2009)
4.	Ritsner, Michael S: 5 articles (04/2018 - 01/2010)
5.	Naylor, Jennifer C: 4 articles (01/2020 - 07/2009)
6.	Morrow, A Leslie: 4 articles (12/2010 - 06/2006)
7.	Banday, Abid H: 3 articles (01/2021 - 12/2010)
8.	Mohareb, Rafat M: 3 articles (10/2018 - 12/2013)
9.	Wang, Liang-Jen: 3 articles (01/2018 - 01/2017)
10.	Wu, Chih-Ching: 3 articles (01/2018 - 01/2017)

Related Diseases

1.	Schizophrenia (Dementia Praecox) 01/01/2012 - "In addition, early phase proof-of-concept clinical trials have indicated that pregnenolone is effective in reducing the negative symptoms and cognitive deficits of schizophrenia patients. " 12/01/2017 - "Adjunctive Pregnenolone Ameliorates the Cognitive Deficits in Recent-Onset Schizophrenia: An 8-Week, Randomized, Double-Blind, Placebo-Controlled Trial." 11/01/2017 - "While this trial may suggest a potential effect of pregnenolone on schizophrenia symptoms, further studies are warranted." 09/01/2014 - "The objective of this study is to conduct a randomized controlled trial of adjunctive pregnenolone in schizophrenia. " 06/01/2014 - "Pregnenolone treatment reduces severity of negative symptoms in recent-onset schizophrenia: an 8-week, double-blind, randomized add-on two-center trial."
2.	Breast Neoplasms (Breast Cancer) 12/01/1979 - "Metabolism of pregnenolone by human breast cancer. " 09/01/1976 - "Adrenal function in breast cancer: the metabolism of pregnenolone in breast cancer patients." 02/01/1985 - "Non-polar pregnenolone conjugate concentrations were found to be highly elevated in the plasma of one pregnant subject, and elevated in the plasma of patients with acne and breast cancer. " 04/01/2014 - "The aim of the present study was to test the efficacy of a titanocene functionalized with pregnenolone (Ti-Preg) in an in vivo breast cancer model. " 01/01/2022 - "Design, synthesis, antiproliferative activity, estrogen receptors binding affinity of C-3 pregnenolone-dihydropyrimidine derivatives for the treatment of breast cancer."
3.	Psychotic Disorders (Schizoaffective Disorder) 06/01/2014 - "Thus, add-on pregnenolone reduces the severity of negative symptoms in recent-onset schizophrenia and schizoaffective disorder, especially among patients who are not treated with concomitant mood stabilizers. " 12/01/2017 - "This study aimed to examine the effect of add-on treatment with the neurosteroid pregnenolone (PREG) on neurocognitive dysfunctions of patients with recent-onset schizophrenia (SZ) and schizoaffective disorder (SA). " 10/01/2010 - "Pregnenolone and dehydroepiandrosterone as an adjunctive treatment in schizophrenia and schizoaffective disorder: an 8-week, double-blind, randomized, controlled, 2-center, parallel-group trial." 07/01/2009 - "We therefore investigated adjunctive pregnenolone for cognitive and negative symptoms in patients with schizophrenia or schizoaffective disorder receiving stable doses of second-generation antipsychotics in a pilot randomized, placebo-controlled, double-blind trial. " 10/01/2019 - "The following is an overview of findings that assess how pregnenolone and/or allopregnanolone concentrations are altered in animal models of stress and after consumption of alcohol or cannabis-type drugs, as well as in patients with depression, anxiety, post-traumatic stress disorder or psychosis and/or in those diagnosed with alcohol or cannabis use disorders. "
4.	Rheumatoid Arthritis 10/12/1956 - "[Pregnenolone in the treatment of rheumatoid arthritis]." 12/01/1951 - "Further observations on the use of pregnenolone in rheumatoid arthritis." 11/01/1951 - "The clinical effects of delta 5 pregnenolone in rheumatoid arthritis." 09/01/1951 - "[Experience with pregnenolone in rheumatoid arthritis]." 07/19/1951 - "[Therapeutic essay with synthetic pregnenolone in a case of rheumatoid arthritis]."
5.	Bipolar Disorder (Manic Depressive Psychosis) 11/01/2014 - "A randomized, double-blind, placebo-controlled trial of pregnenolone for bipolar depression." 01/01/2017 - "Blood samples from a previously published clinical trial of pregnenolone for adult bipolar depression were analyzed at baseline and week 6 of treatment with pregnenolone or placebo for serum MAP2 levels using Western Blot. " 01/01/2017 - "This clinical study is the first to examine serum MAP2 levels in people with bipolar depression and controls, and whether pregnenolone treatment is associated with a change in MAP2 levels. " 01/01/2015 - "The study showed that pregnenolone was significantly decreased in the parietal cortex in the combined group of patients with schizophrenia or bipolar disorder who died by suicide (n = 13) compared with patients with these disorders who died of other causes (n = 17, p = .02). " 01/01/2015 - "Pregnenolone alterations may be relevant to the neurobiology of suicide in schizophrenia and bipolar disorder."

Related Drugs and Biologics

1.	Steroids
2.	titanocene
3.	Androgens
4.	Pregnenolone Carbonitrile (PCN)
5.	Cortisone
6.	Prednisolone (Predate)
7.	Clozapine (Clozaril)
8.	Omega-3 Fatty Acids (Omega 3 Fatty Acids)
9.	Minocycline (Cyclops)
10.	Ethanol (Ethyl Alcohol)

Related Therapies and Procedures

1.	Self Administration (Administration, Self)
2.	Therapeutics
3.	Drug Therapy (Chemotherapy)
4.	Orchiectomy (Orchidectomy)
5.	Castration