Pregnenolone

A 21-carbon steroid, derived from CHOLESTEROL and found in steroid hormone-producing tissues. Pregnenolone is the precursor to GONADAL STEROID HORMONES and the adrenal CORTICOSTEROIDS.

Also Known As:

Networked: 252 relevant articles (8 outcomes, 36 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Marx, Christine E: 8 articles (01/2015 - 06/2006)
2.	Shampine, Lawrence J: 4 articles (01/2015 - 06/2006)
3.	Morrow, A Leslie: 4 articles (12/2010 - 06/2006)
4.	Selleri, Silvia: 3 articles (03/2015 - 05/2008)
5.	Kassiou, Michael: 3 articles (03/2015 - 05/2008)
6.	Martini, Claudia: 3 articles (03/2015 - 12/2009)
7.	Da Pozzo, Eleonora: 3 articles (03/2015 - 12/2009)
8.	Bradford, Daniel W: 3 articles (01/2015 - 08/2006)
9.	Hamer, Robert M: 3 articles (01/2015 - 06/2006)
10.	Kilts, Jason D: 3 articles (01/2015 - 07/2009)

Related Diseases

1.	Schizophrenia (Dementia Praecox) 01/01/2012 - "In addition, early phase proof-of-concept clinical trials have indicated that pregnenolone is effective in reducing the negative symptoms and cognitive deficits of schizophrenia patients. " 09/01/2014 - "The objective of this study is to conduct a randomized controlled trial of adjunctive pregnenolone in schizophrenia. " 06/01/2014 - "Pregnenolone treatment reduces severity of negative symptoms in recent-onset schizophrenia: an 8-week, double-blind, randomized add-on two-center trial." 07/01/2009 - "Proof-of-concept trial with the neurosteroid pregnenolone targeting cognitive and negative symptoms in schizophrenia." 01/01/2015 - "Pregnenolone levels were also lower in the parietal cortex in the individual group of schizophrenia patients who died by suicide (n = 4) compared with schizophrenia patients who died of other causes (n = 11) p = .04). "
2.	Rheumatoid Arthritis 11/13/1953 - "[Pregnenolone in rheumatoid arthritis; study in 18 cases with this steroid]." 10/12/1956 - "[Pregnenolone in the treatment of rheumatoid arthritis]." 12/01/1951 - "Further observations on the use of pregnenolone in rheumatoid arthritis." 11/01/1951 - "The clinical effects of delta 5 pregnenolone in rheumatoid arthritis." 09/01/1951 - "[Experience with pregnenolone in rheumatoid arthritis]."
3.	Bipolar Disorder (Mania) 11/01/2014 - "A randomized, double-blind, placebo-controlled trial of pregnenolone for bipolar depression." 01/01/2015 - "The study showed that pregnenolone was significantly decreased in the parietal cortex in the combined group of patients with schizophrenia or bipolar disorder who died by suicide (n = 13) compared with patients with these disorders who died of other causes (n = 17, p = .02). " 01/01/2015 - "Pregnenolone alterations may be relevant to the neurobiology of suicide in schizophrenia and bipolar disorder." 07/30/2010 - "In a proof-of-concept investigation, 70 participants with bipolar disorder or recurrent major depressive disorder and history of substance abuse/dependence (abstinent for > or =14days prior to enrollment) were randomly assigned to receive pregnenolone (titrated to 100mg/day) or placebo for 8weeks. " 06/01/2006 - "Pregnenolone and dehydroepiandrosterone levels were higher in subjects with schizophrenia and bipolar disorder compared to control subjects in both posterior cingulate and parietal cortex. "
4.	Psychotic Disorders (Schizoaffective Disorder) 06/01/2014 - "Thus, add-on pregnenolone reduces the severity of negative symptoms in recent-onset schizophrenia and schizoaffective disorder, especially among patients who are not treated with concomitant mood stabilizers. " 10/01/2010 - "Pregnenolone and dehydroepiandrosterone as an adjunctive treatment in schizophrenia and schizoaffective disorder: an 8-week, double-blind, randomized, controlled, 2-center, parallel-group trial." 07/01/2009 - "We therefore investigated adjunctive pregnenolone for cognitive and negative symptoms in patients with schizophrenia or schizoaffective disorder receiving stable doses of second-generation antipsychotics in a pilot randomized, placebo-controlled, double-blind trial. " 09/15/2011 - "Treatment with adjunctive pregnenolone significantly decreased negative symptoms in patients with schizophrenia or schizoaffective disorder in a pilot proof-of-concept randomized controlled trial, and elevations in pregnenolone and allopregnanolone post-treatment with this intervention were correlated with cognitive improvements [Marx et al. (2009) Neuropsychopharmacology 34:1885-1903]. "
5.	Breast Neoplasms (Breast Cancer) 12/01/1979 - "Metabolism of pregnenolone by human breast cancer. " 02/01/1985 - "Non-polar pregnenolone conjugate concentrations were found to be highly elevated in the plasma of one pregnant subject, and elevated in the plasma of patients with acne and breast cancer. " 04/01/2014 - "The aim of the present study was to test the efficacy of a titanocene functionalized with pregnenolone (Ti-Preg) in an in vivo breast cancer model. " 05/01/2012 - "When tested for their effects on pregnenolone production in rat C6 glioma cells, nitric oxide release in murine microglia, and cell proliferation in human MCF-7 breast cancer cells, the pyrrolobenzoxazepines (40 μM) displayed functional effects which did not correlate to the binding trend observed in competition assays. " 07/01/1998 - "In order to determine whether human mammary tumors could contribute to progesterone synthesis from pregnenolone in breast cancer patients, homogenates of infiltrating ductal primary breast tumors at different stages of malignancy (Stages II and III) obtained from pre- and post-menopausal patients (n = 7, age 37-66 years) were incubated with [7n-3H]pregnenolone as substrate. "

Related Drugs and Biologics

1.	titanocene
2.	Cortisone
3.	Clozapine (Clozaril)
4.	Ethanol (Ethyl Alcohol)
5.	olanzapine (Zyprexa)
6.	Dehydroepiandrosterone (DHEA)
7.	Steroids
8.	Testosterone (Sustanon)
9.	Cholesterol
10.	Hydrocortisone (Cortisol)

Related Therapies and Procedures

1.	Self Administration (Administration, Self)
2.	Orchiectomy (Orchidectomy)
3.	Injections
4.	Castration
5.	Aftercare (After-Treatment)