Pregnanediol

An inactive metabolite of PROGESTERONE by reduction at C5, C3, and C20 position. Pregnanediol has two hydroxyl groups, at 3-alpha and 20-alpha. It is detectable in URINE after OVULATION and is found in great quantities in the pregnancy urine.

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Networked: 144 relevant articles (2 outcomes, 5 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Kesner, James S: 2 articles (01/2020 - 12/2012)
2.	Meadows, Juliana W: 2 articles (01/2020 - 12/2012)
3.	Havstad, Suzanne: 2 articles (07/2012 - 05/2011)
4.	Wegienka, Ganesa: 2 articles (07/2012 - 05/2011)
5.	Bloom, Michael S: 1 article (01/2021)
6.	Connell, Matthew T: 1 article (01/2021)
7.	Kim, Keewan: 1 article (01/2021)
8.	Kuhr, Daniel L: 1 article (01/2021)
9.	Mumford, Sunni L: 1 article (01/2021)
10.	Nobles, Carrie J: 1 article (01/2021)

Related Diseases

1.	Fetal Weight 02/01/1980 - "In respect of hypotrophy the ratio of pregnanediol : total oestrogen : HPL is equal to 7 : 5 : 1. This shows a sevenfold improved correlation between pregnanediol and fetal weight than between HPL and fetal weight."
2.	Schizophrenia (Dementia Praecox) 08/03/2012 - "Among them, pregnanediol, citrate and α-ketoglutarate (α-KG) were significantly associated with symptomatology of schizophrenia after Bonferroni correction and may be useful biomarkers for monitoring therapeutic efficacy. "
3.	Hirsutism 01/01/1969 - "[Gas chromatography determination of urinary pregnanediol and -triol and its significance for the differentiation of adrenal hirsutism in women]." 02/01/1951 - "The Excretion of Pregnanediol and 17-Ketosteroids during the Menstrual Cycle in Benign Hirsutism." 09/01/1991 - "In the other three cases of congenital adrenal hyperplasia the karyotype was found to be 46XX, the 17-ketosteroids and pregnanediol were high and the patients were found to have hirsutism and were virilized. " 10/01/1971 - "[Parameters of urinary steroid (androsterone, etiocolanolone, estrogenic phenolsteroids pregnanediol, pregnanetriol) in 92 cases of "common" hirsutism]." 09/30/1967 - "[Behavior of the gas-chromatographic fractions of urinary 17-ketosteroids, pregnanediol and pregnanetriol after stimulation with ACTH in hirsutism]."
4.	Toxemia 05/01/1958 - "Pregnanediol excretion in toxemias of pregnancy; a study of thirty cases." 07/01/1976 - "In patients with toxemia, the values of pregnanediol (in the majority of the cases) are decreased, while in pregnant women with antecedents of infertility are increased from the 36th week of pregnancy, although they had protective treatment from first months of pregnancy. " 07/01/1976 - "Employing the technique described by Van Kampen and Anker, modified by Macarulla et al., 180 pregnant women have been studied (66 normals and 114 with different pathology: infertility, toxemia, diabetes, Rh isoinmunization, gemelar pregnancy and abortions), taking 319 determinations of pregnanediol in 24 hours urine samples. " 07/01/1965 - "[Determination of chorionic gonadotropins, pregnanediol and estriol in the pregnancy complicated by toxemia]."
5.	Respiratory Insufficiency (Respiratory Failure) 01/01/1984 - "Study of blood progesterone and diurnal urine pregnanediol revealed that progesterone level substantially increased in the initial stage of cor pulmonale formation (in respiratory failure without heart decompensation). "

Related Drugs and Biologics

1.	Citric Acid (Citrate)
2.	Biomarkers (Surrogate Marker)
3.	Progesterone
4.	Pregnanetriol
5.	17-Ketosteroids (17 Ketosteroids)
6.	Glucuronides
7.	Estrone
8.	Androstenedione (4 Androstene 3,17 dione)
9.	Testosterone (Sustanon)
10.	Sex Hormone-Binding Globulin

Related Therapies and Procedures

1.	Therapeutics
2.	Intravenous Administration
3.	Bariatric Surgery
4.	Hysterectomy
5.	Curettage