Prediabetic State (Prediabetes)

The time period before the development of symptomatic diabetes. For example, certain risk factors can be observed in subjects who subsequently develop INSULIN RESISTANCE as in type 2 diabetes (DIABETES MELLITUS, TYPE 2).

Also Known As:

Networked: 1304 relevant articles (50 outcomes, 234 trials/studies)

Relationship Network

Disease Context: Research Results

Related Diseases

1.	Insulin Resistance
2.	Type 2 Diabetes Mellitus (MODY)
3.	Weight Loss (Weight Reduction)
4.	Overweight
5.	Obesity

Experts

1.	Narayan, K M Venkat: 13 articles (11/2015 - 03/2003)
2.	Rathmann, Wolfgang: 12 articles (11/2015 - 03/2009)
3.	Mohan, Viswanathan: 11 articles (11/2015 - 02/2006)
4.	Gregg, Edward W: 11 articles (12/2014 - 11/2005)
5.	Caprio, Sonia: 9 articles (02/2014 - 09/2003)
6.	Meisinger, Christa: 8 articles (11/2015 - 03/2009)
7.	Dagogo-Jack, Samuel: 8 articles (09/2015 - 01/2011)
8.	Deepa, Mohan: 7 articles (11/2015 - 07/2007)
9.	Thorand, Barbara: 7 articles (11/2015 - 07/2011)
10.	Edeoga, Chimaroke: 7 articles (09/2015 - 01/2011)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Prediabetic State:

1.	Glucose (Dextrose)FDA LinkGeneric 02/01/2015 - "In people with prediabetes, lifestyle interventions and glucose-lowering medications are effective in preventing the progression to type 2 diabetes. " 09/01/2012 - "However, no study has determined the efficacy of exercise training on glucose metabolism in the different prediabetes subtypes. " 03/15/2006 - "Preliminary data from a multicenter study of diet and exercise in prediabetes (the Impaired Glucose Tolerance Neuropathy Study) suggests a diet and exercise counseling regimen based on the Diabetes Prevention Program results in improved metabolic measures and small fiber function. " 09/01/2014 - "In a prospective study, patients diagnosed with prediabetes based on HbA1c (5.7%-6.4%) underwent a 75-g oral glucose tolerance test (OGTT) as the gold standard test to diagnose dysglycemia. " 09/01/2012 - "The magnitude of improvement in glucose metabolism after 12 weeks of exercise training is not uniform across the prediabetes subtypes. "
2.	Insulin (Novolin)FDA Link 01/01/2010 - "The most robust model, which used fasting insulin levels, may provide the most utility as a clinical tool because the highest quartiles suggest significantly greater likelihood of identifying prediabetes." 06/01/2010 - "An ADA diet consisting of 20% of calories as almonds over a 16-week period is effective in improving markers of insulin sensitivity and yields clinically significant improvements in LDL-C in adults with prediabetes." 12/01/2015 - "Our study suggests that in normoglycemic women with PCOS there is peripheral insulin sensitivity similar to that of women with prediabetes. " 04/01/2015 - "Therefore, the objective of this study was to examine the association of circulating FFA under varying conditions with prediabetes in Latino adolescents and to determine the relative relationships of FFA and visceral adiposity to insulin sensitivity, secretion, and β-cell function. " 02/01/2015 - "The use of a model of beta-cell function and impairment of insulin secretion has thus put the utility of the FPG and 2HPG into perspective: We recommend that performing an OGTT be considered pivotal for accurate identification of subjects with impaired beta-cell function (and thus prediabetes) and a revision of the OGTT lower cutoff be considered based on the results of this study."
3.	Metformin (Glucophage)FDA LinkGeneric 01/01/2013 - "Prediabetes can be a reversible process with improved metabolic control and the use of metformin in prediabetes in women with PCOS may prevent or slow down the onset of type 2 diabetes." 11/01/2015 - "The rationale, design, and baseline characteristics of PREVENT-DM: A community-based comparative effectiveness trial of lifestyle intervention and metformin among Latinas with prediabetes." 04/21/2015 - "Only 3.7% of patients with prediabetes were prescribed metformin over the 3-year study window. " 04/01/2014 - "OBJECTIVE The Diabetes Prevention Program (DPP) trial investigated rates of progression to diabetes among adults with prediabetes randomized to treatment with placebo, metformin, or intensive lifestyle intervention. " 04/01/2009 - "The 3 studies varied in ethnicity of the population studied, in the rates of conversion to diabetes from prediabetes, and in the dose of metformin used. "
4.	AcarboseFDA LinkGeneric 01/01/2015 - "The current available data suggest that AGIs (particularly acarbose) may be safe and effective for the treatment of prediabetes and diabetes. " 08/01/2015 - "The aim of this study was to assess differences in the preventive effects of acarbose in Eastern and Western populations with prediabetes. " 08/01/2015 - "The preventive effect of acarbose on the development of diabetes seems superior in Eastern populations with prediabetes compared with Western populations." 08/01/2015 - "Acarbose Monotherapy and Type 2 Diabetes Prevention in Eastern and Western Prediabetes: An Ethnicity-specific Meta-analysis." 01/01/2012 - "It is concluded that acarbose is a convenient long-term treatment option, with benefits for both type 2 diabetics and patients in a prediabetic state."
5.	colesevelam (Welchol)FDA Link 07/01/2010 - "Further study is warranted to determine whether colesevelam slows or prevents progression of prediabetes to type 2 diabetes." 11/01/2009 - "To evaluate the effects of colesevelam HCl in patients with prediabetes, a post-hoc analysis was conducted on data from a 24-week lipid-lowering study. " 09/01/2009 - "However, results of this trial will help to define the extent to which colesevelam HCl can help improve cardiometabolic risk factors for complications of type 2 DM in the first-line environment, and will also indicate the extent to which early intervention with colesevelam HCl can help to correct metabolic abnormalities associated with prediabetes." 05/01/2010 - "This article briefly reviews current treatment guidelines for patients with prediabetes and T2DM and the potential role of colesevelam in the management of prediabetes and T2DM with oral antidiabetes agents." 05/01/2009 - "This article reviews the place of colesevelam HCl in therapy (both for T2DM and prediabetes), the benefits of early, intensive treatment of T2DM, and the importance of safe glycemic control later in the disease process."
6.	Blood Glucose (Blood Sugar)IBA 11/01/2015 - "This study evaluates an employer-based diabetes/prediabetes screening intervention that invited at-risk employees via letters, secure e-mails, and automated voice messages to complete blood glucose testing at a health plan facility. " 01/01/2014 - "We therefore conducted a study to examine the changing trends in blood glucose levels before and after LT in patients with prediabetes or type 2 diabetes. " 09/01/2011 - "Cinnamon's effects on blood glucose have been the subject of many clinical and animal studies; however, the issue of cinnamon intake's effect on fasting blood glucose (FBG) in people with type 2 diabetes and/or prediabetes still remains unclear. " 11/01/2009 - "Controlled, randomized studies have shown that progression to diabetes among those with prediabetes is not inevitable; people with prediabetes who lose weight and increase their physical activity can prevent or delay diabetes and could even return their blood glucose levels to normal. " 11/19/2015 - "Elevated postprandial blood glucose levels constitute a global epidemic and a major risk factor for prediabetes and type II diabetes, but existing dietary methods for controlling them have limited efficacy. "
7.	Vitamin DFDA LinkGeneric 05/01/2010 - "Available data suggest that achieving vitamin D sufficiency may be beneficial in patients with prediabetes, although clinical trials are needed to provide evidence-based recommendations." 05/01/2015 - "This open-label, randomized study in subjects with prediabetes evaluated the effect of 12 months of Vitamin D supplementation on glycemic parameters and progression of prediabetes to diabetes in an ethnically homogeneous Kashmiri population. " 05/01/2015 - "Effect of Vitamin D supplementation on glycemic parameters and progression of prediabetes to diabetes: A 1-year, open-label randomized study." 05/01/2010 - "To review the role of vitamin D in prediabetes on the basis of evidence from human studies. " 06/01/2015 - "EFFECT OF HIGH-DOSE VITAMIN D REPLETION ON GLYCEMIC CONTROL IN AFRICAN-AMERICAN MALES WITH PREDIABETES AND HYPOVITAMINOSIS D."
8.	ThiazolidinedionesIBA 06/01/2009 - "Several clinical trials have shown a high success rate of thiazolidinediones (TZDs) in prediabetes and early type 2 diabetes. " 06/01/2009 - "Thiazolidinediones in prediabetes and early type 2 diabetes: what can be learned about that disease's pathogenesis." 09/29/2007 - "Congestive heart failure and cardiovascular death in patients with prediabetes and type 2 diabetes given thiazolidinediones: a meta-analysis of randomised clinical trials." 03/01/2008 - "Review: thiazolidinediones increase congestive heart failure but not cardiovascular deaths in prediabetes or type 2 diabetes." 11/01/2009 - "Although prevention of prediabetes is a huge challenge, a tight glycemic control with lifestyle modifications and antihyperglycemics like thiazolidinediones play a vital role in increasing the insulin sensitivity of tissues and decreasing the cardiovascular risk factor of diabetes."
9.	Hypoglycemic Agents (Hypoglycemics)IBA 02/01/2010 - "A number of oral antidiabetic agents have been shown to be effective at delaying onset of T2DM in patients with prediabetes. " 04/01/2012 - "To evaluate the efficacy of oral antidiabetic drugs in promoting regression from prediabetes to normoglycemia. " 04/01/2012 - "Randomized controlled trials 12 weeks or more in duration evaluating any of the oral antidiabetic drugs and studying regression from prediabetes to normoglycemia were included. " 01/01/2015 - "Among 623 patients without diabetes, we classified 303 patients with prediabetes (HbA1c ≥5.7-6.4% [39-47 mmol/mol]) naive to antidiabetic drugs. " 04/01/2012 - "In patients with prediabetes, oral antidiabetic drugs were associated with increased odds of regression to normoglycemia versus placebo/control. "
10.	orlistat (Xenical)FDA Link 11/01/2012 - "Baseline GDF-15 was associated with the risk to have prediabetes or diabetes at 4 years by univariate analysis (odds ratio (OR) FOR 1 unit increase in ln GDF-15, 3.2; 95% confidence interval (CI): 1.7-6.1; P<0.001), and after multivariate adjustment for age, gender, treatment allocation (orlistat vs placebo), BMI, waist-to-hip ratio, and glucose control at baseline (OR 2.2; 95% CI: 1.1-4.7; P=0.026). " 12/01/2014 - "In prediabetes, several well-designed preventive trials have shown that lifestyle and pharmacologic interventions such as metformin, thiazolidinediones (TZD), acarbose and, nateglinide and orlistat, are effective in reducing diabetes development. " 11/01/2005 - "Several drugs having different mechanisms of action, such as metformin, glitazones, acarbose, orlistat, nateglinide, glicazide, angiotensin-converting enzymes, angiotensin receptor blockers have been found to be effective in prediabetes to improve the glycaemic status, though they are still not recommended by any professional organisation."

Therapies and Procedures

1.	Mediterranean Diet 01/01/2015 - "To summarise the evidence about the efficacy of a Mediterranean diet on the management of type 2 diabetes and prediabetic states. " 01/01/2015 - "A systematic review of all meta-analyses and randomised controlled trials (RCTs) that compared the Mediterranean diet with a control diet on the treatment of type 2 diabetes and prediabetic states was conducted. " 01/01/2013 - "Mediterranean diet adherence in individuals with prediabetes and unknown diabetes: the [email protected] Study."
2.	Drug Therapy (Chemotherapy) 12/01/2015 - "Current and Emerging Pharmacotherapies for Weight Management in Prediabetes and Diabetes." 03/15/2015 - "Pharmacotherapy must be used with caution in children with prediabetes. " 03/15/2015 - "The effects of pharmacotherapy of prediabetes on growth and pubertal development in children remains unknown. " 10/01/2014 - "What are the pharmacotherapy options for treating prediabetes?" 04/01/2014 - "For centres using HbA1c to screen for underlying prediabetes/diabetes, these data show that a result >40 mmol/mol identifies women who are likely to require pharmacotherapy. "
3.	Immunomodulation 09/01/2009 - "The data indicate that immunomodulation attained at low levels of allogeneic, but not syngeneic, hematopoietic chimerism is effective in resolution of islet inflammation at even relatively late stages in the evolution of the prediabetic state in a preclinical model. "
4.	Drug Prescriptions 01/01/2014 - "Within 3 years in those who had lost ≥ 1 kg, weight was reduced by 3.9 kg, risk factors were improved, and no case of diabetes had developed, while among those with weight loss of < 1 kg or weight gain, 10% of men and 5% of women had developed diabetes type 2. Screening for prediabetes did not increase the number or costs of drug prescriptions. "
5.	Contraception (Birth Control) 05/01/2013 - "The objective of this review was to synthesize evidence related to interconception care for women following a pregnancy complicated by GDM and to suggest principles of care: 1) case finding and multiple patient/clinician reminders for women with prior GDM are necessary so that screening occurs in the postpartum through interconception periods; 2) monitoring of metabolic (glucose) and cardiovascular risk (lipids, blood pressure, adiposity) should occur at regular intervals and more often in women with additional risk factors such as insulin use during pregnancy, early diagnosis of GDM, obesity, prediabetes, and dyslipidemia; 3) breastfeeding and use of long-term contraception should be encouraged; and 4) lifestyle modifications that are effective in preventing and delaying disease should be encouraged."