Prealbumin (Transthyretin)

A tetrameric protein, molecular weight between 50,000 and 70,000, consisting of 4 equal chains, and migrating on electrophoresis in 3 fractions more mobile than serum albumin. Its concentration ranges from 7 to 33 per cent in the serum, but levels decrease in liver disease.

Also Known As:

Networked: 4971 relevant articles (135 outcomes, 449 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Ando, Yukio: 147 articles (09/2022 - 04/2002)
2.	Ueda, Mitsuharu: 99 articles (09/2022 - 02/2004)
3.	Maurer, Mathew S: 97 articles (12/2022 - 03/2010)
4.	Coelho, Teresa: 63 articles (09/2022 - 03/2004)
5.	Rapezzi, Claudio: 62 articles (11/2022 - 09/2005)
6.	Yamashita, Taro: 59 articles (12/2021 - 02/2002)
7.	Damy, Thibaud: 55 articles (10/2022 - 11/2012)
8.	Suhr, Ole B: 53 articles (01/2022 - 03/2002)
9.	Hawkins, Philip N: 50 articles (01/2022 - 06/2002)
10.	Misumi, Yohei: 49 articles (01/2022 - 12/2008)

Related Diseases

1.	Amyloidosis 02/15/1995 - "Contrary to previous perceptions, there is much recent evidence of effective treatment for several different types of systemic and cardiac amyloidosis, including the most common hereditary form caused by mutations in the transthyretin gene. " 06/17/2020 - "We present a case of left bundle branch pacing in a patient with transthyretin cardiac amyloidosis and infra-Hisian conduction disease with a favorable improvement in cardiac function and stable pacing thresholds. " 10/01/2016 - "Corrigendum: Substoichiometric inhibition of transthyretin misfolding by immune-targeting sparsely populated misfolding intermediates: a potential diagnostic and therapeutic for TTR amyloidoses." 01/01/2016 - "Substoichiometric inhibition of transthyretin misfolding by immune-targeting sparsely populated misfolding intermediates: a potential diagnostic and therapeutic for TTR amyloidoses." 10/01/2021 - "Transthyretin cardiac amyloidosis (ATTR-CA) is increasingly diagnosed owing to the emergence of noninvasive imaging and improved awareness. "
2.	Cardiomyopathies (Cardiomyopathy) 09/01/2020 - "This study sought to investigate whether chronotropic incompetence (CI) and blunted HR recovery would be prevalent in patients with mutant transthyretin (ATTRv) cardiomyopathy.Methods" 12/01/2014 - "The "Wagshurst study": p.Val40Ile transthyretin gene variant causes late-onset cardiomyopathy." 10/11/2023 - "The way to a man's heart: prostate samples for the early detection of transthyretin cardiomyopathy." 10/05/2023 - "Transthyretin cardiomyopathy in Greece." 06/01/2023 - "The amyloidogenic transthyretin (TTR) variant, V122I, occurs in 4% of the African American population and frequently presents as a restricted cardiomyopathy. "
3.	Body Weight (Weight, Body) 01/01/2018 - "The patient's overall condition improved, and transthyretin level and body weight increased. " 05/01/2013 - "The purpose of this study was to test the feasibility of implementing the Eat Right food delivery system and measure its impact on residents' food satisfaction, food intake, and subsequent nutritional status, including serum prealbumin levels and changes in body weight. " 04/10/2023 - "The PDCA cycle can improve body weight, BMI, and serum prealbumin in NPC patients. " 04/10/2023 - "The body weight, BMI, and serum prealbumin in the PDCA group were higher than those in the control group, and the difference was statistically significant (p < 0.05). " 01/01/2022 - "The presence of autophony was associated with lower serum prealbumin levels and lower body weight as measured by percentage of ideal body weight. "
4.	Polyneuropathies (Polyneuropathy) 04/21/2000 - "Comparative studies of two transthyretin variants with protective effects on familial amyloidotic polyneuropathy: TTR R104H and TTR T119M." 08/01/1986 - "We also analysed prealbumin mRNAs in the livers of a disease-free individual and one with familial amyloidotic polyneuropathy and confirmed that there is no difference in the levels and sizes of the prealbumin mRNAs between the two. " 01/01/2010 - "The authors reviewed contribution of Kumamoto University group to the progress of the studies on transthyretin (TTR)-related familial amyloidotic polyneuropathy (TTR-related FAP) for 42 years (from 1967 to 2009). " 10/01/2003 - "Transthyretin familial amyloidotic polyneuropathy: histopathological study of the explanted livers." 09/01/1998 - "To study the alterations in the structure and innervation of eccrine glands in familial amyloidotic polyneuropathy (FAP) type I with Val 30 Met transthyretin mutation. "
5.	Malnutrition (Nutritional Deficiencies) 08/01/1986 - "Statistically significant reduction in prealbumin, C3, C4 and TC were found only in group I. The observations suggest a relationship between immunonutritional status and preparation for large-bowel surgery, reproducing a state of acute malnutrition." 11/01/2003 - "It is useful to incorporate prealbumin and BIA parameters in the regular assessment of PD patients, whose survival may be improved by better management of malnutrition and overall health status." 07/01/2009 - "In conclusion, assessment of prealbumin CRII is useful for early prediction of improved nutritional status in patients with malnutrition." 10/01/2021 - "Laboratory studies, including serum prealbumin level, have been shown to have poor predictive value of malnutrition. " 01/01/2020 - " In the current study we measured prealbumin levels in cirrhotic patients with no clinically apparent malnutrition and used it as a malnutrition marker. "

Related Drugs and Biologics

1.	tafamidis
2.	Amyloid (Amyloid Fibrils)
3.	patisiran
4.	Transferrin (beta 2 Transferrin)
5.	Serum Albumin
6.	Proteins (Proteins, Gene)
7.	Albumins
8.	C-Reactive Protein
9.	Retinol-Binding Proteins (Retinoid Binding Proteins)
10.	Biomarkers (Surrogate Marker)

Related Therapies and Procedures

1.	Therapeutics
2.	Nutritional Support (Artificial Feeding)
3.	Length of Stay
4.	Enteral Nutrition (Feeding, Tube)
5.	Liver Transplantation