Prealbumin (Transthyretin)

A tetrameric protein, molecular weight between 50,000 and 70,000, consisting of 4 equal chains, and migrating on electrophoresis in 3 fractions more mobile than serum albumin. Its concentration ranges from 7 to 33 per cent in the serum, but levels decrease in liver disease.

Also Known As:

Networked: 2435 relevant articles (58 outcomes, 195 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Ando, Yukio: 93 articles (12/2015 - 04/2002)
2.	Suhr, Ole B: 38 articles (12/2015 - 03/2002)
3.	Ueda, Mitsuharu: 36 articles (02/2015 - 02/2004)
4.	Saraiva, Maria João: 34 articles (03/2015 - 11/2002)
5.	Kelly, Jeffery W: 30 articles (01/2015 - 01/2003)
6.	Obayashi, Konen: 29 articles (02/2015 - 01/2005)
7.	Ikeda, Shu-ichi: 27 articles (01/2015 - 03/2002)
8.	Saraiva, M J: 26 articles (12/2014 - 04/2000)
9.	Yamashita, Taro: 26 articles (07/2014 - 02/2002)
10.	Merlini, Giampaolo: 25 articles (12/2015 - 06/2002)

Related Diseases

1.	Amyloidosis 02/15/1995 - "Contrary to previous perceptions, there is much recent evidence of effective treatment for several different types of systemic and cardiac amyloidosis, including the most common hereditary form caused by mutations in the transthyretin gene. " 07/01/2015 - "This entity is especially noteworthy in light of emerging treatment options for hereditary transthyretin amyloidosis, which are likely to also be beneficial in wild-type disease." 08/29/2013 - "Safety and efficacy of RNAi therapy for transthyretin amyloidosis." 01/01/1987 - "Amyloidogenesis in the hereditary form of systemic amyloidosis may involve other factors in addition to the presence of a variant precursor prealbumin as indicated by the delayed onset of the disease. " 11/01/2015 - "Differential Myocyte Responses in Patients with Cardiac Transthyretin Amyloidosis and Light-Chain Amyloidosis: A Cardiac MR Imaging Study."
2.	Body Weight (Weight, Body) 05/01/2013 - "The purpose of this study was to test the feasibility of implementing the Eat Right food delivery system and measure its impact on residents' food satisfaction, food intake, and subsequent nutritional status, including serum prealbumin levels and changes in body weight. " 11/01/2015 - "Mini-Mental Status Examination (MMSE) scores were not associated with the changes in serum prealbumin, body weight, or food intake. " 11/01/2015 - "Serum prealbumin levels and body weight increased post intervention for treatment group residents. " 11/01/2015 - "Outcome measures included food and meal service satisfaction, body weight, serum prealbumin, and food intake. " 12/01/2014 - "All patients were subjected to nutritional screening using GNRI and MNA and measurement of weight, body mass index (BMI), mid arm circumference (MAC), and calf circumference (CC), serum levels of total protein, albumin and prealbumin. "
3.	Malnutrition 08/01/1986 - "Statistically significant reduction in prealbumin, C3, C4 and TC were found only in group I. The observations suggest a relationship between immunonutritional status and preparation for large-bowel surgery, reproducing a state of acute malnutrition." 11/01/2003 - "It is useful to incorporate prealbumin and BIA parameters in the regular assessment of PD patients, whose survival may be improved by better management of malnutrition and overall health status." 07/01/2009 - "In conclusion, assessment of prealbumin CRII is useful for early prediction of improved nutritional status in patients with malnutrition." 07/01/2015 - "Patients at high risk of malnutrition or with low prealbumin levels have shown increased mortality risk and, therefore, a nutritional assessment is mandatory in every SSc patient. " 07/01/2015 - "The presence of malnutrition is indicated by anthropometric and biohumoral changes reflecting protein stores (low serum prealbumin) and influenced by organ involvement in SSc (skin and the gastrointestinal tract). "
4.	Infection 03/01/2014 - "Study includes 20 patients with diagnosis of fascial space infections of odontogenic origin to assess efficacy of serum prealbumin and CRP levels as monitoring tools for determining severity of infections, nutritional status, hospital stay and efficacy of treatment. " 03/01/2014 - "Efficacy of Serum Prealbumin and CRP Levels as Monitoring Tools for Patients with Fascial Space Infections of Odontogenic Origin: A Clinicobiochemical Study." 03/01/2015 - "The current study suggests serum prealbumin levels may be an inexpensive screening biomarker for nutritional status and risk stratification for postoperative infection after spine surgery." 09/01/2015 - "Nine of 32 (28.1%) patients with low preoperative prealbumin levels had postoperative infections compared with 2 of 37 (5.4%) patients with high prealbumin levels (P = .010). " 08/01/2015 - "In surgery patients, low preoperative serum transthyretin (TTR) level is associated with greater rates of infection and mortality. "
5.	Familial Amyloid Neuropathies (Familial Amyloid Polyneuropathy) 01/01/1996 - "We have analysed the structure, binding properties, stability and amyloidogenicity of particular transthyretin (TTR) mutations-TTR Met30 and TTR Pro55, both associated with familial amyloid polyneuropathy, and TTR Met119, a non-pathogenic TTR mutation with apparent protective effects on the amyloidogenicity of the Met30 mutation. " 06/01/2014 - "Literature searches were conducted on the topics of transthyretin, familial amyloid polyneuropathy and clinical trials, using PubMed, the United States clinical trials directory, pharmaceutical company websites and news reports. " 01/01/2014 - "Epidemiology of transthyretin-associated familial amyloid polyneuropathy in the Majorcan area: Son Llàtzer Hospital descriptive study." 02/01/2012 - "The objective of this study was to elucidate the natural history of late-onset transthyretin Val30Met-associated familial amyloid polyneuropathy (FAP ATTR Val30Met) in non-endemic areas. " 12/01/2010 - "The purpose of this study was to evaluate cardiac MRI features in a group of patients with transthyretin familial amyloid polyneuropathy (FAP). "

Related Drugs and Biologics

1.	Transferrin (beta 2 Transferrin)
2.	Serum Albumin
3.	Vitamin A (Retinol)
4.	Carrier Proteins (Binding Protein)
5.	Amyloid (Amyloid Fibrils)
6.	C-Reactive Protein
7.	Prealbumin (Transthyretin)
8.	Biological Markers (Surrogate Marker)
9.	Proteins (Proteins, Gene)
10.	tafamidis

Related Therapies and Procedures

1.	Nutritional Support (Artificial Feeding)
2.	Enteral Nutrition (Feeding, Tube)
3.	Liver Transplantation
4.	Lasers (Laser)
5.	Light Coagulation