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Prazosin (Minipress)

A selective adrenergic alpha-1 antagonist used in the treatment of HEART FAILURE; HYPERTENSION; PHEOCHROMOCYTOMA; RAYNAUD DISEASE; PROSTATIC HYPERTROPHY; and URINARY RETENTION.

Also Known As:

Minipress; Douglas Brand of Prazosin Hydrochloride; Pfizer Brand of Prazosin Hydrochloride; Pratsiol; Prazosin HCL; Prazosin Hydrochloride; HCL, Prazosin; Hydrochloride, Prazosin; Furazosin; Piperazine, 1-(4-amino-6,7-dimethoxy-2-quinazolinyl)-4-(2-furanylcarbonyl)-

Networked: 1512 relevant articles (136 outcomes, 215 trials/studies)

Relationship Network

Drug Context: Research Results

Heterocyclic Compounds: 60
- 2-Ring Heterocyclic Compounds
  - Quinazolines: 29
    - Prazosin: 1512

Experts

1.	Raskind, Murray A: 13 articles (09/2013 - 02/2002)
2.	Peskind, Elaine R: 10 articles (09/2013 - 07/2002)
3.	Rasmussen, Dennis D: 5 articles (08/2015 - 02/2009)
4.	Froehlich, Janice C: 5 articles (08/2015 - 02/2009)
5.	Hoff, David J: 5 articles (09/2013 - 07/2002)
6.	Fuchs, Robert: 4 articles (12/2015 - 10/2009)
7.	Raskind, Murray: 3 articles (05/2015 - 02/2009)
8.	Sadjak, Anton: 3 articles (01/2015 - 10/2009)
9.	Koola, Maju Mathew: 3 articles (02/2014 - 01/2014)
10.	Gross, Christopher: 3 articles (09/2013 - 04/2007)

Related Diseases

1.	Hypertension (High Blood Pressure) 10/01/1990 - "These defects were significantly improved with prazosin treatment, and this may render the compound of particular clinical benefit in the treatment of patients with mild hypertension." 01/05/1987 - "Prazosin therapy alone or in combination with low-dose diuretic therapy was effective in the treatment of hypertension in this elderly population. " 01/01/1982 - "This fact appears to be responsible for the therapeutic success of prazosin and why prazosin is the first alpha-adrenoceptor blocking drug to be effective in the treatment of hypertension. " 01/01/1987 - "According to results of several studies discussed, the alpha 1-adrenoceptor blocking-agent prazosin appears to be a safe and effective therapy, causing a minimum of side effects, for treatment of hypertension in patients with these conditions." 04/02/1977 - "We conducted an uncontrolled study of the efficacy of prazosin in the treatment of hypertension in 45 patients. "
2.	Heart Failure 05/01/1981 - "This study shows sustained clinical improvement in most patients with heart failure treated with oral prazosin." 09/01/1981 - "We report our hemodynamic, clinical, and neuroendocrine observations during long-term (8 weeks) prazosin (PZN) administration to assess the efficacy of this agent in the long-term therapy of congestive heart failure (CHF) and to emphasize the potential role of neuroendocrine mechanisms in the determination of overall drug effect. " 05/01/1982 - "Our results show that prazosin is effective in the treatment of congestive heart failure and radiocardiography is a useful non-invasive procedure in assessing cardiac improvement and in designing the appropriate treatment." 01/01/1980 - "These data suggest that long-term prazosin therapy is effective in the treatment of heart failure. " 01/01/1979 - "It is concluded that prazosin is effective in improving cardiac performance in refractory heart failure for its balanced dilator action on the arteriolar and venous vessels."
3.	Post-Traumatic Stress Disorders (PTSD) 06/01/2005 - "Prazosin appeared highly beneficial for combat-related nightmares characteristic of post-traumatic stress disorder among troops recently returned from Operation Iraqi Freedom. " 09/01/2015 - "Prazosin has been proven to be safe and effective in the management of nightmares and sleep disturbances associated with PTSD and is indicated where these distressing symptoms are present." 02/01/2014 - "We report that high-dose prazosin was safe, tolerable and effective for PTSD in adults. " 02/01/2003 - "Total score and symptom cluster scores for reexperiencing, avoidance/numbing, and hyperarousal on the Clinician-Administered PTSD Scale also were significantly more improved in the prazosin condition, and prazosin was well tolerated. " 02/01/2003 - "The authors' goal was to evaluate prazosin efficacy for nightmares, sleep disturbance, and overall posttraumatic stress disorder (PTSD) in combat veterans. "
4.	Wounds and Injuries (Trauma) 02/01/2000 - "The 2 patients who achieved a daily prazosin dose of at least 5 mg were markedly improved, with complete elimination of trauma nightmares and resumption of normal dreaming. " 03/15/2008 - "Prazosin compared with placebo significantly increased total sleep time by 94 min; increased rapid eye movement (REM) sleep time and mean REM period duration without altering sleep onset latency; significantly reduced trauma-related nightmares, distressed awakenings, and total PCL scores; significantly improved CGI-I scores; and changed PDRS scores toward normal dreaming. " 09/01/2013 - "Prazosin was effective for trauma nightmares, sleep quality, global function, CAPS score, and the CAPS hyperarousal symptom cluster. " 10/01/2010 - "Thirteen soldiers seeking relief from distressing trauma nightmares impairing military function in northern Iraq in 2006 received prazosin alone or in combination with other psychotropics. " 04/15/2007 - "The current parallel group trial in a larger sample of veterans evaluated prazosin effects on trauma nightmares, sleep quality, global clinical status, dream characteristics, and comorbid depression. "
5.	Prostatic Hyperplasia (Benign Prostatic Hyperplasia) 01/01/1990 - "The results suggest prazosin HCl may be effective in small doses in symptomatic treatment of benign prostatic hypertrophy." 01/01/1990 - "Oral prazosin appears to be safe and effective in the long-term treatment of patients with benign prostatic hyperplasia." 01/01/1990 - "The efficacy of prazosin HCl in the treatment of urinary flow obstruction due to prostatic hypertrophy." 08/01/2014 - "The results of the study showed that the simultaneous consumption of Seidlitzia rosmarinus and prazosin, compared to the consumption of prazosin alone, results in significant improvements in the clinical symptoms of benign prostatic hyperplasia." 09/01/1992 - "A series of 93 normotensive patients with benign prostatic hyperplasia and maximum urinary flow rates < 15 ml/s, treated at 2 hospital centres using an identical protocol, was randomly assigned to receive a 12-week course of treatment with prazosin or placebo in a double-blind parallel group trial. "

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4.	Hydrochlorothiazide (Esidrix)
5.	Vasodilator Agents (Vasodilators)
6.	Diuretics
7.	Clonidine (ST 155)
8.	Hydralazine (Apresoline)
9.	Nifedipine (Adalat)
10.	Norepinephrine (Noradrenaline)

Related Therapies and Procedures

1.	Drug Therapy (Chemotherapy)
2.	Ligation
3.	Renal Dialysis (Hemodialysis)
4.	Aftercare (After-Treatment)
5.	Catheters