Prajmaline

A derivative of the rauwolfia alkaloid AJMALINE. It is an anti-arrhythmia agent but may cause liver damage.

Also Known As:

Neo-Gilurytmal; Prajmaline Bitartrate; Prajmalium Bitartrate; Bitartrate, Prajmaline; Bitartrate, Prajmalium; Neo Gilurytmal; NeoGilurytmal; N-Propylajmaline; Prajmalium; Ajmalanium, 17,21-dihydroxy-4-propyl-, (17R,21alpha)-

Networked: 41 relevant articles (1 outcomes, 4 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- Alkaloids: 5398
  - Indole Alkaloids: 200
    - Secologanin Tryptamine Alkaloids: 81
      - Ajmaline: 381
        Prajmaline: 41
- Fused-Ring Heterocyclic Compounds
  - 2-Ring Heterocyclic Compounds
    - Indoles: 200
      - Indole Alkaloids: 200
        Secologanin Tryptamine Alkaloids: 81
        Ajmaline: 381
        Prajmaline: 41
    - Indolizines: 3
      - Indolizidines: 2
        Indole Alkaloids: 200
        Secologanin Tryptamine Alkaloids: 81
        Ajmaline: 381
        Prajmaline: 41

Experts

1.	Piekarska, Anna: 1 article (06/2003)
2.	Fischer, S: 1 article (08/2001)
3.	Kettner, W: 1 article (08/2001)
4.	Reinhold, S: 1 article (08/2001)

Related Diseases

1.	Atrial Fibrillation 08/01/1985 - "The Authors refer on the antiarrhythmic efficacy of quinidine polygalacturonate and prajmalium bitartrate combination for the treatment of refractory recurrent paroxysmal atrial fibrillation, in one patient." 08/01/1985 - "[Combination of quinidine polygalacturonate and prajmalium bitartrate in the prevention of disabling paroxysmal atrial fibrillation. " 12/01/1985 - "In comparison with detajmium, prajmalium, ajmaline, quinidine, lidocaine, disopyramide, propranolol, and Ethmozin the substance GS 015 is tested on the aconitin-induced arrhythmia of the rat, the auricular fibrillation by aconitin of the dog, the ventricular arrhythmia induced by ouabaine of the dog, the arrhythmia caused by calcium chloride of the rat, and the arrhythmia induced by barium chloride of the rabbit. "
2.	Myocardial Infarction 01/01/1981 - "The present study was designed to assess the antiarrhythmic Prajmalium Bitartrate (PB) efficacy in the long term treatment of 22 patients with recent myocardial infarction and persistent, frequent, polimorphous, repetitive (two or more in a row) ventricular premature complexes (VPCs). " 09/01/1983 - "[Evaluation with dynamic electrocardiography of the activity of prajmalium bitartrate in patients with ventricular extrasystole and prior myocardial infarct]." 02/01/1990 - "It is suggested that antiarrhythmic effects of prajmalium bromide in the late stage of experimental myocardial infarction are not related to the influence of the drug on the abnormal automaticity in Purkinje fibers." 02/01/1990 - "The effects of prajmalium bromide on normal and abnormal automaticity were studied in Purkinje fibers from dog hearts at late stages of experimental myocardial infarction. " 05/01/1980 - "Comparison of antiarrhythmic effects of oral prajmalium bitartrate and intravenous lidocaine in acute myocardial infarction."
3.	Ventricular Premature Complexes (Premature Ventricular Contraction) 07/01/1986 - "15 patients with ventricular ectopic beats classified to at least Lown class III with more than 100 ventricular ectopic beats in one hour were treated with N-prajmalium bitartrate (NPAB) in increasing dosages. " 01/01/1981 - "The present study was designed to assess the antiarrhythmic Prajmalium Bitartrate (PB) efficacy in the long term treatment of 22 patients with recent myocardial infarction and persistent, frequent, polimorphous, repetitive (two or more in a row) ventricular premature complexes (VPCs). " 09/01/1983 - "[Evaluation with dynamic electrocardiography of the activity of prajmalium bitartrate in patients with ventricular extrasystole and prior myocardial infarct]." 02/13/1976 - "[Effect of prajmalium bitartrate and procaine amide on ventricular extrasystoles (author's transl)]." 08/15/2001 - "We describe a 56-year-old man in whom oral prajmalium bitartrate therapy previously prescribed for symptomatic ventricular extrasystoles unmasked an electrographic pattern characteristic of a Brugada syndrome. "
4.	Premature Cardiac Complexes (Extrasystoles) 07/01/1986 - "In an open randomized therapeutic study, 20 patients known to have frequent ventricular premature beats (VPB) and/or ventricular pairs (VP) were treated with both 2 X 200 mg flecainide (F) and 4 X 20 mg prajmalium-bitartrate (P) for 3 months each. " 02/13/1976 - "Prajmalium bitartrate (Neo-Gilurytmal) was given to 19 patients, who had either runs of ventricular extrasystoles or frequent extrasystoles. " 01/01/1986 - "Because of recurrent ventricular premature beats in 11 patients after acute ajmaline administration further oral application of prajmalium bitartarate (Neo-Gilurytmal) was necessary. " 01/01/1986 - "[Comparative effectiveness of neogilurytmal, novocainamide, ethmozin, disopyramide and ethacizin in supraventricular extrasystole]."
5.	Stable Angina 01/01/1995 - "40 patients with various type of arrhytmia with stable angina were treated with 3 x 20mg Prajmalin (Neo-Gilurytmal) over 6-day period. " 01/01/1995 - "[Antiarrhythmic effects of prajmaline (Neo-Gilurythmal) in stable angina pectoris in light of Holter electrocardiographic monitoring]." 01/01/1985 - "The safety, tolerability and haemodynamic effects of oral prajmaline bitartrate were assessed in a double-blind, randomized, placebo-controlled, crossover trial in 21 patients with stable angina pectoris and coronary artery disease. "

Related Drugs and Biologics

1.	quinidine polygalacturonate
2.	Lidocaine (Xylocaine)
3.	Flecainide (Tambocor)
4.	Prajmaline
5.	Ajmaline (Wolfina)
6.	Anti-Arrhythmia Agents
7.	Procainamide (Procan)
8.	Disopyramide (Norpace)
9.	Bromides
10.	Moricizine (Moracizine)

Related Therapies and Procedures

1.	Intravenous Administration
2.	Therapeutics