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Prader-Willi Syndrome (Syndrome, Prader-Willi)

An autosomal dominant disorder caused by deletion of the proximal long arm of the paternal chromosome 15 (15q11-q13) or by inheritance of both of the pair of chromosomes 15 from the mother (UNIPARENTAL DISOMY) which are imprinted (GENETIC IMPRINTING) and hence silenced. Clinical manifestations include MENTAL RETARDATION; MUSCULAR HYPOTONIA; HYPERPHAGIA; OBESITY; short stature; HYPOGONADISM; STRABISMUS; and HYPERSOMNOLENCE. (Menkes, Textbook of Child Neurology, 5th ed, p229)
Also Known As:
Syndrome, Prader-Willi; Labhart Willi Syndrome; Labhart-Willi-Prader-Fanconi Syndrome; Prader Labhart Willi Syndrome; Prader-Labhart-Willi Syndrome; Royer's Syndrome; Willi-Prader Syndrome; Labhart Willi Prader Fanconi Syndrome; Prader Willi Syndrome; Royers Syndrome; Syndrome, Labhart-Willi; Syndrome, Labhart-Willi-Prader-Fanconi; Syndrome, Prader-Labhart-Willi; Syndrome, Royer; Syndrome, Royer's; Syndrome, Willi-Prader; Willi Prader Syndrome; Labhart-Willi Syndrome; Royer Syndrome
Networked: 1152 relevant articles (35 outcomes, 115 trials/studies)

Relationship Network

Disease Context: Research Results

Related Diseases

1. Obesity
2. Disorders of Excessive Somnolence (Hypersomnia)
3. Morbid Obesity
4. Hyperphagia (Overeating)
5. Sleep Apnea Syndromes (Sleep Apnea)

Experts

1. Butler, Merlin G: 41 articles (06/2022 - 06/2003)
2. Grugni, Graziano: 31 articles (03/2022 - 10/2004)
3. Driscoll, Daniel J: 26 articles (05/2022 - 06/2002)
4. Hokken-Koelega, Anita C S: 23 articles (04/2022 - 04/2009)
5. Crinò, Antonino: 21 articles (03/2022 - 12/2008)
6. Wevrick, Rachel: 20 articles (01/2020 - 03/2003)
7. Miller, Jennifer L: 17 articles (05/2022 - 05/2009)
8. Grugni, G: 17 articles (10/2021 - 04/2000)
9. Höybye, Charlotte: 17 articles (05/2021 - 05/2003)
10. Haqq, Andrea M: 17 articles (03/2021 - 01/2003)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Prader-Willi Syndrome:
1. Growth Hormone (Somatotropin)IBA
2. Human Growth Hormone (Saizen)FDA LinkGeneric
3. Oxytocin (Pitocin)FDA LinkGeneric
4. Gonadal Steroid Hormones (Sex Hormones)IBA
5. Modafinil (Provigil)FDA Link
6. semaglutideIBA
7. Selective Serotonin Reuptake Inhibitors (Serotonin Reuptake Inhibitors)IBA
8. Glucagon-Like Peptide 1 (GLP 1)IBA
9. Brain-Derived Neurotrophic Factor (BDNF)IBA
10. CarbohydratesIBA

Therapies and Procedures

1. Therapeutics
2. Glycemic Control
3. Vagus Nerve Stimulation
4. Gastrectomy
5. Resistance Training