Potassium Cyanide

A highly poisonous compound that is an inhibitor of many metabolic processes, but has been shown to be an especially potent inhibitor of heme enzymes and hemeproteins. It is used in many industrial processes.

Also Known As:

Networked: 148 relevant articles (4 outcomes, 7 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Petrikovics, Ilona: 2 articles (10/2012 - 12/2011)
2.	Martin, Sarah: 2 articles (10/2012 - 12/2011)
3.	Schultz, Harold D: 2 articles (04/2010 - 09/2005)
4.	Machado, Benedito H: 2 articles (06/2007 - 05/2002)
5.	Bonagamba, Leni G H: 2 articles (06/2007 - 05/2002)
6.	Ikeya, Yukinobu: 2 articles (03/2007 - 07/2004)
7.	Aburada, Masaki: 2 articles (03/2007 - 07/2004)
8.	Yamaguchi, Takuji: 2 articles (03/2007 - 07/2004)
9.	Menani, José V: 2 articles (05/2006 - 10/2004)
10.	Colombari, Eduardo: 2 articles (05/2006 - 10/2004)

Related Diseases

1.	Anoxia (Hypoxia) 01/01/1964 - "[ELECTROENCEPHALOGRAPHIC AND ELECTROCARDIOGRAPHIC STUDY, IN THE AWAKE RABBIT, OF HISTOTOXIC ANOXIA INDUCED BY POTASSIUM CYANIDE. " 05/31/2002 - "Although intravenous (iv) injection of potassium cyanide (KCN) activates the arterial chemoreflex, it has been questioned whether cytotoxic hypoxia reproduces a physiological stimulus such as hypoxic hypoxia (low inspired O2 tension). " 05/31/2002 - "Cardiovascular responses to chemoreflex activation with potassium cyanide or hypoxic hypoxia in awake rats." 08/01/2001 - "Using confocal microscopy, we investigated mechanisms underlying loss of plasma membrane integrity during necrotic death of cultured hepatic sinusoidal endothelial cells exposed to 2.5 mM potassium cyanide (chemical hypoxia). " 04/01/2001 - "Finally, compound 5 (and, to a minor extent, compound 13) protected mice against potassium cyanide induced hypoxia."
2.	Ischemia 06/01/1988 - "The average gasping duration in complete ischemia and survival time in potassium cyanide injection of control mice were 21.0 +/- 0.1 and 26.1 +/- 0.4 sec (mean +/- SEM), respectively. " 03/12/1984 - "Intraperitoneal sublethal potassium cyanide doses induce strong and reversible changes in high-energy phosphate compounds in the brain, similar in part to those induced by ischemia. " 08/01/2003 - "However, when cells were pre-exposed to potassium cyanide on the preceding day (chemical preconditioning), the sequestration induced by either isoproterenol or chemical/metabolic ischemia was attenuated. " 08/01/2003 - "Similarly, treatment of cells with potassium cyanide and 2-deoxy-D-glucose (chemical/metabolic ischemia) induced similar receptor sequestration. " 05/18/1999 - "Ischemia was induced by potassium cyanide/deoxyglucose, and permeability was measured by albumin flux. "
3.	Poisoning 06/01/2002 - "Protective efficacy of graded doses of alpha-KG (p.o.) as pretreatment, simultaneous treatment or post-treatment was evaluated against acute potassium cyanide (KCN) poisoning (p.o.) in female rats. " 01/01/1952 - "[Studies on potassium cyanide poisoning with the help of a test-spot method]." 12/01/1994 - "Passive mechanical properties of carotid arteries were measured in situ in the presence or the absence of smooth muscle cell activity (potassium cyanide poisoning). " 03/01/1994 - "The poisoning has been caused by intravenous potassium cyanide, 1 mg/kg. The aqueous solution of the complex was added the same to cyanide in doses of 40 and 80 mg/kg. The poison and antidote effects were controlled by bioelectrical tests of the brain and heart. " 05/01/1993 - "Because the AKBR changes in relation to electron transport in liver mitochondria, it seems to be a logical parameter for evaluating the effect of potassium cyanide poisoning on electron transport. "
4.	Brain Ischemia (Cerebral Ischemia) 10/01/2007 - "Yimucao injection significantly lowered the cerebral index of mice with cerebral ischemia, prolonged the survival time of mice poisoned with potassium cyanide, resulting also in significantly decreased MDA content and increased activities of SOD and LDH in the brain tissue of rats after a 10-min cerebral ischemia followed by 30 min of reperfusion. " 09/01/2014 - "The flavonoids from the stems and leaves of Scutellaria baicalensis Georgi were originally found to have a polyhydric structure and to protect against cerebral hypoxia in in vitro and in vivo models, including hypoxia induced by potassium cyanide or cerebral ischemia. " 06/01/1988 - "The cerebral protective effects of minaprine were examined using the following methods, i.e., complete ischemia by decapitation in mice, histotoxic anoxia by potassium cyanide (KCN) in mice, hypobaric hypoxia in mice, asphyxic anoxia in normal rats and cerebral ischemia induced by bilateral carotid artery occlusion (BCAO) in strokeprone spontaneously hypertensive rats (SHR-SP). " 10/01/2007 - "Mouse models of cerebral ischemia induced by bilateral carotid artery occlusion or potassium cyanide and rat models of middle cerebral artery occlusion (MCAO)-induced cerebral ischemia/reperfusion injury were established to evaluate the protective effect of Yimucao injection by measuring the changes in cerebral malondialdehyde (MDA) content and the activities of superoxide dismutase (SOD) and lactate dehydrogenase (LDH) after the injections. "
5.	Decapitation 06/01/1988 - "The cerebral protective effects of minaprine were examined using the following methods, i.e., complete ischemia by decapitation in mice, histotoxic anoxia by potassium cyanide (KCN) in mice, hypobaric hypoxia in mice, asphyxic anoxia in normal rats and cerebral ischemia induced by bilateral carotid artery occlusion (BCAO) in strokeprone spontaneously hypertensive rats (SHR-SP). "

Related Drugs and Biologics

1.	2-(nitrooxy)ethyl apovincaminate
2.	apovincaminic acid
3.	minaprine (Cantor)
4.	Melatonin
5.	Nitroprusside (Sodium Nitroprusside)
6.	Paraquat
7.	Thioctic Acid (Lipoic Acid)
8.	Kainic Acid (Kainate)
9.	arginine thiazolidinecarboxylate (ATCA)
10.	Deoxyglucose (2 Deoxy D glucose)

Related Therapies and Procedures

1.	Subcutaneous Injections
2.	Injections
3.	Intraperitoneal Injections
4.	Intravenous Injections
5.	Euthanasia (Mercy Killing)