Postpericardiotomy Syndrome

A nonspecific hypersensitivity reaction caused by TRAUMA to the PERICARDIUM, often following PERICARDIOTOMY. It is characterized by PERICARDIAL EFFUSION; high titers of anti-heart antibodies; low-grade FEVER; LETHARGY; loss of APPETITE; or ABDOMINAL PAIN.

Also Known As:

Networked: 69 relevant articles (7 outcomes, 6 trials/studies)

Relationship Network

Disease Context: Research Results

Related Diseases

1.	Pericardial Effusion
2.	Atrial Fibrillation
3.	Pleural Effusion (Pleural Effusions)
4.	Pericarditis
5.	Cardiac Tamponade

Experts

1.	Imazio, Massimo: 9 articles (12/2014 - 09/2005)
2.	Adler, Yehuda: 5 articles (09/2014 - 12/2002)
3.	Spodick, David H: 4 articles (02/2015 - 11/2011)
4.	Belli, Riccardo: 4 articles (09/2014 - 09/2005)
5.	Trinchero, Rita: 4 articles (11/2011 - 09/2005)
6.	Cemin, Roberto: 3 articles (09/2014 - 11/2011)
7.	Brucato, Antonio: 3 articles (09/2014 - 11/2011)
8.	Finkelstein, Yaron: 3 articles (09/2014 - 12/2002)
9.	Ferrazzi, Paolo: 3 articles (09/2014 - 11/2011)
10.	COPPS Investigators: 3 articles (11/2011 - 10/2007)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Postpericardiotomy Syndrome:

1.	ColchicineFDA LinkGeneric 12/01/2010 - "Colchicine as an effective treatment for postpericardiotomy syndrome following a lung lobectomy." 06/01/2011 - "To review literature regarding the safety and efficacy of colchicine for the primary prevention of the postpericardiotomy syndrome (PPS). " 12/01/2007 - "Rationale and design of the COPPS trial: a randomised, placebo-controlled, multicentre study on the use of colchicine for the primary prevention of postpericardiotomy syndrome." 10/01/2007 - "Colchicine for the prevention of the postpericardiotomy syndrome: the COPPS trial." 09/10/2014 - "The primary end point of postpericardiotomy syndrome occurred in 35 patients (19.4%) assigned to colchicine and in 53 (29.4%) assigned to placebo (absolute difference, 10.0%; 95% CI, 1.1%-18.7%; number needed to treat = 10). "
2.	Indomethacin (Indometacin)FDA LinkGeneric 09/01/1995 - "A diagnosis of postpericardiotomy syndrome was made, and the patient improved while receiving oral indomethacin. " 05/01/1978 - "Natural history, relationship to postpericardiotomy syndrome, and a prospective study of therapy with indomethacin versus placebo." 09/01/1990 - "Two of the five with right atrial catheters experienced a postpericardiotomy syndrome (fever, pericardial rub, and pulmonary infiltrates) that responded promptly to indomethacin. " 08/01/1990 - "The results of this study demonstrate that both ibuprofen and indomethacin provide safe and effective symptomatic treatment for postpericardiotomy syndrome." 08/01/1990 - "The present study was designed to evaluate the effectiveness of nonsteroidal antiinflammatory drugs (NSAIDs) in the treatment of postpericardiotomy syndrome, in a double-blind, placebo-controlled randomized trial with a 10-day course of ibuprofen or indomethacin. "
3.	Adrenal Cortex Hormones (Corticosteroids)IBA 03/01/1994 - "The objective of this study was to assess the efficacy of corticosteroids in hastening the recovery of children with postpericardiotomy syndrome, using a randomized double-blind placebo-controlled trial in a tertiary care referral center for pediatric cardiology and cardiac surgery. " 10/01/1984 - "Following the administration of corticosteroids for presumed postpericardiotomy syndrome, both patients improved symptomatically and defervesced, only to have positive blood cultures for Staphylococcus epidermidis shortly thereafter. " 03/01/1994 - "Double-blind placebo-controlled trial of corticosteroids in children with postpericardiotomy syndrome." 05/01/2013 - "Corticosteroids are a second choice for difficult cases requiring multi-drug therapies and specific medical conditions (i.e., specific cases with systemic autoimmune diseases, postpericardiotomy syndrome, and pregnancy). "
4.	Ibuprofen (Motrin)FDA LinkGeneric 08/01/1990 - "The results of this study demonstrate that both ibuprofen and indomethacin provide safe and effective symptomatic treatment for postpericardiotomy syndrome." 08/01/1990 - "The present study was designed to evaluate the effectiveness of nonsteroidal antiinflammatory drugs (NSAIDs) in the treatment of postpericardiotomy syndrome, in a double-blind, placebo-controlled randomized trial with a 10-day course of ibuprofen or indomethacin. "
5.	Methotrexate (Mexate)FDA LinkGeneric 04/01/2003 - "Methotrexate in recurrent postpericardiotomy syndrome." 04/01/2003 - "We describe a rare case of chronic postpericardiotomy syndrome, with recurrent pericardial effusions and steroid dependency, that was treated successfully with a low weekly dose of methotrexate."
6.	Non-Steroidal Anti-Inflammatory Agents (NSAIDs)IBA 08/01/1990 - "The present study was designed to evaluate the effectiveness of nonsteroidal antiinflammatory drugs (NSAIDs) in the treatment of postpericardiotomy syndrome, in a double-blind, placebo-controlled randomized trial with a 10-day course of ibuprofen or indomethacin. " 12/01/2014 - "The research was then redefined adding separately the keywords postpericardiotomy syndrome, NSAIDs, steroids and colchicine. "
7.	AntibodiesIBA 07/01/2002 - "To assess the role of anti-heart antibodies (AHA) in postpericardiotomy syndrome (PPS) and the timing of their appearance in relation to the initial manifestations of PPS. " 07/01/2002 - "Anti-heart antibodies in postpericardiotomy syndrome: cause or epiphenomenon? " 01/01/1992 - "Antiheart antibodies following open heart surgery: incidence and correlation with postpericardiotomy syndrome." 03/01/1974 - "The Postpericardiotomy syndrome and antiheart antibodies." 02/01/1973 - "Circulating heart-reactive antibodies in the postpericardiotomy syndrome."
8.	SteroidsIBA 11/01/2004 - "Suspecting postpericardiotomy syndrome, systemic steroids were administered, and the symptoms resolved without affecting wound healing. " 06/01/2003 - "This is the first report of postpericardiotomy syndrome after the Nuss procedure treated with systemic steroids." 11/01/2004 - "Manifestation of a pericardial effusion combined with bilateral pleural effusion after MIRPE, especially in patients after cardiac surgery, may indicate a postpericardiotomy syndrome that can be treated successfully by intravenous steroids." 12/01/2014 - "The research was then redefined adding separately the keywords postpericardiotomy syndrome, NSAIDs, steroids and colchicine. "
9.	Aspirin (Acetylsalicylic Acid)FDA LinkGeneric 12/01/1994 - "The delayed presentation (3 weeks postoperatively) and associated findings in the 10 year old were typical of postpericardiotomy syndrome, and he had an uneventful recovery after a course of aspirin therapy. " 11/01/2009 - "The effect of short-term prophylactic acetylsalicylic acid on the incidence of postpericardiotomy syndrome after surgical closure of atrial septal defects." 09/27/2005 - "A total of 120 patients (mean age 56.9+/-18.8 years, 54 males) with a first episode of acute pericarditis (idiopathic, viral, postpericardiotomy syndromes, and connective tissue diseases) were randomly assigned to conventional treatment with aspirin (group I) or conventional treatment plus colchicine 1.0 to 2.0 mg for the first day and then 0.5 to 1.0 mg/d for 3 months (group II). "
10.	Anticardiolipin AntibodiesIBA 11/01/1994 - "The significance of anticardiolipin antibodies and anti-heart muscle antibodies for the diagnosis of postpericardiotomy syndrome." 11/01/1992 - "No association was found between these antibodies, including anticardiolipin antibodies, and the occurrence of postpericardiotomy syndrome."

Therapies and Procedures

1.	Pericardiectomy 07/01/2012 - "Two cases of postpericardiotomy syndrome (PPS) after thymothymectomy associated with pericardiotomy are described. " 04/01/2001 - "Repeated postpericardiotomy syndrome following a temporary transvenous pacemaker insertion, a permanent transvenous pacemaker insertion and surgical pericardiotomy." 07/01/1985 - "Postoperative complications consisted of pulmonary problems in four patients (two after pericardiectomy and two after extensive pericardiectomy), cardiac arrhythmia in one patient after tube drainage and postpericardiotomy syndrome in one patient after extensive pericardiectomy. " 10/01/1980 - "To define the relationship between postpericardiotomy syndrome and pericardial effusion, we performed four to seven serial echocardiograms (echoes) between postoperative day 0 and postoperative day 10 in 40 children who had operation requiring pericardiotomy. " 05/01/1974 - "Chronic pericardial effusion requiring pericardiectomy in the postpericardiotomy syndrome."
2.	Cardiopulmonary Bypass (Heart-Lung Bypass) 11/01/1992 - "Autoantibody production after cardiopulmonary bypass with special reference to postpericardiotomy syndrome." 10/01/2007 - "Surgical closure of ventricular septal defect is safe, however, the inherent risks associated with cardiopulmonary bypass and the potential early and late postsurgical complications including complete heart block, arrhythmias, postpericardiotomy syndrome, and rare deaths have led physicians to prefer transcatheter occlusion technique for closure of such defects. " 01/01/2001 - "Cardiovascular surgery with cardiopulmonary bypass (CPB) can lead to postoperative complications like postpericardiotomy syndrome (PPS), capillary leak syndrome, or multiple organ failure. " 01/01/2010 - "GC therapy has been studied in non-autoimmune and non-inflammatory indications such as acute myocardial infarction, angina, postpericardiotomy syndrome and other pericardial diseases, endocarditis and cardiac amyloidosis, as well as in invasive cardiology, coronary interventions, and cardiopulmonary-bypass surgery. " 05/01/2001 - "The effect of short-term prophylactic methylprednisolone on the incidence and severity of postpericardiotomy syndrome in children undergoing cardiac surgery with cardiopulmonary bypass."
3.	Coronary Artery Bypass (Coronary Artery Bypass Surgery) 09/01/1998 - "Postpericardiotomy syndrome following minimally invasive coronary artery bypass." 01/01/1997 - "Because of its atypical late appearance, a case of a 65 year old man is presented who developed a postpericardiotomy syndrome and subsequently a pericardial clot nearly two years after aortocoronary bypass grafting." 05/01/1981 - "However, none had postpericardiotomy syndrome complicating coronary artery bypass surgery. " 05/01/1988 - "Postpericardiotomy syndrome has been recognized as a frequent complication following coronary artery bypass graft (CABG) surgery. "
4.	Catheters 06/05/2007 - "The most common major adverse events for the HSO group was device embolization requiring catheter retreival (1.7%), and in the surgery group was postpericardiotomy syndrome (6.3%), including one death because of tamponade. " 09/01/1990 - "Two of the five with right atrial catheters experienced a postpericardiotomy syndrome (fever, pericardial rub, and pulmonary infiltrates) that responded promptly to indomethacin. "
5.	Transplants (Transplant) 05/01/1988 - "Postpericardiotomy syndrome has been recognized as a frequent complication following coronary artery bypass graft (CABG) surgery. " 06/01/2015 - "We also outline a structured approach to evaluation and present an overview of diagnostic and management considerations for mediastinitis, postpericardiotomy syndrome, prosthetic valve endocarditis, aortic vascular graft infections, and ventricular assist device infections. "