Postpericardiotomy Syndrome

A nonspecific hypersensitivity reaction caused by TRAUMA to the PERICARDIUM, often following PERICARDIOTOMY. It is characterized by PERICARDIAL EFFUSION; high titers of anti-heart antibodies; low-grade FEVER; LETHARGY; loss of APPETITE; or ABDOMINAL PAIN.

Also Known As:

Networked: 89 relevant articles (7 outcomes, 10 trials/studies)

Relationship Network

Disease Context: Research Results

Related Diseases

1.	Pericardial Effusion
2.	Atrial Fibrillation
3.	Pericarditis
4.	Coronary Artery Disease (Coronary Atherosclerosis)
5.	Pleural Effusion (Pleural Effusions)

Experts

1.	Imazio, Massimo: 11 articles (01/2018 - 09/2005)
2.	Adler, Yehuda: 5 articles (09/2014 - 12/2002)
3.	Brucato, Antonio: 4 articles (01/2018 - 11/2011)
4.	Spodick, David H: 4 articles (02/2015 - 11/2011)
5.	Belli, Riccardo: 4 articles (09/2014 - 09/2005)
6.	Trinchero, Rita: 4 articles (11/2011 - 09/2005)
7.	Cemin, Roberto: 3 articles (09/2014 - 11/2011)
8.	Ferrazzi, Paolo: 3 articles (09/2014 - 11/2011)
9.	Finkelstein, Yaron: 3 articles (09/2014 - 12/2002)
10.	COPPS Investigators: 3 articles (11/2011 - 10/2007)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Postpericardiotomy Syndrome:

1.	ColchicineFDA LinkGeneric 12/01/2010 - "Colchicine as an effective treatment for postpericardiotomy syndrome following a lung lobectomy." 06/01/2011 - "To review literature regarding the safety and efficacy of colchicine for the primary prevention of the postpericardiotomy syndrome (PPS). " 12/01/2007 - "Rationale and design of the COPPS trial: a randomised, placebo-controlled, multicentre study on the use of colchicine for the primary prevention of postpericardiotomy syndrome." 10/01/2007 - "Colchicine for the prevention of the postpericardiotomy syndrome: the COPPS trial." 09/10/2014 - "The primary end point of postpericardiotomy syndrome occurred in 35 patients (19.4%) assigned to colchicine and in 53 (29.4%) assigned to placebo (absolute difference, 10.0%; 95% CI, 1.1%-18.7%; number needed to treat = 10). "
2.	Indomethacin (Indometacin)FDA LinkGeneric 09/01/1995 - "A diagnosis of postpericardiotomy syndrome was made, and the patient improved while receiving oral indomethacin. " 05/01/1978 - "Natural history, relationship to postpericardiotomy syndrome, and a prospective study of therapy with indomethacin versus placebo." 09/01/1990 - "Two of the five with right atrial catheters experienced a postpericardiotomy syndrome (fever, pericardial rub, and pulmonary infiltrates) that responded promptly to indomethacin. " 08/01/1990 - "The results of this study demonstrate that both ibuprofen and indomethacin provide safe and effective symptomatic treatment for postpericardiotomy syndrome." 08/01/1990 - "The present study was designed to evaluate the effectiveness of nonsteroidal antiinflammatory drugs (NSAIDs) in the treatment of postpericardiotomy syndrome, in a double-blind, placebo-controlled randomized trial with a 10-day course of ibuprofen or indomethacin. "
3.	Adrenal Cortex Hormones (Corticosteroids)IBA 03/01/1994 - "The objective of this study was to assess the efficacy of corticosteroids in hastening the recovery of children with postpericardiotomy syndrome, using a randomized double-blind placebo-controlled trial in a tertiary care referral center for pediatric cardiology and cardiac surgery. " 10/01/1984 - "Following the administration of corticosteroids for presumed postpericardiotomy syndrome, both patients improved symptomatically and defervesced, only to have positive blood cultures for Staphylococcus epidermidis shortly thereafter. " 03/01/1994 - "Double-blind placebo-controlled trial of corticosteroids in children with postpericardiotomy syndrome." 05/01/2013 - "Corticosteroids are a second choice for difficult cases requiring multi-drug therapies and specific medical conditions (i.e., specific cases with systemic autoimmune diseases, postpericardiotomy syndrome, and pregnancy). "
4.	Ibuprofen (Motrin)FDA LinkGeneric 08/01/1990 - "The results of this study demonstrate that both ibuprofen and indomethacin provide safe and effective symptomatic treatment for postpericardiotomy syndrome." 08/01/1990 - "The present study was designed to evaluate the effectiveness of nonsteroidal antiinflammatory drugs (NSAIDs) in the treatment of postpericardiotomy syndrome, in a double-blind, placebo-controlled randomized trial with a 10-day course of ibuprofen or indomethacin. "
5.	SteroidsIBA 11/01/2004 - "Suspecting postpericardiotomy syndrome, systemic steroids were administered, and the symptoms resolved without affecting wound healing. " 06/01/2003 - "This is the first report of postpericardiotomy syndrome after the Nuss procedure treated with systemic steroids." 05/01/1981 - "Six patients (three in each group) had a postpericardiotomy syndrome that required steroid treatment and prolonged hospitalization for 10 more days. " 11/01/2004 - "Manifestation of a pericardial effusion combined with bilateral pleural effusion after MIRPE, especially in patients after cardiac surgery, may indicate a postpericardiotomy syndrome that can be treated successfully by intravenous steroids." 03/01/2008 - "We describe a patient with chronic postpericardiotomy syndrome and steroid dependency who was successfully treated by single administration of high-dose intravenous immunoglobulin."
6.	Methotrexate (Mexate)FDA LinkGeneric 04/01/2003 - "Methotrexate in recurrent postpericardiotomy syndrome." 04/01/2003 - "We describe a rare case of chronic postpericardiotomy syndrome, with recurrent pericardial effusions and steroid dependency, that was treated successfully with a low weekly dose of methotrexate."
7.	Non-Steroidal Anti-Inflammatory Agents (NSAIDs)IBA 01/01/2017 - "Our final diagnosis was postpericardiotomy syndrome after extended pneumonectomy and further treatment with nonsteroidal anti-inflammatory drugs (NSAIDs) was recommended. " 08/01/1990 - "The present study was designed to evaluate the effectiveness of nonsteroidal antiinflammatory drugs (NSAIDs) in the treatment of postpericardiotomy syndrome, in a double-blind, placebo-controlled randomized trial with a 10-day course of ibuprofen or indomethacin. " 12/01/2014 - "The research was then redefined adding separately the keywords postpericardiotomy syndrome, NSAIDs, steroids and colchicine. " 05/03/2021 - "Aim    To compare features of the disease course and the effectiveness of nonsteroidal anti-inflammatory drug (NSAID) treatment of postpericardiotomy syndrome (PPS) in patients after coronary bypass (CB) surgery who were treated with antiplatelet drugs and in patients after surgical correction of heart valve disease (CHVD) who received the anticoagulant warfarin for prevention of thrombotic complications. Material and methods    This study included 89 patients of whom 53 patients had underwent CB and 36 patients had underwent CHVD. "
8.	AnticoagulantsIBA 01/01/1987 - "Possible etiological factors included anticoagulant therapy (19 patients), excessive mediastinal drainage in the postoperative period (10 patients), postpericardiotomy syndrome (4 patients), and coagulation disorders (1 patient). " 06/01/1981 - "Late cardiac tamponade after open heart surgery: incidence, role of anticoagulants in its pathogenesis and its relationship to the postpericardiotomy syndrome." 05/03/2021 - "Aim    To compare features of the disease course and the effectiveness of nonsteroidal anti-inflammatory drug (NSAID) treatment of postpericardiotomy syndrome (PPS) in patients after coronary bypass (CB) surgery who were treated with antiplatelet drugs and in patients after surgical correction of heart valve disease (CHVD) who received the anticoagulant warfarin for prevention of thrombotic complications. Material and methods    This study included 89 patients of whom 53 patients had underwent CB and 36 patients had underwent CHVD. "
9.	Warfarin (Coumadin)FDA LinkGeneric 07/01/2003 - "Serial echocardiographic monitoring up to 28 days postoperatively is indicated in selected high risk patients such as those with symptoms of postpericardiotomy syndrome and those given warfarin." 05/03/2021 - "Aim    To compare features of the disease course and the effectiveness of nonsteroidal anti-inflammatory drug (NSAID) treatment of postpericardiotomy syndrome (PPS) in patients after coronary bypass (CB) surgery who were treated with antiplatelet drugs and in patients after surgical correction of heart valve disease (CHVD) who received the anticoagulant warfarin for prevention of thrombotic complications. Material and methods    This study included 89 patients of whom 53 patients had underwent CB and 36 patients had underwent CHVD. "
10.	Platelet Aggregation Inhibitors (Antiplatelet Drugs)IBA 05/03/2021 - "Aim    To compare features of the disease course and the effectiveness of nonsteroidal anti-inflammatory drug (NSAID) treatment of postpericardiotomy syndrome (PPS) in patients after coronary bypass (CB) surgery who were treated with antiplatelet drugs and in patients after surgical correction of heart valve disease (CHVD) who received the anticoagulant warfarin for prevention of thrombotic complications. Material and methods    This study included 89 patients of whom 53 patients had underwent CB and 36 patients had underwent CHVD. "

Therapies and Procedures

1.	Therapeutics 05/03/2021 - "Peculiarity of clinical course of postpericardiotomy syndrome in different methods of surgery and postoperative antithrombotic therapy." 05/01/1988 - "Three patients had postpericardiotomy syndrome, and 4 had recurrent atrial fibrillation requiring therapy. " 04/01/1985 - "Two patients resolved their problems (postpericardiotomy syndrome, late pericarditis) with medical therapy. " 03/01/1983 - "Cardiac tamponade is a rare complication of the postpericardiotomy syndrome in the absence of anticoagulation therapy. " 01/01/2010 - "GC therapy has been studied in non-autoimmune and non-inflammatory indications such as acute myocardial infarction, angina, postpericardiotomy syndrome and other pericardial diseases, endocarditis and cardiac amyloidosis, as well as in invasive cardiology, coronary interventions, and cardiopulmonary-bypass surgery. "
2.	Pericardiectomy 07/01/2012 - "Two cases of postpericardiotomy syndrome (PPS) after thymothymectomy associated with pericardiotomy are described. " 04/01/2001 - "Repeated postpericardiotomy syndrome following a temporary transvenous pacemaker insertion, a permanent transvenous pacemaker insertion and surgical pericardiotomy." 07/01/1985 - "Postoperative complications consisted of pulmonary problems in four patients (two after pericardiectomy and two after extensive pericardiectomy), cardiac arrhythmia in one patient after tube drainage and postpericardiotomy syndrome in one patient after extensive pericardiectomy. " 10/01/1980 - "To define the relationship between postpericardiotomy syndrome and pericardial effusion, we performed four to seven serial echocardiograms (echoes) between postoperative day 0 and postoperative day 10 in 40 children who had operation requiring pericardiotomy. " 05/01/1974 - "Chronic pericardial effusion requiring pericardiectomy in the postpericardiotomy syndrome."
3.	Percutaneous Coronary Intervention 01/01/2022 - "It is considered standard-of-care therapy for pericarditis, and several clinical trials have evaluated its role in postoperative and postablation atrial fibrillation, postpericardiotomy syndrome, coronary artery disease, percutaneous coronary interventions, and cerebrovascular disease. "
4.	Cardiopulmonary Bypass (Heart-Lung Bypass) 10/01/2007 - "Surgical closure of ventricular septal defect is safe, however, the inherent risks associated with cardiopulmonary bypass and the potential early and late postsurgical complications including complete heart block, arrhythmias, postpericardiotomy syndrome, and rare deaths have led physicians to prefer transcatheter occlusion technique for closure of such defects. " 01/01/2001 - "Cardiovascular surgery with cardiopulmonary bypass (CPB) can lead to postoperative complications like postpericardiotomy syndrome (PPS), capillary leak syndrome, or multiple organ failure. " 01/01/2010 - "GC therapy has been studied in non-autoimmune and non-inflammatory indications such as acute myocardial infarction, angina, postpericardiotomy syndrome and other pericardial diseases, endocarditis and cardiac amyloidosis, as well as in invasive cardiology, coronary interventions, and cardiopulmonary-bypass surgery. " 05/01/2001 - "The effect of short-term prophylactic methylprednisolone on the incidence and severity of postpericardiotomy syndrome in children undergoing cardiac surgery with cardiopulmonary bypass." 11/01/1992 - "Autoantibody production after cardiopulmonary bypass with special reference to postpericardiotomy syndrome."
5.	Coronary Artery Bypass (Coronary Artery Bypass Surgery) 09/01/1998 - "Postpericardiotomy syndrome following minimally invasive coronary artery bypass." 01/01/1997 - "Because of its atypical late appearance, a case of a 65 year old man is presented who developed a postpericardiotomy syndrome and subsequently a pericardial clot nearly two years after aortocoronary bypass grafting." 05/01/1988 - "Postpericardiotomy syndrome has been recognized as a frequent complication following coronary artery bypass graft (CABG) surgery. " 05/01/1981 - "However, none had postpericardiotomy syndrome complicating coronary artery bypass surgery. "