Porphobilinogen

12/01/2008 - "Improved identification of acute porphyria requires heightened clinical awareness and access to urinary porphobilinogen measurement. "
07/01/2000 - "The goal of this study was evaluate 300 psychiatric patients and 150 control subjects to detect acute intermittent porphyria by measurement of porphobilinogen (PBG) deaminase activity in blood. "
05/01/1997 - "Molecular analysis of porphobilinogen (PBG) deaminase gene mutations in acute intermittent porphyria: first study in patients of Slavic origin."
09/01/2011 - "Demonstration of substantially increased urinary excretion of porphobilinogen is the cornerstone of diagnosing acute porphyria crisis. "
08/15/2011 - "Accurate determinations of 5-aminolevulinic acid (ALA) and porphobilinogen (PBG) in physiologic fluids are required for the diagnosis and therapeutic monitoring of acute porphyrias. "

09/01/2011 - "The aim of this study was to critically describe and to evaluate a semi-quantitative rapid test for urinary porphobilinogen determination which is commercially available and recommended by the American Porphyria Foundation. "
09/01/2015 - "Once suspected, the diagnosis of porphyria can be rapidly established by checking random urinary porphobilinogen. "
09/01/2001 - "Measurement of porphobilinogen (PBG) is useful in the diagnosis of the acute neurologic porphyrias. "
03/01/1996 - "Porphyria has been associated with an increase in plasma levels of 5-aminolevulinic acid and porphobilinogen. "
03/01/1992 - "Postoperatively urinary porphobilinogen excretion (625 mumol.day-1) exceeded the upper limit of normal but no symptoms of porphyria developed. "

10/01/1996 - "Simple screening tests, urinary porphobilinogen (PBG) for acute intermittent porphyria (AIP) and fecal coproporphyrin for hereditary coproporphyria (HCP), were performed in a family study of AIP and HCP. "
01/01/2006 - "Summary A Caucasian male had symptoms of acute porphyria, with increases in urinary delta-aminolaevulinic acid (ALA), porphobilinogen (PBG) and coproporphyrin that were consistent with hereditary coproporphyria (HCP). "
08/01/2000 - "Especially, we measured the coproporphyrin isomers I and III. The group of hereditary coproporphyria patients exhibited a significantly higher (p<0.0001) excretion of urinary porphyrin precursors, delta-aminolevulinic acid (median = 84 micromol/24 h) and porphobilinogen (median = 39 micromol/24 h), as compared to controls (delta-aminolevulinic acid: 22 micromol/24 h, porphobilinogen: 3 micromol/24 h; median, n = 20). "
02/01/2008 - "Large increases of urinary porphobilinogen (PBG) indicate acute porphyria, which may be due to acute intermittent porphyria, variegate porphyria, or hereditary coproporphyria. "
12/01/1979 - "As a consequence of this secondary control, there is excessive excretion of the porphyrin precursors delta-aminolaevulinic acid and porphobilinogen in the acute porphyrias and excessive excretion of porphyrins leading to solar photosensitivity in the non-acute porphyrias and in variegate and hereditary coproporphyria. "

02/01/1972 - "In iron-deficiency anaemia the excretion of both porphobilinogen and delta-aminolevulinic acid was increased, whereas in patients with rheumatoid arthritis only the porphobilinogen excretion was increased.A further study on the erythrocyte activity of delta-aminolevulinic acid dehydrase showed a higher activity in the erythrocytes from patients with rheumatoid arthritis compared with healthy controls."

01/01/1983 - "The laboratory findings were consistent with hemolytic anemia and the study of porphyrin metabolism revealed very significant increases in the urinary excretion of uroporphyrin and coproporphyrin, while the urinary excretion of delta aminolevulinic and porphobilinogen were normal."