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Polysorbates (PSML)

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Sorbitan mono-9-octadecanoate poly(oxy-1,2-ethanediyl) derivatives; complex mixtures of polyoxyethylene ethers used as emulsifiers or dispersing agents in pharmaceuticals.

Also Known As:

PSML; Polysorbate 80; Polysorbate 20; Tweens; Tween 20; Tween 80; Polyoxyethylene Sorbitan Monolaurate; Tween 60; Tween 81; Tween 85; 20, Polysorbate; 20, Tween; 60, Tween; 80, Polysorbate; 80, Tween; 81, Tween; 85, Tween; Derivatives, Sorbitan; Monolaurate, Polyoxyethylene Sorbitan; Sorbitan Monolaurate, Polyoxyethylene; Sorbitan Derivatives

Networked: 359 relevant articles (15 outcomes, 30 trials/studies)

Relationship Network

Drug Context: Research Results

Experts

1.	Hattori, Yoshiyuki: 7 articles (01/2015 - 07/2007)
2.	Banerjee, Anirban: 6 articles (10/2015 - 09/2006)
3.	Moore, Ernest E: 6 articles (10/2015 - 09/2006)
4.	Maitani, Yoshie: 5 articles (02/2013 - 07/2007)
5.	Zhao, Zi-Gang: 3 articles (06/2015 - 07/2013)
6.	Niu, Chun-Yu: 3 articles (06/2015 - 07/2013)
7.	Fujii, Nobutaka: 3 articles (01/2015 - 01/2013)
8.	Ohno, Hiroaki: 3 articles (01/2015 - 01/2013)
9.	Kreuter, Jörg: 3 articles (08/2011 - 02/2006)
10.	Cushing, Daniel J: 3 articles (10/2009 - 04/2009)

Related Diseases

1.	Neoplasms (Cancer) 12/07/2013 - "The in vitro study showed that these Tween [email protected] complexes could efficiently produce (1)O2 to kill cancer cells under 980 nm NIR excitation. " 01/01/1991 - "These findings resulted in studies to explain the previous observation that Tween 80 (polyoxyethylenesorbitan monooleate) has anticancer activity in the SJL/J tumor system. " 01/01/2015 - "Starting from the day immediately after AOM treatment, three groups of rats were orally administered once a day for 2 months either 10% Tween 20 (5 mL/kg, cancer control), DECPR (250 mg/kg, low dose), or DECPR (500 mg/kg, high dose). " 01/01/2014 - "The higher pharmacokinetic parameters for rectally administered DCT/P407/P188/Tween 80/NaTC (0.25%/11%/15%/10%/0.1% by weight, respectively) resulted in significant anti-tumor efficacy. " 10/01/2012 - "The in vivo antitumor experiment on A549-xenograft tumor model showed that VAAP dispersed in Tween 80 or loaded in PEG-PCL nanoparticles had long blood circulation times and thereby high accumulation in tumors and exerted a significant in vivo inhibitory effect on tumor growth with low systemic toxicity. "
2.	Hemolysis 01/01/2014 - "In vitro and in vivo evaluation revealed that PSO had exceptionally low hemolysis and histamine release rates compared with commercial polysorbate 80. " 04/01/2010 - "To establish kinetic assay method for the analysis of hemolysis and to investigate dynamic hemolytic process of polysorbate 80. " 12/01/1998 - "Hemolysis testing as an in vitro assay indicated that LCC was safer than Polysorbate 80 (TO-10M) as intravenous surfactant in terms of induction of membrane damage. " 12/01/1984 - "Tween 20 hemolysis values were negatively correlated with RBC tocopherol levels in kids. " 05/20/2003 - "The hemolysis test of PEtOz-PCL performed in vitro indicated that the toxicity of PEtOz-PCLs to lipid membrane was not significant compared with Tween 80, and was comparable to that observed with Cremophore EL. "
3.	Leukemia 12/01/2012 - "These results suggest that Polysorbate 80 stabilized LDC-NPs can be explored for treatment of meningeal leukemia owing to their ability of providing sustained drug release, stability and improved cytotoxicity in leukemic EL-4 cell line." 08/01/2011 - "These results suggest that polysorbate 80 coated Cyt-NLC can be explored for treatment of meningeal leukemia owing to their ability of sustained drug release and improved cytotoxic effect in leukemic EL-4 cell line." 08/01/2011 - "Therefore, nanostructured lipid carriers (NLC) were prepared and coated with polysorbate 80 to overcome the blood brain barrier for achieving effective treatment of meningeal leukemia. " 01/01/1978 - "The antitumor activity and toxicity of N-trifluoroacetyladriamycin-14-valerate (AD 32) dissolved in 10% Tween 80 in distilled water were compared to those of adriamycin dissolved in distilled water in 10% Tween 80 in distilled water, in mice bearing L1210 leukemia, P388 leukemia, Gross leukemia, and solid Sarcoma 180. " 04/30/1978 - "The dilution of adriamycin in a 10% water solution of Tween 80 produced a significant increase of the antitumor activity in mice against ascites tumors (L 1210 leukemia), disseminated leukemias (transplanted leukemias originally induced by Gross leukemai virus and Moloney leukemia virus), and solid tumors (Sarcoma 180, MS-2 sarcoma). "
4.	Infection 08/09/2005 - "In the presence of 0.01 % Tween 80 as an emulsifier, TTO treatments at concentrations between 3 and 30 ppmv (parts per million by volume) lowered the prevalence and significantly reduced the parasite burden of sticklebacks naturally infected with Gyrodactylus spp. In addition, Tween 80 alone exhibited parasiticidal activity against Gyrodactylus spp. These findings show the potential of TTO in combination with Tween 80 as an effective treatment of Gyrodactylus spp. infection of fishes." 01/01/2012 - "Ultrasonography and histopathological examination of hamsters was performed at week 0, 20, 24 and 28 of OV infection or at the start of water/Tween-80 administration to controls. " 12/20/2006 - "Lice exposed to the Tween 80 only in vitro, showed high levels of survival and zero infection. " 12/20/2006 - "anisopliae formulated in 0.03% Tween 80 developed infections; at the highest concentration (1x10(8)conidia ml-1) a mean of 71% (+/-11.52%, 95% C.I.) of lice became infected. " 11/15/1997 - "All three cases of PSML were detected by imaging studies performed in routine follow-up of cases of chronic liver disease associated with HCV infection. "
5.	Shock 12/01/2006 - "Studies have focused on the toxic mediators that develop in the post-shock mesenteric lymph (PSML). " 01/01/2014 - "Western blotting revealed that the expressions of the RhoA and phospho-RhoA in SMA tissue obtained from the shock group were significantly decreased, and the PSML drainage markedly enhanced these protein expressions. " 09/01/2006 - "We hypothesize that the relative bioactivity of PSML depends on the depth and duration of circulatory shock. " 09/01/2006 - "PSML flow depends on depth of shock, but not duration of shock or resuscitation volume. " 07/01/2013 - "Vascular hyporeactivity is an important factor in irreversible shock, and post-shock mesenteric lymph (PSML) blockade improves vascular reactivity after hemorrhagic shock. "

Related Drugs and Biologics

1.	Vitamin E
2.	Dithiothreitol (Cleland's Reagent)
3.	Polysorbates (PSML)
4.	Cyanoacrylates
5.	Poloxamer (Poloxamer 407)
6.	Calcium
7.	Scopolamine (Hyoscine)
8.	Nerve Growth Factor (NGF)
9.	1- Methyl- 4- phenyl- 1,2,3,6- tetrahydropyridine (MPTP)
10.	Small Interfering RNA (siRNA)

Related Therapies and Procedures

1.	Dye Lasers
2.	Intravenous Injections
3.	Heterologous Transplantation (Xenotransplantation)
4.	Intravenous Infusions
5.	Injections