Polyradiculoneuropathy (Polyradiculoneuritis)

Diseases characterized by injury or dysfunction involving multiple peripheral nerves and nerve roots. The process may primarily affect myelin or nerve axons. Two of the more common demyelinating forms are acute inflammatory polyradiculopathy (GUILLAIN-BARRE SYNDROME) and POLYRADICULONEUROPATHY, CHRONIC INFLAMMATORY DEMYELINATING. Polyradiculoneuritis refers to inflammation of multiple peripheral nerves and spinal nerve roots.

Also Known As:

Networked: 218 relevant articles (11 outcomes, 12 trials/studies)

Relationship Network

Disease Context: Research Results

Related Diseases

1.	Infection
2.	Pain (Aches)
3.	Demyelinating Diseases (Demyelinating Disease)
4.	Papilledema
5.	Monoclonal Gammopathy of Undetermined Significance

Experts

1.	Dispenzieri, Angela: 7 articles (10/2015 - 07/2011)
2.	Tracy, Jennifer A: 3 articles (03/2015 - 06/2010)
3.	Dyck, P James B: 3 articles (06/2011 - 01/2010)
4.	Kusunoki, Susumu: 2 articles (04/2013 - 01/2009)
5.	Matiasek, Kaspar: 2 articles (03/2013 - 09/2012)
6.	Viala, K: 2 articles (06/2011 - 12/2006)
7.	Lynfield, Ruth: 2 articles (01/2010 - 10/2009)
8.	Amoura, Z: 2 articles (05/2003 - 08/2001)
9.	Delattre, J Y: 2 articles (05/2003 - 08/2001)
10.	Benyahia, B: 2 articles (05/2003 - 08/2001)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Polyradiculoneuropathy:

1.	Immunoglobulins (Immunoglobulin)IBA 03/01/2006 - "Neurophysiological examinations suggested demyelinating polyradiculoneuropathy, which improved dramatically after high-dose intravenous immunoglobulin treatment. " 01/01/2009 - "Intravenous immunoglobulin treatment successfully improved subacute progressive polyradiculoneuropathy with polyclonal gammopathy." 01/01/1996 - "Prolonged remission of SLE-associated polyradiculoneuropathy after a single course of intravenous immunoglobulin." 09/01/2012 - "Clinical course of acute canine polyradiculoneuritis following treatment with human IV immunoglobulin." 12/01/2006 - "These dysimmune processes can result in various neuropathies, such as inflammatory demyelinating polyradiculoneuropathy, or neuropathies secondary to the secretion of a monoclonal immunoglobulin. "
2.	Immunoglobulin G (IgG)IBA 01/01/2009 - "Based on his progressive disease course, elevated serum IgG, nerve conduction study and enhanced MRI findings, we diagnosed him as suffering from immune-mediated subacute polyradiculoneuropathy with polyclonal gammopathy, which might be related to Guillain-Barré syndrome. " 11/01/1989 - "The aim of the study was to check the hypothesis of involvement of the structure of the central nervous system on the basis of the analysis of the integrity of blood-brain barrier and the degree of IgG synthesis in the intrathecal space of patients with inflammatory demyelinization polyradiculoneuropathy. " 06/01/2011 - "Auto-immune polyradiculoneuropathy and a novel IgG biomarker in workers exposed to aerosolized porcine brain." 04/01/2004 - "Case 1: a 53 year old female with predominantly sensory sensory motor demyelinating polyradiculoneuropathy, associated to IgG lambda MGUS. " 01/01/1995 - "A previously healthy 43 year-old female developed IgG lambda monoclonal gammopathy of undetermined significance (MGUS) and ascending sensorimotor polyradiculoneuropathy which relapsed 11 times within 2 years. "
3.	SteroidsIBA 01/01/1989 - "The results provide experimental evidence supporting the trial of high dose steroids in human demyelinating polyradiculoneuropathy." 06/01/2013 - "The polyradiculoneuropathy as well as the papilledema and elevated cerebrospinal fluid (CSF) pressure improved under steroids. " 09/01/2000 - "Chronic inflammatory demyelinating polyradiculoneuropathy responds to steroids but a variant multifocal motor neuropathy and the acute forms of inflammatory demyelinating polyradiculoneuropathy do not. "
4.	Prednisone (Sone)FDA LinkGeneric 04/01/1982 - "Neurologic improvement with use of prednisone, in some cases on several occasions, was demonstrated in seven patients who had a chronic progressive polyradiculoneuropathy with nerve conduction velocity and electromyographic findings consistent with segmental demyelination and axonal degeneration and increases protein concentration in the cerebrospinal fluid. "
5.	Carmustine (FIVB)FDA Link 01/01/1995 - "The close temporal correlation between clinical relapse and recurrence of the IgG paraprotein and its permanent absence in stable clinical remission after carmustine treatment suggest a causal relationship between the paraprotein and the polyradiculoneuropathy. " 01/01/1995 - "Chronic relapsing polyradiculoneuropathy in IgG lambda monoclonal gammopathy of undetermined significance (MGUS)--complete remission following carmustine treatment."
6.	AntibodiesIBA 10/01/1999 - "Clinicopathological study of an autopsy case with sensory-dominant polyradiculoneuropathy with antiganglioside antibodies." 09/01/2013 - "A case of severe chronic progressive axonal polyradiculoneuropathy temporally associated with anti-CV2/CRMP5 antibodies." 03/01/2013 - "Anti-GM2 ganglioside antibodies are a biomarker for acute canine polyradiculoneuritis." 05/01/2003 - "Another patient with SLE and a clinical picture of demyelinating polyradiculoneuropathy had anti-Hu antibodies. " 01/01/1992 - "Guillain-Barré acute primary polyradiculoneuritis has come to be associated with chronic and recurrent forms and, more recently, with multifocal demyelinating neuropathy with persistent conduction blocks and antibodies to GM1. "
7.	Intravenous Immunoglobulins (IVIG)FDA Link 07/16/2012 - "[Painful diabetic polyradiculoneuropathy: treatment with intravenous immunoglobulins]." 01/01/2012 - "Neurological diseases, including autoimmune neuromuscular disorders such as acute and chronic polyradiculoneuropathies and multifocal motor neuropathy, are the main indications of intravenous immunoglobulins. " 10/01/2011 - "Chronic inflammatory demyelynating polyradiculoneuropathy in childhood and response to IVIg." 02/01/2006 - "We report 4 cases of a characteristic severe extensive eczematous reaction that occurred approximately 10 days after IVIG infusion for polyradiculoneuritis. " 01/01/1999 - "IVIG indications in SLE could be categorized as already validated as for chronic polyradiculoneuropathy or thrombocytopenia; failure of classical treatment in threatening active disease; undetermined manifestation as reactive hemophagocytic syndrome which could be both disease-specific or iatrogenic, infection-related. "
8.	Immunoglobulin M (IgM)IBA 04/01/2004 - "Case 2: a 65 year old female with demyelinating sensory motor polyradiculoneuropathy associated to IgM kappa MGUS. " 08/01/1985 - "Antibody to glycolipid in a patient with IgM paraproteinemia and polyradiculoneuropathy." 05/01/1996 - "Idiopathic polyradiculoneuropathies had different electrophysiologic features than polyneuropathies associated with IgM monoclonal gammopathy and anti-MAG activity, these later presenting more distal and homogeneous abnormalities." 01/01/2006 - "Acute and chronic polyradiculoneuritis are characterized by diffuse and multifocal, but predominantly proximal lesions, multifocal motor and sensory-motor neuropathies with persistent conduction blocks are restricted to some nerve trunks, while neuropathies due to monoclonal IgM with anti-MAG (Myelin Associated Glycoprotein) activity show distal and symmetric distribution. " 10/01/1995 - "Neuropathologic findings at autopsy showed an "inflammatory demyelinating polyradiculoneuropathy" in the motor cranial nerves and motor roots of peripheral nerves, an extensive deposition of IgG and focal accumulations of IgM in the peripheral nerve motor roots, and loss of motor neurons. "
9.	Adrenal Cortex Hormones (Corticosteroids)IBA 09/01/1995 - "In the treatment of chronic polyradiculoneuritis corticosteroids do have a place. " 05/01/1982 - "[Acute polyradiculoneuritis treated with corticosteroids]." 01/01/1979 - "[Corticosteroids in polyradiculoneuritis therapy in childhood]." 05/01/1966 - "[Treatment of post-diphtheric polyradiculoneuritis by corticoids]." 01/01/1992 - "[The therapy of severe forms of acute polyradiculoneuritis: corticosteroids, plasmapheresis or their combination?]."
10.	AntigensIBA 10/21/1972 - "[Inflammatory polyradiculoneuritis and cellular immunity: study of the cellular immune response towards peripheral nerve antigens by the leukocyte migration test]." 06/01/2011 - "We postulate that this outbreak is an auto-immune polyradiculoneuropathy triggered by occupational exposure to multiple aerosolized porcine neural tissue antigens that result in neural damage where the blood-nerve barrier is the least robust." 09/01/1989 - "T lymphocyte activation antigens in Guillain-Barré syndrome and chronic idiopathic demyelinating polyradiculoneuropathy." 04/01/2005 - "Therefore our results suggest the hypothesis that the polyradiculoneuritis causative etiopathogenetic mechanism might be a delayed immunological response to wasp antigens followed by an allergy-triggered autoimmune reaction, as previously suggested by other authors; they found lymphocytic infiltrates in demyelinization areas and at perivascular levels, by histologic examination of autoptical and bioptical material of patients with nervous system lesions after hymenoptera stings." 06/01/1998 - "The different clinical cases illustrate several aspects of late borreliosis: false negative serology due to narrow antigen composition of the used ELISA format, the need for prolonged antibiotic treatment in chronic or recurrent forms and typical presentations of late Lyme disease, such as lymphocytic meningo-encephalitis and polyradiculoneuritis."

Therapies and Procedures

1.	Plasma Exchange 11/01/1998 - "Comparative study of efficacy of plasma exchange versus intravenous gammaglobulin treatment on acute postinfectious polyradiculoneuropathy: a preliminary report." 02/01/1994 - "Plasma exchange procedures can be used in pregnant women and the results of this treatment are similar to those in patients presenting with polyradiculoneuritis alone." 01/01/1988 - "The neurologic lesion in the first case was due to a cytomegalovirus, and plasma exchange appeared to provide additional benefits (to antiviral treatment) during the first attack of polyradiculoneuritis. " 01/01/1986 - "[Corticotherapy and plasma exchange in myasthenia and polyradiculoneuritis]." 09/01/1984 - "report the results obtained with Plasma Exchange (P.E.) therapy on 24 cases of polyradiculoneuritis; eleven patients had typical Guillain-Barré Syndrome (G.B.S.) ten suffered from a chronic progressive form and three were affected by a relapsing form. "
2.	Plasmapheresis 01/01/1992 - "A comparative examination was made of 62 patients with acute polyradiculoneuritis using hormonal therapy (HT), plasmapheresis (PA), their combination (HTPA) and maintenance therapy (MT). " 01/01/1991 - "In recent years, plasmapheresis has become a well established treatment of acute and chronic polyradiculoneuritis (Guillain-Barré syndrome, GBS). " 01/01/1990 - "[Use of plasmapheresis in the treatment of Guillain-Barre acute polyradiculoneuritis]." 01/01/1990 - "[Plasmapheresis in the complex treatment of polyradiculoneuritis in children]." 01/01/1988 - "[Intensive plasmapheresis in the treatment of acute polyradiculoneuritis]."
3.	Tonsillectomy 10/01/1948 - "Albumino-cytological dissociation within the cerebrospinal fluid in a patient with polyradiculoneuritis cured after tonsillectomy."
4.	Hypnosis (Mesmerism) 01/01/1992 - "The use of hypnosis for pain relief for patients with polyradiculoneuritis."
5.	Kidney Transplantation 06/04/1994 - "We observed two characteristic cases with acute polyradiculoneuropathy which occurred after renal transplantation. " 04/01/2004 - "Plasma exchange for polyradiculoneuropathy following kidney transplantation: a case report." 04/01/2004 - "We describe a case of polyradiculoneuropathy (PRN) following living donor kidney transplantation, without clinical evidence of preexisting infection. " 01/01/1993 - "We report our experience in 11 patients in a situation of therapeutic failure including three cases of renal transplantation, two cases each of chronic polyradiculoneuritis and neurological paraneoplastic syndromes, and one case each of Wegener's syndrome, polymyositis, sclerokeratitis, and antiphospholipid antibodies during pregnancy. " 10/01/2012 - "Twenty months before renal transplantation the patient received pulse doses of corticosteroids, together with immunoglobulins and plasmapheresis, for the treatment of an acute polyradiculoneuritis Guillaine Barré. "