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Polyradiculopathy (Cauda Equina Syndrome)

Subscribe to New Research on Polyradiculopathy

Disease or injury involving multiple SPINAL NERVE ROOTS. Polyradiculitis refers to inflammation of multiple spinal nerve roots.

Also Known As:

Cauda Equina Syndrome; Abdominal Polyradiculopathies; Abdominal Polyradiculopathy; Cauda Equina Syndromes; Polyradiculitides; Polyradiculopathies; Polyradiculopathies, Abdominal; Syndrome, Cauda Equina; Syndromes, Cauda Equina; Polyradiculitis; Polyradiculopathy, Abdominal

Networked: 330 relevant articles (15 outcomes, 12 trials/studies)

Relationship Network

Disease Context: Research Results

Nervous System Diseases: 6158
- Neuromuscular Diseases: 1068
  - Peripheral Nervous System Diseases: 5557
    - Polyneuropathies: 3436
      - Polyradiculoneuropathy: 218
        Polyradiculopathy: 330

Related Diseases

1.	Encephalitis (Encephalitis, Rasmussen)
2.	Pain (Aches)
3.	Ankylosing Spondylitis
4.	Acquired Immunodeficiency Syndrome (AIDS)
5.	Cysts

Experts

1.	Marsala, M: 3 articles (01/2003 - 01/2000)
2.	Kafka, J: 3 articles (01/2003 - 01/2000)
3.	Marsala, J: 3 articles (01/2003 - 01/2000)
4.	Singh, Gurpreet: 2 articles (07/2015 - 01/2013)
5.	Fukuta, Shoji: 2 articles (01/2015 - 09/2008)
6.	Radcliff, Kristen E: 2 articles (02/2014 - 12/2013)
7.	Xing, Shunming: 2 articles (01/2014 - 01/2013)
8.	Chen, Dechun: 2 articles (01/2014 - 01/2013)
9.	Shen, Lianbing: 2 articles (01/2014 - 01/2013)
10.	Tan, Junming: 2 articles (01/2014 - 01/2013)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Polyradiculopathy:

1.	Ganciclovir (Cytovene)FDA LinkGeneric 07/01/1993 - "We review the literature and describe two patients with CMV polyradiculopathy whose conditions improved only after prolonged therapy with ganciclovir. " 08/01/1994 - "Cytomegalovirus polyradiculopathy caused by a ganciclovir-resistant strain." 11/01/1993 - "Cytomegalovirus polyradiculopathy caused by a ganciclovir-resistant strain." 07/01/1993 - "Once initiated, ganciclovir should be administered indefinitely to patients with CMV polyradiculopathy." 01/30/1993 - "[Lumbosacral polyradiculitis caused by cytomegalovirus in a patient with AIDS who responded well to gancyclovir]."
2.	Foscarnet FDA LinkGeneric 05/01/1996 - "Cytomegalovirus polyradiculopathy treated successfully with foscarnet." 07/01/2013 - "Here, we report a case of CMV polyradiculopathy 6 months after renal transplantation that presented as a Guillain-Barre like syndrome and was successfully treated with foscarnet. " 06/01/1994 - "Polyradiculopathy due to cytomegalovirus infection: report of a case in which an AIDS patient responded to foscarnet therapy." 03/01/1999 - "Ganciclovir and foscarnet have improved the prognosis of multifocal neuropathy and polyradiculopathy, but response rates for encephalitis are low. " 01/01/1998 - "Ganciclovir and foscarnet efficacy in AIDS-related CMV polyradiculopathy."
3.	DNA (Deoxyribonucleic Acid)IBA 01/01/1995 - "Of the 14 patients with > 1,000 copies/microliters of HCMV DNA in CSF, 11(79%) had HCMV polyradiculopathy including all 3 with > 10,000 copies/microliters. " 08/01/1997 - "Nine (90%) of 10 patients with polyradiculopathy and follow-up CSF culture showed a drop in CMV DNA after treatment; however, only 2 (20%) improved clinically. " 03/01/1999 - "The diagnostic approach relies on the detection of CMV DNA in the cerebrospinal fluid for polyradiculopathy, encephalitis, and neuropathy. " 04/01/1997 - "CMV DNA was detected in CSF of five of seven patients with CMV encephalitis and in two of two with CMV associated polyradiculopathy but without CMV encephalitis. " 01/01/1995 - "These data indicate that quantities of HCMV DNA in CSF are higher in persons with HCMV-related polyradiculopathy than encephalitis, and that quantitation of HCMV DNA can be useful in monitoring antiviral therapy."
4.	Intravenous Immunoglobulins (IVIG)FDA Link 07/01/2004 - "Recently, intravenous immunoglobulins have been found to produce dramatic improvement in both clinical and electrophysiological parameters in patients with diabetic polyradiculopathy." 01/01/2013 - "He was diagnosed with diabetic polyradiculopathy with diaphragmatic involvement and was started on intravenous immunoglobulin (IVIg) therapy. "
5.	infliximab (Remicade)FDA Link 06/01/2009 - "Dramatic efficacy of infliximab in cauda equina syndrome complicating ankylosing spondylitis." 11/01/2013 - "We report the clinical, electrophysiological, and pathological findings of a patient with subacute sensory polyradiculopathy 1 month after infliximab therapy for psoriasis vulgaris. " 11/01/2013 - "This is the first reported case of sensory polyradiculopathy with positive anti-ganglioside antibodies following infliximab therapy. " 11/01/2013 - "Successful treatment of infliximab-associated immune-mediated sensory polyradiculopathy with intravenous immunoglobulin."
6.	Pentoxifylline (Trental)FDA LinkGeneric 12/15/2008 - "Two patients with progressive worsening RI lumbosacral polyradiculopathy experienced over several years a significant clinical improvement in their neurological sensorimotor symptoms with long-term pentoxifylline-tocopherol-clodronate treatment, and good safety." 12/15/2008 - "Significant clinical improvement in radiation-induced lumbosacral polyradiculopathy by a treatment combining pentoxifylline, tocopherol, and clodronate (Pentoclo)."
7.	Clodronic Acid (Clodronate)IBA 12/15/2008 - "Two patients with progressive worsening RI lumbosacral polyradiculopathy experienced over several years a significant clinical improvement in their neurological sensorimotor symptoms with long-term pentoxifylline-tocopherol-clodronate treatment, and good safety." 12/15/2008 - "Significant clinical improvement in radiation-induced lumbosacral polyradiculopathy by a treatment combining pentoxifylline, tocopherol, and clodronate (Pentoclo)."
8.	Acyclovir (Aciclovir)FDA LinkGeneric 05/01/2002 - "Initially, coma and CSF pleocytosis improved with acyclovir treatment, but brain stem encephalitis, transverse myelitis, and lumbosacral polyradiculitis subsequently occurred. "
9.	Lidocaine (Xylocaine)FDA LinkGeneric 02/01/2014 - "The present study provides the basis for understanding and evaluating the effect of Rg1 in the in vivo treatment of lidocaine-induced transient neurological symptoms and cauda equina syndrome by lidocaine." 02/01/2014 - "However, studies have shown that lidocaine may induce transient neurological symptoms and cauda equina syndrome. " 09/01/2003 - "Concern about the use of spinal lidocaine began in 1991 with published reports of cauda equina syndrome after continuous spinal anaesthesia. " 09/01/2000 - "Furthermore, there are seven cases of cauda equina syndrome following single-shot hyperbaric lidocaine. " 04/01/1999 - "Cauda equina syndrome after spinal anaesthesia with hyperbaric 5% lignocaine: a review of six cases of cauda equina syndrome reported to the Swedish Pharmaceutical Insurance 1993-1997."
10.	Adrenocorticotropic Hormone (ACTH)FDA Link 11/01/1959 - "[The necessity of very high doses of ACTH in desperate cases of polyradiculitis Guillain-Barre]." 04/24/1954 - "[Treatment of polyradiculitis Guillain-Barré with corticotropin (ACTH)]." 01/01/1995 - "To our knowledge, this represents the first case of an adrenocorticotropic hormone-producing pituitary carcinoma presenting with the cauda equina syndrome. " 01/01/1995 - "ACTH-producing pituitary carcinoma presenting as the cauda equina syndrome." 10/01/2014 - "This study describes a rare case of the drop metastasis of adrenocorticotropic hormone-producing pituitary adenocarcinoma to the cauda equina, causing cauda equina syndrome. "

Therapies and Procedures

1.	Decompression 02/01/2014 - "Efficacy of delayed decompression of lumbar disk herniation causing cauda equina syndrome." 01/01/2014 - "Patients with cauda equina syndrome generally need emergency decompression to pelvic visceral function, especially that of the urinary bladder. " 10/01/2013 - "We present a case of rapid accumulation of edematous adipose tissue causing cauda equina syndrome after a lumbar decompression and fusion surgery. " 10/01/2013 - "The patient's cauda equina syndrome resolved after spinal decompression and the removal of epidural fat. " 06/01/2012 - "We present a case of a 28-year-old woman who sustained an H-type fracture of the sacrum with complete cauda equina syndrome treated with cauda equina decompression and pelvic percutaneous stabilization with an iliosacral screw. "
2.	Laminectomy 09/01/1999 - "Among those, the initial clinical presentation and the level of the lesion (60% of the patients with cauda equina syndrome and 53% of that with lesions in the lombar region improved their neurological status after laminectomy) were the most important factors affecting the outcome. " 01/01/2014 - "The patient developed acute cauda equina syndrome and required an emergent decompressive laminectomy resulting in partial resolution of neurological symptoms. " 06/01/2008 - "Cauda equina syndrome results from an injury to the lumbosacral nerve roots below the tip of the conus medullaris, occuring in between 2 and 6% of all laminectomies performed for lumbar disc herniation. " 01/01/1990 - "[Cauda equina syndrome due to early postoperative migration of an adipose tissue flap following laminectomy]." 04/01/1985 - "The second patient developed acute cauda equina syndrome, and, despite emergency laminectomy, had permanent neurologic sequelae. "
3.	Drug Therapy (Chemotherapy) 03/01/1992 - "Specific chemotherapy was followed by both clinical improvement of the polyradiculopathy and complete remission on a second bone-marrow biopsy. " 11/01/2009 - "Treatment consisted of chemotherapy alone, one patient have had a cauda equina syndrome and surgical decompression was performed in emergency. " 06/01/2013 - "A case of the cauda equina syndrome associated with the intrathecal chemotherapy in a patient with primary central nervous system lymphoma." 04/15/2008 - "We report a case of a 30-year-old man diagnosed with acute lymphoblastic leukaemia who developed subacute anterior lumbosacral polyradiculopathy following intrathecal methotrexate, an unusual complication of intrathecal chemotherapy in adults. "
4.	Radiotherapy 01/01/2007 - "Clinical symptoms such as cranial nerve dysfunction or a cauda equina syndrome can be treated with local radiotherapy. " 02/01/1988 - "The patient, with cauda equina syndrome, was treated by partial resection and post-operative radiotherapy and remains well 12 months after treatment." 10/01/2012 - "Effective radiotherapy cured cauda equina syndrome caused by remitted intracranial germinoma depositing."
5.	Aftercare (After-Treatment) 02/01/1988 - "The patient, with cauda equina syndrome, was treated by partial resection and post-operative radiotherapy and remains well 12 months after treatment." 08/01/1997 - "Nine (90%) of 10 patients with polyradiculopathy and follow-up CSF culture showed a drop in CMV DNA after treatment; however, only 2 (20%) improved clinically. " 03/01/1990 - "The 2nd patient developed syphilitic polyradiculopathy and a positive CSF VDRL 3 months after treatment with IV penicillin. "