Polyphosphates

01/01/2023 - "A growing number of studies have shown that soluble toxic factor(s) in the ACM cause non-cell autonomous MN death, including our recent identification of inorganic polyphosphate (polyP) that is excessively released from mouse primary astrocytes (SOD1, TARDBP, and C9ORF72) and human induced pluripotent stem cells (iPSC)-derived astrocytes (TARDBP) to kill MNs. "
01/01/2022 - "Mitochondrial Inorganic Polyphosphate (polyP) Is a Potent Regulator of Mammalian Bioenergetics in SH-SY5Y Cells: A Proteomics and Metabolomics Study."
06/14/2021 - "Polyphosphate (PolyP) for alveolar cleft repair: study protocol for a pilot randomized controlled trial."
11/19/2019 - "Inorganic polyphosphate (polyP) is ubiquitous across all forms of life, but the study of its metabolism has been mainly confined to bacteria and yeasts. "
01/01/2018 - "In this study, the effect of inorganic polyphosphate (polyP) on the initial phase of angiogenesis and vascularization was investigated, applying the HUVEC cell tube formation assay. "

09/01/2022 - "Osteogenesis was improved by both polyphosphate and blood clots. "
11/01/2020 - "Modern concepts including recently discovered new paradigms in thrombosis, such as neutrophil extracellular traps, mast cells, and polyphosphate, are summarized."
04/01/2017 - "Thrombosis mechanisms involved with IVCF placement and removal, the blood-contacting medical device inducing clotting, and the inorganic polyphosphate in the contact activation pathway were analyzed. "
01/01/2017 - "Thus, the mechanism by which platelet polyphosphate contributes to thrombus formation remains unclear. "
03/01/2016 - "Recent research has shown that inorganic polyphosphate found in platelets activates FXII in vivo and can induce coagulation in pathological thrombus formation. "

01/01/2023 - "In mammals, polyphosphates play a vital role in the regulation of cellular metabolism, coagulation, and inflammation. "
01/01/2022 - "Porphyromonas gingivalis initiates coagulation and secretes polyphosphates - A mechanism for sustaining chronic inflammation?"
11/01/2021 - "We previously showed that Lactobacillus brevis-derived polyphosphate (poly P) exerts a curative effect on intestinal inflammation. "
11/01/2020 - "Inorganic polyphosphate is a major constituent of platelet-dense granules and promotes blood coagulation and inflammation. "
01/01/2019 - "These results suggest new roles for extracellular polyphosphate as a mediator of wound healing and inflammation and also provide a potential link between platelet activation and the progression of fibrosing diseases."

03/01/2008 - "Inorganic polyphosphate was useful in the treatment of periodontitis in the elderly, indicating a probable effect of anti-ageing, with similar bone regenerations occurring in both groups."
03/01/2008 - "The purpose of this study was to clarify the effects of inorganic polyphosphate on periodontitis. "
03/01/2008 - "Subgingival local irrigation with inorganic polyphosphate was studied in a randomised double-blind study of 33 patients with periodontitis. "
03/01/2008 - "Effect of inorganic polyphosphate in periodontitis in the elderly."
07/01/2019 - "The objective of this study was to investigate the drug loading and in vitro release of minocycline from novel calcium polyphosphate microspheres intended for use in treating periodontitis. "

03/01/2008 - "Patients in whom both the bleeding on probing and gingival index at 1 week had improved were significantly older in the inorganic polyphosphate group than in the control group (p < 0.05). "
01/01/2019 - "Other studies are investigating treatments that block polyphosphate function as novel antithrombotics with the possibility of reduced bleeding side effects."
01/01/2019 - "Polyphosphate has received attention as a possible therapeutic, with some recent studies exploring the use of polyphosphate in a variety of formulations to control bleeding. "
10/01/2008 - "These results suggest that polyphosphate may have utility in reversing anticoagulation and in treating bleeding episodes in patients with hemophilia."
12/20/2012 - "Polyphosphate inhibitors therefore might act as novel antithrombotic/anti-inflammatory agents with reduced bleeding side effects. "