Polyphloretin Phosphate

A polymeric mixture of polyesters of phosphoric acid and phloretin. It blocks some cellular responses to prostaglandins.

Also Known As:

Phosphate, Polyphloretin; 1-Propanone, 3-(4-hydroxyphenyl)-1-(2,4,6-trihydroxyphenyl)-, phosphate, homopolymer

Networked: 12 relevant articles (1 outcomes, 0 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Organic Chemicals: 133
- Ketones: 2618
  - Propiophenones: 1
    - Hydroxypropiophenone: 6
      - Phloretin: 200
        Polyphloretin Phosphate: 12
        diphloretin phosphate: 1
- Hydrocarbons: 1713
  - Cyclic Hydrocarbons: 97
    - Aromatic Hydrocarbons: 291
      - Benzene Derivatives: 17
        Phenols: 677
        Phloroglucinol: 132
        Phloretin: 200
        Polyphloretin Phosphate: 12
        diphloretin phosphate: 1
Heterocyclic Compounds: 198
- 1-Ring Heterocyclic Compounds
  - Pyrans: 130
    - Benzopyrans: 195
      - Chromones: 159
        Flavonoids: 9773
        Phloretin: 200
        Polyphloretin Phosphate: 12
        diphloretin phosphate: 1
Macromolecular Substances: 97
- Polymers: 13051
  - Polyphloretin Phosphate: 12
    - diphloretin phosphate: 1
Biomedical and Dental Materials
- Polymers: 13051
  - Polyphloretin Phosphate: 12
    - diphloretin phosphate: 1
Technology, Industry, and Agriculture
- Manufactured Materials
  - Biomedical and Dental Materials
    - Polymers: 13051
      - Polyphloretin Phosphate: 12
        diphloretin phosphate: 1

Related Diseases

1.	Miosis 09/01/1969 - "1. The effects of intracameral injections of prostaglandins E(1), E(2), F(1a), F(2a), and A(1) were studied on the intraocular pressure (IOP) of rabbits anaesthetized with urethane.2. With the exception of prostaglandin F(1a), all the prostaglandins studied were found to be capable of producing a large, sustained rise in IOP, accompanied in many cases by miosis.3. A marked decrease in response to repeated injections was found with all the prostaglandins studied; this effect was more pronounced following a large initial response to the prostaglandin.4. The descending order of potency in their ability to raise IOP was as follows: prostaglandin E(1) approximately E(2)>F(2a)>A(1)>F(1a).5. Intracameral injections of prostaglandins E(1) and E(2) resulted in an increase in the protein content of the aqueous humour, which was related to the magnitude of the sustained increase in IOP.6. Stabilization of the blood-aqueous barrier with polyphloretin phosphate markedly reduced both the IOP response and the effect of prostaglandin E(2) on the protein content of the aqueous humour.7. It is concluded that the production of local vasodilatation and increased permeability of the blood-aqueous barrier play an important part in the effect of prostaglandins on the IOP. "
2.	Ocular Hypertension (Glaucoma, Suspect) 01/01/1972 - "The mechanism of the antagonism of experimentally induced ocular hypertension by polyphloretin phosphate." 07/01/1961 - "PREVENTION OF EXPERIMENTAL OCULAR HYPERTENSION WITH POLYPHLORETIN PHOSPHATE." 12/01/1974 - "Formaldehyde-induced ocular hypertension: the effects of polyphloretin phosphate and (plus)-catechin."
3.	Edema (Dropsy) 05/25/1960 - "The edema-inhibiting action of polyphloretin phosphate (PPP) in some types of capillary damage. " 09/01/1995 - "Edema, determined by the edema-disk gravimetric technique, was inhibited in a dose-dependent manner by the intraperitoneally administered prostaglandin antagonists polyphloretin phosphate (PPP) or di-4-phloretin phosphate (DPP). "
4.	Urticaria (Hives) 01/01/1976 - "Polyphloretin phosphate (PPP) suppressed the reaction in controls but in patients with urticaria it increased the reactions to Trafuril and had little effect on the kallikrein reaction. "
5.	Pain (Aches) 09/01/1976 - "by polyphloretin phosphate) reduces the pain producing effect of bradykinin. "

Related Drugs and Biologics

1.	Prostaglandins
2.	Urethane (Ethyl Carbamate)
3.	Proteins (Proteins, Gene)
4.	Prostaglandins E
5.	Prostaglandin Antagonists (Prostaglandin Antagonist)
6.	Phosphates (Orthophosphate)
7.	Alprostadil (Muse)
8.	Phospholipases A2 (Phospholipase A2)
9.	Xanthine Oxidase
10.	Phloretin

Related Therapies and Procedures

1.	Injections
2.	Intracameral Injection