Polymyxins (Polymyxin)

Basic lipopeptide antibiotic group obtained from Bacillus polymyxa. They affect the cell membrane by detergent action and may cause neuromuscular and kidney damage. At least eleven different members of the polymyxin group have been identified, each designated by a letter.

Also Known As:

Networked: 729 relevant articles (62 outcomes, 86 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Li, Jian: 49 articles (04/2022 - 09/2006)
2.	Velkov, Tony: 32 articles (04/2022 - 09/2013)
3.	Falagas, Matthew E: 21 articles (01/2021 - 01/2005)
4.	Nation, Roger L: 21 articles (12/2020 - 09/2006)
5.	Tsuji, Brian T: 14 articles (01/2020 - 12/2010)
6.	Zhou, Qi Tony: 12 articles (02/2022 - 02/2016)
7.	Forrest, Alan: 11 articles (06/2021 - 12/2010)
8.	Kaye, Keith S: 10 articles (06/2021 - 02/2013)
9.	Michalopoulos, Argyris: 10 articles (04/2010 - 01/2005)
10.	Azad, Mohammad A K: 9 articles (02/2022 - 09/2013)

Related Diseases

1.	Infections 04/21/2020 - "Due to the limitations of our study, we cannot draw a firm conclusion on the optimal treatment of CRAB infections, but polymyxins would be a relatively effective treatment for CRAB infections. " 05/01/2010 - "Novel polymyxin derivatives are effective in treating experimental Escherichia coli peritoneal infection in mice." 11/01/2021 - "It is suggested that long course of polymyxins B is safe and effective for intracranial infection caused by CRAB." 01/01/2022 - "Therefore, new polymyxin analogs with improved safety properties are needed to combat serious infections caused by resistant Gram-negative pathogens. " 04/12/2019 - "Inhaled polymyxins will continue to be an adjunctive option for pulmonary infections but further clinical trials are needed to clarify the efficacy of inhaled polymyxins. "
2.	Sepsis (Septicemia) 09/01/1949 - "Polymyxin effective in the treatment of pyocyaneus sepsis; report of a case." 01/01/2001 - "A prospective, open and randomized trial of the effect of immobilized polymyxin fibers (PMX-F) on the survival of patients with sepsis throughout a follow-up period of 28 days or until discharge, if earlier, was carried out. " 01/01/2023 - "As polymyxins are given routinely, the prevalence of their resistance is on the rise and increases mortality rates of sepsis patients. " 11/01/2021 - "This article reviews the clinical treatment of polymyxin in bloodstream infections of drug-resistant Acinetobacter baumannii, to provide reference for clinical medication." 11/01/2021 - "[Application progress of polymyxin in bloodstream infection of drug-resistant Acinetobacter baumannii]."
3.	Gram-Negative Bacterial Infections 01/01/2019 - "Broad-range investigations on such critical issues in relation to polymyxins can be beneficial for the implementation of effective treatment against MDR Gram-negative bacterial infections." 04/01/2010 - "In recent reports polymyxins have been considered an effective and safe treatment option for the management of multidrug-resistant (MDR) Gram-negative bacterial infections. " 01/01/2023 - "Polymyxins are increasingly regarded as a last-line therapeutic option for the treatment of multidrug-resistant (MDR) Gram-negative bacterial infections. " 02/11/2021 - "Resistance to polymyxins when treating multidrug-resistant (MDR) Gram-negative bacterial infections limit therapeutic options. " 11/11/2020 - "Bi-functional OligoG-polymyxin conjugates have potential therapeutic benefits in the treatment of multidrug-resistant (MDR) Gram-negative bacterial infections, directly reducing toxicity whilst retaining antimicrobial and antibiofilm activities."
4.	Septic Shock (Toxic Shock Syndrome) 01/01/2018 - "Prolonged polymyxin therapy might be associated with better clinical outcomes than 2-h polymyxin therapy in patients with septic shock. " 06/01/2013 - "The use of polymyxin hemoperfusion in patients with septic shock of intra-abdominal origin can significantly improve hemodynamic and respiratory functions." 01/01/2020 - "Analysis of the 14-day survival probability showed that mortality was higher among the patients who had sepsis or septic shock at the time of polymyxin prescription (P = 0.028 and P<0.001, respectively). " 06/01/2008 - "Multiple logistic regression analysis revealed that independent predictors of mortality during treatment were treatment with polymyxins, higher Acute Physiological and Chronic Health Evaluation II (APACHE II) score, septic shock, delay in starting treatment and renal failure. " 12/11/2013 - "Epuration of circulating endotoxin using hemoadsorption on polymyxin columns is a new treatment in septic shock showing encouraging preliminary results. "
5.	Meningitis 10/01/2020 - "The aim of our study was to evaluate the efficacy and safety of polymyxin in the treatment of post-neurosurgical meningitis due to the extensively drug-resistant bacillary in children. " 08/01/2019 - "Intrathecal or intraventricular polymyxin administration is expected to be an effective choice for meningitis but requires further study." 01/01/2022 - "A combination of intravenous and intraventricular (IVT)/intrathecal (IT) polymyxins achieves good therapeutic outcomes for cases of healthcare-associated MDR/XDR-Ab meningitis/ventriculitis. " 10/01/2020 - "We performed a retrospective study on post-neurosurgical meningitis caused by the extensively drug-resistant bacillary in children, who were treated with polymyxin for ≥ 3 days. " 01/01/2007 - "We reviewed the available clinical evidence regarding intraventricular/intrathecal administration of polymyxins in patients with meningitis, focusing on effectiveness and safety. "

Related Drugs and Biologics

1.	Anti-Bacterial Agents (Antibiotics)
2.	Polymyxins (Polymyxin)
3.	Colistin (Coly-Mycin)
4.	Polymyxin B (Aerosporin)
5.	Tigecycline (Tygacil)
6.	Neomycin
7.	Vancomycin
8.	Carbapenems (Carbapenem Antibiotics)
9.	Aminoglycosides
10.	Tobramycin (Nebcin)

Related Therapies and Procedures

1.	Therapeutics
2.	Hemoperfusion
3.	Catheters
4.	Urinary Catheters
5.	Hemodiafiltration