Polygeline

A 3.5 per cent colloidal solution containing urea-cross-linked polymerized peptides. It has a molecular weight of approximately 35,000 and is prepared from gelatin and electrolytes. The polymeric solution is used as a plasma expander.

Also Known As:

Networked: 110 relevant articles (6 outcomes, 17 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Padrazzi, Bruno: 2 articles (06/2007 - 02/2006)
2.	Durand-Zaleski, Isabelle: 2 articles (06/2007 - 02/2006)
3.	Golly, Dominique: 2 articles (06/2007 - 02/2006)
4.	Rittoo, D: 2 articles (11/2005 - 01/2004)
5.	Gosling, P: 2 articles (11/2005 - 01/2004)
6.	Smith, S R G: 2 articles (11/2005 - 01/2004)
7.	Vohra, R K: 2 articles (11/2005 - 01/2004)
8.	Simms, M H: 2 articles (11/2005 - 01/2004)
9.	Zent, Olaf: 2 articles (12/2004 - 01/2003)
10.	Arish, A: 2 articles (07/2001 - 03/2001)

Related Diseases

1.	Septic Shock (Toxic Shock Syndrome) 09/12/1990 - "Septic shock following infected Haemaccel." 07/11/1990 - "Septic shock following infected Haemaccel." 07/01/1987 - "We compared, at constant preload maintained by polygeline (gelatin) infusion, the hemodynamic effects of continuous infusion of norepinephrine (0.5, 1, and 1.5 micrograms/kg X min) in anesthetized dogs with and without hyperdynamic endotoxic shock. " 11/01/2014 - "Compatibility and stability of the polygeline-based blood plasma expander/plasma substitute Haemaccel with different drug products i.e., Profenid, Stemetil, and Lasix were examined in the context of its potential use in surgical, spinal, septic shock and in circulatory insufficiency, because treatment, safety, acceptability and efficacy of drug product may be affected by drug instability or incompatibility. " 03/01/2005 - "To compare the efficacy of crystalloid (Normal saline) and colloid (polymer from degraded Gelatin in saline Haemaccel) intravenous fluid in restoration of circulating volume in children with septic shock. "
2.	Ovarian Hyperstimulation Syndrome 03/01/2003 - "Comparative efficacy of hydroxyethyl starch and haemaccel in the treatment of severe ovarian hyperstimulation syndrome." 06/01/2002 - "Efficacy of hydroxyethyl starch and haemaccel for the treatment of severe ovarian hyperstimulation syndrome."
3.	Hypotension (Low Blood Pressure) 09/01/2014 - "10 min before the institution of SAB in Group I and preloading with 500 ml of polygeline 3.5% i.v. over 10 min prior to SAB in Group II. Patients in both groups were closely monitored for pulse rate, systolic blood pressure; any hypotension, requirement of rescue therapy and adverse effects. " 01/01/1978 - "[A fundamental study on volume: Effect of plasma expander (Haemaccel) in hypotension due to high spinal anesthesia (author's transl)]." 07/01/2003 - "The increase in skin blood flow was absent in rats treated with high doses (-20 +/- 5% at 2.0 kPa), even when the anesthesia-induced hypotension was corrected by gelofusine infusion (-20 +/- 10% at 2.0 kPa). " 06/01/1995 - "Use of polygeline was associated with an outbreak of fever and hypotension in a SICU. " 09/01/2014 - "The primary outcome of this study was the attenuation of hypotension due to SAB using ephedrine or polygeline 3.5%. "
4.	Neoplasms (Cancer) 06/01/2012 - "Injection of Gelofusine significantly reduced the renal retention of labeled RAFT-RGD, while increasing the tumor over healthy tissue ratio. " 06/01/2012 - "Gelofusine significantly induced a >50% reduction of the renal reabsorption of (111)In-DOTA-RAFT-RGD and A700-RAFT-RGD, without affecting tumor uptake. " 06/01/2012 - "We studied the effect of Gelofusine on RAFT-RGD renal retention in tumor-bearing mice. " 03/01/2011 - "Gelofusine and lysine coinjection with the tracer reduces the renal uptake while tumor uptake is improved. " 03/01/2011 - "Gelofusine and lysine coadministration improved tumor uptake. "
5.	Shock 12/27/1969 - "A trial of a plasma volume expander (haemaccel) in shock." 07/01/2000 - "Hypovolaemic shock was then induced in dogs who were then actively resuscitated via this route using normal saline, Haemaccel and whole blood. " 08/01/1990 - "After a 60 min. endotoxin (20 mg/kg. hr E coli 0127-B8) or saline (control) infusion anesthetized rats were volume loaded (3 ml/10 min. 100 g for 10 min.) at t = 120 min. with saline (shock group n = 8; control group n = 8) or Haemaccel (shock group n = 6; control group n = 8). " 07/01/1972 - "[Use of Haemaccel, new plasma substitute in the treatment of shock]." 06/28/1963 - "[Shock and its management with the plasma expander Haemaccel]."

Related Drugs and Biologics

1.	Polygeline
2.	Hetastarch (Pentastarch)
3.	Colloids (Colloid)
4.	Ephedrine
5.	crystalloid solutions
6.	Propofol (Diprivan)
7.	Gelatin
8.	Polymers
9.	Lysine (L-Lysine)
10.	Ketoprofen (Orudis)

Related Therapies and Procedures

1.	Spinal Anesthesia
2.	Resuscitation
3.	Intravenous Infusions
4.	Cesarean Section (Caesarean Section)
5.	Cardiopulmonary Bypass (Heart-Lung Bypass)