Polyethyleneimine

Strongly cationic polymer that binds to certain proteins; used as a marker in immunology, to precipitate and purify enzymes and lipids. Synonyms: aziridine polymer; Epamine; Epomine; ethylenimine polymer; Montrek; PEI; Polymin(e).

Also Known As:

Networked: 415 relevant articles (19 outcomes, 69 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Wagner, Ernst: 14 articles (02/2014 - 08/2002)
2.	Ogris, Manfred: 12 articles (01/2013 - 01/2003)
3.	Lu, Weiyue: 9 articles (08/2015 - 08/2011)
4.	Wei, Yuquan: 9 articles (01/2015 - 01/2011)
5.	Uludağ, Hasan: 8 articles (12/2015 - 02/2010)
6.	Zhao, Xia: 8 articles (01/2015 - 10/2010)
7.	Kim, Sun Hwa: 7 articles (07/2015 - 01/2005)
8.	Jeong, Ji Hoon: 7 articles (07/2015 - 01/2005)
9.	Kim, Sung Wan: 6 articles (07/2015 - 06/2004)
10.	Choi, Donghoon: 6 articles (07/2015 - 09/2006)

Related Diseases

1.	Neoplasms (Cancer) 11/01/2009 - "In this study, we exploited the potential of (64)Cu-labeled polyethylenimine (PEI) for cell trafficking and tumor imaging as compared to copper-64-pyruvaldehyde-bis(N (4)-methylthiosemicarbazone) ((64)Cu-PTSM). " 07/01/2009 - "In this study, we evaluated the potential of spherical polyethylenimine nanogels (M-PEIs) as a novel vector for intravenous delivery of plasmids to tumor cells. " 03/01/2007 - "In this study, we took advantage of a modified polyethylenimine (M-PEI) with high transfection efficiency for tumor cells and tissues, and targeted FAK function through both in vitro and in vivo approaches. " 01/20/2016 - "Polyethylenimine (PEI) has been used as a vehicle to deliver genes to cancer cells and somatic cells. " 10/28/2015 - "Polyethylenimine-coated SPION exhibits potential intrinsic anti-metastatic properties inhibiting migration and invasion of pancreatic tumor cells."
2.	Pressure Ulcer (Bedsore) 08/01/2012 - "In vivo pressure sore-healing efficacy of β-cyclodextrin/polyethyleneimine/silk fibroin xerogel." 10/01/2012 - "A hydrogel composed of β-cyclodextrin (β-CD), polyethyleneimine (PEI) and silk fibroin (SF) was assessed for use in healing of pressure sores. " 10/01/2012 - "A β-cyclodextrin, polyethyleneimine and silk fibroin hydrogel containing Centella asiatica extract and hydrocortisone acetate: releasing properties and in vivo efficacy for healing of pressure sores."
3.	Carcinoma (Carcinomatosis) 04/01/2006 - "Linear polyethylenimine (L-PEI) is an efficient transfection agent for ovarian carcinoma cells in vitro and ex vivo. " 04/01/2006 - "Intraperitoneal linear polyethylenimine (L-PEI)-mediated gene delivery to ovarian carcinoma nodes in mice." 09/01/2003 - "Pegylated polyethylenimine-Fab' antibody fragment conjugates for targeted gene delivery to human ovarian carcinoma cells." 03/01/2001 - "Reporter gene plasmids were complexed with polyethylenimine with an average molecular weight of 25 kDa (PEI 25), or other agents, to transfect confluent monolayers of ovine mammary epithelial cells (OMEC II) or human carcinoma cells (CaCo-2) in vitro. " 03/01/2001 - "Improvement of nonviral p53 gene transfer in human carcinoma cells using glucosylated polyethylenimine derivatives."
4.	Hepatocellular Carcinoma (Hepatoma) 02/01/2003 - "Molecular weight-dependent gene transfection activity of unmodified and galactosylated polyethyleneimine on hepatoma cells and mouse liver." 02/15/2002 - "Polyethylenimine-mediated suicide gene transfer induces a therapeutic effect for hepatocellular carcinoma in vivo by using an Epstein-Barr virus-based plasmid vector." 02/01/2011 - "[Application of orthogonal design in optimization of the transfection efficiency of polyethylenimine mediated gene transfer to hepatoma carcinoma cells]." 11/01/2004 - "This study was to evaluate targeting delivery effect of c-myc ASODN mediated by galactose-polyethyleneimine (Gal-PEI) on human hepatocellular carcinoma cell line Bel-7402. " 03/01/2014 - "We have engineered a system for inducing self-assembly of model H35 rat hepatoma spheroids using a copolymer comprised of biocompatible elastin-like polypeptide (ELP) chemically conjugated to positively charged polyethyleneimine (PEI). "
5.	Melanoma (Melanoma, Malignant) 01/01/2009 - "Furthermore, ASO-116 against DeltaEx2/3 coupled to magnetic nanobead polyethyleneimine (MNB/PEI) carriers significantly inhibited malignant melanoma growth, which correlated with a shift in the balance between endogenous TAp73 and DeltaEx2/3 towards apoptotic full-length p73. " 11/01/2008 - "Polyethylenimine-mediated in vivo gene transfer of a transmembrane superantigen fusion construct inhibits B16 murine melanoma growth." 10/01/2015 - "Delivery of PUMA Apoptosis Gene Using Polyethyleneimine-SMCC-TAT/DNA Nanoparticles: Biophysical Characterization and In Vitro Transfection Into Malignant Melanoma Cells." 11/01/2008 - "More specifically, we used a nonviral vector, the cationic polymer, polyethylenimine (PEI), to express a transmembrane SEA fusion construct (pSEA-TM) in B16F10-induced subcutaneous melanoma in mice. " 06/01/2011 - "In our previous studies, we demonstrated the efficacy of stearic acid-modified polyethylenimine (PEI-StA) in promoting small interfering RNA (siRNA) silencing of STAT3 in B16.F10 melanoma in vitro and in vivo. "

Related Drugs and Biologics

1.	Polymers
2.	Folic Acid (Vitamin M)
3.	Silk
4.	Fibroins (Fibroin)
5.	Small Interfering RNA (siRNA)
6.	Polyethylene Glycols (Polyethylene Glycol)
7.	ferric oxide (iron oxide)
8.	Liposomes (Liposome)
9.	Antigens
10.	Carbon Monoxide

Related Therapies and Procedures

1.	Heterologous Transplantation (Xenotransplantation)
2.	Injections
3.	Photochemotherapy (Photodynamic Therapy)
4.	Lasers (Laser)
5.	Drug Therapy (Chemotherapy)