Polychlorinated Biphenyls (PCBs)

Industrial products consisting of a mixture of chlorinated biphenyl congeners and isomers. These compounds are highly lipophilic and tend to accumulate in fat stores of animals. Many of these compounds are considered toxic and potential environmental pollutants.

Also Known As:

Networked: 966 relevant articles (3 outcomes, 188 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Hennig, Bernhard: 22 articles (12/2015 - 03/2002)
2.	Robertson, Larry W: 18 articles (05/2014 - 03/2002)
3.	Toborek, Michal: 17 articles (12/2012 - 03/2002)
4.	Jacobs, David R: 13 articles (04/2015 - 03/2007)
5.	Lee, Duk-Hee: 13 articles (04/2015 - 03/2007)
6.	Carpenter, David O: 11 articles (01/2015 - 06/2002)
7.	Furue, Masutaka: 9 articles (10/2015 - 04/2007)
8.	van Bavel, Bert: 9 articles (10/2014 - 06/2003)
9.	Ayotte, Pierre: 8 articles (08/2014 - 04/2002)
10.	Longnecker, Matthew P: 8 articles (07/2014 - 09/2004)

Related Diseases

1.	Breast Neoplasms (Breast Cancer) 09/01/2004 - "The relationship between PCBs concentrations in serum and risk factor was mainly due to serum levels of PCB153, which were significantly higher in breast cancer women than in disease-free subjects (1.63+/-1.26 ppb vs. 0.63+/-0.78 ppb, p<0.0001), even after accounting for other potential risk factors. " 07/01/2015 - "The aim of this study was to investigate the association between serum concentrations of a group of organochlorine pesticides/polychlorinated biphenyls with xenoestrogenic potential and the risk of breast cancer in a female population from Tunisia. " 04/01/2015 - "In this study, we sought to determine whether bioaccumulation of PCBs differs within regions of the human breast and whether PCB levels are associated with clinical and pathological characteristics in breast cancer patients. " 12/01/2013 - "To further clarify the role of PCBs in the etiology of breast cancer, the present study aimed to examine the relation of 24 PCB congener levels, which were considered individually and in combinations, with mammographic density, one of the risk factors most strongly associated with breast cancer. " 04/01/2011 - "This study was designed to evaluate the relation between polychlorinated biphenyls (PCB) exposure and breast cancer risk in Mexican women. "
2.	Body Weight (Weight, Body) 01/01/2002 - "In the adult chickens, PCBs caused no significant changes in body weight, respiration, heart rate, body temperature, red and white blood cell number, but induced a marked decrease in the testicular weight, and severe damage of the seminiferous tubules. " 01/01/2015 - "The PCBs, Hg, As, Cd, and Pb exposures of the fishermen was estimated to be 2.8, 0.02, 4.5, 0.09, and 0.5 pg/kg body weight/day, respectively. " 01/01/2014 - "The mean upper bound (UB) intakes for cumulative PCDDs, PCDFs, and DL-PCBs were 0.67, 0.63-0.92, and 0.27-0.63 pg WHO2005-TE kg(-1) body weight (bw) day(-1) for toddlers, children and adults, respectively. " 10/01/2011 - "When maximal and 95th percentile concentration of ndl PCBs was used, weekly intakes exceeded a "guidance value" with one exception i.e., when 95th percentile of concentration along with 95th percentile of body weight were used. " 01/01/2011 - "Dietary intake of dioxin+dioxin-like PCBs and indicator PCBs from fish, dairy products, edible oil, egg and meat was 0.509 pg WHO-TEQ1998/kg bw (body weight)/day and 839 pg/kg bw/day in Afyon and 0.588 pg WHO-TEQ1998/ kg bw/day and 1070 pg/kg bw/day in Kocaeli, respectively. "
3.	Acquired Immunodeficiency Syndrome (AIDS) 02/01/2009 - "The present study enriches our understanding of the environmental toxicology of reptiles and aids in the interpretation of health conditions documented in field-collected turtles contaminated with PCBs." 12/01/1990 - "Knowledge of the entry of polychlorinated biphenyls through the skin into the body and subsequent disposition aids estimation of potential for human health hazard. " 01/01/2007 - "The removal efficiencies of UC, PCDD/Fs, coplanar PCBs, and PCBs are further improved by adding flotation aids during the flotation process. "
4.	Neoplasms (Cancer) 02/15/2013 - "In contrast, TEQ and total PCBs in fillet in this study exceeded USEPA tissue screening levels for cancer (1E-6 risk) and noncancer (hazard quotient [HQ]=1) toxicity for human fish consumers. " 01/01/2013 - "Overall, index of additive cancer risk (IACR) and hazard quotient (HQ) for PAHs and PCBs was lower than safe limit of 1, indicating no environmental and human health risk from PAHs and PCBs in this area of study." 10/01/2009 - "The weight of evidence in studies of environmental exposure or increased mortality in subjects professionally exposed does not support a causal association for PCBs and human cancer. " 10/01/2009 - "A lot of studies treat the issue of PCBs and cancer. " 03/01/2009 - "To study the relationship of PCBs to TGCT, prediagnostic serum samples from 736 cases and 913 controls in the Servicemen's Testicular Tumor Environmental and Endocrine Determinants study were analyzed. "
5.	Endometriosis (Adenomyosis) 07/01/2010 - "In that study, the association between endometriosis and the sum of 4 antiestrogenic PCBs (PCBs 105, 114, 126, and 169) was borderline significant (P = 0.079), whereas an association was not found (P = 0.681) with the sum of 12 estrogenic PCBs. " 04/01/2009 - "The study results suggested that women having higher concentration of PCBs and GSTM1 null (*0/*0) polymorphism might have an increased susceptibility of endometriosis. " 05/01/2012 - "The GSTP1 wild-type genotype in the presence of medium-high blood levels of PCB153, total PCBs, or of high levels of PCB180 significantly increased the risk of endometriosis, suggesting a multiplicative interaction. " 09/01/2010 - "We evaluated serum concentrations of certain noncoplanar PCBs, which have no or only weak dioxin-like properties, as risk factors for endometriosis. " 09/01/2010 - "Non-dioxin-like polychlorinated biphenyls and risk of endometriosis."

Related Drugs and Biologics

1.	polychlorodibenzo-4-dioxin
2.	Polychlorinated Biphenyls (PCBs)
3.	Dichlorodiphenyl Dichloroethylene (DDE)
4.	Dioxins
5.	Halogenated Diphenyl Ethers
6.	chlorinated dibenzofurans
7.	DDT
8.	Hexachlorobenzene (HCB)
9.	Hormones
10.	Carcinogens

Related Therapies and Procedures

1.	Aftercare (After-Treatment)
2.	Induced Abortion (Induced Abortions)
3.	Homologous Transplantation (Allograft)
4.	Therapeutics
5.	Lasers (Laser)