Poly I-C

Interferon inducer consisting of a synthetic, mismatched double-stranded RNA. The polymer is made of one strand each of polyinosinic acid and polycytidylic acid.

Also Known As:

Poly(I-C); Poly(rI).Poly(rC); Polyinosinic-Polycytidylic Acid; Polyinosinic-Polycytidylic Acid (High MW); Polyriboinosinic-Polyribocytidylic Acid; Polyribose Inosin-Cytidil; Inosin-Cytidil, Polyribose; Poly I C; Polyinosinic Polycytidylic Acid; Polyriboinosinic Polyribocytidylic Acid; Polyribose Inosin Cytidil; 5'-Inosinic acid, homopolymer, complex with 5'-cytidylic acid homopolymer (1:1)

Networked: 2220 relevant articles (146 outcomes, 236 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Nucleic Acids, Nucleotides, and Nucleosides: 1
- Nucleotides: 15763
  - Polynucleotides: 218
    - Polyribonucleotides: 23
      - Poly C: 296
        Poly I-C: 2220
        poly ICLC: 121
        poly(I).poly(c12,U): 51
        BO-112: 6
        PIKA adjuvant: 2
        poly I-5-mercapto-poly C: 2
        poly ICL: 1
        poly IC-polylysine carboxymethyl dextran
        poly(2'-azido-2'-deoxyinosinic acid).polycytidylic acid
        poly(2'-chloro-2'-deoxyinosinic acid).polycytidylic acid
        poly(2'-fluoro-2'-deoxyinosinic acid).polycytidylic acid
        poly(G,I).poly(C)
        poly(I,8-azidoI).poly(C)
        poly(I,8-azidoI).poly(C12,U)
        Retrogen D
      - Poly I: 163
        Poly I-C: 2220
        poly ICLC: 121
        poly(I).poly(c12,U): 51
        BO-112: 6
        PIKA adjuvant: 2
        poly I-5-mercapto-poly C: 2
        poly ICL: 1
        poly IC-polylysine carboxymethyl dextran
        poly(2'-azido-2'-deoxyinosinic acid).polycytidylic acid
        poly(2'-chloro-2'-deoxyinosinic acid).polycytidylic acid
        poly(2'-fluoro-2'-deoxyinosinic acid).polycytidylic acid
        poly(G,I).poly(C)
        poly(I,8-azidoI).poly(C)
        poly(I,8-azidoI).poly(C12,U)
        Retrogen D

Experts

1.	Tian, Zhigang: 20 articles (01/2019 - 11/2005)
2.	Imaizumi, Tadaatsu: 15 articles (01/2021 - 08/2004)
3.	Sun, Rui: 15 articles (01/2019 - 11/2004)
4.	Wei, Haiming: 15 articles (01/2019 - 11/2005)
5.	Meyer, Urs: 13 articles (01/2021 - 07/2006)
6.	Tanaka, Hiroshi: 12 articles (01/2019 - 01/2011)
7.	Yoshida, Hidemi: 12 articles (01/2019 - 08/2004)
8.	Qin, Qiwei: 11 articles (04/2022 - 05/2013)
9.	Matsumiya, Tomoh: 11 articles (01/2019 - 01/2011)
10.	Seya, Tsukasa: 11 articles (04/2018 - 12/2006)

Related Diseases

1.	Infections 09/01/2017 - "Taken together, the results of our study are beneficial for better understanding of the immune system and defense mechanisms of yellow catfish in response to poly I:C infection." 10/31/2019 - "However, infection with wtCSFV or Npro overexpression led not only to significant reduction of IRF1 expression and its promoter activity in poly(I:C)-treated IPEC-J2 cells but also to blockage of IRF1 nuclear translocation. " 01/01/2011 - "Our study presented the first evidence to show that activation of TLR3 is effective in blocking DENV2 replication via IFN-β, providing an experimental clue that poly(I:C) may be a promising immunomodulatory agent against DENV infection and might be applicable for clinical prevention." 10/01/1985 - "Prophylactic and therapeutic efficacy of poly(I,C)-LC against Rift Valley fever virus infection in mice." 05/01/2014 - "Future studies may be aimed at assessing the efficacy of the poly I:C and CpG combination adjuvant in protecting against AIV infection."
2.	Neoplasms (Cancer) 01/01/2020 - "We further demonstrate that treatment with radiation and polyinosinic-polycytidylic acid significantly expands the proportion of proliferating CD8+ T cells in the tumor with enhanced cytolytic potential and requires T cell migration from lymph nodes for therapeutic efficacy. " 01/01/2020 - "Furthermore, Au@PP/poly(I:C) plus TMZ significantly improved the overall survival of the tumor-bearing mice compared with group TMZ only. " 02/01/2016 - "The combination poly(I:C)/BCG was much more effective in reducing MBT-2 tumor growth in mice than either treatment alone. " 01/01/2019 - "Of note, using a novel cytotoxicity assay, Poly(I:C), but not IMQ, was effective in triggering the cytotoxic activity of TC-Mϕ against cancer cells. " 09/01/2016 - "The present study reports the efficacy of CPV2.NS1 along with poly (I:C) not only in inhibiting the mammary tumor growth but also in generating an active anti-tumor immune response without any visible toxicity. "
3.	Virus Diseases (Viral Diseases) 01/01/2017 - "Collectively, our results establish that necroptosis is a contributing factor in poly(I:C)-triggered abnormal pregnancy and thereby indicate a novel therapeutic strategy for reducing the severity of the adverse effects of viral infections in pregnancy." 02/12/2009 - "It is considered that the present immunization method using Poly(I:C) followed by a live virus injection could offer protection against various viral infections in a broader range of fish species." 09/01/2020 - "In the present study, an in vitro viral infection model was established by exposing head kidney-derived macrophages of large yellow croaker to virus analog, poly(I:C). " 05/05/2019 - "In this study, PSCs were exposed to poly(I:C) stimulation to mimic viral infection during the proliferation and differentiation phases at 0, 12, 24 and 48 hours (h) of the stimulation. " 12/01/2016 - "Polyinosinic-polycytidylic acid (polyI:C) has recently been used as a standard model of viral infections, and recent in vitro studies have shown that microglia are activated by polyI:C. "
4.	Melanoma (Melanoma, Malignant) 12/01/1972 - "Studies on the mechanism of the anti-melanoma effect of polyinosinic-polycytidylic acid (PIC). " 11/22/2019 - "LL37 is known to bind poly I:C where it is thought to compete for receptor binding on the surface of some immune cells, metastatic melanoma and lung cells. " 05/01/2011 - "Intratumoral injection of Poly(I:C) and CpG, combined with systemic transfer of activated pmel-1 T cells, specific for gp100(25-33), led to enhanced survival and eradication of 9-day established subcutaneous B16F10 melanomas in a proportion of mice. " 07/01/2008 - "IFN-producing killer dendritic cells contribute to the inhibitory effect of poly I:C on the progression of murine melanoma." 04/15/2007 - "Recent evidence indicates that melanoma differentiation-associated gene-5 is the prominent host component mediating IFN production after exposure to the dsRNA analog, poly(I:C). "
5.	Neoplasm Metastasis (Metastasis) 12/01/2022 - "In an in vivo model of stroma-rich CC, poly(I:C) treatment significantly increased systemic cytotoxic T cell activity (p<0.05) and reduced liver metastases (p<0.0002). " 01/01/2019 - "More importantly, the microparticles exhibit a comparative antitumor effect with polyinosinic-polycytidylic acid (PolyI:C) in B16 pulmonary metastasis model. " 01/01/2018 - "However, poly (I:C), when used at lower concentration that cannot remarkably inhibit proliferation and induce apoptosis in HCC cells, enhanced the migration and invasion in vitro and the metastasis in vivo. " 02/01/2015 - "The results of the aforesaid experiments showed that there was a gradual increase of cellular survivability, growth, and metastasis after the cell surface stimulation of TLR-3 with Poly (I:C). " 09/15/2013 - "Using the TLR3 agonist poly(I:C), we showed as proof-of-principle that perioperative administration of a nonspecific innate immune stimulant can inhibit surgery-induced dysfunction in NK cells and attenuate metastases. "

Related Drugs and Biologics

1.	Poly I-C
2.	Vaccines
3.	Interferons
4.	poly ICLC
5.	Lysine (L-Lysine)
6.	Peptides (Polypeptides)
7.	Carboxymethylcellulose Sodium (Polycell)
8.	Antiviral Agents (Antivirals)
9.	CPG-oligonucleotide
10.	Proteins (Proteins, Gene)

Related Therapies and Procedures

1.	Therapeutics
2.	Immunotherapy
3.	Injections
4.	Drug Therapy (Chemotherapy)
5.	Intranasal Administration