Poly I

01/01/2019 - "Poly (I) treatments before infection alleviated the proinflammatory effects of Boxb in abdominal cavity extracted macrophages. "
04/01/1993 - "Untreated H9 cells infected with HIV-1 start to release the virus 3 days post-infection, while in the presence of 40 micrograms/ml (80 micrograms/ml) of poly(I).poly(C12U) the onset of virus production and release is retarded and does not occur before day 5 (day 6). "
01/01/1981 - "Encephalomyocarditis (EMC) virus causes lethal infection of hamsters against which poly(I) . "
09/01/1980 - "However, mice protected against encephalomyocarditis virus infection by multiple treatments with the colloidal complex form of poly(I) . "
01/01/1976 - "After infection poly C and poly I are both more effective by the intravenous route but before infection they are most effective when administered by the same route as the virus. "

05/01/2008 - "In in vitro studies, the addition of poly(I) before virus infection resulted in a specific inhibition of adenovirus-induced gene expression in a J774 macrophage cell line and in primary Kupffer cells. "
01/01/1995 - "Neither anti-Semliki Forest virus hyperimmune serum nor the potent interferon inducer poly I:CLC given intraperitoneally are protective when used therapeutically after an intracranial virus infection, but a combination of 1,000 U hyperimmune serum and 80 micrograms/mouse of poly I:CLC results in a 50% survival rate. "
01/01/1981 - "poly(C) treated hamsters protects other hamsters against EMC virus infection with maximum protection with serum removed 3h after poly(I) . "
01/01/1969 - "Use of poly I-poly C in the prophylaxis and treatment of acute viral infections."
07/01/1987 - "In the absence of virus infection, decreased levels of p68 kinase occur in cells following incubation with poly(I).poly(C)."

01/01/2009 - "These characteristics make poly(I:C12U) a suitable agent for use as an adjuvant in cancer directed immunotherapeutic regimes."
01/01/2009 - "Importantly, poly(I:C12U) has a comparable effect on the maturation and function of DC derived either from healthy donors or cancer patients indicating that it is able to overcome any immune suppressive factors associated with the tumour bearing state. "
10/01/1982 - "MCT released from alloimmune mice stimulated with syngeneic or allogeneic tumor cells were resolved by molecular sieving into a major peak at 140,000--160,000 daltons, called "alpha-MCT," and into a minor peak at 60,000 daltons, called "beta-MCT." However, supernatants from thioglycollate-induced PEMM, stimulated with poly I . "
10/01/1982 - "Resident peritoneal macrophages did not release MCT either spontaneously or after treatment with tumor cells, poly I . "
12/01/1992 - "Poly(I).poly(C12U) is capable, in experimental models, of limiting the development of viruses (including HIV), reducing tumor growth, eliminating metastases, and, according to one report, preventing steady declines in T-cell counts in HIV-positive patients. "

06/01/1976 - "Poly(I), poly(C7I) and poly(c7A)exerted a distinct inhibitory effect on turine leukemia virus, while under the same conditions poly(c3I) and poly(c3A) showed little, if any, inhibitory effect."
01/01/1975 - "These cases, resistent to the known therapeutic regimes (combination chemotherapy), responded well when treated with MPC along, or in combination with poly I. The experiments indicate that the development of modified polynucleotids with structural similarities to functional templates may be of potential use in the future chemotherapy of leukemia."
10/15/1983 - "Mouse thymocytes and spleen cells from unprimed C57BL/6 donors generate broadly reactive cytotoxic cells during 5 days of culture in vitro with polyinosinic acid (5') (poly(I] and/or supernatant from PMA-treated EL4 leukemia cells which contains interleukin 2 (IL-2) activity. "
01/01/1983 - "There was no apparent effect on L-1210R leukemia cells whereas in L-1210S cells the level of both enzymes was enhanced in response to treatment of mice with IFN or poly(I) X poly(C). "
03/01/1970 - "Some effects of adenosine 3',5'-monophosphate and double stranded RNA, poly I poly C, on Friend leukemia in mice."

09/01/1998 - "The activity towards poly(I) was stronger in two colon carcinoma cell lines than in three other epithelial cell lines. "
01/01/1999 - "Inhibition of metastatic carcinoma cell growth in livers by poly(I):poly(C)/cationic liposome complex (LIC)."
09/01/2003 - "We have evaluated and compared the efficacy of systemic administration of lipoplex formulations containing plasmids encoding IFN-beta or IFN-gamma, and a synthetic double-strand RNA poly I:poly C (pI:pC), a type I IFN inducer, in a lung metastasis model in which colon carcinoma CT-26 cells were inoculated intravenously into immunocompatible mice. "
06/01/1985 - "The cytocidal activity of human immune interferon (IFN-gamma) in combination with the synthetic double-stranded RNA, poly(I).poly(C), was investigated in human colon carcinoma cell line HT-29. "
05/01/1985 - "The effect of polyinosinic X polycytidylic acid [poly(I) X poly(C)] on the cell lethality produced by 5-fluorouracil [FUra] and 5-fluorouridine [FUrd] was examined in human colon carcinoma cell line HT-29. "