Polynucleotide Adenylyltransferase (Polymerase, Poly A)

An enzyme that catalyzes the synthesis of polyadenylic acid from ATP. May be due to the action of RNA polymerase (EC 2.7.7.6) or polynucleotide adenylyltransferase (EC 2.7.7.19). EC 2.7.7.19.

Also Known As:

Polymerase, Poly A; Polyadenylate Polymerase; ATP-RNA Adenylyltransferase; ATP RNA Adenylyltransferase; Adenylyltransferase, ATP-RNA; Adenylyltransferase, Polynucleotide; Polymerase, Polyadenylate; Synthetase, Polyadenylate; Poly A Polymerase; Polyadenylate Synthetase; ATP:polynucleotide adenylyltransferase

Networked: 82 relevant articles (0 outcomes, 5 trials/studies)

Bio-Agent Context: Research Results

Experts

1.	Gershon, Paul D: 3 articles (06/2007 - 06/2002)
2.	Cysewski, Dominik: 2 articles (01/2021 - 01/2017)
3.	Dziembowski, Andrzej: 2 articles (01/2021 - 01/2017)
4.	Gewartowska, Olga: 2 articles (01/2021 - 01/2017)
5.	Gruchota, Jakub: 2 articles (01/2021 - 01/2017)
6.	Mroczek, Seweryn: 2 articles (01/2021 - 01/2017)
7.	Bruni, Francesco: 2 articles (01/2020 - 12/2014)
8.	Chrzanowska-Lightowlers, Zofia M A: 2 articles (01/2020 - 12/2014)
9.	Scorilas, Andreas: 2 articles (02/2008 - 05/2005)
10.	Thomadaki, Hellinida: 2 articles (02/2008 - 05/2005)

Related Diseases

1.	Neoplasms (Cancer) 01/01/2021 - "The high frequent mutation of family with sequence similarity 46, member C (FAM46C) is closely related with the occurrence and progression of MM. Recently, FAM46C has been identified as a non-canonical poly(A) polymerase (PAP) that functions as a tumor suppressor in MM. This study aimed to elucidate the structural features of this novel non-canonical PAP and how MM-related mutations affect the structural and biochemical properties of FAM46C, eventually advancing our understandings towards FAM46C mutation-related MM occurrence. " 04/08/1986 - "Cell-free synthesis of tumor-type poly(A) polymerase." 08/02/1965 - "[Distribution of a polyadenylate synthetase in adult and embryonal normal tissues and in tumor tissues]." 01/01/2021 - "To elucidate the role of the most-studied mammalian poly(A) polymerase, poly(A) polymerase α (PAPOLA), in cancer, we assessed its expression in 221 breast cancer samples and found it to correlate strongly with the aggressive triple-negative subtype. " 01/01/2020 - "Family‑with‑sequence‑similarity‑46c (Fam46c), a non‑canonical poly(A) polymerase, has been reported to be critical in NCTD‑mediated effects in numerous types of cancer, including hepatoma. "
2.	Hepatocellular Carcinoma (Hepatoma) 02/01/1985 - "Structural and immunological identity of rat hepatoma and fetal liver nuclear poly(A) polymerase." 08/01/1976 - "Nuclear poly(A) polymerase from rat liver and a hepatoma. " 03/11/1975 - "Mitochondrial poly(A) polymerase from a poorly differentiated hepatoma: purification and characteristics." 09/13/1974 - "Expression of purified mitochondrial poly(A)polymerase of hepatomas by an endogenous primer from liver.." 01/01/2020 - "Family‑with‑sequence‑similarity‑46c (Fam46c), a non‑canonical poly(A) polymerase, has been reported to be critical in NCTD‑mediated effects in numerous types of cancer, including hepatoma. "
3.	Body Weight (Weight, Body) 12/01/1980 - "To study the role of post-transcriptional polyadenylation in the mechanism of estrogen action, we measured free nucleoplasmic poly(A) polymerase activity in intact uterine nuclei of immature rabbits at timed intervals after a single intravenous dose of estradiol (20 microgram/kg body weight). "
4.	Vaccinia 06/29/2007 - "Vaccinia poly(A) polymerase (VP55) interacts with > or = 33-nucleotide (nt) primers via uridylates at two sites (-27/-26 and -10). " 06/14/1995 - "VP39, the stimulatory subunit of vaccinia poly(A) polymerase, interacted with the immobilized 6His-VP55. " 09/12/1973 - "Polyadenylate polymerase from vaccinia virions." 06/01/2002 - "At the 3' end it acts as a processivity factor for the vaccinia poly(A) polymerase (VP55), promoting poly(A) tail elongation. " 07/01/1999 - "RNA binding characteristics and overall topology of the vaccinia poly(A) polymerase-processivity factor-primer complex."
5.	Multiple Myeloma 01/01/2021 - "Structural and functional characterization of multiple myeloma associated cytoplasmic poly(A) polymerase FAM46C." 01/01/2020 - "We report the crystal structure of FAM46C to provide the basis for its poly(A) polymerase activity and rationalize mutations associated with multiple myeloma. " 01/01/2020 - "FAM46C, a non-canonical poly(A) polymerase, is frequently mutated in multiple myeloma. " 01/01/2020 - "FAM46C, frequently mutated in multiple myeloma (MM), has recently been shown to encode a non-canonical poly(A) polymerase (ncPAP). " 01/01/2017 - "Here the authors show that FAM46C is a poly(A) polymerase and that loss of function of FAM46C drives multiple myeloma through the destabilisation of ER response transcripts."

Related Drugs and Biologics

1.	Enzymes
2.	Antibodies
3.	Messenger RNA (mRNA)
4.	RNA Precursors (Precursor, mRNA)
5.	Estrogens (Estrogen)
6.	Estradiol (Delestrogen)
7.	rifamycin SV
8.	Proteins (Proteins, Gene)
9.	Poly A
10.	RNA (Ribonucleic Acid)