Pneumothorax

An accumulation of air or gas in the pleural space, which may occur spontaneously or as a result of trauma or a pathological process, or be introduced deliberately ( = PNEUMOTHORAX, ARTIFICIAL). (Dorland, 27th ed)

Networked: 4347 relevant articles (171 outcomes, 231 trials/studies)

Relationship Network

Disease Context: Research Results

Related Diseases

1.	Pleural Effusion (Pleural Effusions)
2.	Blister (Bulla)
3.	Hemothorax
4.	Malignant Pleural Effusion
5.	Emphysema

Experts

1.	Chen, Jin-Shing: 15 articles (07/2014 - 01/2004)
2.	Kanazawa, Susumu: 12 articles (11/2015 - 10/2006)
3.	Hsu, Hsao-Hsun: 12 articles (05/2014 - 01/2004)
4.	Hiraki, Takao: 11 articles (11/2015 - 10/2006)
5.	Gobara, Hideo: 10 articles (11/2015 - 10/2006)
6.	Inaba, Kenji: 9 articles (12/2015 - 10/2010)
7.	Fujiwara, Hiroyasu: 9 articles (11/2015 - 10/2006)
8.	Moss, Joel: 9 articles (01/2015 - 12/2005)
9.	Takaki, Haruyuki: 8 articles (12/2015 - 03/2007)
10.	Yamakado, Koichiro: 8 articles (12/2015 - 12/2005)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Pneumothorax:

1.	TalcFDA Link 10/01/1994 - "We conclude from these observations that the insufflation of 2 g of talc into the pleural space is a safe effective treatment for control of recurrent spontaneous pneumothorax." 11/01/2004 - "Feasibility, safety and efficacy of VATS for management of recurrent primary spontaneous pneumothorax following thoracoscopic talc poudrage are strongly suggested." 07/01/2012 - "The aim of this study was to compare talc poudrage and pleural abrasion in the treatment of spontaneous pneumothorax. " 07/01/2012 - "Comparative study of talc poudrage versus pleural abrasion for the treatment of primary spontaneous pneumothorax." 10/01/2011 - "A complete response was obtained in all patients with pneumothorax in both the iodopovidone and talc groups. "
2.	OxygenIBA 01/01/1993 - "Patients with severe airspace enlargement (2.6-40 mm internal diameter) had a significantly greater incidence of pneumothorax (8 versus 2, p < 0.05), were ventilated using higher peak airway pressures (56 +/- 18 cmH2O versus 44 +/- 10 cmH2O, p < 0.05) and tidal volumes (12 +/- 3 ml/kg versus 9 +/- 2 ml/kg, p < 0.05), were exposed significantly longer to toxic levels of oxygen (8.6 +/- 9.4 days versus 1.9 +/- 2 days at FIO2 > 0.6, p < 0.05) and lost more weight (6.3 +/- 9.2 kg versus 0.75 +/- 5.8 kg, p < 0.05) than patients with mild airspace enlargement (1-2.5 mm internal diameter). " 12/01/2013 - "Following interventional treatment, pneumothorax occurred in 1 patient who was cured after oxygen therapy. " 10/15/2013 - "Among 73 cases of pneumothorax (n = 73, 11.7%), 65 cases (n = 65, 10.4%) of mild pneumothorax (lung compression < 20%) were cured by sufficient oxygen inhalation and repose while 8 cases (1.3%) suffered lung compression ≥ 75% recovered via closed thoracic drainage. " 06/01/2000 - "Traditionally, supplemental oxygen is administered to patients with asymptomatic pneumothorax to accelerate spontaneous resolution. " 06/30/2012 - ""We undertook this study to investigate the adequate oxygen concentration that can be applied safely to the treatment of pneumothorax. "
3.	Fibrin Tissue Adhesive (Fibrin Sealant)IBA 07/01/2015 - "Pneumothorax with intractable air leakage often needs interventional treatments like endobroncheal occlusion (EBO) or thoracographic fibrin glue sealing method (TGF) as well as urgent thoracoscopic surgery. " 06/01/2012 - "Use of fibrin glue in the treatment of pneumothorax in premature infant." 01/01/2007 - "The recurrence rate after thoracoscopic bullectomy with fleece-coated fibrin glue was significantly lowered and we consider this procedure to be the treatment of choice for the management of spontaneous pneumothorax." 07/01/2006 - "Fibrin glue for persistent pneumothorax in an extremely low birth weight infant." 02/01/2003 - "Intrapleural administration of a large amount of diluted fibrin glue for intractable pneumothorax. "
4.	Minocycline (Cyclops)FDA LinkGeneric 11/01/2011 - "The current study is designed to compare the effectiveness of brushing the pleura vs. instillation of minocycline for the management of primary spontaneous pneumothorax, and to assess the sensitivity of echography in defining areas of defects. " 03/01/2012 - "After a mean follow-up of 26.1 months, recurrent ipsilateral pneumothorax occurred in 3 patients (3.8%) in the pleurectomy group and 3 patients (3.8%) in the abrasion/minocycline group. " 03/01/2012 - "To compare the efficacy and safety between apical pleurectomy and pleural abrasion with minocycline in primary spontaneous pneumothorax (PSP) with high recurrence risk. " 07/01/2008 - "Intrapleural minocycline following simple aspiration for initial treatment of primary spontaneous pneumothorax." 03/01/2006 - "After a mean follow-up of 29 mo (12-47 mo), recurrent ipsilateral pneumothorax was noted in two patients in the minocycline group and eight patients in the observation group (p = 0.044 by the Kaplan-Meier method and log-rank test). "
5.	Polyglycolic Acid (Polyglycolide)IBA 06/01/2013 - "Efficacy of polyglycolic acid sheet after thoracoscopic bullectomy for spontaneous pneumothorax." 11/01/2015 - "Covering the staple line with a polyglycolic acid sheet after bullectomy for primary spontaneous pneumothorax prevents postoperative recurrent pneumothorax." 01/01/2012 - "Staple line coverage with a polyglycolic acid sheet plus pleural abrasion by thoracoscopic surgery is a useful method for preventing morbidity and the postoperative recurrence of pneumothorax." 01/01/2012 - "We investigated surgical results of staple line coverage with a polyglycolic acid sheet plus pleural abrasion by thoracoscopic surgery for treating primary spontaneous pneumothorax in young patients. " 01/01/2012 - "Staple line coverage with a polyglycolic acid sheet plus pleural abrasion by thoracoscopic surgery for primary spontaneous pneumothorax in young patients."
6.	lipoarabinomannan (LAM)IBA 06/15/2010 - "We hypothesized that targeted screening of an LAM-enriched population of nonsmoking women between the ages of 25 and 54 years, who present with a sentinel pneumothorax indicated by high-resolution computed tomography (HRCT), will facilitate early identification, definitive therapy, and improved quality of life for patients with LAM. " 01/01/2014 - "We report a case of young female with pulmonary LAM presenting with recurrent pneumothorax. " 12/01/2010 - "We believe that TPC is a safe and reliable procedure for the management of intractable pneumothorax secondary to LAM. " 12/01/2010 - "The patient was a 28-year-old woman with bilateral pneumothorax secondary to LAM who had undergone thoracoscopic surgery in another hospital. " 06/15/2010 - "The diagnosis of LAM is typically delayed until after the second pneumothorax. "
7.	Tetracycline (Achromycin)FDA LinkGeneric 11/07/1990 - "This prospective, multicenter, randomized, "unblinded," controlled clinical trial was designed to determine if the intrapleural instillation of 1500 mg of tetracycline hydrochloride would be effective in diminishing the ipsilateral rate of recurrence for spontaneous pneumothorax. " 01/01/1992 - "Between 1983 and 1987 the Department of Veterans Affairs conducted a cooperative study at 13 medical centers to assess the utility of the intrapleural instillation of tetracycline for the prevention of recurrent pneumothorax. " 03/06/1991 - "Intrapleural tetracycline for recurrent pneumothorax." 11/07/1990 - "Use of tetracycline seemed to reduce the recurrence rates for patients with either primary or secondary spontaneous pneumothorax and for patients with either an initial or a recurrent pneumothorax. " 11/07/1990 - "Intrapleural tetracycline for the prevention of recurrent spontaneous pneumothorax. "
8.	PicibanilIBA 11/01/2006 - "Thoracic drainage and bullectomy by thoracoscopy did not improve the pneumothorax, so pleurodesis with OK-432 was done. " 04/01/2006 - "Although the long-term outcome of this treatment is not known, pleurodesis using autologous blood plus OK-432 may be an effective way of treatment for spontaneous pneumothorax in cases with high surgical risk." 04/01/2006 - "[Pleurodesis using autologous blood plus OK-432 for intractable spontaneous pneumothorax with high surgical risk]." 01/01/1988 - "[OK432 chemical pleurodesis as a standard therapy of spontaneous pneumothorax]." 02/01/1990 - "For the treatment of obstinately continuing right pneumothorax resection of bullae in combination with pleuropexy using OK 432 was effective. "
9.	Anti-Bacterial Agents (Antibiotics)IBA 12/01/2013 - "Despite treatment with a combination of antibiotics showing in vitro susceptibility, the pathogen persisted in the respiratory secretions for longer than 6 months and the patient suffered a spontaneous pneumothorax 14 months into treatment. " 04/01/2010 - "Because of the increasing respiratory distress an intercostal drain was placed in the left pneumothorax and broad-spectrum antibiotics were administered. " 11/11/1978 - "Patients suffering from uncomplicated pneumothorax, haemothorax or haemopneumothorax of clinical significance are treated with fluid replacement, intercostal under-water drainage, antibiotics and routine physiotherapy. " 12/01/1958 - "[Endobronchial instillations with chemio-antibiotics combined with pneumothorax in therapy of caverns included in blocked areas]." 05/01/1954 - "[Effect of thoracic surgery and antibiotics on the indications and management of intrapleural pneumothorax]."
10.	Prostaglandins A (PGA)IBA 01/01/2014 - "The differences in the gender, smoking habits, lesion site, location, comorbidities, ipsilateral spontaneous pneumothorax (ISP), contralateral spontaneous pneumothorax (CSP) and surgery for ISP did not reach statistical significance between the patients treated with a covering of ROCM and those treated with PGA/TC, although the age of the patients was significantly different in these groups, with the ROCM group having younger patients (p = 0.024). " 01/01/2012 - "The incidence of initial air leakage (58.3% [14/24] vs. 93.8% [30/32], p<0.05) and relapse rate of pneumothorax in 6 months (4% [1/24] vs. 25% [8/32], p<0.05) were also significantly lower in patients who used an absorbable PGA patch in the operation compared with those who did not use a PGA patch. " 04/01/2011 - "These data suggested that apical tenting method with a PGA sheet can reduce the recurrence rate of the pneumothorax after bullectomy, while it can not inhibit recurrent bullous formation." 10/01/2003 - "The relapse of pneumothorax after surgery developed in 2 patients in PGA group (10.5%) and 8 patients in non-reinforce group (26.7%). " 06/01/2013 - "The purpose of this study was to determine the efficacy of a polyglycolic acid (PGA) sheet and pleural abrasion for prevention of recurrent postoperative pneumothorax. "

Therapies and Procedures

1.	Pleurodesis 01/01/2000 - "VATS combined with mechanical brush pleurodesis using the electrical brush system is a highly effective and safe treatment for patients with recurrent primary spontaneous pneumothorax." 09/01/2007 - "Spontaneous pneumothorax is a common problem and in patients at risk of recurrence, excision of the source of the air leak and pleurodesis is very effective in reducing further episodes. " 01/01/1988 - "We conclude that thoracoscopy enables accurate assessment of the type of pneumothorax, and can play an important role in the management of SP. Chemical pleurodesis causes a significant reduction of the recurrence rate in the treatment of idiopathic SP." 02/01/2004 - "We describe an 8-year-old boy with acute lymphoblastic leukaemia complicated by chronic GVHD-related BO, and subsequent pneumothorax with persistent air leak, who was treated successfully with autologous blood pleurodesis." 01/01/2011 - "Chemical pleurodesis is an effective treatment for persistent air leakage and secondary pneumothorax. "
2.	Chest Tubes (Chest Tube) 12/01/2009 - "In 210 (86.4%), the pneumothorax had resolved completely on follow-up chest radiographs without chest tube placement. " 11/01/2006 - "In 87 of the 102 patients (85.3%), the pneumothorax had resolved completely on follow-up chest radiographs without chest tube placement, but chest tube placement was required in 15 patients. " 10/01/2006 - "The pneumothorax had resolved completely on follow-up chest radiographs without chest tube placement in 121 of the 133 pneumothoraces (91.0%). " 04/01/2005 - "In 95 of the 104 pneumothoraces (91.3%), the pneumothorax had resolved completely on follow-up chest radiographs without chest tube placement. " 10/01/2011 - "Among patients with a pneumothorax, the proportion of cases biopsied in the supine position was significantly greater in the chest tube placement group (58.3%; 7/12) than in the nonchest tube placement group (28.4%; 23/81) (P=0.026). "
3.	Catheters 07/03/2007 - "With higher curative effect and lower expenses, pleural drainage by using central venous catheter is superior to simple aspiration in treatment of spontaneous pneumothorax, and can be the first choice." 08/01/2001 - "The visibility of a pneumothorax (p < 0.01), vascular catheters (p < 0.001), the minor fissure (p < 0.001), and the anterior segmental bronchus of the right upper lobe (p < 0.001) improved significantly after applying edge enhancement to soft copies of neonatal chest radiographs, whereas the visibility of the aortic arch did not improve. " 03/01/2013 - "Small-bore pigtail catheters have been found to be effective in the treatment of primary spontaneous pneumothorax (PSP) in adults. " 10/01/2012 - "Our findings suggest that drainage via a catheter or via a CT is similarly effective in the management of pneumothorax. " 12/01/1990 - "To assess the efficacy of simple aspiration as a treatment for pneumothorax, 40 consecutive pneumothoraces (28 spontaneous, 12 iatrogenic, all estimated at greater than or equal to 20% collapse on visual inspection of the chest X-ray) in 38 symptomatic patients were treated initially by small-lumen catheter (SLC) aspiration. "
4.	Thoracostomy 08/01/1994 - "Most cases of spontaneous pneumothorax can be handled either expectantly or by tube thoracostomy with good results. " 06/01/1994 - "Conservative treatment, including tube thoracostomy, was effective for primary and secondary spontaneous pneumothorax. " 09/01/2010 - "The existing evidence leads to the conclusion that observation is at least as safe and effective as tube thoracostomy for management of occult pneumothorax." 01/01/2008 - "The existing evidence indicates that needle aspiration is at least as safe and effective as tube thoracostomy for management of primary spontaneous pneumothorax. " 05/01/2013 - "Each patient underwent tube thoracostomy with improvement in pneumothorax and respiratory status."
5.	Thoracotomy 06/01/1998 - "There was no significant difference in complications and recurrences among the three groups We conclude from findings that VATS is superior to thoracotomy in the treatment of primary spontaneous pneumothorax. " 01/01/1995 - "Videothoracoscopy techniques are very useful and are good alternatives to conventional thoracotomy in managing cases of pneumothorax, benign pulmonary lesions and in taking biopsies.(ABSTRACT TRUNCATED AT 250 WORDS)" 08/01/2004 - "A prospective, randomized study was carried out on patients with primary spontaneous pneumothorax, with the aim of determining if video-assisted thoracoscopy is superior to axillary thoracotomy in the surgical treatment of this condition. " 08/01/1994 - "We conclude from our findings that VATS is superior to thoracotomy in the treatment of primary spontaneous pneumothorax.(ABSTRACT TRUNCATED AT 250 WORDS)" 01/01/2008 - "To determine whether video-assisted thoracoscopic surgery is as effective as the traditional open method through axillary thoracotomy for the management of primary spontaneous pneumothorax in adults. "