Pneumoperitoneum

A condition with trapped gas or air in the PERITONEAL CAVITY, usually secondary to perforation of the internal organs such as the LUNG and the GASTROINTESTINAL TRACT, or to recent surgery. Pneumoperitoneum may be purposely introduced to aid radiological examination.

Networked: 2387 relevant articles (69 outcomes, 315 trials/studies)

Relationship Network

Disease Context: Research Results

Related Diseases

1.	Neoplasms (Cancer)
2.	Pain (Aches)
3.	Acidosis
4.	Renal Insufficiency (Renal Failure)
5.	Neoplasm Metastasis (Metastasis)

Experts

1.	Kitano, S: 13 articles (08/2005 - 11/2000)
2.	Koninckx, Philippe Robert: 12 articles (03/2011 - 11/2002)
3.	Ishida, H: 12 articles (04/2005 - 02/2000)
4.	Canis, Michel: 10 articles (06/2012 - 04/2007)
5.	Gutt, C N: 10 articles (12/2006 - 05/2000)
6.	Shiraishi, N: 10 articles (08/2005 - 11/2000)
7.	Matsuzaki, Sachiko: 9 articles (06/2012 - 04/2007)
8.	Koninckx, P R: 9 articles (02/2010 - 03/2000)
9.	Binda, Maria Mercedes: 8 articles (12/2013 - 09/2003)
10.	Mage, Gérard: 8 articles (05/2011 - 04/2007)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Pneumoperitoneum:

1.	Carbon MonoxideIBA 02/01/2003 - "With similar settings of tidal volume and ventilation rate for the two groups, the measured end-tidal CO(2) value was significantly greater for group 1 than for group 2 patients after the creation of a CO(2) pneumoperitoneum (34.2 +/- 2.7 vs. 30.7 +/- 3.6 mm Hg; P =.012). " 07/01/2007 - "CO(2) pneumoperitoneum is a very useful technique. " 08/01/2011 - "Improved ventilation-perfusion matching with increasing abdominal pressure during CO(2) -pneumoperitoneum in pigs." 07/01/2012 - "Therefore, we planned this prospective clinical trial to study the effect of steep Tredelenburg position with high-pressure CO(2) pneumoperitoneum on hemodynamic parameters in a patient undergoing RALRP using FloTrac/Vigileo™1.10. " 06/01/2012 - "The objective of this study was, therefore, to evaluate body temperature patterns in pigs subjected to pneumoperitoneum with CO(2). "
2.	Carbon DioxideIBA 09/01/2007 - "The placement of a 2-mm needle port, mandatory to insufflate carbon dioxide and to monitor the pneumoperitoneum, was helpful for further retraction of the gallbladder. " 04/01/1996 - "In pneumoperitoneum, carbon dioxide eliminated in expired gas (carbon dioxide output) contains both metabolic and absorbed carbon dioxide from the peritoneal cavity. " 05/01/2015 - "This study investigated the extent of the raised intracranial pressure resulting from carbon dioxide (CO2) pneumoperitoneum by ultrasonographically measuring optic nerve sheath diameter (ONSD) in children undergoing laparoscopic surgery. " 08/01/2014 - "A recent study demonstrated that high pressure of carbon dioxide (CO2) pneumoperitoneum before liver resection impairs postoperative liver regeneration. " 08/01/2013 - "As seen in previous studies, basement membrane nudity appeared after carbon dioxide pneumoperitoneum could be attributable to mesothelial cell apoptosis, deterioration of the cell structure, and cell organelles."
3.	HeliumIBA 05/01/2008 - "Helium ameliorates renal alterations when used for pneumoperitoneum, and it might be used for patients with compromised renal function who have to undergo laparoscopic surgery." 12/01/2006 - "Improved abdominal wall wound healing by helium pneumoperitoneum." 01/01/2005 - "The aim of this study was to investigate the effect of CO2 and helium pneumoperitoneum on the recovery of postoperative gastrointestinal motility. " 09/01/2002 - "For this study, 30 male WAG/Rij rats were randomized into two groups to obtain pneumoperitoneum with CO2 (n=15) or helium (n = 15). " 07/01/2002 - "Therefore, the aim of this study was to investigate in spontaneously breathing rats the effects of CO2 and helium, insufflation pressure, and duration of pneumoperitoneum on blood pressure, arterial pH, pCO2, pO2, HCO3-, base excess, and respiratory rate. "
4.	OxygenIBA 01/01/2010 - "Although human studies are lacking, animal data indicate that peritoneal adhesions can be reduced by over 80% with a good surgical technique, with adequate pneumoperitoneum conditioning as adding 3-4% of oxygen to the CO2 pneumoperitoneum, prevention of desiccation and slight cooling. " 08/01/2009 - "The aim of this study was to evaluate the effect of pneumoperitoneum in a 30 degrees Trendelenburg position on cerebral oxygenation using regional cerebral oxygen saturation (rSO2). " 12/01/2004 - "This study confirms that adhesion formation is decreased with the addition of 3% oxygen to the CO2 pneumoperitoneum. " 05/01/2015 - "Pneumoperitoneum and Trendelenburg position cause more obvious cerebral blood backflow in elderly patients than in middle-aged patients but do not affect cerebral metabolism of oxygen." 02/01/2014 - "Both monitors showed a clinically irrelevant decrease in cerebral oxygen saturation of less than 5% over 4 h in a steep Trendelenburg position combined with CO2 pneumoperitoneum in patients undergoing robotic assisted prostatic surgery. "
5.	DexmedetomidineFDA Link 01/01/2014 - "This study was intended to investigate the effect of dexmedetomidine on oxidative stress response in pneumoperitoneum established in rats. " 08/01/2003 - "In the conditions of our study, dexmedetomidine has inhibited catecholamine release during tracheal intubation and pneumoperitoneum, however, has not prevented blood pressure increase in response to peritoneal inflation." 03/01/2015 - "Group D received dexmedetomidine loading dose 1 mcg/kg over a period of 15 min and maintenance 0.5 mcg/kg/h throughout the pneumoperitoneum. " 01/01/2014 - "Dexmedetomidine decreases oxidative stress caused by pneumoperitoneum and strengthens the antioxidant defense system." 01/01/2014 - "Animals were randomized into three groups, group S: with no pneumoperitoneum, group P: with pneumoperitoneum established, and group D: given 100 mcg intraperitoneal dexmedetomidine 30 min before establishment of pneumoperitoneum. "
6.	salicylhydroxamic acid (SHAM)IBA 10/01/2004 - "Two study groups were subjected to laparoscopic and open bowel injury, and 2 control groups underwent pneumoperitoneum and sham open surgery, respectively, without bowel injury. " 01/01/2002 - "For this study, 50 male Sprague-Dawley rats were divided into five equal groups: control (group 1); sham operation (group 2); 5, 10, or 15 mmHg (group 3, 4, or 5) pneumoperitoneum with CO2 groups. " 01/01/2014 - "The control group (S) was subjected to a sham operation without pneumoperitoneum. " 07/05/2012 - "Twenty-four 40-kg female pigs were allocated to four groups: 25 mmHg IAH with CO2 pneumoperitoneum (n = 8), >20 mmHg IAH caused by addition of volume (n = 8), and two corresponding sham groups (each n = 4). " 07/01/2012 - "A total of 32 rats were randomly allocated into four groups consisting of eight in each as follows: Group I was subjected to a sham operation without pneumoperitoneum (Pp). "
7.	Fentanyl (Sublimaze)FDA LinkGeneric 04/01/2015 - "Laparoscopic surgeries have attained the status of a gold standard for most of the abdominal pathology; we therefore performed this study to assess feasibility and safety of major laparoscopic surgeries like laparoscopic cholecystectomy (LC) and laparoscopic assisted vaginal hysterectomy (LAVH)/total laparoscopic hysterectomy (TLH) under regional anesthesia that is combined spinal epidural anesthesia (CSE) with normal pressure pneumoperitoneum using intrathecal fentanyl with bupivacain. " 03/01/2015 - "Heart rate (HR), systolic blood pressure, diastolic blood pressure and mean arterial pressure (MAP) were recorded preoperative, after study drug, after induction, after intubation, after pneumoperitoneum at 15 min intervals, post pneumoperitoneum and postoperative period after 15 min. Propofol induction dose, intraoperative fentanyl requirement and sedation score were also recorded. " 02/01/2012 - "Compared with the control group, the use of hypocapnia before and during pneumoperitoneum was associated with significantly lower arterial blood pressures, lower PaCO(2) and EtCO(2) values, a higher Pa-ETCO(2), a higher RR (p < 0.001), and less need for supplemental doses of fentanyl and labetalol. " 07/01/2011 - "The thoracic epidural anesthesia with 0.75% ropivacaine and fentanyl for elective laparoscopic cholecystectomy is efficacious and has preserved ventilation and hemodynamic changes within physiological limits during pneumoperitoneum with minimal treatable side effects." 06/01/2004 - "This study involved 16 dogs anesthetized with sodium thiopental and fentanyl, which were divided in two groups: Group 1: volume controlled; and Group 2: pressure controlled, both submitted to 10 and 15 mmHg pneumoperitoneum. "
8.	BariumIBA 03/01/1984 - "Pneumoperitoneum, upper gastrointestinal barium studies, and liver/spleen scans were all diagnostically helpful in selected patients. " 01/01/1975 - "The diagnosis was usually established by serial chest roentgenography, in a few cases supplemented by barium contrast studies, angiography or air insufflation in the abdomen (pneumoperitoneum). " 01/01/1990 - "The authors used diagnostic pneumoperitoneum in combination with contrast (barium + air) examination of the colon. " 04/01/1982 - "A patient had pneumoperitoneum after an air contrast barium examination. " 01/01/1979 - "Chest X-ray, barium meal and pneumoperitoneum are required to detect a late herniation. "
9.	Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)IBA 08/01/2006 - "All chemically vagotomized animals had significantly reduced TNF-alpha levels compared to their saline-treated counterparts (p < 0.05 for all), except among the CO2 pneumoperitoneum-treated animals. " 08/01/2006 - "Serum tumor necrosis factor-alpha (TNF-alpha) levels were consistently suppressed among the saline-CO2 pneumoperitoneum groups compared to saline-LPS only control groups (p < 0.05 for all four experiments). " 01/01/2001 - "Although peak plasma TNF-alpha levels in the pneumoperitoneum group were seen immediately after the procedure, other changes in plasma cytokine levels did not differ significantly between the 3 groups. " 01/01/2001 - "PLF TNF-alpha and IL-1beta levels in the pneumoperitoneum group were significantly lower than levels in the control and laparotomy groups soon after the procedure (p < 0.05). " 09/01/2006 - "Because IL-10 is known to downregulate TNF-alpha, the increase in IL-10 and the decrease in TNF-alpha found among the CO2-insufflated animals in our study provide evidence for a mechanism whereby CO2 pneumoperitoneum reduces mortality via IL-10-mediated downregulation of TNF-alpha."
10.	Bupivacaine (Bupivacaine Hydrochloride)FDA LinkGeneric 02/01/2012 - "The sprayed intraperitoneal bupivacaine (SIB) group received 4.4 mg/kg of sprayed intraperitoneal bupivacaine diluted to 0.25% with an equivalent volume of saline after pneumoperitoneum. " 12/01/2006 - "We aimed to investigate the effect of intraperitoneal bupivacaine administration to the subhepatic area before the creation of the pneumoperitoneum. " 07/01/2006 - "Although the effect of bupivacaine peritoneal instillation is also noticeable when used after creation of pneumoperitoneum, it confers significantly lower benefits." 07/01/2006 - "Group B received 2 mg/kg of bupivacaine in 200 ml of normal saline after creation of pneumoperitoneum. " 07/01/2006 - "Group A received 2 mg/kg of bupivacaine in 200 ml of normal saline before creation of pneumoperitoneum. "

Therapies and Procedures

1.	Laparoscopic Cholecystectomy 08/01/1993 - "This study demonstrated a significant reduction in common femoral venous flow during laparoscopic cholecystectomy coincident with pneumoperitoneum and reverse Trendelenburg's position. " 01/01/2012 - "We think that 10 mmHg pressure pneumoperitoneum is superior to 14 mmHg pressure pneumoperitoneum in laparoscopic cholecystectomy." 01/01/2002 - "Gasless laparoscopic cholecystectomy is a feasible, safe and effective alternative to the pneumoperitoneum technique. " 04/01/2014 - "Comparison of standard-pressure and low-pressure pneumoperitoneum in laparoscopic cholecystectomy: a double blinded randomized controlled study." 02/01/2014 - "Further to study the safety of low pressure pneumoperitoneum in laparoscopic cholecystectomy. "
2.	Surgical Instruments (Clip) 04/01/2008 - "This study shows that that when performed by an experienced laparoscopic surgeon the direct trocar insertion technique is a safe and effective alternative for creation of pneumoperitoneum." 06/01/2008 - "Initial laparoscopic access using an optical trocar without pneumoperitoneum is safe and effective in the morbidly obese." 06/01/2008 - "The aim of this study was to examine the safety and efficacy of accessing the peritoneal cavity using an optical, bladeless trocar without previous pneumoperitoneum in morbidly obese patients. " 12/01/2000 - "Efficacy of establishment of pneumoperitoneum with the Veress needle, Hasson trocar, and modified blunt trocar (TrocDoc): a randomized study." 05/01/2008 - "The operation steps involved open insertion of trocar and creation of pneumoperitoneum, meticulous adhesiolysis, direct choledochotomy followed by clearance of biliary stones. "
3.	Laparotomy 12/01/2006 - "On POD1 all animals had diminished NKA when compared to controls; NKA after pneumoperitoneum was significantly greater than after laparotomy. " 04/01/2015 - "Though traditionally, anterior approach of the presacral tumours meant laparotomy, but recently, laparoscopy has been reported as a safe and effective option for these tumours with the advantages of a magnified view in the narrow pelvis, easier development of natural planes by pneumoperitoneum, faster recovery and less complications if expertise is available. " 02/01/2008 - "In the present study we emphasize that pneumoperitoneum is not an absolute indication for exploratory laparotomy in NEC cases. " 12/01/2006 - "The current study investigated the gas-dependent effects of pneumoperitoneum on laparotomy wound healing. " 11/01/2006 - "The aim of this study is to present that an insertion of Veres needle in the region of umbilicus is a safe method for creating a pneumoperitoneum for laparoscopic operations after previous laparotomy. "
4.	Positive-Pressure Respiration (PEEP) 12/01/2010 - "RM combined with 10 cm H2O of PEEP improved EELV, respiratory mechanics, and oxygenation during pneumoperitoneum whereas PEEP alone did not." 11/01/2007 - "Changes of lung volume correlated with changes of oxygenation (linear regression, R2 = 0.524, P < 0.001) so that during pneumoperitoneum, only the combination of the BC position and PEEP improved oxygenation. " 05/01/2010 - "This study investigated whether positive end-expiratory pressure (PEEP) of 5 cmH(2)O in pressure-controlled ventilation (PCV) mode can improve ventilatory and oxygenation parameters during pneumoperitoneum. " 11/01/2014 - "Pneumoperitoneum stiffened the chest wall and the respiratory system (increased elastance), but did not stiffen the lung, and positive end-expiratory pressure reduced Ecw during pneumoperitoneum. " 09/01/2013 - "Effects of high positive end-expiratory pressure on haemodynamics and cerebral oxygenation during pneumoperitoneum in the Trendelenburg position."
5.	Drug Therapy (Chemotherapy) 01/01/2011 - "The combination of the old technique of therapeutic pneumoperitoneum along with the current antituberculosis treatment proved to be effective in this advanced case of pulmonary TB initially unresponsive to drug therapy alone." 01/01/2006 - "Artificial pneumoperitoneum (PP) was applied to the study group patients (n = 95) during adequate chemotherapy. " 02/01/2012 - "Controversies associated with the procedure include the thoroughness of dissection, the high rate of chemotherapy exposure and the potential deleterious effects of pneumoperitoneum. " 01/01/2009 - "In Group 2 (n = 54), lymphotropic procedure was employed alone during standard chemotherapy; in Group 3 (n = 46), only pneumoperitoneum was used in combination of chemotherapy. " 10/18/1996 - "A chest radiogram, taken on the 18th day of chemotherapy to exclude pulmonary infiltration, revealed pneumoperitoneum. "