of Sheep Progressive Interstitial Pneumonia (Maedi)

Chronic respiratory disease caused by the VISNA-MAEDI VIRUS. It was formerly believed to be identical with jaagsiekte (PULMONARY ADENOMATOSIS, OVINE) but is now recognized as a separate entity.

Also Known As:

Networked: 62 relevant articles (2 outcomes, 1 trials/studies)

Relationship Network

Disease Context: Research Results

Related Diseases

1.	Visna
2.	Infection
3.	Encephalitis (Encephalitis, Rasmussen)
4.	Arthritis (Polyarthritis)
5.	Pneumonia (Pneumonitis)

Experts

1.	Peterhans, E: 3 articles (11/2001 - 04/2000)
2.	Minguijón, E: 2 articles (02/2015 - 04/2013)
3.	Zanoni, R: 2 articles (11/2001 - 04/2000)
4.	Esparza-Baquer, A: 1 article (02/2015)
5.	Larruskain, A: 1 article (02/2015)
6.	Juste, R A: 1 article (02/2015)
7.	Mateo-Abad, M: 1 article (02/2015)
8.	Pérez, V: 1 article (02/2015)
9.	Jugo, B M: 1 article (02/2015)
10.	Benavides, J: 1 article (02/2015)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to of Sheep Progressive Interstitial Pneumonia:

1.	AntigensIBA 10/01/2011 - "Three animals (1.12%), out of 267 samples tested, were found to be seropositive to the visna-maedi antigens in both tests. " 01/01/2003 - "The results suggest that (i) MVV causes heterogeneous lesions in homogeneously reared ewes, (ii) MVV p28 antigen is detectable not only in inflammed target organs, but also in pulmonary lymph nodes, spleen and bone marrow, and (iii) immunohistochemistry and PCR are useful methods for Maedi-Visna diagnosis in suspected cases, also when serological tests are negative." 01/01/1993 - "In the present paper antigen preparation is described to be used for diagnostics of Maedi-Visna disease by immunodiffusion test (IDT). " 01/01/1993 - "[Preparation of precipitation antigens for the diagnosis of Maedi-Visna]." 04/01/1988 - "Sera from 74 sheep culled from one flock on the basis of performance and response to immunological tests for paratuberculosis or maedi visna were used to evaluate the serological response to a sonicated antigen of Mycobacterium paratuberculosis by crossed immunoelectrophoresis. "
2.	Sodium Dodecyl Sulfate (Sodium Lauryl Sulfate)IBA 10/01/1990 - "We report the efficacy of an anionic detergent, sodium dodecyl sulfate (SDS) for preparing maedi-visna antigens for an indirect enzyme-linked immunosorbent assay (i-ELISA). "
3.	PeptidesIBA 04/15/2013 - "ENV-TM ELISAs based on peptides 126M1 (Se: 82%; Sp: 95%) and 126M2 0,65 0.77 (Se: 68%; Sp: 88%) detected preferentially caprine arthritis encephalitis (CAEV, type B) and visna/maedi (VMV, type A) virus infections respectively, which may help to perform a preliminary CAEV vs. VMV-like typing of the flock. "
4.	Detergents (Detergent)IBA 10/01/1990 - "We report the efficacy of an anionic detergent, sodium dodecyl sulfate (SDS) for preparing maedi-visna antigens for an indirect enzyme-linked immunosorbent assay (i-ELISA). "
5.	Transcription Factor AP-1 (Transcription Factor AP 1)IBA 08/15/2006 - "Previous studies with the closely related maedi visna lentivirus have indicated that viral transcription is dependent upon the AP-1 transcription factor. "
6.	Transcription Factors (Transcription Factor)IBA 08/15/2006 - "Previous studies with the closely related maedi visna lentivirus have indicated that viral transcription is dependent upon the AP-1 transcription factor. "
7.	AntibodiesIBA 10/01/2013 - "No standard reference test for the diagnosis of maedi visna has been validated up to the present, and it is puzzling that tests which detect antibodies against the virus and tests which detect the proviral genome may render opposite results. " 05/01/1995 - "[Serologic investigations on the occurrence of Maedi-Visna antibodies in game ruminants]." 11/01/1990 - "In a period of one year blood samples of 374 sheep of Lower Austrian flocks were examined in intervals of two months for antibodies against Maedi-Visna (MV). " 02/01/1990 - "883 sheep from 68 flocks were tested for the prevalence of antibodies against Maedi/Visna-(M/V)virus. " 01/01/1990 - "Survey for antibodies against maedi-visna in sheep in Poland."
8.	RNA (Ribonucleic Acid)IBA 07/01/2008 - "The stimulatory RNA of the Visna-Maedi retrovirus ribosomal frameshifting signal is an unusual pseudoknot with an interstem element." 01/01/1978 - "Lack of maedi viral related RNA in pulmonary carcinoma of sheep (jaagsiekte)." 08/01/1972 - "Properties of maedi nucleic acid and the presence of ribonucleic acid- and deoxyribonucleic acid-dependent deoxyribonucleic acid polymerase in the virions." 11/01/2001 - "Cell cultures from these organs were positive for viral enzymatic reverse transcriptase and for maedi-visna RNA." 10/01/1985 - "A recently isolated Israeli retrovirus from a sheep with maedi-visna was compared with other retroviruses, using cDNA-RNA hybridization in solution. "
9.	DNA (Deoxyribonucleic Acid)IBA 01/01/2011 - "Pairwise DNA distance and phylogenetic analyses revealed that all SRLV sequences obtained from sheep clustered tightly with prototypical Maedi visna sequences from America. " 05/01/2006 - "Maedi-visna proviral DNA sequences were detected in renal and lung tissue samples from these nine sheep by PCR, and the specificity of the amplified products was further verified by DNA sequencing. " 04/01/2000 - "The detection of proviral DNA by semi-nested polymerase chain reaction and phylogenetic analysis of Czech Maedi-Visna isolates based on gag gene sequences." 08/01/1972 - "Properties of maedi nucleic acid and the presence of ribonucleic acid- and deoxyribonucleic acid-dependent deoxyribonucleic acid polymerase in the virions."
10.	Histocompatibility Antigens Class IIIBA 01/01/1996 - "A large proportion of the alveolar lymphocytes in spontaneous maedi, but not in experimentally-infected lambs, express high levels of MHC class II antigen, suggesting an activated phenotype. " 10/01/1992 - "Alveolar lymphocytes of both subsets displayed increased expression of MHC class II antigens in animals with naturally occurring maedi but not in experimentally infected ones. " 12/01/1985 - "It is suggested that LV-IFN induced by the inflammatory cells in visna-maedi lesions may induce Ia antigen expression in macrophages, thereby indirectly causing the lymphoproliferative response and restricted virus replication." 06/01/1990 - "Macrophage activation is also demonstrated by the observation of a significant (x3) increase of spontaneous fibronectin release by alveolar macrophages from maedi lungs, and furthermore by the high level expression of major histocompatibility complex class II antigens on most of these cells. "