Pneumoconiosis

A diffuse parenchymal lung disease caused by inhalation of dust and by tissue reaction to their presence. These inorganic, organic, particulate, or vaporized matters usually are inhaled by workers in their occupational environment, leading to the various forms (ASBESTOSIS; BYSSINOSIS; and others). Similar air pollution can also have deleterious effects on the general population.

Also Known As:

Networked: 1800 relevant articles (26 outcomes, 184 trials/studies)

Relationship Network

Disease Context: Research Results

Related Diseases

1.	Silicosis
2.	Chronic Obstructive Pulmonary Disease (COPD)
3.	Lung Diseases (Lung Disease)
4.	Asbestosis
5.	Anthracosis

Experts

1.	Laney, A Scott: 21 articles (11/2023 - 08/2009)
2.	Halldin, Cara N: 13 articles (01/2023 - 10/2014)
3.	Blackley, David J: 12 articles (11/2023 - 10/2014)
4.	Petsonk, Edward L: 12 articles (01/2023 - 10/2010)
5.	Cohen, Robert A: 10 articles (06/2023 - 01/2014)
6.	Yao, Wu: 10 articles (01/2023 - 07/2005)
7.	Chen, Weihong: 9 articles (01/2023 - 12/2004)
8.	Green, Francis H Y: 8 articles (01/2023 - 12/2004)
9.	Rose, Cecile S: 7 articles (11/2023 - 03/2016)
10.	Li, Tao: 7 articles (09/2023 - 04/2009)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Pneumoconiosis:

1.	Coal (Coals)IBA 01/01/2017 - "Improved participation could allow more precise characterisation of the burden and characteristics of pneumoconiosis in US coal miners and provide an important early detection tool to prevent cases of severe disease." 05/20/2019 - "Conclusion: The comprehensive rehabilitation treatment of individualized exercise program improved the endurance and exercise ability of pneumoconiosis patients, improved the respiratory status and quality of life of pneumoconiosis patients in Huaibei Coal Mine, improved the lung function of pneumoconiosis patients, and improved the forced vital capacity of patients, but the small airway function has not been significantly improved. " 01/01/2015 - "These results establish the need to generate an intervention strategy aimed at preventing the identified factors, as well as a timely identification and effective treatment of pneumoconiosis in coal miners, in which the commitment of the General Health and Social Security System and the workers compensation system is ensured. " 02/01/2024 - "The aim of the study is to summarize Coal Workers' Health Surveillance Program findings since 2014, focusing on prevalence of radiographic pneumoconiosis and abnormal spirometry by region. " 12/01/2022 - "This study examines the radiographic evidence for postexposure progression of pneumoconiosis in a population of former coal miners no longer occupationally exposed to coal mine dust who were seen at a community radiology clinic in eastern Kentucky. "
2.	AerosolsIBA 01/01/2013 - "That helped to formulate a concept of contemporary pneumoconiosis caused by complex industrial aerosol over last 10-15 years." 01/01/1997 - "Results of the examination helped to identify clinical and immunologic features of various pneumoconioses induced by complex industrial aerosols." 01/01/2013 - "The article deals with features of development and formation of various pneumoconioses diagnosed after 1996: less benign course, early complaints, marked functional and X-ray changes in lungs, early complications--these result mainly from lower content of chemicals with fibrogenous effect in industrial aerosol and presence of allergic, cytotoxic and irritating agents. " 01/01/2011 - "The authors provide results of metabolic disorders analysis in the patients vairable in tolerance to industrial aerosol, to forecast pneumoconiosis course after discontinued contact with the hazard." 01/01/2001 - "The authors represent review of literature on fibrogenic effects of welding aerosols and results of own clinical and epidemiologic studies concerning pneumoconiosis course in electric welders compared to other occupational groups. "
3.	AntioxidantsIBA 01/01/2007 - "Results are improved bronchial drainage, normal pro- and antioxidant status, lower inflammatory activity in patients with pneumoconiosis and occupational dust bronchitis." 01/01/1993 - "AD was characteristically depressed, which necessitates the antioxidant treatment of patients with pneumoconiosis and dust bronchitis." 01/01/1993 - "[Lipid peroxidation and antioxidant defence in patients with pneumoconiosis and dust-induced bronchitis]." 01/01/1992 - "Comparative study of the variations of the phagocytic capacity of polymorphonuclear leukocytes and of total plasma antioxidants in patients with pneumoconioses and lung cancer." 01/01/1996 - "No differences were found either in erythrocyte antioxidant enzyme activities or in total plasma antioxidants between the groups of retired miners without and with pneumoconiosis. "
4.	AsbestosIBA 06/01/2009 - "Assessing agreement among experts who study pneumoconiosis, and diagnose and treat patients with asbestos-related respiratory conditions may be the first step in clarifying clinical and forensic/administrative issues associated with asbestos-related pulmonary conditions. " 01/01/1979 - "In a collaborative study with the Pneumoconiosis Medical Panel, 232 asbestos workers were seen between 1967 and 1975. " 01/01/1967 - "[Experimental contribution to the study of asbestos pneumoconiosis. " 01/01/2019 - "An effective screening method for pneumoconiosis in workers exposed to asbestos-contaminated minerals is still lacking. " 11/01/2009 - "[A model to diagnose occupational, asbestos-related pneumoconiosis and thickening of the pleura]."
5.	MineralsIBA 05/01/2010 - "Careful histologic analyses in this study demonstrated that farmwork was significantly associated with mineral dust small airways disease and pneumoconiosis (macules and/or nodules). " 01/01/1980 - "Recent advances in the study of mineral pneumoconiosis." 04/05/2024 - "Pneumoconiosis is a kind of lung dysfunction caused by the inhalation of mineral dust. " 02/20/2021 - "Foundry worker's pneumoconiosis is mainly distributed in the general equipment manufacturing industry and special equipment manufacturing industry, and cement pneumoconiosis is mainly distributed in the non-metallic mineral products industry. " 02/20/2021 - "The proportion of women with new pneumoconiosis in the non-metallic mineral products industry was the highest, and the differences were statistically significant (P<0.05) . "
6.	AluminumIBA 06/01/2024 - "Due to his history of aluminum toxicity from welding, aluminosis pneumoconiosis was suspected. " 01/01/2021 - "Pulmonary aluminosis (PA) is a rare form of pneumoconiosis caused by aluminum powders and vapors. " 05/01/2016 - "Additionally, we review the literature on aluminum-induced pneumoconiosis and demonstrate the use of ancillary techniques including backscattered electron imaging and energy-dispersive spectrometry to aid in diagnosis. " 05/01/2016 - "We present a case of aluminum-induced pneumoconiosis in the setting of a bilateral lung transplant patient. " 05/01/2016 - "Aluminum-induced pneumoconiosis confirmed by analytical scanning electron microscopy: A case report and review of the literature."
7.	Oxygen (Dioxygen)IBA 09/20/2021 - "The oxygen partial pressure in pneumoconiosis combined AECOPD group was lower than that in control group (P<0.05) . " 06/01/2013 - "WLL can remarkably improve the oxygen uptake and ventilatory efficiency in patients with pneumoconiosis during exercise, so it can improve the exercise capacity of these patients." 09/01/1987 - "[The role of active forms of oxygen in the pathogenesis of pneumoconiosis (review of the literature)]." 05/01/1966 - "[The degree of relative saturation of oxygen of the blood in patients with pneumoconiosis of southern Kirghizia]." 01/20/2017 - "Conclusion: The pulmonary surfac-tant autotransfusion may reduce expiratory resistance, work of breathing, airway pressure; improve lung compliance, alveolar ventilation function; increase oxygen partial pressure and decrease the surgery recovery time in patients with pneumoconiosis. "
8.	tetrandrineIBA 01/01/2012 - "To study the healing effect of pneumoconiosis with tetrandrine and massive whole-lung lavage. " 01/01/2012 - "[Study on the healing effect of pneumoconiosis with tetrandrine and massive whole-lung lavage]." 03/20/2023 - "Conclusion: Tetrandrine can improve the clinical symptoms and pulmonary ventilation function of pneumoconiosis patients, most of the adverse reactions are mild, and the clinical application is safe. " 03/20/2023 - "Objective: To analyze the safety, effectiveness, economics, innovation, suitability and accessibility of tetrandrine in the treatment of pneumoconiosis, and provide evidence-based basis for health policy decision-making and clinical practice. " 03/20/2023 - "[Drug clinical comprehensive evaluation of tetrandrine in the treatment of pneumoconiosis]."
9.	AutoantibodiesIBA 01/01/2023 - "Pneumoconiosis combined with CTD or positive autoantibodies was a major adverse outcome. " 06/20/2020 - "During the 5-year observation period, there was no significant difference of small shadow shape, pneumoconiosis stage, and the pneumoconiosis promotion in 5 years between the autoantibody positive group and the autoantibody negative group (P>0.05). " 06/20/2020 - "Follow-up observation of X-ray chest radiographs, chest CT, forced expiratory volume in one second (FEV(1)) and forced expired flow at 50% of FVC (MEF(50)) of pneumoconiosis patients for 5 years, to analyze the influence of positive autoantibody on the morphology of X-ray chest film, the pneumoconiosis promotion in 5 years and lung function. " 06/20/2020 - "Objective: To explore the progress of small shadow and the change of lung function in pneumoconiosis with positive autoantibody, so as to provide basis for clinical treatment of pneumoconiosis. " 06/20/2020 - "[A 5-year follow-up study of pneumoconiosis patients with positive autoantibody]."
10.	SeleniumIBA 10/01/2001 - "The aim of the study was to determine the diagnostic value of digital selenium radiography in patients with pneumoconiosis. " 10/01/2001 - "Hence, in the diagnosis of pneumoconiosis, digital selenium radiography can replace the tested analog screen-film system." 10/01/2001 - "For this purpose chest x-rays by digital selenium radiography and analog screen-film system were compared according to the ILO classification of pneumoconiosis. " 10/01/2001 - "Comparison of digital selenium radiography with an analog screen-film system in the diagnostic process of pneumoconiosis according to ILO classification. " 10/01/2001 - "[Comparison of digital selenium radiography with an analog screen-film system in the diagnostic process of pneumoconiosis according to ILO classification]."

Therapies and Procedures

1.	Therapeutics 10/01/2022 - "Effective therapy options for pneumoconiosis are lacking. " 01/20/2021 - "The diagnosis, treatment, and rehabilitation therapy of pneumoconiosis should be enhanced in primary medical institutions." 07/01/2019 - "The pathogenesis of pneumoconiosis is not clear,and there is still no effective therapy. " 11/01/2014 - "[Pulmonary rehabilitation therapy of pneumoconiosis patients]." 06/01/1991 - "[Miner's pneumoconiosis: bases, current aspects for prevention, diagnosis and therapy]."
2.	Drug Therapy (Chemotherapy) 01/01/2023 - "Patients with history of pneumoconiosis and patients who received the treatments of surgery and chemotherapy also had significant increasing risk of PTB. " 10/01/1987 - "These results suggest that the 2SHRZ/7HR regimen is satisfactory in treating anthrasilicotic or silicotic patients with pulmonary tuberculosis, though antituberculosis chemotherapy seemed less effective in patients with pneumoconiosis than in those without pneumoconiosis." 03/01/1997 - "[A case of small cell lung carcinoma associated with pneumoconiosis who responded well to the over twenty chemotherapy treatments, resulting in prolonged survival]." 07/01/1969 - "A controlled trial of anti-tuberculosis chemotherapy in the early complicated pneumoconiosis of coalworkers." 10/01/1987 - "This is the first prospective clinical trial recorded to date of short-course chemotherapy in pulmonary tuberculosis complicated by pneumoconiosis. "
3.	Chinese Traditional Medicine (Traditional Chinese Medicine) 07/01/2019 - "In the past three years,it is found that traditional Chinese medicine is effective in the treatment of pneumoconiosis. " 05/01/2024 - "Analysis of series transcriptome data often uses a single comparison method, and there are few reports on using such data to predict the treatment of pneumoconiosis with traditional Chinese medicine (TCM). " 05/01/2024 - "Time-/dose- series transcriptome data analysis and traditional Chinese medicine treatment of pneumoconiosis." 10/01/2022 - "Traditional Chinese medicine (TCM) presents a favorable prospect in the treatment of pneumoconiosis. " 07/01/2019 - "Through clinical observation,if traditional Chinese medicine is properly used,and pathogenesis and syndrome differentiation-based treatment is provided,traditional Chinese medicine can relieve the clinical symptoms,and improve the exercise tolerance and the quality of life of patients with pneumoconiosis."
4.	Activities of Daily Living (ADL) 10/01/2014 - "The study results showed that the 6-min walking test reduced the anxiety about dyspnea of the pneumoconiosis patients during the exercise, moderated the dyspnea index after the performance of the activities, and improved the patients' ability to perform activities of daily living. " 10/01/2014 - "The purpose of this study was to examine the effects of walking exercise through a 6-min walking test on subjective dyspnea, pulmonary function test, arterial blood gas analysis, and activities of daily living to provide base data for the nursing intervention of pneumoconiosis patients. " 10/01/2014 - "Effects of the six-minute walking test on dyspnea and activities of daily living in pneumoconiosis patients."
5.	X-Ray Film 11/01/2013 - "After appropriate image post-processing on DR machine purchased from GE Healthcare, the DR chest films can meet all requirements for the quality of chest X-ray films in the Chinese diagnostic criteria for pneumoconiosis." 04/01/2008 - "[Comparison of computed X-ray and high-voltage X-ray films in screening and survey of pneumoconiosis]." 10/01/2004 - "[How to evaluate the competence in reading chest X-ray film of pneumoconiosis]." 06/01/1998 - "The results on the agreement between microcomputer and experts for the diagnosis of pneumoconiosis from X-ray films are presented in this paper. " 06/01/1998 - "[Comparing the diagnoses of pneumoconiosis made by computer and experts from X-ray films]."