Pneumoconiosis

A diffuse parenchymal lung disease caused by inhalation of dust and by tissue reaction to their presence. These inorganic, organic, particulate, or vaporized matters usually are inhaled by workers in their occupational environment, leading to the various forms (ASBESTOSIS; BYSSINOSIS; and others). Similar air pollution can also have deleterious effects on the general population.

Also Known As:

Networked: 1309 relevant articles (17 outcomes, 127 trials/studies)

Relationship Network

Disease Context: Research Results

Related Diseases

1.	Silicosis
2.	Neoplasms (Cancer)
3.	Tuberculosis (Tuberculoses)
4.	Pulmonary Tuberculosis
5.	Asbestosis

Experts

1.	Petsonk, Edward L: 8 articles (01/2015 - 10/2010)
2.	Laney, A Scott: 8 articles (01/2015 - 08/2009)
3.	Yao, Wu: 6 articles (09/2014 - 07/2005)
4.	Attfield, Michael D: 6 articles (01/2014 - 08/2009)
5.	Chen, Weihong: 5 articles (12/2014 - 12/2004)
6.	Mao, Ling: 5 articles (08/2014 - 10/2009)
7.	Kimura, Kiyonobu: 5 articles (02/2014 - 06/2003)
8.	Altin, Remzi: 5 articles (09/2007 - 04/2004)
9.	Centers for Disease Control and Prevention (CDC): 4 articles (06/2015 - 04/2003)
10.	Abraham, Jerrold L: 4 articles (01/2015 - 08/2002)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Pneumoconiosis:

1.	CoalIBA 01/01/2015 - "These results establish the need to generate an intervention strategy aimed at preventing the identified factors, as well as a timely identification and effective treatment of pneumoconiosis in coal miners, in which the commitment of the General Health and Social Security System and the workers compensation system is ensured. " 04/01/2010 - "In the 1950s the Pneumoconiosis Field Research (PFR) programme was set up to study the health of British coal workers. " 01/01/2008 - "Three hundred five coal dust workers and 200 non-dust workers without pneumoconiosis from five coal mines in Shanxi province were enrolled in this study. " 01/01/2005 - "The aim of this study was to determine the prevalence of coal miner pneumoconiosis among lignite miners and to evaluate the effects of working conditions. " 11/01/2004 - "To analyze the data of pneumoconiosis from one coal mine with the historical study and to predict its development tendency by the grey model of GM (1,1). "
2.	AsbestosIBA 01/01/1979 - "In a collaborative study with the Pneumoconiosis Medical Panel, 232 asbestos workers were seen between 1967 and 1975. " 01/01/1967 - "[Experimental contribution to the study of asbestos pneumoconiosis. " 11/01/2009 - "[A model to diagnose occupational, asbestos-related pneumoconiosis and thickening of the pleura]." 01/01/2009 - "The health-related dangers of asbestos exposure were recognized early in the 20th century when occupational exposure was found to be associated with excess pneumoconiosis among asbestos industry workers. " 04/01/2008 - "Navy Asbestos Medical Surveillance Program B-reading reports were analyzed for variability in identifying pneumoconiosis in 278,944 chest radiographs done from 1990 to 2004 using commercial database and statistical software. "
3.	OxygenIBA 06/01/2013 - "WLL can remarkably improve the oxygen uptake and ventilatory efficiency in patients with pneumoconiosis during exercise, so it can improve the exercise capacity of these patients." 11/01/2005 - "[Clinical analysis of home oxygen therapy in patients with pneumoconiosis at Iwamizawa Rosai Hospital]." 09/01/1987 - "[The role of active forms of oxygen in the pathogenesis of pneumoconiosis (review of the literature)]." 05/01/1966 - "[The degree of relative saturation of oxygen of the blood in patients with pneumoconiosis of southern Kirghizia]." 04/01/2008 - "A 70-year-old man with pneumoconiosis receiving home oxygen therapy presented with chest pain. "
4.	SeleniumIBA 10/01/2001 - "The aim of the study was to determine the diagnostic value of digital selenium radiography in patients with pneumoconiosis. " 10/01/2001 - "Hence, in the diagnosis of pneumoconiosis, digital selenium radiography can replace the tested analog screen-film system." 10/01/2001 - "For this purpose chest x-rays by digital selenium radiography and analog screen-film system were compared according to the ILO classification of pneumoconiosis. " 10/01/2001 - "Comparison of digital selenium radiography with an analog screen-film system in the diagnostic process of pneumoconiosis according to ILO classification. " 10/01/2001 - "[Comparison of digital selenium radiography with an analog screen-film system in the diagnostic process of pneumoconiosis according to ILO classification]."
5.	AutoantibodiesIBA 07/20/1974 - "These autoantibodies were found in 13% of the miners with simple pneumoconiosis and 45% of those with category C progressive massive fibrosis (P for the trend=0.01)." 12/01/1981 - "A significantly greater prevalence of autoantibodies was observed in subjects with pneumoconiosis than in control subjects; however, a rheumatoid factor prevalence of 16% with observed inthe control subjects. " 09/01/1992 - "2) Immunological studies of patients with pneumoconiosis: As for humoral immunity, elevation of polyclonal gamma-globulin, especially IgG, has been often reported together with high positive rate of autoantibodies such as antinuclear antibodies. "
6.	Polyvinyl Chloride (PVC)IBA 08/01/1997 - "Clinical and radiological abnormalities cleared on removal from exposure, suggesting that in its early stages PVC pneumoconiosis is reversible." 02/01/1991 - "The conclusion was drawn that a low grade of pneumoconiosis and a small degree of lung function impairment is associated with PVC dust exposure. " 07/01/1985 - "[A case of pneumoconiosis caused by polyvinyl chloride]." 10/01/1983 - "An association between PVC dust and pneumoconiosis also has been demonstrated. " 10/01/1981 - "Under the conditions of this experiment, inhaled PVC produced a benign pneumoconiosis."
7.	Rheumatoid FactorIBA 02/01/1990 - "Influence of rheumatoid factor in coalminers' pneumoconiosis in the Fujian Shaowu colliery, south China." 01/01/1963 - "[MANIFESTATION OF PNEUMOCONIOSES AND OF THE RHEUMATOID FACTOR]." 07/20/1974 - "A similar but less striking trend was seen with rheumatoid factor, ranging from 6% in simple pneumoconiosis to 18% in category C progressive massive fibrosis. " 12/01/1981 - "A significantly greater prevalence of autoantibodies was observed in subjects with pneumoconiosis than in control subjects; however, a rheumatoid factor prevalence of 16% with observed inthe control subjects. " 01/01/1982 - "Sera from 2421 coalminers, representing all the radiological categories of pneumoconiosis, and from 260 healthy blood donors, as controls, were examined for antinuclear factor and rheumatoid factor. "
8.	Reactive Oxygen Species (Oxygen Radicals)IBA 10/01/1990 - "The obtained results testify both to the essential part of active oxygen form during pathologic processes with pneumoconiosis, and also to a great similarity among biochemical processes, characterizing interaction of alveolar macrophages and monocytes with mineral dust." 01/01/1996 - "This result is in agreement with the hypothesis that reactive oxygen species are involved in cell injury induced by coal mine dust, and may be predictive of the degree of inflammation and pneumoconiosis induced by coal mine dust. " 05/01/2005 - "These results indicate that the activation of reactive oxygen species may play a central role in asbestos-induced T-cell apoptosis, and anti-oxidants may help to prevent complications of pneumoconiosis." 12/01/1988 - "Generation of free oxygen radicals from human polymorphonuclear granulocytes by cytokines from human mononuclear cells, treated with quartz dust DQ12 or coal mine dust TF-1--new aspects in pathogenesis of pneumoconiosis."
9.	Oxidants (Oxidizing Agents)IBA 01/01/2011 - "Role of oxidants in interstitial lung diseases: pneumoconioses, constrictive bronchiolitis, and chronic tropical pulmonary eosinophilia." 09/01/2009 - "In this review of the literature on oxidants and antioxidants in diffuse lung diseases, the focus is on idiopathic pulmonary fibrosis, sarcoidosis, pneumoconiosis and pulmonary fibrosis associated with systemic sclerosis." 05/01/2005 - "These results indicate that the activation of reactive oxygen species may play a central role in asbestos-induced T-cell apoptosis, and anti-oxidants may help to prevent complications of pneumoconiosis." 10/20/1990 - "Pneumoconiosis, irritant bronchitis, focal emphysema, and carcinoma may be produced by oxidants either directly through lipid peroxidation and protein inactivation, or indirectly by oxidant-mediated release of cytokines such as platelet-derived growth factor. "
10.	ManganeseIBA 09/01/1973 - "Experimental infective manganese pneumoconiosis in guinea pigs." 07/27/2000 - "In order to investigate occupational diseases related to welding fume exposure, such as nasal septum perforation, pneumoconiosis and manganese intoxication, we built a welding fume exposure system that included a welding fume generator, exposure chamber and fume collector. " 01/01/2000 - "Among 6 nosologic entities of occupational diseases diagnosed in 323 electric welders of Moscow suburb, the most frequent one was pneumoconiosis caused by welding aerosol, then neurosensory deafness, chronic toxic dust bronchitis and chronic manganese intoxication. " 01/01/2008 - "Rhythmocardiography helped to define autonomous cardioneuropathy on background of vibration disease, pneumoconiosis, chronic occupational fluorine-manganese intoxication--this is a pathogenetic basis for early clinical manifestation of CHD."

Therapies and Procedures

1.	Drug Therapy (Chemotherapy) 10/01/1987 - "These results suggest that the 2SHRZ/7HR regimen is satisfactory in treating anthrasilicotic or silicotic patients with pulmonary tuberculosis, though antituberculosis chemotherapy seemed less effective in patients with pneumoconiosis than in those without pneumoconiosis." 03/01/1997 - "[A case of small cell lung carcinoma associated with pneumoconiosis who responded well to the over twenty chemotherapy treatments, resulting in prolonged survival]." 07/01/1969 - "A controlled trial of anti-tuberculosis chemotherapy in the early complicated pneumoconiosis of coalworkers." 10/01/1987 - "This is the first prospective clinical trial recorded to date of short-course chemotherapy in pulmonary tuberculosis complicated by pneumoconiosis. " 11/01/1984 - "[The present status of pneumoconiosis in Japan and the results of chemotherapy of silico-tuberculosis]."
2.	Activities of Daily Living (ADL) 10/01/2014 - "The study results showed that the 6-min walking test reduced the anxiety about dyspnea of the pneumoconiosis patients during the exercise, moderated the dyspnea index after the performance of the activities, and improved the patients' ability to perform activities of daily living. " 10/01/2014 - "The purpose of this study was to examine the effects of walking exercise through a 6-min walking test on subjective dyspnea, pulmonary function test, arterial blood gas analysis, and activities of daily living to provide base data for the nursing intervention of pneumoconiosis patients. " 10/01/2014 - "Effects of the six-minute walking test on dyspnea and activities of daily living in pneumoconiosis patients."
3.	X-Ray Film 11/01/2013 - "After appropriate image post-processing on DR machine purchased from GE Healthcare, the DR chest films can meet all requirements for the quality of chest X-ray films in the Chinese diagnostic criteria for pneumoconiosis." 04/01/2008 - "[Comparison of computed X-ray and high-voltage X-ray films in screening and survey of pneumoconiosis]." 10/01/2004 - "[How to evaluate the competence in reading chest X-ray film of pneumoconiosis]." 04/01/1998 - "X-ray films of the chest showed multiple nodular shadows consistent with pneumoconiosis. " 02/01/1996 - "Forced expiratory volume in one second (FEV1) and forced vital capacity (FVC) were obtained on 1286 miners with no evidence of pneumoconiosis on x ray film. "
4.	Anesthesia 03/01/2013 - "[Study on modified anesthesia in the bronchoalveolar lavage of pneumoconiosis]." 01/01/2010 - "[Anesthesia effect in operation of whole lung lavage for treatment pneumoconiosis]." 01/01/2003 - "To present a patient with pneumoconiosis who developed a complex, life-threatening atrial tachyarrhythmia during anesthesia. "
5.	Bronchoscopes 01/01/1959 - "[Value of a method for the experimental study of pneumoconioses: intrabronchial introduction of dust after tracheal intubation with the aid of a bronchoscope in the dog]." 09/01/2014 - "[Application of intravenous anesthesia in pneumoconiosis diagnosis and treatment with Bronchoscope]."