Pneumatosis Cystoides Intestinalis

A condition characterized by the presence of multiple gas-filled cysts in the intestinal wall, the submucosa and/or subserosa of the INTESTINE. The majority of the cysts are found in the JEJUNUM and the ILEUM.

Also Known As:

Networked: 156 relevant articles (4 outcomes, 2 trials/studies)

Relationship Network

Disease Context: Research Results

Related Diseases

1.	Intestinal Pseudo-Obstruction (Intestinal Pseudoobstruction)
2.	Ileus
3.	Polymyositis
4.	Granulomatosis with Polyangiitis (Wegener's Granulomatosis)
5.	Cysts

Experts

1.	Tanimoto, Yasushi: 2 articles (10/2021 - 01/2006)
2.	Antonopulos, Christos: 2 articles (05/2020 - 01/2020)
3.	Braham, Hamdi: 2 articles (05/2020 - 01/2020)
4.	Charre, Lionel: 2 articles (05/2020 - 01/2020)
5.	El Arbi, Najib: 2 articles (05/2020 - 01/2020)
6.	Police, Andrea: 2 articles (05/2020 - 01/2020)
7.	Volpin, Enrico: 2 articles (05/2020 - 01/2020)
8.	Fujii, Hisao: 2 articles (01/2010 - 10/2008)
9.	Fukui, Hiroshi: 2 articles (01/2010 - 10/2008)
10.	Tsujimoto, Tatsuhiro: 2 articles (01/2010 - 10/2008)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Pneumatosis Cystoides Intestinalis:

1.	Oxygen (Dioxygen)IBA 09/17/2017 - "Several previous reports have supported the efficacy of hyperbaric oxygen for treating pneumatosis cystoides intestinalis. " 06/01/1996 - "We report the successful management of pneumatosis cystoides intestinalis of the small intestine with the use of hyperbaric oxygen." 06/01/1996 - "Pneumatosis cystoides intestinalis confined to the small intestine treated with hyperbaric oxygen." 06/01/1991 - "At Prince Henry Hospital (PHH) between 1980 and 1986, 8 patients with pneumatosis cystoides intestinalis (PCI) underwent 11 courses of hyperbaric oxygen treatment (HBO). " 06/01/1991 - "Pneumatosis cystoides intestinalis: an experience with hyperbaric oxygen treatment."
2.	Prednisolone (Predate)FDA LinkGeneric 06/26/2013 - "In this case, pneumatosis cystoides intestinalis was improved with the reduction of prednisolone, and therefore we thought a direct relationship between pneumatosis cystoides intestinalis and prednisolone might become clear, such as whether it is dose dependent. " 06/26/2013 - "Amelioration of pneumatosis cystoides intestinalis was observed with tapering of the prednisolone, suggesting that prednisolone may have been involved in the pathogenesis of pneumatosis cystoides intestinalis in this patient." 06/26/2013 - "Even before we had experienced a case of this, the relationship between pneumatosis cystoides intestinalis and prednisolone was unclear. " 06/26/2013 - "We report the case of a patient who was diagnosed as having pneumatosis cystoides intestinalis while being treated with prednisolone for bronchial asthma. " 01/01/2004 - "Three months after the administration of prednisolone and cyclosporine, he noticed mild abdominal distension, and a radiographic examination showed intraperitoneal free gas and intramural gas, suggestive of pneumatosis cystoides intestinalis (PCI). "
3.	Trichloroethylene (Trichloroethene)IBA 11/01/2000 - "In recent immunological studies, it has been suggested that trichloroethylene (TCE) participates in the onset of pneumatosis cystoides intestinalis (PCI) through a certain mechanism; however, the mechanism by which it develops remains unknown. " 01/01/2015 - "[A degreasing worker with pneumatosis cystoides intestinalis caused by trichloroethylene exposure]." 11/01/1990 - "Four cases of primary pneumatosis cystoides intestinalis (PCI) were studied in relation to occupational trichloroethylene (TRI) exposure. " 11/01/1990 - "[Trichloroethylene concentration in the work environment in relation to the development of pneumatosis cystoides intestinalis]." 01/01/1988 - "A report of a worker suffering from pneumatosis cystoides intestinalis following trichloroethylene exposure."
4.	AcarboseFDA LinkGeneric 04/01/2011 - "Pneumatosis cystoides intestinalis is a rare complication in acarbose-treated patients. " 09/08/2009 - "Pneumatosis cystoides intestinalis of the ascending colon related to acarbose treatment: a case report." 11/01/2002 - "[A case of pneumatosis cystoides intestinalis assumed to be induced by acarbose administration for diabetes mellitus and pemphigus vulgaris]." 09/08/2009 - "This is the first report of pneumatosis cystoides intestinalis after 12 years of treatment with the alpha-glucosidase inhibitor acarbose. " 09/01/2012 - "Detailed imaging studies of gas cysts in the intestinal mucosa (pneumatosis cystoides intestinalis) have been reported in around 20 patients taking acarbose, miglitolor voglibose, i.e. "
5.	voglibose (Basen)IBA 09/01/2022 - "Case of pneumatosis cystoides intestinalis with intra-abdominal free air developed during treatment with voglibose." 09/01/2012 - "Detailed imaging studies of gas cysts in the intestinal mucosa (pneumatosis cystoides intestinalis) have been reported in around 20 patients taking acarbose, miglitolor voglibose, i.e. "
6.	Glycoside Hydrolase InhibitorsIBA 10/21/2008 - "Pneumatosis cystoides intestinalis following alpha-glucosidase inhibitor treatment: a case report and review of the literature." 08/01/2002 - "Regression of pneumatosis cystoides intestinalis after discontinuing of alpha-glucosidase inhibitor administration." 02/01/1999 - "Pneumatosis cystoides intestinalis after treatment with an alpha-glucosidase inhibitor." 05/01/2020 - "Pneumatosis cystoides intestinalis induced by the alpha-glucosidase inhibitor complicated from sigmoid volvulus in a diabetic patient." 01/01/2020 - "Correction to: Pneumatosis cystoides intestinalis induced by the alpha-glucosidase inhibitor complicated from sigmoid volvulus in a diabetic patient."
7.	SteroidsIBA 10/10/2011 - "[Case report; Two cases with pneumatosis cystoides intestinalis following steroid therapy]." 06/26/2013 - "Improvement of pneumatosis cystoides intestinalis after steroid tapering in a patient with bronchial asthma: a case report." 03/01/1993 - "[Pneumatosis cystoides intestinalis following steroid treatment in a nephrotic syndrome patient: report of a case]." 07/01/2011 - "[A case of pneumatosis cystoides intestinalis induced by steroid pulse therapy for severe acute hepatitis B]." 11/01/2021 - "Pneumatosis cystoides intestinalis, which is a rare complication, should be kept in mind, especially in patients with intestinal GVHD and receiving intensive immunosuppressive, octreotide, and steroid treatment after HSCT."
8.	HydrogenIBA 05/10/1999 - "The aetiology and pathogenesis of pneumatosis cystoides intestinalis are unknown, although deficient hydrogen metabolism and gasforming bacteria that penetrate the mucosal barrier may be involved. " 02/01/1993 - "Pneumatosis cystoides intestinalis (PCI) is characterized by high levels of breath hydrogen. " 02/01/1993 - "Impaired hydrogen metabolism in pneumatosis cystoides intestinalis." 11/01/1979 - "Breath hydrogen in pneumatosis cystoides intestinalis." 01/01/2014 - "α-GI medications may increase internal intestinal tract pressure by releasing carbon dioxide and hydrogen gas, potentially causing pneumatosis cystoides intestinalis (PCI) or PVG. "
9.	Adrenal Cortex Hormones (Corticosteroids)IBA 10/01/2019 - "Although pneumatosis cystoides intestinalis (PCI) is observed in patients who are on corticosteroid treatment, most patients have underlying diseases requiring long-term corticosteroid treatment. " 02/21/2013 - "The etiology of pneumatosis cystoides intestinalis in this case was likely multifactorial and involved both effects of the corticosteroids as well as the advanced nature of the gastrointestinal sarcoidosis. " 01/01/1998 - "On day 57, the patient developed pneumatosis cystoides intestinalis (PCI) when she received cyclosporin A and corticosteroids for graft-versus-host disease (GVHD). " 09/01/2006 - "The authors report a case report of rare disease interesting the digestive tract and often associated to the other gastrointestinal pathologies and/or pulmonary diseases and can be also associated to not gastrointestinal conditions such as collagen-vascular disease, transplantation, AIDS, use of corticosteroid and chemotherapy; other causes can be iatrogenic such as traumatic gastrointestinal endoscopy (a mucoses biopsy, a polipectomy) or the assumption of lattulosio; in 15-20% of cases the pneumatosis cystoides intestinalis is considered primitive. "
10.	Sunitinib (Sutent)FDA Link 11/09/2017 - "Pneumatosis cystoides intestinalis associated with sunitinib and a literature review." 11/01/2019 - "We report a case of pneumatosis cystoides intestinalis linked to sunitinib treatment for renal cell carcinoma. " 11/01/2019 - "Pneumatosis cystoides intestinalis linked to sunitinib treatment for renal cell carcinoma." 05/01/2018 - "Pneumatosis Cystoides Intestinalis Secondary to Sunitinib Treatment for Gastrointestinal Stromal Tumor." 02/01/2014 - "[A case of pneumatosis cystoides intestinalis secondary to sunitinib treatment for renal cell carcinoma]."

Therapies and Procedures

1.	Therapeutics 01/01/2004 - "Evaluation of HBO2 therapy in pneumatosis cystoides intestinalis." 12/01/1995 - "They review the current literature on pneumatosis cystoides intestinalis, focusing on possible etiologies and potential therapies." 04/01/1990 - "A review of the literature is presented with emphasis on the etiology, diagnosis, differential diagnosis, and therapy of pneumatosis cystoides intestinalis. " 12/01/1985 - "While therapy is seldom indicated in benign forms of pneumatosis cystoides intestinalis, mortality rates with fulminant pneumatosis cystoides intestinalis are high, regardless of the type of therapy." 11/01/1968 - "[Therapy of experimental pneumatosis cystoides intestinalis]."
2.	Hyperbaric Oxygenation 01/01/2021 - "The Role of Hyperbaric Oxygen Therapy in Pneumatosis Cystoides Intestinalis-A Scoping Review." 09/01/2001 - "Pneumatosis cystoides intestinalis treated with hyperbaric oxygen therapy: usefulness of an endoscopic ultrasonic catheter probe for diagnosis." 02/01/2000 - "[A case of chronic idiopathic intestinal pseudo-obstruction and pneumatosis cystoides intestinalis with pneumatoperitoneum, improved by the hyperbaric oxygen therapy]." 09/17/2017 - "We therefore suggest that hyperbaric oxygen therapy could be a candidate treatment for pneumatosis cystoides intestinalis in patients with granulomatosis with polyangiitis." 09/17/2017 - "Successful treatment with hyperbaric oxygen therapy for pneumatosis cystoides intestinalis as a complication of granulomatosis with polyangiitis: a case report."
3.	Drug Therapy (Chemotherapy) 04/01/1981 - "Pneumatosis cystoides intestinalis: a complication of systemic chemotherapy." 01/01/2023 - "Pneumatosis cystoides intestinalis mimicking free intraabdominal air following chemotherapy for relapsed acute myeloblastic leukemia in a transplanted neutropenic child: a case report." 12/01/2012 - "[A case of pneumatosis cystoides intestinalis receiving chemotherapy for esophageal and tonsillar cancers]." 01/01/2012 - "[Pneumatosis cystoides intestinalis during palliative chemotherapy for colorectal cancer]." 03/01/2010 - "Free air intraperitoneally during chemotherapy for acute lymphoblastic leukemia: consider pneumatosis cystoides intestinalis."
4.	Laparotomy 12/17/2021 - "Laparoscopy with conversion to exploratory laparotomy revealed bowel abnormalities at the distal transverse colon and splenic flexure, which were identified as pneumatosis cystoides intestinalis by pathology. There was no evidence of bowel perforation. " 01/01/2013 - "Treatment of pneumatosis cystoides intestinalis ranges from supportive care to laparotomy. " 04/29/2009 - "A second laparotomy, was done and exploration was systematically performed and denoted hugely distended stomach with cicatrisation at the site of previous closure of perforated duodenal ulcer and the whole length of small gut was completely free from the already described pneumatosis cystoides intestinalis. " 12/01/1991 - "Laparotomy showed pneumatosis cystoides intestinalis without intestinal perforation. " 08/01/1984 - "A case of pneumatosis cystoides intestinalis discovered at laparotomy for a perforated duodenal ulcer is described. "
5.	Hematopoietic Stem Cell Transplantation 11/01/2021 - "Pneumatosis cystoides intestinalis: A rare complication after hematopoietic stem cell transplantation." 10/01/2021 - "Pneumatosis cystoides intestinalis, a rare case in a pediatric patient following allogeneic hematopoietic stem cell transplantation: CT findings and literature review." 07/01/2008 - "Late-onset pneumatosis cystoides intestinalis associated with non-infectious pulmonary complications after allogeneic hematopoietic stem cell transplantation." 01/01/2020 - "[Pneumatosis cystoides intestinalis developing subsequent to allogeneic hematopoietic stem cell transplantation for mixed phenotype acute leukemia]." 11/01/2017 - "[Pneumatosis Cystoides Intestinalis after Hematopoietic Stem Cell Transplantation for Malignant Lymphoma - A Case Report]."