Pleurisy (Pleuritis)

06/01/2011 - "In the carrageenan-induced pleurisy model, the RDV-8 (3 mg/kg) treatment induced a significant reduction in the exudate volume, in the polymorphonuclear leukocyte migration and in the pleural exudate NO levels. "
01/01/2011 - "Carrageenan-induced mouse paw oedema and rat pleurisy models were utilized to demonstrate the efficacy of defined BAs in vivo. "
12/01/2014 - "This study was conducted to explore the anti-inflammatory effect of Jungia sellowii (Asteraceae) using a murine model of pleurisy induced by carrageenan (Cg). "
11/01/2014 - "The present study reports the effects of DEC pretreatment on NF-κB regulation using the pleurisy model induced by carrageenan. "
04/01/2014 - "The aim of this study was to investigate the anti-inflammatory effect of the crude hydroalcoholic extract (CHE) from the aerial parts of Croton antisyphiliticus, its fractions and isolated compounds derived from it on the mouse model of pleurisy induced by carrageenan. "

11/01/2003 - "Our data suggest an important role for NK1 receptor activation with consequent LTB4 release and eosinophil recruitment in a model of allergic pleurisy in the mouse. "
01/01/1991 - "3. In a rat pleurisy model, the administration of A-64077 (p.o., 2 hr pretreatment) caused a marked decrease in LTB4 levels measureable after ionophore stimulation at doses of 3 and 10 mg kg (67 and 96% inhibition, respectively). "
06/11/2009 - "Notably, 11a efficiently blocks 5-LO product formation in human whole blood assays (IC(50) = 0.83-1.6 microM) and significantly prevented leukotriene B(4) production in pleural exudates of carrageenan-treated rats, associated with reduced severity of pleurisy. "
10/01/1985 - "At present, very little is known of the stability of this compound in vivo; therefore, the present study was designed to determine the half-life and metabolic fate of radiolabeled LTB4 during a 2-hr intrapleural incubation in rats with acute carrageenan pleurisy. "
03/01/2004 - "We show here that type VI iPLA2 drives the onset of acute pleurisy through the synthesis of PGE2, LTB4, PAF, and IL-1beta. "

02/01/2009 - "After the diagnosis of lupus pleuritis, the patient was successfully treated with prednisolone."
02/21/1959 - "[Topical treatment with prednisolone of tuberculous exudative pleuritis]."
11/15/1957 - "[Dubos-Middlebrook hemagglutination reaction in serofibrinous pleurisy treated locally with prednisolone]."
10/25/1957 - "[Intrapleural prednisolone treatment of exudative pleuritis]."
05/01/1957 - "[Local prednisolone treatment of primary serofibrinous pleurisy]."

03/01/2002 - "Platelet-activating factor drives eotaxin production in an allergic pleurisy in mice."
05/17/1991 - "Nevertheless, antagonism of PAF-acether may not be relevant to the inhibition observed in the present model of allergic pleurisy, as the inhibition was refractory to three distinct PAF-acether receptor antagonists. "
12/01/1987 - "Pharmacological modulation of PAF-acether-induced pleurisy in rats."
04/01/1986 - "Pleurisy was induced by intrapleural injection of 1 ug of AGEPC into rats. "
07/01/1992 - "1. The current study analyses the effects of endothelin-1 (ET-1) on paw oedema and pleurisy induced by platelet activating factor (PAF) and other inflammatory agents in the mouse. "

09/01/2004 - "Of all the drugs tested, dexamethasone was most effective in inhibiting DL induced pleurisy. "
08/01/2015 - "In the pleurisy model, the drug used as positive control, dexamethasone, was more efficacious. "
07/01/2004 - "Dexamethasone, known to inhibit pleurisy induced by either stimulus, had no effect on bone marrow neutrophil numbers. "
12/01/1960 - "[Serofibrinous pleurisy and dexamethasone]."
01/06/2012 - "The ethanolic and butanol extracts (200mg/kg, p.o.) presented a significant anti-inflammatory activity toward carrageenan-induced pleurisy model in mice in comparison to dexamethasone (0.5mg/kg, s.c.). "

01/01/1994 - "Studies have shown good tolerance and efficacy of elevated doses of recombinant IL-2 after intrapleural administration in the treatment of neoplastic pleurisy. "
11/15/1998 - "Several clinical studies have demonstrated objective antitumoral responses to intrapleural interleukin-2 (IL-2) administration in the treatment of malignant pleurisy. "
12/01/2008 - "Accordingly, in vivo IL-2 or IFN-gamma neutralization abolished T-lymphocyte accumulation 7 days after pleurisy induction. "
01/01/1994 - "[The kinetics of IL-2 after pleural administration in the treatment of neoplastic pleurisy]."
10/01/1990 - "[Eosinophil colony stimulating activity induced by administration of interleukin-2 into the pleural cavity of patients with malignant pleurisy]."

06/01/1983 - "A randomized controlled study was performed to evaluate the efficacy of intrapleural and systemic administration of OK-432, streptococcus preparation, in patients with cancerous pleurisy. "
06/01/1983 - "[Randomized controlled study of OK-432 in the treatment of cancerous pleurisy]."
11/01/1993 - "When OK-432, a well-known streptococcal preparation for an anti-tumour drug, was administered into the pleural cavity of patients with malignant pleurisy, a rapid and prominent leukocytosis, predominantly consisting of neutrophils, was observed in the cavity. "
01/01/1989 - "Treatment of malignant ascites and pleurisy by a streptococcal preparation OK-432 with fresh frozen plasma--a mechanism of polymorphonuclear leukocyte (PMN) accumulation."
01/01/1989 - "A single injection of a streptococcal preparation, OK-432, with fresh frozen plasma (FFP) (or fresh human serum) into the peritoneal or pleural cavity for the treatment of malignant ascites or pleurisy resulted in a complete reduction of ascitic fluid or pleural effusion in 5 out of 11 patients. "

11/01/2009 - "These results demonstrated an interesting anti-inflammatory property of this thiazolidinedione class and strengthen prior evidence that PPAR pathways constitute another important route of inflammatory process inhibition of this pleurisy model."
05/01/2006 - "We report here that when compared with PPAR-alpha wild-type mice, PPAR-alpha knockout mice (PPAR-alphaKO) mice experienced a higher rate of the extent and severity when subjected to carrageenan injection in the paw edema model or to carrageenan administration in the pleurisy model. "
12/01/2009 - "With the aim to characterize the role of PPAR-alpha in estrogen-mediated anti-inflammatory activity, we tested the efficacy of E2 in an experimental model of lung inflammation, carrageenan-induced pleurisy, comparing ovariectomized wild-type (WT) and PPAR-alpha lacking (PPAR-alphaKO) mice. "
02/01/2008 - "With the aim of characterizing the role of PPAR-alpha in GC-mediated anti-inflammatory activity, we tested the efficacy of dexamethasone (DEX), a synthetic GC specific for glucocorticoid receptor, in an experimental model of lung inflammation, carrageenan-induced pleurisy, comparing mice lacking PPAR-alpha (PPAR-alphaKO) with wild-type (WT) mice. "

03/01/2006 - "Management of malignant pleural effusion by multimodality treatment including the use of paclitaxel administered by 24-hour intrathoracic infusion for patients with carcinomatous pleuritis."
06/01/2015 - "Bevacizumab and paclitaxel therapy is potentially effective for the treatment of patients with carcinomatous pleurisy, providing a chance for long-term survival."
06/01/2015 - "A 61-year-old postmenopausal woman with breast cancer and carcinomatous pleurisy was successfully treated with bevacizumab and paclitaxel. "
11/01/2013 - "[A case of recurrent breast cancer with carcinomatous pleurisy responding to bevacizumab and paclitaxel therapy]."
06/01/2015 - "[A Case of Recurrent Breast Cancer with Carcinomatous Pleurisy Successfully Treated with Paclitaxel and Bevacizumab after Radical Mastectomy]."

05/01/2006 - "We report here that when compared with PPAR-alpha wild-type mice, PPAR-alpha knockout mice (PPAR-alphaKO) mice experienced a higher rate of the extent and severity when subjected to carrageenan injection in the paw edema model or to carrageenan administration in the pleurisy model. "
12/01/2009 - "With the aim to characterize the role of PPAR-alpha in estrogen-mediated anti-inflammatory activity, we tested the efficacy of E2 in an experimental model of lung inflammation, carrageenan-induced pleurisy, comparing ovariectomized wild-type (WT) and PPAR-alpha lacking (PPAR-alphaKO) mice. "
02/01/2008 - "With the aim of characterizing the role of PPAR-alpha in GC-mediated anti-inflammatory activity, we tested the efficacy of dexamethasone (DEX), a synthetic GC specific for glucocorticoid receptor, in an experimental model of lung inflammation, carrageenan-induced pleurisy, comparing mice lacking PPAR-alpha (PPAR-alphaKO) with wild-type (WT) mice. "

10/01/2008 - "The increasing incidence of malignant pleurisies enforce a better knowledge of pathogenic mechanisms that led to a new therapeutic approach with promising results--cytoreductive surgery combined with intraoperative hyperthermic intrathoracic chemotherapy. "
10/01/1997 - "These results suggested that systemic chemotherapy is an effective treatment for pleuritis carcinomatosa."
10/01/2008 - "Recent studies about compared results of different types of treatments, function of survival period and side-effects, demonstrate the advantages of association between surgical treatment with the intrapleural administration of hyperthermic chemotherapy, which may have control on pleurisy and pleural involvement. "
01/01/2004 - "The studies have demonstrated that the efficiency of chemotherapy during the complicated course was less than in the uncomplicated one: closure of decay cavities was observed in 69.4% of the patients with specific lesion of the bronchial system, in 78.8% of those with a complication, such as exudative pleurisy (in 81.8% with uncomplicated course). "
10/01/2011 - "Puncture number (p < 0.02) and previous systemic chemotherapy (p < 0.05) were significant risk factors for aseptic pleuritis. "

08/01/2005 - "Total and differential cell analysis at 4 h after induction of pleurisy showed a significant reduction of inflammatory cell migration for all groups treated with active laser. "
11/01/2003 - "2. In patients with pleurisy laser treatment increases regenerative mechanisms of the pleural surface, thus decreasing the quantity of formed adhesions and resulting in better mobility of the diaphragm."
01/01/1997 - "The outcomes of treatment of 140 patients with tuberculous parapneumatic serous pleurisy are presented, Intrapleural low-energy laser radiation, epicutaneous low-energy pulse radiation, and the successive application of both techniques were used during etiotropic therapy and regular exudate aspirations. "
11/01/2003 - "1. Patients with pleurisy undergoing laser stimulation presented with faster resorption of effusion and remission of the subjective symptoms, as well as significant decrease of biochemical acute inflammation parameters in the peripheral blood and therefore with faster recovery. "

12/01/2011 - "We analyzed the epidemiology, pathology, and prognosis characteristics of that group (study group), as compared with the population undergoing pulmonary resection in a curative attempt (overall population) or exploratory thoracotomy in case of unexpected disseminated carcinomatous pleuritis (control group). "
02/01/2015 - "The clinical records of 25 patients (mean age 69 years) diagnosed with carcinomatous pleuritis during a thoracotomy by pathological examination and followed by surgery between 1994 and 2012 were reviewed. "
01/01/2002 - "Thoracoscopy is ineffective in adhesive pleurisy, in the presence of a rigid residual cavity in particular, and thus preference should be given to thoracotomy with pleurectomy and decortication of the lung. "
04/01/2001 - "The data were collected from a questionnaire survey on the survival of the patients with carcinomatous pleuritis found at thoracotomy from 1985 to December 1994 which was conducted by the Japan Clinical Oncology Group (JCOG). "
01/01/2000 - "A questionnaire survey on the survival of patients with carcinomatous pleuritis found at thoracotomy between January 1985 and December 1994 was conducted by the Japan Clinical Oncology Group. "

01/01/2014 - "We here report the first case of pneumonitis with lymphocytic pleurisy following bacillus Calmette-Guerin (BCG) immunotherapy. "
08/01/1995 - "If resection was noncurative because of residual cancer in the chest wall or diaphragm, or because of carcinomatous pleuritis or pleural dissemination, then there was no statistical difference in survival between the control group and the immunotherapy group."
11/01/2013 - "Of the 23 effectively treated patients, skin or regional lymph node metastases disappeared in 3 patients treated with hyperthermia alone, and lung metastases disappeared and carcinomatous pleuritis improved in 1 patient treated with immunotherapy alone. "
04/01/1979 - "From the previous experimental studies and clinical experiences with human tumors, it can be concluded that adjuvant immunotherapy with BCG-CWS is a useful therapeutic modality for lung cancer, especially in cases combined with malignant pleurisy."
05/01/2000 - "These results suggest that IL-15 together with IL-12 may have potential for the immunotherapy of some types of malignant pleurisy."

04/01/1982 - "Proper evaluation of the following factors might have led to the correct diagnosis in many of the patients: A family history of tuberculosis, prior pleurisy, a gastrectomy, diabetes mellitus or end-stage renal failure; all can be associated with an increased incidence of tuberculosis. "
12/01/1988 - "After a total gastrectomy, the patient's serum AFP level rapidly decreased, followed by a recurrence he developed of a carcinomatous pleuritis and death. "
02/01/1995 - "After subtotal gastrectomy, she had high fever, pleuritis, leukopenia, butterfly erythema and hypoxemia, which were improved by 30 mg/day of oral prednisolone. "