Pleural Diseases

12/01/2011 - "There is no effective treatment for asbestos-related benign pleural diseases but these are markers of exposure. "
01/01/2014 - "The study included 80 MPM patients, 79 subjects with past asbestos exposure (SPE), and 134 patients with other benign pleural diseases (OPD) that were included as a control group. "
01/01/2013 - "Functional exercise capacity and health-related quality of life in people with asbestos related pleural disease: an observational study."
02/01/2009 - "The aim of this study was to investigate serum levels of SMRP in malignant and nonmalignant asbestos-related pleural disease. "
01/01/2008 - "While a large number of studies indicate the risks of high-level exposures to asbestos in the workplace setting, a relatively small number of studies describe the risk of pleural disease related to "take-home" asbestos brought into the household by workers exposed to asbestos. "

02/01/2012 - "The results showed that 18F-FDG PET/CT at delayed phase is very useful for the diagnosis of pleural diseases, and SUVmax on PET/CT in the delayed phase is a more reliable prognostic factor than that in the early phase. "
12/01/2009 - "18F-FDG PET/CT imaging correctly identified 13 of 14 cases of benign pleural disease. "
12/01/2003 - "Sixteen consecutive patients with pleural disease on CT scan underwent 18F-FDG imaging. "
12/01/2009 - "Preliminary results of this trial provide evidence that 18F-FDG PET/CT imaging is a highly accurate and reliable noninvasive test to decide for further investigation of differentiating malignant mesothelioma from benign pleural disease."
06/01/2004 - "To evaluate the accuracy of fluorine 18 fluorodeoxyglucose (FDG) positron emission tomography (PET) in differentiation of pleural malignancy and cancer-unrelated pleural disease in patients with non-small cell lung cancer (NSCLC) and pleural abnormalities at computed tomography (CT). "

03/01/2000 - "To investigate the significance of TNF-alpha and its soluble receptors (sTNFR-I and sTNFR-II) in differentiating benign and malignant pleural disease. "
10/15/2007 - "We conclude that tumor-derived TNF-alpha is important in the development of MPE in mice, and provide preclinical evidence supporting the efficacy of TNF-alpha blockade against malignant pleural disease."
03/01/2000 - "There are highly elevated TNF-alpha in tuberculosis pleural effusion; The sTNFR-I and sTNFR-II level in the serum and pleural effusion of malignant pleural effusion patients are significantly higher than those in tuberculosis pleural effusion patients, suggesting they may play some role in differentiating benign and malignant pleural diseases."
09/01/1993 - "It is unlikely that TNF alpha is the sole stimulus for the IL-8 production in pleural disease states."

11/01/1989 - "The development of improved antibiotics and a wider range of interventional techniques has increased the reliance on the radiologic imaging of pleural disease in order to plan appropriate therapy. "
12/01/1984 - "Chronic pleural disease followed, and the organism became resistant to many antibiotics during therapy. "

07/01/2001 - "Further research into the roles of TGFbeta in the pathogenesis of various pleural diseases is needed and may lead to the development of novel treatment strategies."
07/01/2001 - "The many faces of transforming growth factor-beta in pleural diseases."

01/01/2012 - "Procalcitonin is superior to CRP in distinguishing infection from non-infective pleural diseases, even when controlled for the level of systemic inflammation."
01/01/2012 - "Ability of procalcitonin to discriminate infection from non-infective inflammation using two pleural disease settings."

09/01/2015 - "The study suggests that mesothelin cannot be considered a reliable marker for the early stage of malignant degeneration of pleural disease but only an additional criterion for examination of the followed-up individuals."
10/01/2007 - "Mesothelin had a cross-validated sensitivity of 52% for mesothelioma patients, at a sensitivity of 95% relative to individuals with benign lung or pleural disease. "
09/01/2006 - "Our ELISA system has thus far detected much higher serum levels of N-ERC/mesothelin in mesothelioma patients than in healthy controls or patients with other lung or pleural diseases. "
10/01/2011 - "Soluble mesothelin and osteopontin in serum and plasma were significantly elevated in MM patients compared to patients with benign lung and pleural disease. "
09/01/2010 - "At a specificity of 95% relative to individuals with benign lung or pleural disease, serum mesothelin had a sensitivity of 66% and area under the curve of 0.882, whereas urinary mesothelin corrected for urine creatinine concentration had a sensitivity of 53% and area under the curve of 0.787. "

07/01/2010 - "The aim of this study was to compare the results of semiquantitative analysis by(18)F-fluorodeoxyglucose positron emission tomography/computed tomography (PET/CT) with plasma osteopontin levels in the same asbestos-related pleural disease population. "
07/01/2010 - "Preliminary study of positron emission tomography/computed tomography and plasma osteopontin levels in patients with asbestos-related pleural disease."
10/01/2011 - "Soluble mesothelin and osteopontin in serum and plasma were significantly elevated in MM patients compared to patients with benign lung and pleural disease. "
07/10/2010 - "Both soluble mesothelin-related peptide (SMRP) and osteopontin (OP) have utility in distinguishing MM from benign pleural disease. "
07/01/2010 - "PET/CT might be more helpful than plasma osteopontin for distinguishing benign asbestos-related pleural diseases from MPM, and the SUVmax in benign asbestos-related pleural diseases may reflect changes in pleural inflammation."

05/01/2001 - "Of these, MM was diagnosed in 15/37 patients while the remaining patients had either peripheral lung adenocarcinoma (PLA) or benign inflammatory pleural disease (BPD). "
01/01/1998 - "The study group consisted of 95 patients with benign lung and pleural diseases (BLPD), 14 patients with MPM, 41 patients with adenocarcinoma of lung (AC), and 40 patients with squamous cell carcinoma of lung (SQC). "
04/20/2008 - "For advanced lung adenocarcinoma, CT presentation of multiple metastasis of lung or diffused disease,pleural effusion and enhancing contrast disease focus may be a predictor for response when treated by EGFR-TKI. "
11/01/2013 - "Intratumoral microvessel density (MVD), endothelial cell and pericyte (PC) capillary coverage, endothelial cell (EC)-PC relationship, lymphatic endothelium integrity, and the expression of receptor tyrosine kinases were all assessed immunohistochemically in pleural tumor biopsy specimens from 24 patients with lung adenocarcinoma (ADC) with and without pleural disease, with the aim to evaluate the involvement with MPE. "

04/01/2001 - "Moreover, higher VEGF levels were found in the pleural effusions of MM patients than in the effusions of patients with non-malignant pleural disease (1885.7+/-894.9 pg/ml vs. 266.9+/-180.5 pg/ml; p<0.001). "
01/01/2006 - "VEGF is expressed in several parts of the lung and the pleura while it has been shown that changes in its expression play a significant role in the pathophysiology of some of the most common respiratory disorders, such as acute lung injury, asthma, chronic obstructive pulmonary disease, obstructive sleep apnea, idiopathic pulmonary fibrosis, pulmonary hypertension, pleural disease, and lung cancer. "
01/01/2011 - "Serum biomarkers including insulin-like growth factor-II (IGF-II), leptin, prolactin and vascular endothelial growth factor (VEGF) were measured in an observational study of subjects with benign asbestos-related pleural diseases (BARPD) (n=24) and healthy subjects with an asbestos exposure history (n=12). "

01/01/2010 - "In recent studies of a wide range of pleural diseases, iodopovidone was used as a sclerosing agent for pleurodesis and demonstrated good results with low morbidity. "
07/01/2005 - "A national survey of oncologist and chest physicians' attitudes towards empirical anti-oestrogen therapy, early pleurodesis and preference of sclerosing agent in malignant breast and ovarian pleural disease."
06/01/1998 - "Investigations of pleural disease consist initially of needle biopsies, completed sometimes by a thoracoscopy, which enable a precise staging and also the achievement of a pleurodesis. "
06/01/2014 - "A number of effective therapies for the management of malignant pleural disease have been studied in recent years, including chemical pleurodesis and tunnelled pleural catheters, greatly adding to our understanding of which therapy to use in which patient. "
03/01/1996 - "The treatment of pleural disease in potential lung transplant candidates should minimize the extent of pleurodesis. "

10/01/2010 - "Ultrasound-guided pigtail catheters provide a safe and effective method of draining various pleural diseases. "
10/01/2013 - "Recent advances have seen an expansion in the options available for managing patients with pleural disease, with access to local-anaesthetic thoracoscopy, indwelling pleural catheters and thoracic ultrasound all becoming commonplace. "
10/01/2010 - "We strongly suggest that ultrasound-guided pigtail catheters be considered as the initial draining method for a variety of pleural diseases."
10/01/2010 - "There was no significant difference in success rate when different catheter sizes were used to treat pleural diseases. "
10/01/2010 - "Little is known about the efficacy and safety of ultrasound-guided pigtail catheters for the management of various pleural diseases in the emergency department, ward, and intensive care unit. "

11/01/2004 - "These combined features as accomplished in local anesthesia on a remarkably high safety level characterise medical thoracoscopy as a gold standard tool for the management of pleural disease even in comparison to more elaborate surgical procedures."
07/01/2007 - "Scince medical thoracoscopy under local anesthesia is rapid, easy, safe, and well-tolerated procedure with an excellent diagnostic yield, it is recommended as a diagnostic procedure for cases with pleural diseases."
06/01/2002 - "Four-step local anesthesia and sedation for thoracoscopic diagnosis and management of pleural diseases."
12/01/2001 - "The increasing use of thoracoscopy performed under local anesthesia has made contributions to the diagnosis of pleural disease with effusion. "
08/01/2014 - "Medical thoracoscopy using a flex-rigid pleuroscope under local anesthesia is a recent diagnostic procedure for malignant pleural disease. "

09/01/1998 - "During the last 20 years routine application of various methods of multiple "small biopsies" of the lungs such as forceps, transbronchial, trucut percutaneous and so on, has significantly increased the efficacy of diagnostics of bronchopulmonary and pleural diseases. "
11/01/2003 - "Efficacy and safety of single-trocar technique for minimally invasive surgery of the chest in the treatment of noncomplex pleural disease."
09/01/1975 - "The gas sterilized bronchofiberscope has been utilized as a pleuroscope for visual exploration of the pleural space and forceps biopsy of abnormal lesions in 16 patients with undiagnosed pleural disease. "

03/15/2001 - "In this study, patients who had progressive pleural disease after thoracotomy consistently experienced pulmonary metastatic recurrence and had a poor prognosis."
08/01/2013 - "Three papers found that surgery--compared to exploratory thoracotomy--was associated with a survival advantage in cases of minimal pleural disease. "
07/01/1995 - "Thoracoscopy, a less invasive procedure than open thoracotomy, is excellent for the diagnosis of malignancy but is of minimal benefit in the diagnosis of benign pleural disease."
01/01/1959 - "[Observations on sudden thoracotomies in suppurative pulmonary and pleural diseases]."
10/01/1993 - "Morbidity and mortality remained low and length of stay in hospital was favorable in comparison with a subset of patients with malignant pleural disease who underwent thoracotomy for diagnosis. "