Plasminogen

Precursor of plasmin (FIBRINOLYSIN). It is a single-chain beta-globulin of molecular weight 80-90,000 found mostly in association with fibrinogen in plasma; plasminogen activators change it to fibrinolysin. It is used in wound debriding and has been investigated as a thrombolytic agent.

Also Known As:

Networked: 2077 relevant articles (35 outcomes, 200 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Ny, Tor: 10 articles (01/2015 - 03/2005)
2.	Schuster, Volker: 10 articles (11/2011 - 06/2003)
3.	Ranson, Marie: 9 articles (01/2014 - 05/2003)
4.	Li, Jinan: 9 articles (06/2012 - 03/2005)
5.	Schmitt, Manfred: 9 articles (10/2010 - 01/2002)
6.	Lund, Leif R: 8 articles (01/2015 - 04/2005)
7.	Pizzo, Salvatore V: 8 articles (09/2014 - 03/2002)
8.	Carmeliet, Peter: 8 articles (03/2013 - 12/2002)
9.	Collen, D: 8 articles (08/2009 - 06/2000)
10.	Waisman, David M: 7 articles (12/2014 - 02/2003)

Related Diseases

1.	Thrombosis (Thrombus) 01/01/1993 - "Assessment of BatPA using animal models of arterial thrombosis has demonstrated efficacy but without activation of systemic plasminogen. " 05/01/2012 - "Further studies are needed to confirm whether plasminogen availability and thrombus structure impact IVH clot removal. " 01/15/1999 - "The results of our study indicated that enrichment of the thrombus with exogenous plasminogen does not significantly improve the percentage of successful recanalization of peripheral arteries with a local low dose of SK, but significantly shortens the duration of treatment up to reperfusion. " 04/16/2015 - "The interaction of plasminogen with platelets and their localization during thrombus formation and fibrinolysis under flow are not defined. " 04/16/2015 - "Plasminogen associates with phosphatidylserine-exposing platelets and contributes to thrombus lysis under flow."
2.	Neoplasms (Cancer) 11/01/2011 - "In this study, we offer genetic evidence that plasminogen receptor S100A10 is essential for recruitment of macrophages to the tumor site. " 05/01/2004 - "Many studies have indicated that the plasminogen activation system may have a prominent role in cancer. " 01/01/2004 - "Clinical and experimental studies provide evidence that the plasminogen activation system plays a pivotal role in the pathogenesis of tumor growth and metastatic spread. " 01/01/1996 - "Plasminogen activation system in active even in thyroid tumors; an immunohistochemical study." 09/01/2015 - "Development of Recombinant Adeno-Associated Virus Serotype 2/8 Carrying Kringle Domains of Human Plasminogen for Sustained Expression and Cancer Therapy."
3.	Hemorrhage 10/01/2010 - "The drugs available on the market that prevent the activation of plasminogen have been used successfully, but have some side effects and limited efficacy for the control of localized bleeding in the surgical setting. " 09/01/2014 - "Long-term visual outcome and its predictive factors following treatment of acute submacular hemorrhage with intravitreous injection of tissue plasminogen factor and gas." 12/01/2013 - "IVintravenousACTactivated coagulation timeDWI MRIdiffusion weighted magnetic resonance imagingIAintra-arterialtPAtissue plasminogen activatorICHintracranial hemorrhage. " 09/01/2013 - "Besides, human plasminogen (HPG) activation by SK is not blood-clot specific and associated with a risk of hemorrhage. " 04/25/2013 - "Coupling this computational technique with a high-quality low-throughput screen identified 5-(4-piperidyl)-3-isoxazolol (4-PIOL) as a potent plasminogen binding inhibitor with the potential for the treatment of various bleeding disorders. "
4.	Myocardial Infarction 07/01/2014 - "The purpose of this study was to investigate the role of plasminogen (Plg) in stem cell-mediated cardiac repair and regeneration after myocardial infarction (MI). " 06/01/2000 - "In the present study we investigated the impact of the plasminogen system on cardiac wound healing and function after myocardial infarction. " 07/01/2014 - "Plasminogen regulates cardiac repair after myocardial infarction through its noncanonical function in stem cell homing to the infarcted heart." 04/01/2004 - "We investigated the acute-phrase and chronic-phase outcomes of patients with acute myocardial infarction (AMI) undergoing percutaneous coronary intervention (PCI) with or without antecedent mutant tissue-type plasminogen (t-PA) administration. " 06/01/2000 - "Myocardial infarction was induced in plasminogen-deficient mice (Plg-/-) and in wild-type controls (Plg+/+). "
5.	Infection 08/01/2014 - "A number of recent studies confirm that this enzyme has the functions of activating the plasminogen, involving in the processes of infection and migration of parasites, reducing the immune function of the host as well as preventing parasites from the immune attack of the host. " 08/01/1995 - "The aim of this study was to measure plasminogen in the cerebrospinal fluid (CSF) of control neonates with no infection or haemorrhage and in infants who had suffered intraventricular haemorrhage (IVH). " 07/03/1989 - "In the present study, the interaction of plasminogen with fimbriae found on Escherichia coli strains causing invasive human infections was studied. " 01/01/2015 - "pneumoniae infections by interaction with human plasminogen. " 12/01/2013 - "These host-derived cells were employed in cell culture infection analyses followed by confocal microscopy to monitor the plasminogen-mediated adherence. "

Related Drugs and Biologics

1.	Urokinase-Type Plasminogen Activator (Urokinase)
2.	Fibrinogen (Factor I)
3.	Plasminogen Activators (Plasminogen Activator)
4.	Tissue Plasminogen Activator (Alteplase)
5.	Fibrin
6.	Streptokinase
7.	Prothrombin (Factor II)
8.	Fibrinolysin
9.	Antithrombin III
10.	Plasminogen Activator Inhibitor 1

Related Therapies and Procedures

1.	Thrombolytic Therapy
2.	Injections
3.	Intra-Arterial Injections
4.	Intravitreal Injections
5.	Transplants (Transplant)