Placental Insufficiency

09/01/1988 - "A randomized, placebo-controlled, double-blind trial was carried out to evaluate the fetal benefits of low-dose aspirin (150 mg/day) as a treatment of placental insufficiency during the last trimester of pregnancy. "
01/01/2018 - "There is general consensus between guidelines (at least 4 of 6 guidelines in agreement) in early pregnancy risk selection, and use of low-dose aspirin for women with major risk factors for placental insufficiency. "
03/01/1995 - "The findings suggest that the optimal therapeutical aspirin doses should be chosen by the gestational age rather than by the severity of placental insufficiency."
03/01/1995 - "The pharmacokinetics and pharmacodynamics of small-dose aspirin (60 mg/day) were studied during the second to the third trimesters in pregnant females at a high risk of placental insufficiency. "
03/01/1995 - "[The pharmacokinetics and pharmacodynamics of prophylactic doses of aspirin in pregnant women from a group at risk for placental insufficiency]."

01/01/2020 - "Overall, 115 (41%) women experienced placental insufficiency complications, with no significant differences between the 2 arms: 50/144 (34.7%) in the LMWH arm and 43/134 (32%) in the control arm (p = 0.64, OR: 1.13, 95% CI: 0.68-1.85). "
01/01/2017 - "These data provide new insights into the non-coagulation-related aspects of perinatal LMWH treatment in the management of placental insufficiency disorders. "
01/01/2016 - "Low-molecular-weight heparin and placental insufficiency: miracle drug or modern day blood letting?"
09/01/2006 - "Recent studies have shown the limits of available procedures for women with constitutional thrombophilia and have helped define the clinical situations in thrombophilia-related placental insufficiency in which prophylactic low-molecular-weight heparin may be indicated."
01/01/2000 - "The authors report the results of application of low molecular weight heparin during pregnancy, delivery and after birth to counter placental insufficiency in case of primary antiphospholipid syndrome. "

01/01/2021 - "Moreover, genes that are found to be differentially expressed as a result of fetal reprogramming show promise in the development of transcriptional biomarkers for clinical use in detecting fetal response to placental insufficiency. "
01/01/2021 - "Aim of this study is to investigate the association between first trimester biomarkers and the presence of maternal vascular malperfusion (MVM), as a marker for placental insufficiency. "
01/01/2020 - "This study aims to establish a procedure to investigate fetal/neonatal transcriptional response to placental insufficiency as part of an initiative to identify cost-effective biomarkers for assessing fetal response to placental insufficiency. "
12/01/2023 - "We conclude that new approaches to detect placental insufficiency should integrate information from diagnostic tools such as maternal serum biomarkers and Doppler ultrasound measurements. "
12/01/2023 - "Perfusion was significantly lower in those with small for gestational age infants, indicating that pCASL-MRI-measured perfusion may be an effective imaging biomarker for placental insufficiency. "

01/01/2020 - "The objective of this study was to establish whether heparin improves the neonatal outcome of fetuses with suspected placental insufficiency. "
08/01/2011 - "Unfractionated heparin for second trimester placental insufficiency: a pilot randomized trial."
01/01/2020 - "In women with very high suspicion of placental insufficiency, heparin may increase fetal growth and prolong pregnancy. "
08/01/2011 - "To conduct a pilot randomized controlled trial of unfractionated heparin (UFH) in women considered at high risk of placental insufficiency in the second trimester. "
01/01/1978 - "Outpatient management of placental insufficiency with heparin."

01/01/2019 - "Sildenafil could be associated with increasing fetal weight at birth in placental insufficiency despite the limitations of this meta-analysis, even though more studies in this field are needed to introduce this drug into obstetric clinical practice."
01/01/2019 - "Sildenafil is a potential new treatment for placental insufficiency in human pregnancies as it reduces the breakdown of vasodilator nitric oxide. "

12/03/2021 - "Pre-clinical studies and a few small randomised clinical trials have suggested that phosphodiesterase type 5 (PDE-5) inhibitors may have protective effects against placental insufficiency in this context; however, robust evidence is lacking. "

01/01/2022 - "Pravastatin and placental insufficiency associated disorders: A systematic review and meta-analysis."
01/01/2018 - "Prevention of placental insufficiency with pravastatin prevented PE-associated cardiovascular complications in both mothers and offspring. "
12/01/2020 - "A previous pilot study showed that pravastatin supplementation improved pregnancy outcomes in women with obstetric antiphospholipid syndrome (OAPS) that developed placental insufficiency despite standard of care treatment low molecular weight heparin plus low dose aspirin (LMWH + LDA). "

04/13/1984 - "The efficacy of a dialysate of calf blood in the treatment of chronic placental insufficiency is assessed using the urinary oestriol elimination as parameter. "
04/13/1984 - "[The effect of calf blood dialysate on the excretion of estriol in placental insufficiency]."

01/01/2019 - "Sildenafil is a potential new treatment for placental insufficiency in human pregnancies as it reduces the breakdown of vasodilator nitric oxide. "

12/01/2003 - "Women with IUGR and placental insufficiency showed statistically significant higher serum levels of TNF-alpha[2.2 pg/mL (1.3-4.1)] and a higher rate of detectable TNF-alpha[85.7% (12/14)] than those in the control group [0 pg/mL (0-2.7) and 32.1% (9/28)] (p = 0.01 and p = 0.001, respectively). "
12/01/2003 - "TNF-alpha is increased in women with IUGR and placental insufficiency but normal in those with IUGR and normal placental perfusion. "
12/01/2003 - "On the contrary, there was no difference in either the TNF-alpha level [1.4 pg/mL (0-4.9)] or the rate of detectable TNF-alpha[57.1% (8/14)] between women with IUGR without placental insufficiency and women in the control group. "

01/01/2022 - "This study may inform the design of sex-specific therapies for placental insufficiency and fetal growth abnormalities with life-long benefits for the offspring."
01/01/2015 - "Currently there are no therapies for IUGR or placental insufficiency. "
01/01/2006 - "The optimal obstetric tactics, the possibilities of therapy and pregnancy prolongation, and indications to operative delivery were defined on the basis of the features of placental dysfunction pathogenesis and a thorough analysis of the features of placental insufficiency in women with a high risk of perinatal complications."
05/01/1987 - "Intensive intrauterine therapy reduces the risk to the fetus due to immunologic complications, as well that due to placental insufficiency, as evidenced by the additional differentiation of villi."
01/01/1987 - "[Therapy of the placental insufficiency syndrome]."

01/01/1994 - "[Experimental validation of the efficacy of laser-magnetic therapy for chronic placental insufficiency]."
01/01/1994 - "Hence, laser magnetic therapy may be regarded as an effective non-drug method for therapy of chronic placental insufficiency."
01/01/1994 - "Daily 5 min sessions of laser magnetic therapy administered to rats with chronic placental insufficiency from pregnancy days 15-16 to 21 normalized uterine horn contractility and resulted in positive morphofunctional changes in the components of the uterine horns and placenta, being associated with a noticeable improvement of fetal functions. "
01/01/2022 - "The aim of the study was to determine if markers of donor placental insufficiency and recipient cardiac dysfunction increase the risk for single fetal demise (SFD) after laser for twin-twin transfusion syndrome (TTTS). "
04/01/2006 - "In those who die despite treatment, recurrence of twin-to-twin transfusion syndrome, placental insufficiency or feto-fetal hemorrhage with anemia/polycythemia are complications that have to be managed with different secondary therapeutic options, such as amnioreduction, cord coagulation, intrauterine transfusion or repeat fetoscopy-guided laser. "

05/01/1977 - "Methods of intensive obstetrical care, introduced since 1973 such as ultrasonic diagnostic, screening for placental insufficiency, amniotic fluid diagnostics tocolysis, cardiotocography and micro-blood analysis, resulted in a significant raise of quality. "
02/01/1978 - "The methods of intensive care and control of high-risk pregnancy and high-risk parturition (ultrasound, cardiotocography, fetal blood analysis; tocolysis, laboratory diagnostics of placental insufficiency), practised since 1974, and the close cooperation with a newborn intensive-care ward of the infant hospital of the Herford center have brought about a definite improvement in perinatologic efficiency."
05/01/1986 - "In view of the connection which exists between premature birth and placental insufficiency and the means which are available for determining the respiratory performance of the fetoplacental unit by way of cardiotocography, the authors investigated the incidence of prepathological findings in the fetal heart frequency parameters for 81 cases of imminent premature delivery before, during and after intravenous tocolysis, and for 10 normal pregnancies between the 28th and 36th week. "
04/01/1979 - "The mean rT3, 3,3'-T2 and T4 values measured in patients with intra-uterine malnutrition, gestation diabetes, tocolysis, placental insufficiency and rhesus incompatibility at 31-40 weeks of gestation were not significantly different from those in uncomplicated pregnancy. "

02/01/1978 - "The methods of intensive care and control of high-risk pregnancy and high-risk parturition (ultrasound, cardiotocography, fetal blood analysis; tocolysis, laboratory diagnostics of placental insufficiency), practised since 1974, and the close cooperation with a newborn intensive-care ward of the infant hospital of the Herford center have brought about a definite improvement in perinatologic efficiency."

07/01/1991 - "The clinical findings (improved flow parameters and perinatal outcome) are not expected to yield any significant improvement when placental insufficiency is treated with bed rest alone."