Placental Insufficiency

08/01/2011 - "Unfractionated heparin for second trimester placental insufficiency: a pilot randomized trial."
08/01/2011 - "To conduct a pilot randomized controlled trial of unfractionated heparin (UFH) in women considered at high risk of placental insufficiency in the second trimester. "
08/01/1989 - "[Heparin therapy of pregnant women with placental insufficiency]."
01/01/1978 - "Outpatient management of placental insufficiency with heparin."
10/01/2014 - "To study the effect of heparin within the placenta, we performed secondary analyses on a pilot trial where 32 women with negative thrombophilia screens and second-trimester evidence of placental insufficiency were randomized to standard care or antenatal self-administration of unfractionated heparin (UFH) 7500 IU twice-daily. "

09/01/2006 - "Recent studies have shown the limits of available procedures for women with constitutional thrombophilia and have helped define the clinical situations in thrombophilia-related placental insufficiency in which prophylactic low-molecular-weight heparin may be indicated."
01/01/2000 - "The authors report the results of application of low molecular weight heparin during pregnancy, delivery and after birth to counter placental insufficiency in case of primary antiphospholipid syndrome. "
05/05/2015 - "There were 3 intrauterine fetal deaths (1 woman had used LMWH); 9 cases of preeclampsia or the hemolysis, elevated liver enzyme level, and low platelet count (HELLP) syndrome (3 women had used LMWH); and 11 cases of intrauterine growth restriction or placental insufficiency (5 women had used LMWH). "

12/01/2003 - "Women with IUGR and placental insufficiency showed statistically significant higher serum levels of TNF-alpha[2.2 pg/mL (1.3-4.1)] and a higher rate of detectable TNF-alpha[85.7% (12/14)] than those in the control group [0 pg/mL (0-2.7) and 32.1% (9/28)] (p = 0.01 and p = 0.001, respectively). "
12/01/2003 - "TNF-alpha is increased in women with IUGR and placental insufficiency but normal in those with IUGR and normal placental perfusion. "
12/01/2003 - "On the contrary, there was no difference in either the TNF-alpha level [1.4 pg/mL (0-4.9)] or the rate of detectable TNF-alpha[57.1% (8/14)] between women with IUGR without placental insufficiency and women in the control group. "

09/01/1988 - "A randomized, placebo-controlled, double-blind trial was carried out to evaluate the fetal benefits of low-dose aspirin (150 mg/day) as a treatment of placental insufficiency during the last trimester of pregnancy. "
11/01/1995 - "We conclude that low dose aspirin therapy is not of benefit in the treatment of pregnancies complicated by fetal growth restriction and umbilical-placental insufficiency between 28 and 36 weeks' gestation."
03/01/1995 - "The findings suggest that the optimal therapeutical aspirin doses should be chosen by the gestational age rather than by the severity of placental insufficiency."
03/01/1995 - "The pharmacokinetics and pharmacodynamics of small-dose aspirin (60 mg/day) were studied during the second to the third trimesters in pregnant females at a high risk of placental insufficiency. "
03/01/1995 - "[The pharmacokinetics and pharmacodynamics of prophylactic doses of aspirin in pregnant women from a group at risk for placental insufficiency]."

03/01/1989 - "A study of the correlations between uteroplacental flow (UPF) and some blood enzymes in 117 pregnant patients at high risk for perinatal disorders and with suspected placental insufficiency has demonstrated a stepwise activation of enzyme systems, which are elements of the adaptive-compensatory placental mechanisms, in the presence of placental insufficiency. "
01/01/1989 - "Having in mind the performed analysis of correlation interconnections between parameters of UPF and some blood enzymes we could assume that activation of various enzymic systems, forming links of adaptation-compensatory mechanisms of the placental system, occurs in the development of placental insufficiency."
07/01/2008 - "Clinical studies suggest that respiratory outcome of infants born preterm may be influenced by placental insufficiency and hemolysis, elevated liver enzymes, low platelets (HELLP) syndrome. "
03/01/2011 - "Obstetric morbidity includes recurrent abortion (early and late) and severe pre-eclampsia (P-EC)/hemolysis, elevated liver enzymes, low platelets (HELLP) syndrome, and/or severe placental insufficiency. "
01/01/2004 - "Hyperhomocysteinemia is a risk factor in obstetrical complications such as pre-eclampsia, 'hemolysis, elevated liver enzymes, low platelet' (HELLP)-syndrome and placental insufficiency. "

06/01/2011 - "The goal of this study was to compare the levels of fetal cardiac troponin T (cTnT) at birth and fetal Doppler parameters according to fetal gender in pregnancies complicated by placental insufficiency before 34 weeks' gestation. "
09/01/2000 - "The aim of this study was to test the hypothesis that severe placental insufficiency and a rise in fetal systemic venous pressure are associated with fetal myocardial cell damage, which in turn leads to increased neonatal troponin T levels. "
06/01/2011 - "Gender-specific differences in fetal cardiac troponin T in pregnancies complicated by placental insufficiency."
04/30/2002 - "In 48 fetuses with placental insufficiency, umbilical artery blood was obtained at delivery for assessment of N-terminal peptide of proatrial natriuretic peptide (NT-proANP) and cardiac troponin-T (cTnT). "
09/01/2000 - "Association of severe placental insufficiency and systemic venous pressure rise in the fetus with increased neonatal cardiac troponin T levels."

03/01/2013 - "Reductions in insulin concentrations and β-cell mass precede growth restriction in sheep fetuses with placental insufficiency."
08/01/2012 - "Placental insufficiency decreases fetal amino acid uptake from the placenta, plasma insulin concentrations, and protein accretion, thus compromising normal fetal growth trajectory. "
05/01/2011 - "Adverse changes in insulin sensitivity have been found to originate in utero; for instance, prenatal events such as placental insufficiency/oxidative stress leading to altered fetal growth trajectories are associated with increased rates of metabolic syndrome in adult life. "
01/01/2015 - "Considering the important role of the skeletal muscle in insulin resistance pathogenesis, understanding the in utero programmed origins of skeletal muscle deficiencies in insulin sensitivity and how they may interact with an adverse postnatal environment, is an important step in highlighting potential therapeutic options for LBW offspring born of pregnancies characterized by placental insufficiency. "
10/15/2012 - "These results demonstrate that fetuses exposed to sustained hypoglycemia have maintained hepatic insulin action in contrast to fetuses exposed to placental insufficiency."

11/01/2014 - "In case of placental insufficiency, reduced delivery of oxygen and/or nutrients to the fetus could be associated with alterations in the umbilical circulation, contributing further to the impairment of maternal-fetal exchanges. "
01/01/2012 - "RFM is thought to represent fetal compensation to conserve energy due to insufficient oxygen and nutrient transfer resulting from placental insufficiency. "
01/01/2012 - "DFM is thought to represent fetal compensation to conserve energy due to insufficient oxygen and nutrient transfer resulting from placental insufficiency. "
02/01/2011 - "Moreover, AMH can lead to reduced oxygen availability to the fetus, similar to a state of placental insufficiency. "
09/22/2003 - "Placental insufficiency is a process leading to progressive deterioration in placental function and a decrease in transplacental transfer of oxygen and nutrients to the fetus. "

01/01/2015 - "Here we investigate the effects of chronic placental insufficiency (CPI) on cell proliferation and the microenvironment in the subventricular zone (SVZ). "
05/01/2011 - "The total scores permitted grades 1 and 2 chronic placental insufficiency (CPI) to be diagnosed in 27.5 and 2.5%, respectively. "
04/01/2003 - "Chronic placental insufficiency (CPI), a known cause of intrauterine growth restriction, can lead to structural alterations in the developing brain that might underlie postnatal neurological deficits. "
04/01/2002 - "We aimed to determine whether a period of chronic placental insufficiency (CPI) in the guinea pig results in long-term alterations to auditory function. "
04/01/2005 - "Chronic placental insufficiency (CPI) was induced via unilateral ligation of the uterine artery from midgestation to near term in the pregnant guinea pig. "

03/01/1999 - "The association between lower birthweight and increased adult blood pressure, established in epidemiologic studies, may be caused by suboptimal maternal diet or placental insufficiency, resulting in transient changes in fetal hormone systems or gene expression that permanently alter the structure and function of the kidney and vasculature."
02/01/1998 - "Thyroid hormone concentrations in preterm infants born to pre-eclamptic women with placental insufficiency."
03/01/1993 - "All the other diagnostic criteria of placental insufficiency are part of obstetrics (placental hormone production, measurement of uterus circulation and of intervillous space). "
07/01/1991 - "Placental insufficiency in the examined group was characterized by enlarged intervillous space and a longer period necessary for filling this space, reduced linear rate of the blood stream in this space, as well as by reduced levels of the fetoplacental hormones and activation of lipid peroxidation. "
01/01/1987 - "In agreement with hypoglycemia and hyperuremia observed at birth in hypotrophic lambs, with the litter size recorded for each experimental group and with previous results, placental insufficiency linked to a large litter size gestation could be at the origin of low thyroid hormone levels."

05/01/1977 - "Methods of intensive obstetrical care, introduced since 1973 such as ultrasonic diagnostic, screening for placental insufficiency, amniotic fluid diagnostics tocolysis, cardiotocography and micro-blood analysis, resulted in a significant raise of quality. "
02/01/1978 - "The methods of intensive care and control of high-risk pregnancy and high-risk parturition (ultrasound, cardiotocography, fetal blood analysis; tocolysis, laboratory diagnostics of placental insufficiency), practised since 1974, and the close cooperation with a newborn intensive-care ward of the infant hospital of the Herford center have brought about a definite improvement in perinatologic efficiency."
05/01/1986 - "In view of the connection which exists between premature birth and placental insufficiency and the means which are available for determining the respiratory performance of the fetoplacental unit by way of cardiotocography, the authors investigated the incidence of prepathological findings in the fetal heart frequency parameters for 81 cases of imminent premature delivery before, during and after intravenous tocolysis, and for 10 normal pregnancies between the 28th and 36th week. "
04/01/1979 - "The mean rT3, 3,3'-T2 and T4 values measured in patients with intra-uterine malnutrition, gestation diabetes, tocolysis, placental insufficiency and rhesus incompatibility at 31-40 weeks of gestation were not significantly different from those in uncomplicated pregnancy. "

01/01/1994 - "[Experimental validation of the efficacy of laser-magnetic therapy for chronic placental insufficiency]."
01/01/1994 - "Hence, laser magnetic therapy may be regarded as an effective non-drug method for therapy of chronic placental insufficiency."
01/01/1994 - "Daily 5 min sessions of laser magnetic therapy administered to rats with chronic placental insufficiency from pregnancy days 15-16 to 21 normalized uterine horn contractility and resulted in positive morphofunctional changes in the components of the uterine horns and placenta, being associated with a noticeable improvement of fetal functions. "
04/01/2006 - "In those who die despite treatment, recurrence of twin-to-twin transfusion syndrome, placental insufficiency or feto-fetal hemorrhage with anemia/polycythemia are complications that have to be managed with different secondary therapeutic options, such as amnioreduction, cord coagulation, intrauterine transfusion or repeat fetoscopy-guided laser. "

02/01/1978 - "The methods of intensive care and control of high-risk pregnancy and high-risk parturition (ultrasound, cardiotocography, fetal blood analysis; tocolysis, laboratory diagnostics of placental insufficiency), practised since 1974, and the close cooperation with a newborn intensive-care ward of the infant hospital of the Herford center have brought about a definite improvement in perinatologic efficiency."

07/01/1991 - "The clinical findings (improved flow parameters and perinatal outcome) are not expected to yield any significant improvement when placental insufficiency is treated with bed rest alone."

01/01/1995 - "[Doppler ultrasound studies in placental insufficiency as an indication of the effectiveness of hemodilution therapy]."
06/01/1981 - "Isovolemic hemodilution is proposed to be of potential value in cases of EPH-gestosis with normovolemia, hypertension, intrauterine fetal growth retardation or other symptoms of placental insufficiency, at least as a subject to further studies."