Placenta Accreta

Abnormal placentation in which all or parts of the PLACENTA are attached directly to the MYOMETRIUM due to a complete or partial absence of DECIDUA. It is associated with POSTPARTUM HEMORRHAGE because of the failure of placental separation.

Also Known As:

Placenta Increta; Placenta Percreta; Accreta Spectrum, Placenta; Accreta, Placenta; Adherent Placenta, Morbidly; Increta, Placenta; Morbidly Adherent Placentas; Percreta, Placenta; Placenta, Morbidly Adherent; Morbidly Adherent Placenta; Placenta Accreta Spectrum

Networked: 1495 relevant articles (36 outcomes, 147 trials/studies)

Relationship Network

Disease Context: Research Results

Urogenital Diseases: 126
- Female Urogenital Diseases and Pregnancy Complications
  - Pregnancy Complications: 2961
    - Placenta Diseases: 80
      - Placenta Accreta: 1495
    - Obstetric Labor Complications: 62
      - Placenta Accreta: 1495

Related Diseases

1.	Placenta Previa
2.	Hemorrhage
3.	Placenta Accreta
4.	Postpartum Hemorrhage
5.	Uterine Hemorrhage (Uterine Bleeding)

Experts

1.	Matsubara, Shigeki: 18 articles (12/2022 - 04/2012)
2.	Matsuzaki, Shinya: 18 articles (01/2022 - 09/2014)
3.	Kayem, Gilles: 15 articles (01/2022 - 09/2002)
4.	Sentilhes, Loïc: 14 articles (01/2022 - 12/2006)
5.	Belfort, Michael A: 12 articles (01/2022 - 11/2010)
6.	Fox, Karin A: 12 articles (01/2022 - 12/2015)
7.	Shamshirsaz, Alireza A: 11 articles (01/2022 - 12/2015)
8.	Kimura, Tadashi: 10 articles (01/2021 - 01/2012)
9.	Matsuo, Koji: 9 articles (01/2022 - 01/2020)
10.	Silver, Robert M: 9 articles (01/2022 - 06/2006)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Placenta Accreta:

1.	Methotrexate (Mexate)FDA LinkGeneric 12/01/2022 - "Aim of the study: This article reports on a series of patients with placenta accreta spectrum (PAS) disorder who were treated conservatively with Methotrexate (MTX) administration with or without embolization. " 04/01/2020 - "Methotrexate for placenta accreta spectrum disorders: Is it needed?" 07/01/2018 - "On postpartum day 5, this patient was diagnosed with placenta accreta and treated with intramuscular methotrexate for 3 consecutive days. " 07/01/2018 - "Here we report a 29-year-old woman subjected to methotrexate treatment for placenta accreta. " 07/01/2018 - "High-Dose Methotrexate Treatment in a Breastfeeding Mother with Placenta Accreta: A Case Report."
2.	Messenger RNA (mRNA)IBA 04/01/2010 - "Six false-positive results were found on ultrasound, all from patients without placenta accreta and an insignificant rise in cell-free placental mRNA levels. " 01/01/2015 - "Cell-free mRNA is an acceptable, easy made, functional test with sensitivity, specificity, PPV and NPV more than Doppler ultrasound for diagnosis and prediction of incidence of placenta accrete and we recommend the use of cell-free mRNA test for diagnosis of placenta accreta." 01/01/2015 - "In this cross-sectional study, 50 pregnant women at risk for placenta accreta underwent color Doppler and assessment of cell-free placental mRNA. " 09/01/2014 - "An increased level of cell-free β-HCG mRNA in the maternal plasma of women with placenta accreta may arise from direct uteroplacental transfer of cell-free placental mRNA molecules. " 08/01/2011 - "Higher circulating mRNA levels of placental specific genes in a patient with placenta accreta."
3.	Hemostatics (Antihemorrhagics)IBA 05/25/2023 - "Placenta Accreta Spectrum Part II: hemostatic considerations based on an extended review of the literature." 08/01/2004 - "To describe an accurate approach, hemostatic procedures and uterine repair in patients with anterior placenta percreta. " 08/01/2018 - "To avoid these complications, we performed a novel hemostatic suture with a contrivance for a case of uterine posterior placenta increta. " 01/01/2019 - "IIA and AA occlusions have similar hemostatic effects in pernicious placenta previa patients with placenta accrete underwent cesarean delivery, while AA occlusion is more effective in reducing EBL in placenta percreta subgroup." 08/23/2023 - "This study aimed to evaluate the outcomes of a new uterine-preserving technique (called the combined approach, including surgical hemostasis, bilateral ligation of the descending branches of the uterine arteries, and hemostatic external supraplacental stitch with the use of the Zhukovsky double-balloon tamponade in patients with placenta accreta spectrum disorders) during cesarean delivery in women with placenta accreta spectrum disorders vs the surgical technique used until 2014. "
4.	Posterior Pituitary HormonesIBA 08/01/2020 - "The aim of this study is to evaluate the efficacy of prophylactic internal iliac artery balloon occlusion combined with Pituitrin intra-arterial infusion in the control of postpartum hemorrhage in women with placenta accreta spectrum (PAS). " 08/01/2020 - "Control of postpartum hemorrhage in women with placenta accreta spectrum using prophylactic balloon occlusion combined with Pituitrin intra-arterial infusion."
5.	recombinant FVIIa (rFVIIa)FDA Link 08/01/2008 - "We describe a case of successful treatment with rFVIIa for PPH due to placenta accreta. " 02/01/2010 - "We experienced unusual repeated ante-partum intra-abdominal bleedings in a woman with placenta percreta invading into the left broad ligament, in whom recombinant factor VIIa was effective for controlling severe retro-peritoneal bleeding. " 02/01/2010 - "Successful treatment of severe retro-peritoneal bleeding with recombinant factor VIIa in women with placenta percreta invading into the left broad ligament: unusual repeated ante-partum intra-abdominal bleeding."
6.	Progestins (Progestagens)IBA 01/01/2010 - "The use of estrogen and progestogen together with methotrexate in combination may be simple and potentially effective for placenta accreta and placenta increta."
7.	Estrogens (Estrogen)FDA Link 01/01/2010 - "The use of estrogen and progestogen together with methotrexate in combination may be simple and potentially effective for placenta accreta and placenta increta."
8.	Anesthetics (Anesthetic Agents)IBA 11/01/2015 - "The aim of this study was to describe the anesthetic management of placenta accreta in a low-resource setting. " 09/19/2023 - "To explore the management and experiences of healthcare providers around anesthetic care in placenta accreta spectrum (PAS). " 06/01/2023 - "The anesthetic approach to a patient with placenta accreta spectrum." 04/24/2023 - "Intra-aortic balloon occlusion was used in a Fontan-palliated parturient with placenta increta with successful anesthetic management." 04/24/2023 - "Herein, we report the case of an intra-aortic balloon occlusion used for a Fontan-palliated parturient with placenta increta with successful anesthetic management. "
9.	Vascular Endothelial Growth Factor A (Vascular Endothelial Growth Factor)IBA 12/01/2021 - " levels of VEGF and sFlt-1 could be used as auxiliary indicators to diagnose PPP and distinguish between placenta accreta and increta." 12/01/2021 - "It was found that both VEGF and sFlt-1 had diagnostic value for PPP and placenta accreta/increta combined PPP. " 07/01/2022 - "Maternal age, gravidity, C/S, and serum levels of VEGF and PLGF were assessed between NP and PAS, and among NP and PAS sub-groups, including Placenta Accreta (PA), Placenta Increta (PI), and Placenta Percreta (PP). " 12/01/2021 - "In summary, the levels of VEGF and sFlt-1 could be used as auxiliary indicators to diagnose PPP and distinguish between placenta accreta and increta.KEY POINTSThe levels of VEGF and sFlt-1 could be used to distinguish placenta accreta from placenta increta.VEGF is negatively correlated with sFlt-1 in PPP patients.The" 12/01/2021 - "In addition, the levels of VEGF and sFlt-1 could be used to distinguish placenta accreta from placenta increta. "
10.	Intercellular Signaling Peptides and Proteins (Growth Factors)IBA 10/01/2018 - "Extravillous trophoblast invasion in placenta accreta is associated with differential local expression of angiogenic and growth factors: a cross-sectional study." 10/01/2018 - "Placenta accreta histology shows dysregulation of angiogenic and growth factors." 01/01/2018 - "While the postoperative levels of vascular endothelial growth factorand soluble fms-like tyrosine kinase 1 levels were higher in placenta percreta (p=0.001 and p<0.001, respectively), placental growth factor levels were similar in both groups. " 01/01/2022 - "Our study aimed to distinguish patients with placenta accreta (crete, increta, and percreta) from those with placenta previa using maternal plasma levels of soluble fms-like tyrosine kinase-1 (sFlt-1) and placental growth factor (PLGF) and the sFlt-1/PLGF ratio. " 01/01/2018 - "The findings of this study suggest that a decrease in vascular endothelial growth factor, placental growth factor and soluble fms-like tyrosine kinase 1 levels may be related to placenta percreta etiopathogenesis."

Therapies and Procedures

1.	Hysterectomy 01/01/2012 - "We review the techniques used to ensure a good outcome and the advantages of a minimally invasive approach to hysterectomy in this patient with placenta percreta." 10/12/2023 - "Currently, the first-line treatment for placenta accreta spectrum recommended worldwide is hysterectomy. " 05/01/2019 - "UAE following cesarean delivery but before hysterectomy in patients with placenta increta appears to be safe and effective in decreasing EBL, transfusion requirements, and length of ICU stay compared with C-hyst alone." 06/01/2010 - "Prophylactic pelvic artery catheterization and embolization in women with placenta accreta is safe and effective in prevention of hysterectomy and should be considered in woman wishing to preserve fertility." 03/01/2021 - "The efficacy of LigaSure™ open instruments in cases of cesarean hysterectomy due to placenta percreta: a retrospective, record-based, comparative study."
2.	Cesarean Section (Caesarean Section) 01/01/2018 - "Application of preoperative transfemoral abdominal aorta balloon occlusion during cesarean section is a safe and effective strategy for patients with placenta increta and/or percreta. " 05/01/2015 - "A stepwise cesarean section is safe and effective procedure that can be applied in placenta percreta." 12/01/2023 - "These findings suggest that prophylactic radiologic interventions prior to planned cesarean section may help to limit perioperative blood loss in women with clear signs of placenta accreta spectrum disorder on ultrasonography, but there was no evidence of a difference within the subgroup without such ultrasonographic signs. " 08/28/2022 - "Efficacy of low extra-abdominal aortic block in cesarean section for placenta accreta spectrum disorders and its effect on the expression of MDA and SOD." 08/01/2021 - "Comparison of the efficacy of prophylactic balloon occlusion of the abdominal aorta at or below the level of the renal artery in women with placenta accreta undergoing cesarean section."
3.	Conservative Treatment 12/01/2008 - "Embolization was also effective when utilized early as an adjunct in the conservative treatment of placenta accreta, leaving the entire placenta or just the adherent portion in situ as an alternative to radical management. " 02/19/2021 - "This study shows that TCM is safe and effective for treating placenta accreta, and it is worth recommending TCM as a conservative treatment along with other treatments. " 08/20/2022 - "A randomized controlled study comparing two uterine sparing techniques in conservative management of placenta accreta spectrum." 01/01/2020 - "The objective of our study was to demonstrate planned conservative management of placenta increta and percreta in a single tertiary center. " 03/01/2018 - "Only studies describing conservative treatment for placenta percreta (without placental removal) were included in the systematic review. "
4.	Sutures (Suture) 08/01/2011 - "All eight patients with placenta accreta were treated successfully with the placement of multiple sutures in the placental bed and UAE. " 01/01/2019 - "Re: Nausicaa suture for placenta accreta spectrum: further studies are needed." 01/01/2019 - "Author's reply re: Nausicaa suture for placenta accreta spectrum: further studies are needed: Nausicaa suture: which uterine compression suture will remain in the future?" 01/01/2019 - "Nausicaa suture for placenta accreta spectrum: further studies are needed." 01/01/2015 - "The purpose of this study is to evaluate the efficacy and safety of a reflexed compression suture in controlling severe atonic PPH with placenta accreta. "
5.	Uterine Artery Embolization 12/01/2012 - "Uterine artery embolization is safe and effective for the management of secondary postpartum haemorrhage associated with placenta accreta." 10/01/2020 - "The aim of this study is to compare immediate and long-term obstetrical outcomes of patients who underwent cesarean delivery with and without uterine artery embolization (UAE) for the management of placenta accreta spectrum disorder. " 08/01/2014 - "The purpose of the study was to estimate the absorbed dose (AD) to the fetus for pregnant patients with placenta accreta undergoing fluoroscopy imaging during prophylactic catheterization and uterine artery embolization. " 11/01/2023 - "To evaluate the feasibility and safety of early and proactive involvement of interventional radiology (IR) in the management of placenta accreta spectrum (PAS) by performing the cesarean operation and prophylactic uterine artery embolization in the IR angiography suite as a combined procedure. " 11/01/2023 - "Prophylactic Uterine Artery Embolization in Placenta Accreta Spectrum-An Active Intervention to Reduce Morbidity and Promote Uterine Preservation."