Placenta Accreta

Abnormal placentation in which all or parts of the PLACENTA are attached directly to the MYOMETRIUM due to a complete or partial absence of DECIDUA. It is associated with POSTPARTUM HEMORRHAGE because of the failure of placental separation.

Also Known As:

Networked: 605 relevant articles (10 outcomes, 39 trials/studies)

Relationship Network

Disease Context: Research Results

Related Diseases

1.	Hemorrhage
2.	Placenta Accreta
3.	Placenta Previa
4.	Uterine Inertia
5.	Postpartum Hemorrhage

Experts

1.	Sheiner, Eyal: 5 articles (03/2013 - 08/2003)
2.	Salim, Raed: 4 articles (11/2015 - 06/2010)
3.	Mazor, Moshe: 4 articles (08/2015 - 08/2003)
4.	Kanagawa, Takeshi: 4 articles (04/2015 - 01/2012)
5.	Kimura, Tadashi: 4 articles (04/2015 - 01/2012)
6.	Goffinet, François: 4 articles (10/2013 - 03/2010)
7.	Sentilhes, Loïc: 4 articles (10/2013 - 03/2010)
8.	Kocarslan, Sezen: 3 articles (01/2016 - 02/2015)
9.	Shalev, Eliezer: 3 articles (11/2015 - 06/2010)
10.	Silver, Robert M: 3 articles (06/2015 - 06/2006)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Placenta Accreta:

1.	Messenger RNA (mRNA)IBA 04/01/2010 - "Six false-positive results were found on ultrasound, all from patients without placenta accreta and an insignificant rise in cell-free placental mRNA levels. " 01/01/2015 - "Cell-free mRNA is an acceptable, easy made, functional test with sensitivity, specificity, PPV and NPV more than Doppler ultrasound for diagnosis and prediction of incidence of placenta accrete and we recommend the use of cell-free mRNA test for diagnosis of placenta accreta." 01/01/2015 - "In this cross-sectional study, 50 pregnant women at risk for placenta accreta underwent color Doppler and assessment of cell-free placental mRNA. " 09/01/2014 - "An increased level of cell-free β-HCG mRNA in the maternal plasma of women with placenta accreta may arise from direct uteroplacental transfer of cell-free placental mRNA molecules. " 08/01/2011 - "Higher circulating mRNA levels of placental specific genes in a patient with placenta accreta."
2.	Methotrexate (Mexate)FDA LinkGeneric 08/01/2015 - "Successful treatment of Placenta Percreta through a combinatorial treatment involving a Bakri Balloon and Methotrexate--a case report." 06/01/2015 - "To observe efficacy following methotrexate (MTX) management in women with placenta accreta. " 06/01/2015 - "Methotrexate management for placenta accreta: a prospective study." 01/01/2015 - "Here, we present a case of placenta percreta diagnosed by magnetic resonance imaging, and treated with systemic administration of methotrexate. " 01/01/2015 - "Preservation of fertility and subsequent childbirth after methotrexate treatment of placenta percreta: a case report."
3.	recombinant FVIIa (rFVIIa)IBA 08/01/2008 - "We describe a case of successful treatment with rFVIIa for PPH due to placenta accreta. " 02/01/2010 - "We experienced unusual repeated ante-partum intra-abdominal bleedings in a woman with placenta percreta invading into the left broad ligament, in whom recombinant factor VIIa was effective for controlling severe retro-peritoneal bleeding. " 02/01/2010 - "Successful treatment of severe retro-peritoneal bleeding with recombinant factor VIIa in women with placenta percreta invading into the left broad ligament: unusual repeated ante-partum intra-abdominal bleeding."
4.	Estrogens (Estrogen)FDA Link 01/01/2010 - "The use of estrogen and progestogen together with methotrexate in combination may be simple and potentially effective for placenta accreta and placenta increta."
5.	STF 62247IBA 11/01/2012 - "UAE immediately after a caesarean performed in the cath lab is a feasible therapeutic option for conservative treatment of placenta accreta. " 11/01/2012 - "A retrospective study included all patients who had a planned caesarean in the cath lab for conservative treatment of placenta accreta at Angers University Hospital, which is a tertiary care centre, from April 2001 to September 2010. " 11/01/2012 - "To evaluate the feasibility and efficacy of routine uterine artery embolization (UAE) immediately after planned caesareans performed in the cath lab for conservative treatment of placenta accreta. " 11/01/2012 - "Planned caesarean in the interventional radiology cath lab to enable immediate uterine artery embolization for the conservative treatment of placenta accreta."
6.	Chorionic Gonadotropin (Human Chorionic Gonadotropin)FDA LinkGeneric 09/01/2014 - "Placental blood flow disappears coincident with a fall in human chorionic gonadotropin to undetectable levels in conservative management of placenta accreta." 08/01/2011 - "In this series of cases of conservative management of placenta accreta, the pulsatility index of the uterine arteries showed a better correlation with the uteroplacental circulation than serum β fraction of human chorionic gonadotropin." 08/01/2011 - "Three patients under conservative management of placenta accreta were followed using the pulsatility index of the uterine arteries and the β fraction of human chorionic gonadotropin to determine the degree of vascularity between the uterus and the placenta. " 08/01/2011 - "Utility of the pulsatility index of the uterine arteries and human chorionic gonadotropin in a series of cases of placenta accreta." 09/01/2014 - "This study aimed to determine whether maternal plasma mRNA levels of the β subunit of human chorionic gonadotropin (β-HCG) could predict placenta accreta prenatally. "
7.	Dihydrotachysterol (AT 10)IBA 01/01/2003 - "Patients who had a diagnosis of placenta accreta, increta, or percreta by clinical course or pathologic examination of the uterus and who had had a sonographic examination at 10 weeks or earlier were included in this study. " 05/01/2014 - "Cervical pregnancy with placenta percreta diagnosed after pregnancy termination at 10 weeks." 01/01/2003 - "In a patient with a previous cesarean delivery, a sac lying in the lower uterine segment on a scan at 10 weeks or earlier suggests the possibility of placenta accreta." 10/01/2012 - "Bleeding from placenta percreta at 10 weeks' gestation."
8.	Angiopoietin-2IBA 02/01/2006 - "These observations suggest that the participation of up-regulated angiopoietin-2 and down-regulated Tie-2 in the placental tissues may indicate a role for these angiogenic factors in the development of placenta accreta." 02/01/2006 - "Enzyme-linked immunosorbent assay in the placental lysates showed that women with placenta accreta demonstrated significantly higher angiopoietin-2 and lower Tie-2 concentrations than did women with normal pregnancies (P = .026 and .003, respectively). " 06/01/2006 - "We have found, in pregnancies complicated by placenta accreta: upregulated epidermal growth factor receptor and downregulated c-erbB-2 oncoprotein in syncytiotrophoblasts; downregulated vasculoendothelial growth factor receptor-2 expression in syncytiotrophoblasts and increased vasculoendothelial growth factor in placental lysates; and downregulated Tie-2 expression in syncytiotrophoblasts and enhanced angiopoietin-2 level in placental lysates. " 02/01/2006 - "The purpose of this study was to investigate the differential expression of angiopoietin-1, angiopoietin-2, and Tie receptors (Tie-1 and Tie-2) in placentas from pregnancies complicated by placenta accreta. " 02/01/2006 - "Paraffin sections of 46 placental specimens with (cases) and 46 without (controls) placenta accreta were studied immunohistochemically for the expression of Tie receptors and angiopoietin-2 in trophoblast populations. "
9.	Cadherins (E-Cadherin)IBA 06/01/2015 - "The invasive phenotype of placenta accreta extravillous trophoblasts associates with loss of E-cadherin." 01/01/2016 - "This study aimed to evaluate whether trophoblastic transforming growth factor beta (TGF-β) and E-cadherin expression levels have a role in placenta percreta (PP) aetiopathogenesis. " 01/01/2016 - "Trophoblastic E-cadherin and TGF-beta expression in placenta percreta and normal pregnancies."
10.	RNA (Ribonucleic Acid)IBA 01/01/2015 - "A comparison of cell-free placental messenger ribonucleic acid and color Doppler ultrasound for the prediction of placental invasion in patients with placenta accreta." 05/01/2006 - "mRNA expression of MMP-9 in the placenta accreta was (3.21 +/- 0.76) copies/microg total RNA, significantly higher (P < 0.05) than that of normal placenta [(3.84 +/- 0.24) copies/microg total RNA)]. " 01/01/2015 - "The aim of the present study was to comparison between cell-free placental messenger ribonucleic acid (mRNA) and Doppler ultrasound for the prediction of placental invasion in women with placenta accreta. " 05/01/2006 - "mRNA expression of TIMP-1 in normal placenta and placenta accreta was (5.91 +/- 0.56) and (5.92 +/- 0.46) copies/microg total RNA, respectively, with no significant difference between the two groups. "

Therapies and Procedures

1.	Hysterectomy 01/01/2012 - "We review the techniques used to ensure a good outcome and the advantages of a minimally invasive approach to hysterectomy in this patient with placenta percreta." 06/01/2010 - "Prophylactic pelvic artery catheterization and embolization in women with placenta accreta is safe and effective in prevention of hysterectomy and should be considered in woman wishing to preserve fertility." 07/01/2015 - "There were 4,592 births in the period of study, and 125 obstetric hysterectomies were performed, with 40 confirmed cases of accreta (8.7 per thousand births) with 20 in scheduled and 20 in urgent surgeries, with the most frequent type being placenta accreta. " 07/01/2015 - "The aim of this study was to compare the results of scheduled hysterectomy vs. urgent hysterectomy in patients with placenta accreta in a high specialty medical unit. " 02/01/2014 - "Descriptive study, data were obtained from clinical records of patients diagnosed with placenta accreta and whose management was by our modified technique cesarean-hysterectomy by a multidisciplinary team. "
2.	Sutures (Suture) 08/01/2011 - "All eight patients with placenta accreta were treated successfully with the placement of multiple sutures in the placental bed and UAE. " 12/01/2015 - "The purpose of this study is to evaluate the efficacy and safety of a reflexed compression suture in controlling severe atonic PPH with placenta accreta. " 06/01/2014 - "In this limited study, a history of continuous sutures on the inner side of the uterine wall showed potential to influence the development of placenta accreta in PPPC patients." 01/01/2013 - "In recent studies, uterine compression sutures have been used in placenta accreta. " 06/01/2014 - "No difference was found comparing single-layer with double-layer closure in the incidence of placenta accreta (37.1 versus 39.7%, P = 0.805); however, a significant difference was found comparing continuous with interrupted sutures (58.1 versus 29.9%, P = 0.008). "
3.	Uterine Artery Embolization 12/01/2012 - "Uterine artery embolization is safe and effective for the management of secondary postpartum haemorrhage associated with placenta accreta." 08/01/2014 - "The purpose of the study was to estimate the absorbed dose (AD) to the fetus for pregnant patients with placenta accreta undergoing fluoroscopy imaging during prophylactic catheterization and uterine artery embolization. " 12/01/2012 - "To evaluate the efficacy and safety of uterine artery embolization for the management of secondary postpartum haemorrhage associated with placenta accreta. " 12/01/2012 - "Uterine artery embolization for the management of secondary postpartum haemorrhage associated with placenta accreta." 08/01/2010 - "Application of 3-d angiography in the management of placenta percreta treated with repeat uterine artery embolization."
4.	Cesarean Section (Caesarean Section) 05/01/2015 - "A stepwise cesarean section is safe and effective procedure that can be applied in placenta percreta." 09/01/2015 - "This paper presents the management of a woman undergoing her fifth caesarean section in the presence of a placenta percreta. " 09/01/2015 - "Emergency cesarean section was done and intraoperatively it was diagnosed as a case of placenta percreta with pregnancy in right noncommunicating horn of uterus. " 05/01/2015 - "A dramatic rise in the rates of Cesarean section and intrauterine surgical procedure is considered to be the main factor responsible for the growing incidence of placenta accreta. " 05/01/2015 - "To describe a modified surgical approach in the form of stepwise cesarean section in placenta percreta. "
5.	Catheters 11/01/2015 - "In a randomized trial, women with a prenatal diagnosis of placenta accreta were randomized to either preoperative prophylactic balloon catheters (intervention group) or to a control group. " 09/01/2012 - "The objective of the study was to compare outcomes between patients who did and did not receive preoperative uterine artery balloon catheters in the setting placenta accreta. " 11/01/2015 - "In women with preoperative suspicion of placenta accreta, preoperative placement of prophylactic balloon catheters did not affect the number of packed RBC units transfused. " 11/01/2015 - "Precesarean Prophylactic Balloon Catheters for Suspected Placenta Accreta: A Randomized Controlled Trial." 08/01/2014 - "Pre-operative placement of intravascular balloon catheters is a feasible treatment for AIP, and is particularly useful in cases of placenta percreta."