Pityriasis Rubra Pilaris

A chronic skin disease characterized by small follicular papules, disseminated reddish-brown scaly patches, and often, palmoplantar hyperkeratosis. The papules are about the size of a pin and topped by a horny plug.

Networked: 165 relevant articles (13 outcomes, 3 trials/studies)

Relationship Network

Disease Context: Research Results

Related Diseases

1.	Granuloma Annulare
2.	Psoriasis (Pustulosis Palmaris et Plantaris)
3.	Darier Disease (Darier's Disease)
4.	Lichen Planus (Lichen Ruber Planus)
5.	Rosacea (Acne Rosacea)

Experts

1.	Landthaler, M: 4 articles (11/2012 - 02/2005)
2.	Babilas, P: 2 articles (11/2012 - 10/2010)
3.	Klein, A: 2 articles (11/2012 - 01/2007)
4.	Coras, B: 2 articles (11/2012 - 02/2005)
5.	Szeimies, R-M: 2 articles (10/2010 - 01/2007)
6.	Karrer, S: 2 articles (10/2010 - 01/2007)
7.	Youn, Sang Woong: 1 article (11/2015)
8.	Belhadjali, Hichem: 1 article (11/2015)
9.	Hammedi, Faten: 1 article (11/2015)
10.	Kim, Bo Ri: 1 article (11/2015)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Pityriasis Rubra Pilaris:

1.	Vitamin A (Retinol)FDA LinkGeneric 06/01/1959 - "[Pityriasis rubra pilaris with post-anginal acute onset, greatly improved by treatment with synthetic vitamin A]." 11/01/1953 - "[Pityriasis rubra pilaris cured by vitamin A (pharmacodynamic action)]." 05/01/2012 - "A pediatric case of pityriasis rubra pilaris successfully treated with low-dose vitamin a." 05/01/1989 - "Our understanding of the relationship between vitamin A metabolism and pityriasis rubra pilaris is discussed. " 01/01/1989 - "Possible significance of aqueous emulsified vitamin A in effective therapy for pityriasis rubra pilaris."
2.	Isotretinoin (Accutane)FDA LinkGeneric 10/01/2006 - "Efficacy of isotretinoin in pityriasis rubra pilaris: unapproved use." 02/01/1987 - "Five patients with pityriasis rubra pilaris were treated with isotretinoin from September 1982 through 1985. " 02/01/1987 - "Isotretinoin treatment of pityriasis rubra pilaris." 04/01/1982 - "Forty-five patients with pityriasis rubra pilaris were treated with oral 13-cis-retinoic acid (isotretinoin). " 04/01/1982 - "Pityriasis rubra pilaris response to 13-cis-retinoic acid (isotretinoin)."
3.	adalimumab (Humira)FDA Link 06/01/2010 - "Rapid and sustained remission of pityriasis rubra pilaris with adalimumab treatment." 11/01/2015 - "Clinical remission of pityriasis rubra pilaris with adalimumab in an adolescent patient." 01/01/2014 - "Successful treatment of pityriasis rubra pilaris with adalimumab - case report." 11/01/2012 - "Adalimumab for the treatment of pityriasis rubra pilaris: a case report." 10/01/2010 - "Pityriasis rubra pilaris successfully treated with adalimumab."
4.	alitretinoinFDA Link 01/01/2011 - "The present case shows that alitretinoin might be an alternative in the treatment of recalcitrant pityriasis rubra pilaris type I. Further studies are needed to investigate the benefit of this encouraging result." 08/01/2013 - "Successful treatment of atypical adult pityriasis rubra pilaris with oral alitretinoin." 01/01/2011 - "Oral alitretinoin for the treatment of recalcitrant pityriasis rubra pilaris." 07/01/2010 - "Treatment of refractory pityriasis rubra pilaris with oral alitretinoin: case report." 03/01/2015 - "Alitretinoin (9-cis retinoic acid) is effective against pityriasis rubra pilaris: a retrospective clinical study."
5.	Tretinoin (Retinoic Acid)FDA LinkGeneric 08/01/1980 - "The effect of 13-cis retinoic acid on epidermal lysosomal hydrolase activity in Darier's disease and pityriasis rubra pilaris." 04/01/1980 - "Evaluation of 13-cis retinoic acid in lamellar ichthyosis, pityriasis rubra pilaris and Darier's disease." 01/01/1972 - "Topical administration of vitamin A acid (retinoic acid) in palmar keratoses: callosities, hyperkeratotic eczema, hypertrophic lichen planus, pityriasis rubra pilaris." 03/01/2015 - "Alitretinoin (9-cis retinoic acid) is effective against pityriasis rubra pilaris: a retrospective clinical study." 01/01/1973 - "Pilot studies of serum level of vitamin A and liver function tests during administration of retinoic acid in hyperkeratosis follicularis et parafollicularis (Kyrle's disease), pityriasis rubra pilaris, and keratosis follicularis (Darier's disease)."
6.	infliximab (Remicade)FDA Link 01/01/2013 - "Effectiveness of infliximab in pityriasis rubra pilaris is associated with pro-inflammatory cytokine inhibition." 07/01/2011 - "Long-term infliximab treatment for refractory type III juvenile pityriasis rubra pilaris." 01/01/2008 - "Type III juvenile pityriasis rubra pilaris: a successful treatment with infliximab." 01/01/2007 - "Pityriasis rubra pilaris successfully treated with infliximab." 05/01/2006 - "Successful treatment of type I adult-onset pityriasis rubra pilaris with infliximab."
7.	TNFR-Fc fusion protein (etanercept)FDA Link 03/01/2011 - "Treatment of pityriasis rubra pilaris with etanercept." 11/01/2008 - "Treatment of juvenile pityriasis rubra pilaris with etanercept." 03/01/2008 - "Successful use of etanercept in type I pityriasis rubra pilaris." 07/01/2012 - "Etanercept-induced clinical remission of type II pityriasis rubra pilaris with rheumatoid arthritis." 12/01/2007 - "Clinical improvement of pityriasis rubra pilaris with combination etanercept and acitretin therapy."
8.	VitaminsIBA 09/01/1981 - "Pityriasis rubra pilaris controlled by synergism of vitamins A and E." 10/01/1957 - "[Pityriasis rubra pilaris, erythro-dermic type; improvement with vitamin A; cure by combined vitamins A & B]."
9.	tazarotene (Tazorac)FDA Link 01/01/2008 - "We report juvenile circumscribed pityriasis rubra pilaris (type IV) in a 12-year-old Afghani girl in whom local therapy with tazarotene led to rapid, sustained remission. " 01/01/2008 - "Tazarotene might be considered a useful treatment for circumscribed pityriasis rubra pilaris." 01/01/2008 - "Response of juvenile circumscribed pityriasis rubra pilaris to topical tazarotene treatment."
10.	poly(dG-dA)n.poly(dC-dT)n (((GA)n))IBA 11/01/2012 - "The therapeutic efficacy and side-effects of fumarate therapy were analysed retrospectively in patients with granuloma annulare (GA, n = 4), cutaneous sarcoidosis (SA, n = 1), lichen planus (LP, n = 3), pityriasis rubra pilaris (PRP, n = 1) or chronic discoid lupus erythematosus (CDLE, n = 1). "

Therapies and Procedures

1.	Photochemotherapy (Photodynamic Therapy) 11/01/1990 - "[Efficacy of photochemotherapy in a case of pityriasis rubra pilaris]." 03/01/2014 - "Pityriasis rubra pilaris triggered by photodynamic therapy with response to tumor necrosis factor α-blocking agents and acitretin."
2.	Biological Therapy 11/01/2008 - "Infliximab monotherapy as first-line treatment for adult-onset pityriasis rubra pilaris: case report and review of the literature on biologic therapy." 10/01/2010 - "Should ustekinumab really be used as first-line biological therapy in pityriasis rubra pilaris?"
3.	Phototherapy (Light Therapy) 03/01/2009 - "Pityriasis rubra pilaris sensitive to narrow band-ultraviolet B light therapy." 02/01/2001 - "Phototesting and phototherapy in pityriasis rubra pilaris." 01/01/1994 - "Pityriasis rubra pilaris exacerbated by ultraviolet B phototherapy." 01/01/2005 - "Clinical and histopathologic examination were consistent with pityriasis rubra pilaris, and treatment consisted of acitretin and narrow-band ultraviolet B phototherapy. " 01/01/2009 - "He had been treated with oral retinoids, steroids, and phototherapy for the diagnoses of drug eruption, pityriasis rubra pilaris, and exfoliative dermatitis at other hospitals. "
4.	Photopheresis 05/01/2004 - "Extracorporeal photochemotherapy for the treatment of exanthematic pityriasis rubra pilaris." 04/01/1999 - "Extracorporeal photochemotherapy for the treatment of erythrodermic pityriasis rubra pilaris."
5.	Transplants (Transplant) 02/01/2015 - "We present a case of cutaneous acute graft-versus-host disease (aGVHD) with confluent erythematous perifollicular hyperkeratosis and ichthyosiform scale in the clinical pattern of type II (atypical adult) pityriasis rubra pilaris (PRP), which developed 26 days after allogeneic peripheral blood stem cell transplant. "