Pityriasis Rubra Pilaris

A chronic skin disease characterized by small follicular papules, disseminated reddish-brown scaly patches, and often, palmoplantar hyperkeratosis. The papules are about the size of a pin and topped by a horny plug.

Networked: 327 relevant articles (29 outcomes, 10 trials/studies)

Relationship Network

Disease Context: Research Results

Related Diseases

1.	Hidradenitis Suppurativa
2.	Psoriasis (Pustulosis Palmaris et Plantaris)
3.	Atopic Dermatitis (Atopic Eczema)
4.	Granuloma Annulare
5.	Lichen Planus (Lichen Ruber Planus)

Experts

1.	Landthaler, M: 4 articles (11/2012 - 02/2005)
2.	English, Joseph C: 3 articles (01/2022 - 10/2012)
3.	Aragón-Miguel, Raquel: 3 articles (01/2020 - 08/2018)
4.	Velasco-Tamariz, Virginia: 3 articles (01/2020 - 08/2018)
5.	Hisaw, Lisa D: 3 articles (01/2019 - 11/2017)
6.	Maloney, Nolan J: 3 articles (01/2019 - 11/2017)
7.	Worswick, Scott: 3 articles (01/2019 - 11/2017)
8.	Balakirski, G: 2 articles (08/2022 - 01/2018)
9.	Greiling, Teri M: 2 articles (01/2022 - 01/2020)
10.	Haynes, Dylan: 2 articles (01/2022 - 01/2020)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Pityriasis Rubra Pilaris:

1.	Ustekinumab (CNTO 1275)FDA Link 03/01/2023 - "Ustekinumab, in particular, is emerging as a first-line agent for patients with pityriasis rubra pilaris with CARD14 gene variations. " 11/01/2020 - "CARD14-mutations in pityriasis rubra pilaris and therapeutic response to ustekinumab - a hypothesis." 08/01/2018 - "Therapierefraktäre Pityriasis rubra pilaris mit gutem Ansprechen auf Ustekinumab." 08/01/2018 - "Erythrodermic pityriasis rubra pilaris managed at home: intensive community care followed by ustekinumab." 03/01/2018 - "Successful treatment of juvenile pityriasis rubra pilaris with ustekinumab in a 7-year-old girl."
2.	Interleukin-17 (Interleukin 17)IBA 02/01/2022 - "Studies evaluated the efficacy of IL-17 inhibitors for the following conditions: hidradenitis suppurativa (HS), pityriasis rubra pilaris (PRP), Behçet's disease, alopecia areata, and allergic contact dermatitis. " 01/01/2020 - "IL-17A is associated with the pathogenesis of inflammatory diseases, including psoriasis, atopic dermatitis, hidradenitis suppurativa, alopecia areata, pityriasis rubra pilaris, pemphigus, and systemic sclerosis. " 01/01/2022 - "Pityriasis Rubra Pilaris Response to IL-17A Inhibition Is Associated with IL-17C and CCL20 Protein Levels." 05/01/2018 - "Here, we report the case of a 68-year-old man with pityriasis rubra pilaris, who was successfully treated with ixekizumab, an interleukin-17A inhibitor." 01/01/2019 - "Case of pityriasis rubra pilaris progressed to generalized erythroderma following blockade of interleukin-17A, but improved after blockade of interleukin-12/23 p40."
3.	secukinumabIBA 09/01/2022 - "Juvenile Pityriasis Rubra Pilaris in a 4-year-old Child Treated Successfully with Secukinumab." 11/01/2022 - "Secukinumab was effective in treating pityriasis rubra pilaris. " 01/01/2021 - "Secukinumab is an effective and safe treatment for refractory pityriasis rubra pilaris." 11/01/2022 - "This trial was registered with ClinicalTrials.gov: 'Cosentyx (secukinumab) for the treatment of adult onset pityriasis rubra pilaris' - NCT03342573. " 11/01/2022 - "Secukinumab for the treatment of adult-onset pityriasis rubra pilaris: a single-arm clinical trial with transcriptomic analysis."
4.	Vitamin A (Retinol)FDA LinkGeneric 06/01/1959 - "[Pityriasis rubra pilaris with post-anginal acute onset, greatly improved by treatment with synthetic vitamin A]." 11/01/1953 - "[Pityriasis rubra pilaris cured by vitamin A (pharmacodynamic action)]." 05/01/2012 - "A pediatric case of pityriasis rubra pilaris successfully treated with low-dose vitamin a." 05/01/1989 - "Our understanding of the relationship between vitamin A metabolism and pityriasis rubra pilaris is discussed. " 06/01/1983 - "A patient with short-duration pityriasis rubra pilaris was successfully treated with high-dose, toxic vitamin A (retinol), but the disease subsequently recurred in new areas. "
5.	ixekizumabIBA 11/01/2022 - "A previous trial demonstrated efficacy of the anti-IL-17A drug ixekizumab for pityriasis rubra pilaris. " 09/01/2022 - "Pityriasis rubra pilaris rapidly cleared with ixekizumab in an HIV-positive patient." 01/01/2020 - "Evaluation of Ixekizumab Treatment for Patients With Pityriasis Rubra Pilaris: A Single-Arm Trial." 01/01/2023 - "Pityriasis Rubra Pilaris Transcriptomics Implicate T Helper 17 Signaling and Correlate with Response to Ixekizumab, with Distinct Gene Expression Profiles in Nonresponders." 08/01/2020 - "[Pityriasis rubra pilaris : Successful treatment with ixekizumab]."
6.	Isotretinoin (Accutane)FDA LinkGeneric 10/01/2006 - "Efficacy of isotretinoin in pityriasis rubra pilaris: unapproved use." 05/01/2023 - "Misdiagnosed Pityriasis Rubra Pilaris Successfully Managed With Isotretinoin: A Case Series." 03/01/2016 - "He was diagnosed with classic juvenile (type III) pityriasis rubra pilaris (PRP) and treated with oral isotretinoin for 6 months. " 02/01/1987 - "Five patients with pityriasis rubra pilaris were treated with isotretinoin from September 1982 through 1985. " 02/01/1987 - "Isotretinoin treatment of pityriasis rubra pilaris."
7.	Infliximab (Remicade)FDA Link 07/01/2011 - "Long-term infliximab treatment for refractory type III juvenile pityriasis rubra pilaris." 01/01/2008 - "Type III juvenile pityriasis rubra pilaris: a successful treatment with infliximab." 01/01/2007 - "Pityriasis rubra pilaris successfully treated with infliximab." 05/01/2006 - "Successful treatment of type I adult-onset pityriasis rubra pilaris with infliximab." 04/01/2005 - "Infliximab for the treatment of adult-onset pityriasis rubra pilaris."
8.	Adalimumab (Humira)FDA Link 06/01/2010 - "Rapid and sustained remission of pityriasis rubra pilaris with adalimumab treatment." 11/01/2015 - "Clinical remission of pityriasis rubra pilaris with adalimumab in an adolescent patient." 07/01/2021 - "Therapieresistente Pityriasis rubra pilaris erfolgreich therapiert mit Adalimumab." 04/16/2014 - "Successful treatment of pityriasis rubra pilaris with adalimumab - case report." 11/01/2012 - "Adalimumab for the treatment of pityriasis rubra pilaris: a case report."
9.	Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)IBA 11/01/2013 - "Pityriasis rubra pilaris types 1 and 2: different responses to treatment with TNF-alpha antagonists." 08/01/2010 - "Treatment of refractory adult-onset pityriasis rubra pilaris with TNF-alpha antagonists: a case series." 09/01/1999 - "The relationship between pityriasis rubra pilaris and inflammatory arthritis: case report and response of the arthritis to anti-tumor necrosis factor immunotherapy." 05/01/2015 - "Ineffectiveness of tumor necrosis factor-α blockers and ustekinumab in a case of type IV pityriasis rubra pilaris." 03/01/2014 - "Pityriasis rubra pilaris triggered by photodynamic therapy with response to tumor necrosis factor α-blocking agents and acitretin."
10.	AlitretinoinFDA Link 03/01/2015 - "Alitretinoin (9-cis retinoic acid) is effective against pityriasis rubra pilaris: a retrospective clinical study." 04/18/2011 - "The present case shows that alitretinoin might be an alternative in the treatment of recalcitrant pityriasis rubra pilaris type I. Further studies are needed to investigate the benefit of this encouraging result." 06/01/2016 - "Classic Juvenile Pityriasis Rubra Pilaris Treated with Oral Alitretinoin." 03/01/2016 - "Circumscribed juvenile pityriasis rubra pilaris responsive to alitretinoin." 08/01/2013 - "Successful treatment of atypical adult pityriasis rubra pilaris with oral alitretinoin."

Therapies and Procedures

1.	Therapeutics 06/01/2023 - "Anti-interleukin-17A (anti-IL-17A) therapy has been increasingly employed as a treatment option for pityriasis rubra pilaris (PRP). " 03/15/2020 - "The purpose of this letter is to emphasize the potential benefit of dual therapy in patients who fail traditional pityriasis rubra pilaris treatment regimens." 01/01/2020 - "Use of Biologics in Pityriasis Rubra Pilaris Refractory to First-Line Systemic Therapy: A Systematic Review [Formula: see text]." 03/01/2019 - "Systemic therapies of pityriasis rubra pilaris: a systematic review." 01/01/2019 - "We report herein a case of a 72-year-old man with pityriasis rubra pilaris (PRP) that was refractory to conventional therapies. "
2.	Biological Therapy 11/01/2008 - "Infliximab monotherapy as first-line treatment for adult-onset pityriasis rubra pilaris: case report and review of the literature on biologic therapy." 10/01/2010 - "Should ustekinumab really be used as first-line biological therapy in pityriasis rubra pilaris?" 05/01/2018 - "Refractory pityriasis rubra pilaris (PRP) often is treated off-label with the same biologic therapies that are approved for the treatment of psoriasis, most commonly tumor necrosis factor (TNF) α antagonists and ustekinumab; however, the IL-17A antagonist secukinumab also has shown efficacy in the treatment of PRP. "
3.	Aftercare (After-Treatment) 09/01/2022 - "Pityriasis Rubra Pilaris Significantly Improved after Treatment for Chronic Focal Infection." 08/01/2018 - "Refractory pityriasis rubra pilaris with good response after treatment with ustekinumab." 05/01/2023 - "Kaposi's Varicelliform Eruption After Treatment With Ixekizumab in a Patient With Pityriasis Rubra Pilaris."
4.	Photochemotherapy (Photodynamic Therapy) 11/01/1990 - "[Efficacy of photochemotherapy in a case of pityriasis rubra pilaris]." 03/01/2014 - "Pityriasis rubra pilaris triggered by photodynamic therapy with response to tumor necrosis factor α-blocking agents and acitretin."
5.	Physical Therapy Modalities (Physical Therapy Technique) 10/01/2022 - "The physical therapy rehabilitation program used in this case study significantly improved the patient's functional independence by reducing pain and improving joint mobility, muscle strength, endurance, and gait. After six weeks of rehabilitation, there was an improvement in the ranges of the joint, strength of muscle, gait, and functional independence significantly using physical therapy techniques. This case study shows the value of comprehensive physical therapy in a case of pityriasis rubra pilaris with rickets in a 15-year-old boy."