Pirinitramide (Piritramide)

01/01/1999 - "We conclude that a PCA regimen with a bolus dose of piritramide 0.75 mg and a lockout time of 5 min was effective in the treatment of postoperative pain, but did not reduce the occurrence of side effects."
10/01/1999 - "After extubation of the trachea, 120 patients were randomly allocated to three different methods of postoperative pain relief for 72 hrs. In group 1, patients received PCA with a bolus of 1.5 mg piritramide combined with a 10-min lockout interval. "
11/01/1998 - "PCA using the subarachnoid route is a promising concept for treatment of postoperative pain in orthopaedic patients, while the PCA piritramide regime of this study warrants improvement."
01/01/2015 - "Variant OPRM1 118G allele is associated with decreased acute postoperative pain relief after piritramide. "
01/01/2015 - "OPRM1 and ABCB1 polymorphisms and their effect on postoperative pain relief with piritramide."

01/01/2012 - "The efficacy of tested additive medications on piritramide consumption and pain relief is weak and there is no clear-cut difference between the non-opioid drugs used."
11/01/2005 - "Patients experiencing pain were free to receive additional piritramide at any time as rescue medication; however, these patients were withdrawn from the study. "
02/01/1997 - "The results of this study show that postoperative patient-controlled pain therapy in children with piritramide is - in a similar way as with adults - a safe method involving a low incidence of side effects. "
06/01/1992 - "On request or when complaining of stronger pain, the patients received an additional bolus infusion of 125 ml over 10 min. In case of insufficient pain reduction despite repeated infusion of 125-ml boli or consumption of the entire infusion solution, the patients discontinued the study and received demand-adapted intravenous titration of piritramide. "
03/01/1990 - "The mean consumption of piritramide during the study was 46.5 mg in the group with 1.5 mg per bolus and 68.6 mg in the group with 3.0 mg. The resulting pain relief was satisfactory in both groups. "

05/01/1990 - "It has been established that anesthesia with dipidolor ensures adequate protection against the operation stress both in patients with tetralogy of Fallot previously subject to interarterial anastomoses and patients with tetralogy of Fallot without anastomoses. "

01/01/2014 - "Altogether, 60 patients were enrolled in our study; one half in the group with wound infusion of a local anaesthetic, and the other half in the standard (piritramide) group. "
06/01/2013 - "Altogether 60 patients were enrolled in the prospective randomized study; half in wound infusion of local anaesthetic and half in the standard (piritramide) group. "
08/01/2003 - "After lumbar disc surgery, patients were monitored for visual analog scores for pain at rest and on movement, patient-controlled analgesia (PCA) piritramide requirements, and von Frey thresholds in the wound area. "
12/01/1999 - "Ten milliliters of each solution was administered subcutaneously and 20 mL was injected into the wound drain which was clamped for 10 min. Supplemental postoperative pain relief was provided by patient-controlled anesthesia using the opioid piritramid (3.5-mg boluses, 6-min lock-out). "
06/01/2013 - "In the recovery room and on the first day after surgical procedure, the wound infusion of local anaesthetic group reported less acute and chronic pain, a lower consumption of piritramide and metoclopramide, but their alertness after the surgical procedure was higher compared to the standard group. "

01/01/2000 - "No significant differences between the groups were observed concerning the amount of piritramide required, side-effects such as nausea and vomiting or the total cost of anaesthesia. "
01/01/1996 - "Nausea and vomiting were more frequent (P < 0.05) in the piritramide group. "
12/01/2014 - "Nausea: with approximately 4 % in the piritramide group across all 4 specialties the incidence of nausea was markedly higher in the piritramide group than in the oxycodone group; however, this difference was statistically significant only for general and orthopedic surgery. "
08/01/2003 - "Intensity of nausea correlated inversely (P=0.01) with morphine consumption but not with piritramide consumption. "
03/01/1998 - "A monitoring regimen was used to assess efficacy (pain intensity estimated by the mother), adverse effects (sedation score, occurrence of nausea and vomiting) and piritramide consumption. "