Pimozide (Orap)

A diphenylbutylpiperidine that is effective as an antipsychotic agent and as an alternative to HALOPERIDOL for the suppression of vocal and motor tics in patients with Tourette syndrome. Although the precise mechanism of action is unknown, blockade of postsynaptic dopamine receptors has been postulated. (From AMA Drug Evaluations Annual, 1994, p403)

Also Known As:

Networked: 339 relevant articles (43 outcomes, 43 trials/studies)

Relationship Network

Drug Context: Research Results

Experts

1.	Salamone, John D: 4 articles (04/2013 - 02/2005)
2.	McMonagle, T: 3 articles (01/2007 - 01/2000)
3.	Cavanna, Andrea E: 2 articles (12/2012 - 12/2011)
4.	Rizzo, Renata: 2 articles (12/2012 - 12/2011)
5.	Gulisano, Mariangela: 2 articles (12/2012 - 12/2011)
6.	Griffin, James D: 2 articles (07/2012 - 03/2011)
7.	Walker, Sarah R: 2 articles (07/2012 - 03/2011)
8.	Bar-Natan, Michal: 2 articles (07/2012 - 03/2011)
9.	Frank, David A: 2 articles (07/2012 - 03/2011)
10.	Barrett, Rosemary: 2 articles (07/2012 - 03/2011)

Related Diseases

1.	Tourette Syndrome (Tourette's Syndrome) 03/10/1999 - "Short-term versus longer term pimozide therapy in Tourette's syndrome: a preliminary study." 03/01/1984 - "Controlled study of pimozide vs. placebo in Tourette's syndrome." 10/01/1987 - "Significant interindividual variability of pimozide pharmacokinetics was found in both adults and children with Tourette's syndrome. " 10/01/1987 - "Mean elimination half-life of pimozide in children was 66 hours compared with 111 hours in adults with Tourette's syndrome. " 10/01/1987 - "A comparison of the pharmacokinetics of pimozide was made in children and adults with Tourette's syndrome. "
2.	Schizophrenia (Dementia Praecox) 01/01/1979 - "Brief representative case histories are presented, and dosage recommendations for the effective treatment of acute schizophrenia with pimozide are discussed." 01/01/1979 - "It is concluded that oral pimozide is an effective treatment for the whole range of symptoms accompanying acute schizophrenia. " 01/01/2000 - "All randomised trials relating to people with schizophrenia, or similar disorders comparing pimozide to other drug treatments were sought. " 01/01/2000 - "All randomised trials relating to people with schizophrenia, or similar disorders comparing pimozide to other drug treatments were sought. " 03/01/1982 - "Antipsychotic effects of pimozide in schizophrenia. "
3.	Tics (Tic) 03/10/1999 - "Chronic, longer term treatment with pimozide appears to be more effective in controlling the course of tics than using the drug acutely to treat an exacerbation." 06/01/1989 - "However, pimozide proved immediately effective in suppressing tics and this improvement was maintained at follow-up. " 07/01/2001 - "The symptoms improved considerably in 82% of the patients with eye tics on treatment with a neuroleptic (pimozide). " 03/31/2000 - "Pimozide is an antipsychotic agent also used to treat facial tics. " 06/01/1990 - "Pimozide in children with chronic motor tics."
4.	Paranoid Schizophrenia (Delusional Disorder) 01/01/1993 - "Some reports indicate that at least pimozide may be effective in delusional disorder as well. " 02/01/1998 - "1. The effects of pimozide on the psychopathology of delusional disorder were studied. " 02/01/1998 - "Effects of pimozide on the psychopathology of delusional disorder." 02/01/1993 - "A case of querulous-litigious delusional disorder successfully treated with low-dose pimozide is reported. " 10/01/1992 - "We believe pimozide's established benefit in the treatment of delusional disorders warrants its consideration in alleviating other delusions, including "the delusion of doubles.""
5.	Dystonia (Limb Dystonia) 01/01/2004 - "Pimozide overdose in children may be associated with delayed onset of symptoms, including dystonia." 01/01/2004 - "Delayed dystonia following pimozide overdose in a child." 02/01/1996 - "Therapy with pimozide almost completely controlled the dystonia." 01/01/2004 - "We report dystonia, hypotension and drowsiness following pimozide ingestion in a child. " 11/01/1984 - "When benzhexol treatment alone fails in adults with severe disabling axial dystonia, or in children with life-threatening generalised dystonia, combined therapy with tetrabenazine, pimozide and benzhexol may give valuable symptomatic relief."

Related Drugs and Biologics

1.	Haloperidol (Haldol)
2.	Antipsychotic Agents (Antipsychotics)
3.	Risperidone (Risperdal Consta)
4.	Apomorphine
5.	Dopamine Receptors (Dopamine Receptor)
6.	Chlorpromazine (Thorazine)
7.	Sulpiride (neogama)
8.	Clozapine (Clozaril)
9.	Domperidone (Domperidon)
10.	Dopamine Antagonists

Related Therapies and Procedures

1.	Aftercare (After-Treatment)
2.	Injections
3.	Intraventricular Injections
4.	Intraperitoneal Injections
5.	Induced Hypothermia