Picibanil

A lyophilized preparation of a low-virulence strain (SU) of Streptococcus pyogenes (S. hemolyticus), inactivated by heating with penicillin G. It has been proposed as a noncytotoxic antineoplastic agent because of its immune system-stimulating activity.

Also Known As:

Networked: 1103 relevant articles (195 outcomes, 158 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Okamoto, Masato: 21 articles (01/2018 - 11/2002)
2.	Sato, Mitsunobu: 13 articles (07/2013 - 11/2002)
3.	Ohta, Nobuo: 11 articles (03/2022 - 03/2003)
4.	Tano, Tomoyuki: 11 articles (07/2013 - 11/2002)
5.	Oshikawa, Tetsuya: 11 articles (09/2006 - 11/2002)
6.	Fukase, Shigeru: 10 articles (03/2022 - 03/2003)
7.	Ryoma, Yoshiki: 10 articles (08/2007 - 09/2002)
8.	Moriya, Yoichiro: 8 articles (01/2008 - 11/2002)
9.	Aoyagi, Masaru: 7 articles (02/2014 - 03/2003)
10.	Kan, Shin: 7 articles (07/2013 - 11/2004)

Related Diseases

1.	Neoplasms (Cancer) 11/01/1987 - "However, it was also observed that most of the R1-3B3- cells that killed MADB106 tumor cells were: 1) phenotypically or functionally different from either cytotoxic T-cells or typical NK cells; 2) observed only in MADB106 tumor-bearing rats challenged with OK-432; 3) not present on day 1-2 following OK-432 injection, the time when YAC-1 killing was maximally augmented; and 4) present in high numbers in a secondary response following reinoculation of the MADB106 tumor cells into cured rats. " 11/01/1992 - "The present study was designed to determine the optimal therapeutic protocol for OK-432, a streptococcal preparation, and to clarify the kinetics of various immunological parameters following intracutaneous administration of OK-432 in 39 disease-free postoperative patients with early cancer. " 09/01/1991 - "A randomized prospective study of 1011 gastrectomized cancer patients treated with oral OK432 showed significantly good results, especially in n(+) cases with curative resection. " 10/01/2005 - "Anti-tumor effect of OK-432 in TLR9-deficient mice was significantly but partially reduced as compared with that in wild-type mice, while the effect of OK-432 was almost completely eliminated in TLR4-deficient mice. " 12/15/1994 - "However, analysis based on stage showed that a preoperative intratumoral injection of OK-432 significantly improved the 5-year survival rate of patients with Stage III cancer (P = 0.0229), at 47.7% for the OK-432 group and 27.5% for the control group. "
2.	Lymphangioma (Cavernous Lymphangioma) 01/01/2016 - "We report the case of a huge retroperitoneal lymphangioma in a newborn treated successfully with intracystic injection of OK-432." 07/01/2009 - "Although OK-432 is predictably-effective against lymphangioma, it should not perform be applied without careful consideration." 03/01/2003 - "OK-432 injection was effective in approximately one third of children with lymphangioma. " 04/01/2000 - "OK-432 proved to be effective for primitive as well as for residual and recurrent lymphangioma. " 07/01/2007 - "The results of this study so far indicate that OK-432 is an effective and safe tool for the treatment of lymphangioma of head and neck region. "
3.	Stomach Neoplasms (Stomach Cancer) 04/01/2016 - "The efficacy of adjuvant immunochemotherapy with OK-432 after curative resection of gastric cancer: an individual patient data meta-analysis of randomized controlled trials." 07/01/1994 - "Postoperative immunochemotherapy including streptococcal lysate OK-432 is effective for patients with gastric cancer and serosal invasion." 04/01/1987 - "A long term small-dose intratumoral administration of OK-432 seemed to be effective for a local recurrence of gastric cancer." 03/01/1987 - "These results suggested that adjuvant immunochemotherapy using PSK and/or OK-432 combined with MMC and FT is effective for the improved survival of gastrectomized patients with gastric cancer." 09/01/2002 - "Efficacy of adjuvant immunochemotherapy with OK-432 for patients with curatively resected gastric cancer: a meta-analysis of centrally randomized controlled clinical trials."
4.	Neoplasm Metastasis (Metastasis) 10/01/1995 - "As a result, MLN metastasis was significantly suppressed and survival rate was significantly improved in every protocol as compared to mice without OK-432 administration. " 10/01/1995 - "Administration of OK-432 prior to the surgical stress or ASGM 1 was at least partly effective for prevention of the hepatic metastasis and prolonged the survival of the inoculated mice. " 10/01/1988 - "Administration of OK-432 was effective for counteracting the stress-induced facilitation of metastasis." 11/01/1982 - "Preoperative or post-operative (especially the former) administration of OK-432 was effective for preventing both the postlaparotomy facilitation of lung metastasis and the postlaparotomy reduction in PHA lymphoblastogenesis." 01/01/1992 - "In this paper, the protective effects of OK432 against liver metastasis were examined experimentally, as a immunotherapeutic agent under perioperative condition. "
5.	Ranula 05/01/2012 - "We report a very rare case of a plunging ranula extending into the parapharyngeal space, which was treated successfully with OK-432. " 02/01/2002 - "Our experience suggests that OK-432 injection is an effective treatment for ranula. " 02/01/2014 - "The aim of this study was to evaluate the outcome and complications of the OK-432 treatment of patients with ranula extending to the parapharyngeal space. " 02/01/2006 - "This study examined the effectiveness of intracystic injection of OK-432 for treatment of ranula. " 03/28/2022 - "OK-432 treatment is straightforward, secure, and efficacious and can be substituted for surgery in the treatment of ranula extending into the cervical region."

Related Drugs and Biologics

1.	Picibanil
2.	Interleukin-2 (IL2)
3.	Tegafur
4.	Fluorouracil (Carac)
5.	Sclerosing Solutions (Sclerosing Agents)
6.	Fibrinogen (Factor I)
7.	Immunologic Factors (Immunomodulators)
8.	Mitomycin (Mitomycin-C)
9.	Cisplatin (Platino)
10.	Cytokines

Related Therapies and Procedures

1.	Therapeutics
2.	Sclerotherapy
3.	Immunotherapy
4.	Intralesional Injections
5.	Pleurodesis