Vitamin K 1 (Phylloquinone)

A family of phylloquinones that contains a ring of 2-methyl-1,4-naphthoquinone and an isoprenoid side chain. Members of this group of vitamin K 1 have only one double bond on the proximal isoprene unit. Rich sources of vitamin K 1 include green plants, algae, and photosynthetic bacteria. Vitamin K1 has antihemorrhagic and prothrombogenic activity.

Also Known As:

Networked: 511 relevant articles (33 outcomes, 87 trials/studies)

Relationship Network

Drug Context: Research Results

Experts

1.	Booth, Sarah L: 24 articles (01/2022 - 08/2003)
2.	Shearer, Martin J: 8 articles (09/2015 - 03/2002)
3.	Vermeer, Cees: 7 articles (03/2022 - 09/2004)
4.	Shea, M Kyla: 7 articles (01/2022 - 07/2013)
5.	Beulens, Joline W J: 6 articles (01/2020 - 08/2010)
6.	van der Schouw, Yvonne T: 6 articles (01/2020 - 08/2010)
7.	Holden, Rachel M: 5 articles (01/2021 - 04/2010)
8.	Cashman, Kevin D: 5 articles (10/2014 - 07/2004)
9.	Booth, S L: 5 articles (09/2014 - 12/2001)
10.	Ferland, Guylaine: 4 articles (01/2021 - 09/2008)

Related Diseases

1.	Hemorrhage 01/01/2022 - "This study aimed to investigate the efficacy of vitamin K1 in patients undergoing HSCT and find a feasible and safe option for HSCT patients to prevent bleeding. " 12/01/1989 - "Studies of a larger number of patients are necessary before it can be established that maternal antenatal administration of vitamin K1 results in improvement of coagulation and the prevention of intraventricular hemorrhage in premature infants." 12/01/2022 - "There is near-global consensus that all newborns be given parenteral vitamin K1 (VK1 ) at birth as prophylaxis against VK deficiency bleeding (VKDB). " 09/01/2021 - "Lower bleeding incidence was observed among patients administered vitamin K1 relative to those administered placebo during follow-up (4 [10%] vs. 12 [30%] patients, respectively, p = 0.045). " 08/01/2020 - "Patients presented with bleeding from varied sites, often required blood products, factor replacement, and high dose vitamin K1 for stabilization."
2.	Vitamin K Deficiency 10/23/1993 - "A single administration of 1 mg vitamin K1 orally or intramuscularly may not afford complete protection against late vitamin K deficiency in healthy breastfed infants. " 08/01/1993 - "In conclusion, weekly administration of vitamin K1 1 mg offers complete protection against vitamin K deficiency and does not result in an accumulation of vitamin K1 in the blood." 12/01/2009 - "The high proportion of false positive results suggest that poor assay specificity at low phylloquinone concentrations is a common problem, which in the clinical setting could lead to underreporting of vitamin K deficiency." 10/23/1993 - "A regimen of 1 mg per week or 25 micrograms vitamin K1 per day proved to be effective in prevention of vitamin K deficiency and the latter is recommended for breastfed infants during the first three months of life." 05/01/2016 - "The aim of this study was to determine the level of functional vitamin K deficiency and its relation to vitamin K1 intake in HD patients in Upper Silesia in Poland. "
3.	Hypoprothrombinemias (Prothrombin Deficiency) 01/01/1959 - "Efficacy of water-soluble derivatives of vitamin K1 in counteracting drug-induced hypoprothrombinemia." 11/01/1959 - "[A new study on the therapeutic action of vitamin K1 on hypoprothrombinemia in the premature infant]." 12/15/2010 - "Vitamin K1 is frequently used in the treatment and prevention of hypoprothrombinemia and hemorrhagic disease of the newborn. " 07/01/1963 - "Drug-induced hypoprothrombinemia countered with phytonadione." 07/26/1959 - "[Vitamin K1 and hypoprothrombinemias in hepatic diseases]."
4.	Osteoporosis 02/01/2008 - "Both vitamin K1 and K2 have been shown to exert protective effects against osteoporosis. " 09/01/2006 - "Both vitamin K(1) and K(2) have been shown to exert protective effects against osteoporosis. " 01/01/2018 - "The mean serum vitamin k1 level was significantly lower in the postmenopausal osteoporotic women group than in the normal control group (mean=0.794 vs3.61ng/ml, P< 0.0001), and serum vitamin k1 concentration was positively correlated with lumbar spine BMD among postmenopausal osteoporotic women (R=0.533, p = 0.009), and in postmenopausal healthy control (R=0.563, p = 0.02).Diagnostic sensitivity and specificity of vitamin k1 for osteoporosis were 90% and 98%, respectively (cut-off value: 0.853 ng/ml). " 01/01/2018 - "Relation Between Circulating Vitamin K1 and Osteoporosis in the Lumbar Spine in Syrian Post-Menopausal Women." 06/01/1985 - "Electrochemical detection of depressed circulating levels of vitamin K1 in osteoporosis."
5.	Liver Diseases (Liver Disease) 02/01/1995 - "Adverse effects are seen not only in patients with liver-function disturbances but also in patients without liver diseases, and occur mostly after intramuscular or subcutaneous administration of vitamin K1, independent of the total dose. " 03/12/1959 - "[Indications for vitamin K1 in liver disease]." 01/01/1958 - "[Effect of synthetic vitamin K1 in liver diseases in small children]." 02/01/1993 - "Our findings support the observation that liver disease is not a necessary condition for the occurrence of vitamin K1 hypersensitivity." 12/01/2000 - "Oral menadiol appears to be an effective alternative to intravenous phytomenadione in the correction of coagulopathies associated with obstructive liver disease. "

Related Drugs and Biologics

1.	Vitamin K
2.	Vitamin K 1 (Phylloquinone)
3.	Vitamin K 2 (Vitamin K2)
4.	Cetuximab (Erbitux)
5.	Warfarin (Coumadin)
6.	Blood Coagulation Factors (Coagulation Factor)
7.	Vitamins
8.	Prothrombin (Factor II)
9.	Vitamin K 3 (Menadione)
10.	Tocopherols (Tocopherol)

Related Therapies and Procedures

1.	Therapeutics
2.	Intravenous Infusions
3.	Intravenous Administration
4.	Renal Dialysis (Hemodialysis)
5.	Acupuncture Points (Acupuncture Point)