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Phytic Acid (Inositol Hexaphosphate)

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Complexing agent for removal of traces of heavy metal ions. It acts also as a hypocalcemic agent.

Also Known As:

Inositol Hexaphosphate; Phytate; Calcium Phytate; Inositol Hexakisphosphate; Sodium Phytate; Acid, Phytic; Hexakisphosphate, Inositol; Hexaphosphate, Inositol; Phytate, Calcium; Phytate, Sodium; Phytin; myo-Inositol, hexakis(dihydrogen phosphate)

Networked: 373 relevant articles (35 outcomes, 57 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Agarwal, Rajesh: 11 articles (01/2013 - 03/2003)
2.	Weglarz, Ludmiła: 10 articles (03/2013 - 12/2004)
3.	Grases, Felix: 9 articles (09/2015 - 08/2003)
4.	Kapral, Małgorzata: 9 articles (09/2015 - 11/2008)
5.	Vucenik, Ivana: 8 articles (10/2011 - 06/2003)
6.	Grases, F: 8 articles (10/2009 - 04/2000)
7.	Singh, Rana P: 8 articles (02/2009 - 03/2003)
8.	Wawszczyk, Joanna: 7 articles (09/2015 - 11/2010)
9.	Parfiniewicz, Beata: 7 articles (11/2012 - 12/2004)
10.	Agarwal, Chapla: 7 articles (01/2010 - 03/2003)

Related Diseases

1.	Neoplasms (Cancer) 08/01/2004 - "Combination of (99m)Tc phytate and patent blue is effective in SLN detection in early stage cervical cancer." 09/01/2004 - "Inositol hexaphosphate (IP6), a dietary constituent, has shown promising efficacy against various cancers; however, limited studies have been performed with IP6 against PCA. " 09/01/2003 - "Several studies in recent years have shown both preventive and interventive efficacy of inositol hexaphosphate (IP6) in different animal tumor models, however, its effects in PCA and associated mechanisms have not been assessed in detail. " 01/01/2010 - "The increased dietary phytate is discussed in relation to its recognised inhibition of mineral absorption and its merits with regard to protection against some cancers and other diseases of an ageing population." 05/15/2008 - "Chemopreventive efficacy of inositol hexaphosphate against prostate tumor growth and progression in TRAMP mice."
2.	Colorectal Neoplasms (Colorectal Cancer) 04/01/1996 - "Phytic acid, a major constituent of cereals, pulses, and seeds has been advocated as an important antioxidant component of dietary fibre that affords possible protection against colorectal cancer. " 04/01/1996 - "This improved method, developed for the determination of phytic acid in faeces should allow further studies on the role of phytic acid in the aetiology of colorectal cancer to be conducted on a population or case control basis." 01/01/2015 - "Inositol hexaphosphate suppresses growth and induces apoptosis in HT-29 colorectal cancer cells in culture: PI3K/Akt pathway as a potential target." 01/01/2013 - "Pro-apoptotic effect of rice bran inositol hexaphosphate (IP6) on HT-29 colorectal cancer cells." 01/01/2013 - "Preventive inositol hexaphosphate extracted from rice bran inhibits colorectal cancer through involvement of Wnt/β-catenin and COX-2 pathways."
3.	Rickets (Rachitis) 02/01/1979 - "Role of dietary phytate in the aetiology of nutritional rickets." 08/01/1973 - "Phytate and rickets." 04/08/1972 - "Phytic acid and nutritional rickets in immigrants." 09/01/1949 - "The rickets-producing and anti-calcifying action of phytate." 10/01/1939 - "Phytic acid and the rickets-producing action of cereals."
4.	Weight Gain 10/01/2009 - "Addition of phytate also reduced (p < 0.05) weight gain, feed intake, feed efficiency and percentage ash. " 08/01/1984 - "These data corroborate and extend previously published findings on Ca and phytate effects on Zn utilization and show bone Zn accumulation to be a more sensitive criterion than weight gain in this connection. " 08/01/1984 - "Mg and phytate additions did not affect weight gain. " 08/01/1984 - "Weight gain was not influenced by Ca level in the absence of phytate or by phytate at 0.3% Ca; it was increasingly depressed as phytate was increased and by each increase in Ca in the presence of phytate. " 02/01/2014 - "gasseri improved weight gain of broiler chickens to a level comparable to that for chickens fed a control diet adequate in phosphorus, demonstrating proof of principle that administration of phytate-degrading probiotic cultures can improve performance of livestock animals. "
5.	Prostatic Neoplasms (Prostate Cancer) 12/15/2009 - "Here, we assessed the efficacy of inositol hexaphosphate (IP6) against invasive human prostate cancer PC-3 and C4-2B cells and regulation of PI3K-Akt pathway. " 02/01/2009 - "p21/Cip1 and p27/Kip1 Are essential molecular targets of inositol hexaphosphate for its antitumor efficacy against prostate cancer." 01/01/2011 - "Influence of pH on the Cytotoxic Activity of Inositol Hexakisphosphate (IP6) in Prostate Cancer." 07/01/2005 - "Prostate cancer and inositol hexaphosphate: efficacy and mechanisms." 08/01/1995 - "We investigated the effects of inositol hexaphosphate (InsP6) on growth inhibition and differentiation of human prostate cancer cells PC-3 in vitro. "

Related Drugs and Biologics

1.	Phosphorus
2.	Calcium
3.	Phytic Acid (Inositol Hexaphosphate)
4.	6-Phytase (Phytase)
5.	Calcium Oxalate
6.	bone ash
7.	Citric Acid (Citrate)
8.	Inositol (Myoinositol)
9.	Tannins (Tannic Acid)
10.	Oligosaccharides

Related Therapies and Procedures

1.	Drug Therapy (Chemotherapy)
2.	Lymph Node Excision (Lymph Node Dissection)
3.	Hysterectomy
4.	Heterologous Transplantation (Xenotransplantation)
5.	Oral Administration