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Leptophos
An organothiophosphate insecticide.
Also Known As:
Phosvel; Phosphonothioic acid, phenyl-, O-(4-bromo-2,5-dichlorophenyl) O-methyl ester
Networked:
13
relevant articles (
0
outcomes,
0
trials/studies)
Bio-Agent Context: Research Results
Organic Chemicals: 133
Organophosphorus Compounds: 300
Organophosphonates: 424
Organothiophosphonates
Leptophos: 13
desbromoleptophos
leptophos oxon
Organothiophosphorus Compounds
Organothiophosphonates
Leptophos: 13
desbromoleptophos
leptophos oxon
Sulfur Compounds: 278
Organothiophosphorus Compounds
Organothiophosphonates
Leptophos: 13
desbromoleptophos
leptophos oxon
Experts
1.
Alexaki, E
: 1 article (02/2003)
2.
Flaskos, J
: 1 article (02/2003)
3.
Hargreaves, A J
: 1 article (02/2003)
4.
Sachana, M
: 1 article (02/2003)
Related Diseases
1.
Ataxia (Dyssynergia)
02/01/1989 - "
And one out of 9 hens (11.1%) given RIVInj of 3 mg/kg leptophos for 5 days was affected with ataxia.
"
02/01/1985 - "
Hens treated with EPN developed irreversible ataxia after repeated exposure to as little as 1.3 mg/kg dermally or 5 mg/kg/day orally, while leptophos was neurotoxic at doses of 6-7 mg/kg/day dermally and 10 mg/kg/day orally.
"
01/01/1977 - "
Additional particular properties of both Leptophos and EPN were found in their ability to cause delayed neurotoxic ataxia in chickens and sheep fed once on sublethal doses of these compounds.
"
01/01/1977 - "
On the other hand, Leptophos and EPN when administered orally at sublethal or lethal levels clearly produced a delayed neurotoxic ataxia in treated mice.
"
02/01/1989 - "
The repeated intravenous injections (RIVInj) of 5 mg/kg/day leptophos [O-(4-bromo-2, 5-dichlorophenyl) O-methyl phenylphosphonothioate] for 3 consecutive days caused delayed ataxia in 4 out of 9 hens (44.4%).
"
2.
Paralysis (Palsy)
07/01/1983 - "
The results indicated that leptophos induced severe ataxia and paralysis in sheep following about 4 months of treatment.
"
01/01/1978 - "
Thus leptophos caused ataxia, with subsequent paralysis, loss of appetite, and slow-down in the growth rate of the treated birds.
"
01/01/1984 - "
All the TOCP- and leptophos-treated ducks developed clinical signs of delayed neuropathy, as manifested by ataxia and paralysis.
"
3.
Thinness
12/01/1980 - "
[Effect of experimental thinness and obesity on the delayed neurotoxicity of the organophosphorus pesticide "Phosvel" (author's transl)].
"
4.
Peripheral Nervous System Diseases (PNS Diseases)
12/01/1982 - "
Leptophos is a potent acetylcholinesterase inhibitor which causes delayed central-peripheral neuropathy.
"
5.
Obesity
12/01/1980 - "
[Effect of experimental thinness and obesity on the delayed neurotoxicity of the organophosphorus pesticide "Phosvel" (author's transl)].
"
Related Drugs and Biologics
1.
Insecticides
2.
tri-o-cresyl phosphate (TOCP)
3.
cyanophenphos
4.
Carbaryl (Sevin)
5.
Organophosphates
6.
Phenylmethylsulfonyl Fluoride
7.
Pesticides
8.
Esters
9.
Chlorpyrifos (Lorsban)
10.
Diazinon (Dimpylate)
Related Therapies and Procedures
1.
Intravenous Injections