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Phosphorylcholine (Phosphocholine)

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Calcium and magnesium salts used therapeutically in hepatobiliary dysfunction.

Also Known As:

Phosphocholine; Choline Phosphate; Chloride, Choline Phosphate; Chloride, Phosphorylcholine; Phosphate Chloride, Choline; Phosphate, Choline; Choline Chloride Dihydrogen Phosphate; Choline Phosphate Chloride; Phosphorylcholine Chloride; Ethanaminium, N,N,N-trimethyl-2-(phosphonooxy)-, chloride

Networked: 505 relevant articles (22 outcomes, 50 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Organic Chemicals: 58
- Amines: 1422
  - Quaternary Ammonium Compounds: 1159
    - Trimethyl Ammonium Compounds
      - Choline: 3788
        Phosphorylcholine: 505
        erucylphosphocholine: 1408
        miltefosine: 456
        D 21266: 140
        sphingosine phosphorylcholine: 59
        Exosurf: 51
        dodecylphosphocholine: 12
        4-nitrophenylphosphorylcholine: 10
        2-methacryloyloxyethyl phosphorylcholine: 9
        n-octadecylphosphocholine: 6
        oleyloxyethylphosphorylcholine: 6
        erucylphosphohomocholine ErPC3: 3
        phosphorylcholine-bovine serum albumin: 3
        1,6-bis(phosphocholine)-hexane: 2
        poly(2-methacryloyloxyethyl phosphorylcholine-co-n-butyl methacrylate): 2
        18-(4-iodophenyl)octadecylphosphocholine: 1
        hepasteril: 1
        n-tetradecylphosphorylcholine: 1
        poly(2-methacryloyloxyethyl-phosphorylcholine): 1
        1,2-dipalmitoyl-sn-glycero-3-thiophosphocholine
        1,2-dipentadecylmethylidenephosphatidylcholine
        1-0-hexadecyl-2-azelaoyl-sn-glycero-3-phosphocoline
        1-cyano methano phosphocholine
        1-O-phosphocholine-2-O-acetyloctadecane
        1-O-phosphocholine-2-O-methyloctadecane
        1-palmitoyl-2-azelaoyl-sn-glycero-3-phosphocholine
        1-S-phosphocholine-2-O-hexadecanoyl-1-mercapto-2-ethanol
        13-phenyltrideca-6,8,10,12-tetraenylphosphocholine
        13-phenyltrideca-8,10,12-trien-6-ynylphosphocholine
        2-(5,6-epoxyisoprostane A2)phosphorylcholine
        2-acryloyloxyethyl phosphorylcholine
        2-hexadecanoylamino-4-nitrophenylphosphorylcholine
        3,3,4,4,5,5,6,6,7,7,8,8,9,9,10,10,10-heptadecafluorodecylphosphocholine
        4-aminophenylphosphorylcholine
        4-azophenylphosphorylcholine
        4-diazophenylphosphocholine
        4-nitrophenyl-6-(O-phosphocholine)hydroxyhexanoate
        4-nitrophenylphosphocholine
        AWD 56-02
        azido-LPC
        CA-PMB-PMA30 HFM
        cyclopentadecylpentylphosphocholine
        diphenylphosphorylcholine
        eicosanylphosphocholine
        eushearilide
        fosfolip
        irlbacholine
        methyl phosphorylcholine
        N,N',N'-tri-(6-(6-O-phosphorylcoline-b-D-galactopyranosyl-(1'-6)-b - D-galactopyranosyloxy)hexyl)-1,3,5-benzenetriamide
        N-decylphosphorylcholine
        n-octylphosphorylcholine
        O,O-diethylphosphorylcholine iodide
        O-mannopyranosyl-1-2-mannitol-6-phosphocholine
        octadecyl-(2-(N-methylpiperidino)ethyl)phosphate
        P(MMA:MA:APC)terpolymer
        phosphocholine F8C11PC
        phosphorylhomocholine
        poly(2-(dimethylamino)ethyl methacrylate-b-2-methacryloyloxyethyl phosphorylcholine)
        poly(epsilon-caprolactone)-block-poly(2-(methacryloyloxy)ethyl phosphorylcholine)
        poly(MPC-co-MA)
        stigmastanyl-phosphorylcholine
        tocopheryl-6-O-phosphorylcholine
- Onium Compounds
  - Quaternary Ammonium Compounds: 1159
    - Choline: 3788
      - Phosphorylcholine: 505
        erucylphosphocholine: 1408
        miltefosine: 456
        D 21266: 140
        sphingosine phosphorylcholine: 59
        Exosurf: 51
        dodecylphosphocholine: 12
        4-nitrophenylphosphorylcholine: 10
        2-methacryloyloxyethyl phosphorylcholine: 9
        n-octadecylphosphocholine: 6
        oleyloxyethylphosphorylcholine: 6
        erucylphosphohomocholine ErPC3: 3
        phosphorylcholine-bovine serum albumin: 3
        1,6-bis(phosphocholine)-hexane: 2
        poly(2-methacryloyloxyethyl phosphorylcholine-co-n-butyl methacrylate): 2
        18-(4-iodophenyl)octadecylphosphocholine: 1
        hepasteril: 1
        n-tetradecylphosphorylcholine: 1
        poly(2-methacryloyloxyethyl-phosphorylcholine): 1
        1,2-dipalmitoyl-sn-glycero-3-thiophosphocholine
        1,2-dipentadecylmethylidenephosphatidylcholine
        1-0-hexadecyl-2-azelaoyl-sn-glycero-3-phosphocoline
        1-cyano methano phosphocholine
        1-O-phosphocholine-2-O-acetyloctadecane
        1-O-phosphocholine-2-O-methyloctadecane
        1-palmitoyl-2-azelaoyl-sn-glycero-3-phosphocholine
        1-S-phosphocholine-2-O-hexadecanoyl-1-mercapto-2-ethanol
        13-phenyltrideca-6,8,10,12-tetraenylphosphocholine
        13-phenyltrideca-8,10,12-trien-6-ynylphosphocholine
        2-(5,6-epoxyisoprostane A2)phosphorylcholine
        2-acryloyloxyethyl phosphorylcholine
        2-hexadecanoylamino-4-nitrophenylphosphorylcholine
        3,3,4,4,5,5,6,6,7,7,8,8,9,9,10,10,10-heptadecafluorodecylphosphocholine
        4-aminophenylphosphorylcholine
        4-azophenylphosphorylcholine
        4-diazophenylphosphocholine
        4-nitrophenyl-6-(O-phosphocholine)hydroxyhexanoate
        4-nitrophenylphosphocholine
        AWD 56-02
        azido-LPC
        CA-PMB-PMA30 HFM
        cyclopentadecylpentylphosphocholine
        diphenylphosphorylcholine
        eicosanylphosphocholine
        eushearilide
        fosfolip
        irlbacholine
        methyl phosphorylcholine
        N,N',N'-tri-(6-(6-O-phosphorylcoline-b-D-galactopyranosyl-(1'-6)-b - D-galactopyranosyloxy)hexyl)-1,3,5-benzenetriamide
        N-decylphosphorylcholine
        n-octylphosphorylcholine
        O,O-diethylphosphorylcholine iodide
        O-mannopyranosyl-1-2-mannitol-6-phosphocholine
        octadecyl-(2-(N-methylpiperidino)ethyl)phosphate
        P(MMA:MA:APC)terpolymer
        phosphocholine F8C11PC
        phosphorylhomocholine
        poly(2-(dimethylamino)ethyl methacrylate-b-2-methacryloyloxyethyl phosphorylcholine)
        poly(epsilon-caprolactone)-block-poly(2-(methacryloyloxy)ethyl phosphorylcholine)
        poly(MPC-co-MA)
        stigmastanyl-phosphorylcholine
        tocopheryl-6-O-phosphorylcholine

Experts

1.	Frostegård, Johan: 19 articles (02/2015 - 09/2006)
2.	Bhujwalla, Zaver M: 14 articles (06/2015 - 04/2003)
3.	Glunde, Kristine: 14 articles (06/2015 - 10/2003)
4.	de Faire, Ulf: 12 articles (01/2014 - 09/2006)
5.	Leach, Martin O: 8 articles (01/2014 - 09/2003)
6.	Workman, Paul: 7 articles (01/2014 - 11/2003)
7.	Harnett, William: 6 articles (11/2015 - 08/2003)
8.	Gribbestad, Ingrid S: 6 articles (06/2014 - 07/2010)
9.	Su, Jun: 6 articles (01/2014 - 09/2006)
10.	Griffiths, John R: 6 articles (02/2012 - 02/2002)

Related Diseases

1.	Infection 10/01/2015 - "Using mass spectrometry and murine upper airway infection models, we demonstrated that phosphorylcholine (ChoP) moieties that are shared by PAF and the bacterial cell wall allow S. " 02/01/2008 - "Novel phosphorylcholine-containing protein of Pseudomonas aeruginosa chronic infection isolates interacts with airway epithelial cells." 06/15/2003 - "Abs specific for phosphorylcholine (PC) are known to contribute to the immune defense against a variety of microbial infections. " 11/01/1999 - "Phosphorylcholine is an important hapten that modulates the immune responses in Trichinella infections. " 09/01/1999 - "Monoclonal phosphorylcholine-specific IgG2c failed to protect rats against intestinal infection with T. "
2.	Neoplasms (Cancer) 07/01/2006 - "Ex vivo high-resolution magic angle spinning (HRMAS) and 1H MRS of metabolite extracts revealed a significant reduction in phosphocholine and glycerophosphocholine in biopsies of ZD6126-treated tumors, confirming in vivo tCho response. " 01/07/2010 - "Nuclear magnetic resonance (NMR)-based metabolomic studies of human tumors have identified a marked increase in the intracellular concentration of phosphocholine relative to normal tissues. " 09/01/2003 - "Several (31)P MRS studies in tumors in vivo have shown that levels of phosphocholine (PC) and other phosphomonoesters (PME) and phosphodiesters (PDE) are useful prognostic or early-response indicators. " 11/01/2013 - "We demonstrated here that the phosphorylcholine-modified polyplexes can be explored as effective gene vector for selective uptake and high transfection of cancer cells. " 11/01/2013 - "Bioinspired phosphorylcholine-modified polyplexes as an effective strategy for selective uptake and transfection of cancer cells."
3.	Pneumococcal Infections 09/01/1984 - "CRP reacts with the phosphocholine moiety of pneumococcal cell wall C-polysaccharide, and this reaction can lead to complement activation in vitro and protection against pneumococcal infection in vivo. " 12/14/2012 - "We conclude that the phosphocholine-binding pocket on CRP is necessary for CRP-mediated initial protection of mice against lethal pneumococcal infection." 06/01/2007 - "CRP binds to phosphocholine in the Streptococcus pneumoniae cell wall and provides innate defense against pneumococcal infection. " 10/01/2002 - "Phosphorylcholine (PC), an epitope present on the cell-wall C-polysaccharide of all pneumococcal serotypes, is capable of eliciting a protective antibody response to pneumococcal infection in mice and provides an attractive model system for understanding the immune response generated by peptide mimics. " 04/01/1993 - "No protection against types 6A and 14 pneumococcal infection could be demonstrated neither with mouse monoclonal antibodies against C-Ps, specific for phosphorylcholine (PC) or for C-Ps backbone, nor for polyclonal rabbit immunsera against C-Ps. "
4.	Atherosclerosis 08/07/2007 - "The present study evaluated the effect of phosphorylcholine (PC) immunization on the extent of experimental atherosclerosis. " 08/07/2007 - "Phosphorylcholine-targeting immunization reduces atherosclerosis." 04/01/2009 - "Natural antibodies specific for phosphorylcholine (anti-PC) have been implicated as protective factors in atherosclerosis. " 01/01/2012 - "We have reported that anti-phosphorylcholine (anti-PC) IgM is a protection marker for human cardiovascular disease (CVD) and atherosclerosis. " 01/01/2010 - "Low level natural antibodies against phosphorylcholine: a novel risk marker and potential mechanism in atherosclerosis and cardiovascular disease."
5.	Prostatic Neoplasms (Prostate Cancer) 07/05/2010 - "Phosphocholine carbamate analogue 5 is as effective against the prostate cancer cell lines as the corresponding phosphonocholine analogue 1. Cell death induced by 2'-(trimethylammonio)ethyl 4-hexadecyloxy-3(R)-N-methylcarbamoyl-1-butanephosphonate (carbamate analogue 2) appeared to be mediated by apoptosis, as assessed by caspase activation and loss of mitochondrial membrane potential. " 07/01/2011 - "This study demonstrates that high-grade prostate cancer shows significantly higher Ki-67 staining and concentrations of phosphocholine (PC) and glycerophosphocholine (GPC) than does low-grade prostate cancer (2.4 ± 2.8% versus 7.6 ± 3.5%, p < 0.005, and 0.671 ± 0.461 versus 1.87 ± 2.15 mmolal, p < 0.005, respectively). " 05/22/2012 - "More specifically, a decreased glycerophosphocholine (GPC) to phosphocholine (PC) ratio was reported in breast, ovarian, and prostate cancers. " 12/01/2012 - "The spectral resolution enabled the separate detection of phosphocholine, phosphoethanolamine, inorganic phosphate, and other metabolites that could play an important role in the characterization of prostate cancer." 06/01/2014 - "We investigated PC3 prostate cancer, MCF-7 breast cancer and A375 melanoma cells, and determined that, consistent with previous studies, MRS-detectable levels of phosphocholine decreased significantly in all cell lines (to 63%, 50% and 18% of the control, respectively) following MEK inhibition with U0126. "

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