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Phosphoprotein Phosphatases (Phosphatases, Protein)

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A group of enzymes removing the SERINE- or THREONINE-bound phosphate groups from a wide range of phosphoproteins, including a number of enzymes which have been phosphorylated under the action of a kinase. (Enzyme Nomenclature, 1992)

Also Known As:

Phosphatases, Protein; Casein Phosphatase; Ecto-Phosphoprotein Phosphatase; Nuclear Protein Phosphatase; Phosphohistone Phosphatase; Phosphoprotein Phosphatase-2C; Phosphoseryl-Protein Phosphatase; Protein Phosphatase C; Protein Phosphatase C-I; Protein Phosphatase C-II; Protein Phosphatase H-II; Protein-Serine-Threonine Phosphatase; Protein-Threonine Phosphatase; Serine-Threonine Phosphatase; Threonine Phosphatase; Ecto Phosphoprotein Phosphatase; Phosphatase C, Protein; Phosphatase C-I, Protein; Phosphatase C-II, Protein; Phosphatase H-II, Protein; Phosphatase, Casein; Phosphatase, Ecto-Phosphoprotein; Phosphatase, Nuclear Protein; Phosphatase, Phosphohistone; Phosphatase, Phosphoprotein; Phosphatase, Phosphoseryl-Protein; Phosphatase, Protein-Serine-Threonine; Phosphatase, Protein-Threonine; Phosphatase, Serine-Threonine; Phosphatase, Threonine; Phosphatase-2C, Phosphoprotein; Phosphatases, Phosphoprotein; Phosphohydrolase, Phosphoprotein; Phosphoprotein Phosphatase 2C; Phosphoseryl Protein Phosphatase; Protein Phosphatase C I; Protein Phosphatase C II; Protein Phosphatase H II; Protein Phosphatase, Nuclear; Protein Serine Threonine Phosphatase; Protein Threonine Phosphatase; Serine Threonine Phosphatase; Phosphoprotein Phosphatase; Phosphoprotein Phosphohydrolase; Protein Phosphatases

Networked: 377 relevant articles (1 outcomes, 32 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Enzymes and Coenzymes
- Enzymes: 34502
  - Hydrolases: 639
    - Esterases: 217
      - Phosphoric Monoester Hydrolases: 1062
        Phosphoprotein Phosphatases: 377
        Calcineurin: 2469
        Protein Phosphatase 2: 452
        Dual-Specificity Phosphatases: 151
        Protein Phosphatase 1: 139
        Myosin-Light-Chain Phosphatase: 60
        protein phosphatase 2C: 20
        protein phosphatase 5: 20
        Pyruvate Dehydrogenase (Lipoamide)-Phosphatase: 12
        Phosphorylase Phosphatase: 10
        protein phosphatase 4: 10
        protein phosphatase 6: 8
        carboxy-terminal domain phosphatase: 4
        microtubule-associated protein-2 phosphatase: 1
        phosphoaminoacyl-tRNA synthetase phosphatase: 1
        phospholamban phosphatase: 1
        RK 682: 1
        acetyl CoA carboxylase phosphatase
        alpha-ketoisovalerate dehydrogenase phosphatase
        Arabidopsis ABI1 protein
        Arabidopsis ABI2 protein
        Arabidopsis AHG3 protein
        Arabidopsis AP2C1 protein
        Arabidopsis At1g05000 protein
        Arabidopsis At2g33540 protein
        Arabidopsis BSU1 protein
        Arabidopsis CPL1 protein
        Arabidopsis CPL2 protein
        Arabidopsis FASS protein
        Arabidopsis FyPP protein
        Arabidopsis FyPP1 protein
        Arabidopsis HAB1 protein
        Arabidopsis KAPP protein
        Arabidopsis PAPP5 protein
        Arabidopsis PP7 protein
        Arabidopsis TAP38 protein
        Bacillus substilis YvoE protein
        Bacillus subtilis rapA protein
        Bacillus subtilis rapB protein
        Bacteriophage lambda PP-lambda protein
        C elegans CDC14 protein
        C elegans Cdc25.2 protein
        C elegans Fem-2 protein
        C elegans SCPL-1 protein
        C elegans SMK-1 protein
        calmodulin dependent protein kinase II phosphatase
        Drosophila alphabet protein
        Drosophila Fcp1 protein
        Drosophila PpY-55A protein
        Drosophila puc protein
        Drosophila rdgC protein
        Drosophila ssh protein
        Drosophila TAP42 protein
        Drosophila twins protein
        E coli rcsC protein
        E coli SixA protein
        E coli Taz1 protein
        E coli Wzb protein
        E coli YbiV protein
        eIF-2 phosphatase
        Glycogen-Synthase-D Phosphatase
        HMG-CoA reductase phosphatase
        human CTDSP1 protein
        human CTDSP2 protein
        human Dusp27 protein
        human ILKAP protein
        human MDP-1 protein
        human MPPE1 protein
        human PDXP protein
        human PHLPP1 protein
        human PHLPP2 protein
        human PPEF1 protein
        human PPM1F protein
        human PPM1H protein
        human PPM1L protein
        human PPM1M protein
        human PPP1R14A protein
        human PPP1R3A protein
        human PPP1R3C protein
        human PPP1R8 protein
        human slingshot phosphatase 2
        human SSH1 protein
        human UBLCP1 protein
        isocitrate dehydrogenase phosphatase
        mouse cantharidin-binding protein
        mouse JKAP protein
        mouse MDP-1 protein
        mouse Phlpp protein
        mouse Ppef1 protein
        mouse PPP1R3A protein
        mouse protein Ppm1l
        mouse SSH1 protein
        mouse SSH3 protein
        mouse Tensin2 protein
        mouse Tns3 protein
        myosin phosphatase III
        okadaic acid-sensitive phosphatase
        phenylalanine hydroxylase phosphatase
        phosphofructokinase phosphatase
        phosphoprotamine phosphatase
        phosphorylase kinase phosphatase

Experts

1.	Escobar, Javier: 6 articles (03/2012 - 01/2009)
2.	Sastre, Juan: 6 articles (03/2012 - 01/2009)
3.	Pereda, Javier: 6 articles (03/2012 - 01/2009)
4.	López-Rodas, Gerardo: 5 articles (03/2012 - 01/2009)
5.	Sabater, Luis: 5 articles (01/2012 - 01/2009)
6.	Aparisi, Luis: 5 articles (01/2012 - 01/2009)
7.	Fessard, Valérie: 5 articles (04/2009 - 05/2003)
8.	Arduini, Alessandro: 4 articles (01/2012 - 01/2009)
9.	Sandoval, Juan: 4 articles (06/2010 - 01/2009)
10.	Wipf, Peter: 4 articles (12/2009 - 01/2003)

Related Diseases

1.	Post-Traumatic Stress Disorders (PTSD) 01/26/2011 - "Our results underscore the importance of nuclear PP1 in the amygdala as an epigenetic regulator of emotional memory, and the relevance of protein phosphatases as potential targets for therapeutic treatment of brain disorders like PTSD."
2.	Brain Diseases (Brain Disorder) 01/26/2011 - "Our results underscore the importance of nuclear PP1 in the amygdala as an epigenetic regulator of emotional memory, and the relevance of protein phosphatases as potential targets for therapeutic treatment of brain disorders like PTSD."
3.	Neoplasms (Cancer) 01/01/2014 - "Extension studies using tumors from another 96 patients discovered a large number of truncation mutations in tumor suppressors (TP53 and RB1), protein phosphatases (e.g., PTEN, PTPRB, PTPRD, and PTPRT), as well as chromatin remodeling genes (e.g., ASXL3, MLL2, and ARID2). " 06/01/2008 - "These studies provide us with new insights into the role of protein phosphatases in cancer initiation and maintenance." 07/01/2000 - "In the present study the influence of dephosphorylation by Ser/Thr protein phosphatases (PPases) on tumor cell adhesion was investigated. " 03/01/2015 - "Protein serine/threonine phosphatase 2A (PP2A) expression in A549 cancer cells was reduced by TGF-β1 but CDN restored it. " 04/01/2014 - "Furthermore, current challenges on the protein phosphatases field as new targets to cancer therapy will be addressed. "
4.	Leukemia 12/10/2005 - "Using a combination of fluorescence measurements of intracellular Ca(2+) ion concentration ([Ca(2+)](i)) and membrane potential we have investigated the sensitivity to serine/threonine phosphatase inhibition of Ca(2+) entry stimulated by activation of the Ca(2+) release-activated Ca(2+) (CRAC) entry pathway in rat basophilic leukemia cells. " 12/01/1994 - "Multiple apoptotic death types triggered through activation of separate pathways by cAMP and inhibitors of protein phosphatases in one (IPC leukemia) cell line." 06/01/2013 - "Although many studies established a relationship between protein phosphatases and leukemia, little is known about the role of this group of proteins in AML. " 01/01/2007 - "In this study, we show that constitutively active protein phosphatase 2A (PP2A), which is a serine/threonine phosphatase, is essential for T leukemia cell survival. " 06/24/1999 - "Apoptosis and mitotic arrest are two independent effects of the protein phosphatases inhibitor okadaic acid in K562 leukemia cells."
5.	Melanoma (Melanoma, Malignant) 03/01/2014 - "Recent whole genome melanoma sequencing studies have identified recurrent mutations in the gene encoding the catalytic subunit of serine/threonine phosphatase 6 (PPP6C/PP6C). " 09/25/2014 - "However, little is known about protein phosphatases that dephosphorylate and thereby inactivate it in melanoma cells. " 12/01/2001 - "As PP2A is known to be a major cellular serine-threonine phosphatase, and has been implicated not only in the regulation of cell growth and division but also in the control of gene transcription and growth factor signal transduction, alterations in the pattern of the regulatory subunits may affect substrate specificity and subcellular localization of the PP2A holoenzyme in melanoma cells." 09/01/2012 - "Among the newly identified cancer genes was PPP6C, encoding a serine/threonine phosphatase, which harbored mutations that clustered in the active site in 12% of sun-exposed melanomas, exclusively in tumors with mutations in BRAF or NRAS. " 01/01/1999 - "In the present study, the significance of protein tyrosine phosphatases (PTP) and ser/thr protein phosphatases (PP) in alpha4beta1 and alpha5beta1 integrin-mediated mouse melanoma B16F1 cell anchorage and migration on fibronectin was characterized using phosphatase inhibitors. "

Related Drugs and Biologics

1.	Okadaic Acid
2.	Insulin (Novolin)
3.	Threonine (L-Threonine)
4.	Serine (L-Serine)
5.	Enzymes
6.	Protein Kinase C
7.	Calcium
8.	Carcinogens
9.	Retinoblastoma Protein
10.	Phosphotransferases (Kinase)

Related Therapies and Procedures

1.	Therapeutics
2.	Intraperitoneal Injections
3.	Vasectomy (Vas Occlusion)
4.	Transplantation (Transplant Recipients)
5.	Drug Therapy (Chemotherapy)