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Phosphonoacetic Acid (Phosphonoacetate)

Subscribe to New Research on Phosphonoacetic Acid

A simple organophosphorus compound that inhibits DNA polymerase, especially in viruses and is used as an antiviral agent.

Also Known As:

Phosphonoacetate; Disodium Phosphonoacetate; Fosfonet Sodium; Phosphonacetic Acid; Acid, Phosphonacetic; Acid, Phosphonoacetic; Phosphonoacetate, Disodium; Sodium, Fosfonet; Acetic acid, phosphono-

Networked: 84 relevant articles (5 outcomes, 3 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Organic Chemicals: 58
- Organophosphorus Compounds: 163
  - Phosphonic Acids: 103
    - Phosphonoacetic Acid: 84
- Carboxylic Acids: 83
  - Acyclic Acids
    - Acetic Acids: 20
      - Phosphonoacetic Acid: 84
        Foscarnet: 738
        NSC 224131: 193
        methylacetylphosphonate: 1
        2-bromophosphonoacetic acid
        6-methacryloyloxyhexyl phosphonoacetate
        adenosine phosphonoacetic acid
        alpha-chloro-alpha-bromophosphonoacetic acid
        ethyl diethyl-phosphonoformate
        N-(phosphonoacetyl)putrescine
        N-phosphonomethyliminodiacetic acid
        phosphonoacetohydroxamate
        preparation 1311
        triethyl phosphonoacetate

Experts

1.	Thakker, Suhani: 1 article (03/2015)
2.	Purushothaman, Pravinkumar: 1 article (03/2015)
3.	Verma, Subhash C: 1 article (03/2015)
4.	Kellam, Paul: 1 article (11/2009)
5.	Clark, Duncan A: 1 article (11/2009)
6.	Rasaiyaah, Jane: 1 article (11/2009)
7.	Sin, Cheryl S Y: 1 article (11/2009)
8.	Tsao, Edward H: 1 article (11/2009)
9.	Griffiths, Paul D: 1 article (11/2009)
10.	Cruchaga, Carlos: 1 article (09/2006)

Related Diseases

1.	Infection 04/01/1978 - "Phosphonoacetic acid was highly effective in preventing the development of skin lesions, and no latent infections were detected when phosphonoacetic acid ointment was applied 3 h after infection. " 01/01/1980 - "Phosphonoacetic acid treatment of the primary mutant-induced infection abolished the protection against reinfection with parental virus. " 01/01/1993 - "Temporal studies revealed a reduction in class I expression beginning at 8 h post infection (p.i.) which reached a maximum between 10 to 16 h p.i. The loss of class I expression was restored in the presence of phosphonoacetic acid (30 micrograms/ml), a late herpesviral protein synthesis inhibitor. " 07/01/2002 - "Phosphorylation of Sp1 required ICP4; however, the proportion of phosphorylated Sp1 was reduced during infection in the presence of phosphonoacetic acid or in the absence of ICP27. " 04/01/2001 - "(ii) Translocation of wild-type ICP0 requires a function expressed late in infection, inasmuch as phosphonoacetate blocked the translocation of ICP0 in wild-type virus-infected cells but not in d120 mutant-infected cells. "
2.	Herpesviridae Infections (Herpesvirus Infection) 01/01/1982 - "Phosphonoacetic acid effective in herpesvirus infection." 01/01/1978 - "Phosphonoacetic acid was the only compound with a good therapeutic activity against herpesvirus infection, causing a reduction of both the cumulative score and the time to healing. " 12/01/1978 - "Treatment of experimental herpesvirus infections with phosphonoformate and some comparisons with phosphonoacetate." 09/01/1978 - "When applied topically, trisodium phosphonoformate (PFA) displayed activity against established cutaneous herpesvirus infections in guinea pigs similar to that exhibited by the closely related phosphonoacetic acid (PAA); however, unlike PAA, PFA was not locally skin irritating. " 01/01/1980 - "The effects of adenine arabinoside, cytosine arabinoside, iododeoxyuridine, ribavirin, phosphonoacetate and phosphonoformate on virus titers in cutaneous herpesvirus infections of guinea pigs have been determined and compared to their effects on lesion score. "
3.	Virus Diseases (Viral Diseases) 01/01/1981 - "Detectable myxoma virus replication was inhibited at a drug concentration of 100 micrograms/ml. Fibroma virus replication was inhibited at a concentration of 500 micrograms/ml. Because of this difference in sensitivity, myxoma virus was used to infect rabbits to test that efficacy of phosphonoacetic acid in the treatment of a systemic viral disease. "
4.	Iritis 02/01/1976 - "Phosphonoacetic acid was not effective in the treatment of experimental herpetic iritis when applied topically but was significantly effective when administered intravenously and subconjunctivally. "
5.	Fibroma (Fibromatosis) 01/01/1981 - "Detectable myxoma virus replication was inhibited at a drug concentration of 100 micrograms/ml. Fibroma virus replication was inhibited at a concentration of 500 micrograms/ml. Because of this difference in sensitivity, myxoma virus was used to infect rabbits to test that efficacy of phosphonoacetic acid in the treatment of a systemic viral disease. " 01/01/1981 - "Both myxoma and fibroma viruses were found to be sensitive in vitro to the effects of phosphonoacetic acid. "

Related Drugs and Biologics

1.	Acyclovir (Aciclovir)
2.	Thymidine Kinase
3.	Caffeine (No Doz)
4.	Viral DNA
5.	Cycloheximide (Cicloheximide)
6.	DNA (Deoxyribonucleic Acid)
7.	Aphidicolin
8.	Vidarabine (Vira-A)
9.	Foscarnet
10.	Messenger RNA (mRNA)