Phosphoric Monoester Hydrolases (Phosphatases)

A group of hydrolases which catalyze the hydrolysis of monophosphoric esters with the production of one mole of orthophosphate.

Also Known As:

Phosphatases; Hydrolase, Phosphoric Monoester; Hydrolases, Phosphoric Monoester; Monoester Hydrolase, Phosphoric; Phosphatase; Phosphohydrolase; Phosphohydrolases; Phosphomonoesterase; Phosphomonoesterases; Phosphoric Monoester Hydrolase

Networked: 7477 relevant articles (93 outcomes, 692 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Enzymes and Coenzymes: 1
- Enzymes: 152586
  - Hydrolases: 2166
    - Esterases: 1574
      - Phosphoric Monoester Hydrolases: 7477
        Alkaline Phosphatase: 13376
        Acid Phosphatase: 2344
        Protein Tyrosine Phosphatases: 1685
        Phosphoprotein Phosphatases: 1211
        PTEN Phosphohydrolase: 865
        Glucose-6-Phosphatase: 773
        6-Phytase: 241
        Fructose-Bisphosphatase: 197
        myo-inositol-1 (or 4)-monophosphatase: 99
        Mitogen-Activated Protein Kinase Phosphatases: 89
        Phosphatidate Phosphatase: 61
        Phosphofructokinase-2: 60
        synaptojanin: 56
        Nucleotidases: 50
        Phosphoinositide Phosphatases: 50
        phosphatidylinositol-3,4-bisphosphate 4-phosphatase: 36
        phosphoserine phosphatase: 34
        calcineurin phosphatase: 22
        4-Nitrophenylphosphatase: 20
        8-oxodGTPase: 20
        thiamine monophosphatase: 12
        phosphoinositide 5-phosphatase: 10
        sphingosine-1-phosphate phosphatase: 9
        glycerol-2-phosphatase: 6
        inositol-1,4-bisphosphate 1-phosphatase: 6
        phosphoglycolate phosphatase: 6
        trehalose-phosphatase: 6
        multiple inositol-polyphosphate phosphatase: 5
        sugar-phosphatase: 4
        mannose-6-phosphatase: 3
        phosphatidylinositol-3-phosphatase: 3
        polyphosphoinositide phosphatase: 3
        pyridoxine phosphate phosphatase: 3
        phosphocholine phosphatase: 2
        acetylphosphatase: 1
        dolichyl-phosphatase: 1
        glucosylglycerol-phosphate phosphatase: 1
        human PRUNE1 protein: 1
        lysophosphatidic acid phosphatase: 1
        phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase: 1
        Staphylococcal neutral phosphatase: 1
        vaccinia virus capping enzyme: 1
        2-carboxyarabinitol 1-phosphate phosphatase
        2-D-glycero-manno-heptose phosphatase
        3'-phosphoadenosine-5'-phosphosulfate phosphohydrolase
        3-deoxy-manno-octulosonate-8-phosphatase
        3-phytase
        ADP-Ribose 1''-Phosphate Phosphatases
        alkylacetylglycerophosphatase
        Aneurinibacillus thermoaerophilus GmhC protein
        Arabidopsis 5PTase1 protein
        Arabidopsis 5PTase11 protein
        Arabidopsis 5PTase12 protein
        Arabidopsis 5PTase13 protein
        Arabidopsis 5PTase14 protein
        Arabidopsis 5PTase2 protein
        Arabidopsis AT4G12430 protein
        Arabidopsis AT4G29530 protein
        Arabidopsis CVP2 protein
        Arabidopsis FRA3 protein
        Arabidopsis GDP-L-galactose phosphorylase
        Arabidopsis Gpp1 protein
        Arabidopsis Gpp2 protein
        Arabidopsis Hint4 protein
        Arabidopsis myotubulerin protein
        Arabidopsis PECP1 protein
        Arabidopsis PGLP1 protein
        Arabidopsis PSP1 protein
        Arabidopsis PTEN2a protein
        Arabidopsis PTEN2b protein
        Arabidopsis SAC1a protein
        Arabidopsis SAC1b protein
        Arabidopsis SAC1c protein
        Arabidopsis SAC9 protein
        Arabidopsis Sgpp protein
        Arabidopsis VTC4 protein
        Artemia salina capping enzyme
        aspartyl phosphate phosphatase
        Aspergillus nidulans DipA protein
        Bacillus subtilis RsbU protein
        baculovirus phosphatase
        bisphosphoglycerate phosphatase
        Bombyx mori sorbitol-6-phosphatase
        C elegans MTM-6 protein
        C elegans NDX-4 protein
        Campylobacter jejuni UDP-2,4-diacetamido-2,4,6-trideoxy-L-altrose hydrolase
        ceramide-1-phosphate phosphatase
        chicken PHOSPHO1 protein
        chromatin 3'-phosphatase-5'-hydroxy kinase
        Ciona intestinalis voltage-sensor-containing phosphatase
        Drosophila laza protein
        Drosophila ocn protein
        E coli agp protein
        E coli BacA protein
        E coli CysQ protein
        E coli D,D-heptose 1,7-bisphosphate phosphatase
        E coli DUF299 protein
        E coli Had13 protein
        E coli OtsB protein
        E coli SuhB protein

Experts

1.	Eng, Charis: 44 articles (01/2022 - 06/2002)
2.	Zhang, Zhong-Yin: 34 articles (01/2020 - 02/2003)
3.	Pandolfi, Pier Paolo: 22 articles (12/2021 - 05/2002)
4.	Zeng, Qi: 21 articles (09/2019 - 10/2004)
5.	Li, Jie: 20 articles (01/2021 - 10/2004)
6.	Li, Li: 18 articles (01/2022 - 05/2002)
7.	Tremblay, Michel L: 17 articles (01/2021 - 01/2009)
8.	Wu, Hong: 17 articles (01/2018 - 02/2003)
9.	Li, Jun: 16 articles (02/2022 - 10/2012)
10.	Bottini, Nunzio: 16 articles (01/2022 - 07/2002)

Related Diseases

1.	Neoplasms (Cancer) 10/01/2017 - "However, more evidences demonstrate PTEN functions in DNA repair independent of its phosphatase activity, which affects the efficacy of DNA damage anti-tumoral drugs in treating cancer cells with PTEN variations. " 08/15/2012 - "Abrogation of SRC homology region 2 domain-containing phosphatase 1 in tumor-specific T cells improves efficacy of adoptive immunotherapy by enhancing the effector function and accumulation of short-lived effector T cells in vivo." 01/28/2020 - "Complex 2 showed the highest IC50 values for anti-cancer activity towards all three cell lines among the three complexes and complex 3 showed the least activity as observed in the phosphatase activity study. " 01/01/2020 - "In this study, we identified WIP1, a p38 phosphatase frequently overexpressed in cancer, as a suppressor of p38 in a pathway that regulates CSC properties in NSCLC. " 01/01/2019 - "These data suggest that the NCGC00249987 allosteric inhibitor can be used as a chemical probe to study the function of the EYA2 Tyr phosphatase activity in cells and may have the potential to be developed into an antimetastatic agent for cancers reliant on EYA2's Tyr phosphatase activity."
2.	Inflammation (Inflammations) 08/01/2021 - "This study aimed to investigate the correlation of JNK pathway-associated phosphatase (JKAP) with clinical features, inflammation, exacerbation risk, and severity in asthmatic children. " 01/01/2021 - "In this study, we combine proteomics, live imaging, and genetics in the fly to identify a novel regulator of inflammation in vivo; the PTP-type phosphatase Pez. " 10/21/2023 - "However, CNPs are multi-functional nanozymes that exert additional bioactivities independent from the Ce3+/Ce4+ redox switch, such as phosphatase activity, which could conceivably mediate some of the anti-inflammatory effects reported, suggesting that CNPs fight inflammation via pleiotropic actions. " 01/01/2023 - "Treg-specific deletion of the phosphatase SHP-1 impairs control of inflammation in vivo." 01/01/2022 - "These results suggest the hypoexcitability of pyramidal neurons caused by the upregulation of SK channels via Ca2+-dependent phosphatase during acute inflammation in the mPFC. "
3.	Alzheimer Disease (Alzheimer's Disease) 04/01/2001 - "The phosphatases P7-P11 were found to be effective in the dephosphorylation of Alzheimer's disease abnormally hyperphosphorylated tau. " 07/01/2010 - "This requirement of hydrophobic microenvironment around site118 in CnB suggests that, besides the mutations in the catalytic subunit CnA, which impairs Cn phosphatase activity, and had been identified to be associated with diseases such as Alzheimer's disease (AD), the mutations in CnB might also affect Cn enzymatic activity in vivo, and this might be helpful for our further research on mechanisms of diseases associated with Cn." 09/01/2014 - "Phosphotyrosyl phosphatase activator (PTPA) is decreased in the brains of Alzheimer's disease (AD) and AD transgenic mouse models. " 09/01/2014 - "Phosphotyrosyl phosphatase activator (PTPA) is decreased in the brains of Alzheimer's disease (AD) and the AD transgenic mouse models. " 04/01/2014 - "Promoter hypermethylation of the phosphatase DUSP22 mediates PKA-dependent TAU phosphorylation and CREB activation in Alzheimer's disease."
4.	Carcinogenesis 11/15/2001 - "Since measurement of lysophosphatidate phosphatase activity is important in studies of tumorigenesis, we attempted to develop a simpler alternative to the more complex methods currently available. " 08/19/2023 - "Small C-terminal domain phosphatases CTDSP1, CTDSP2, and CTDSPL (also known as SCP1, 2, 3) are involved in the regulation of several important pathways associated with carcinogenesis. " 01/01/2023 - "A target is represented by the cellular phosphatase PTPN14 and its E7-mediated degradation was shown to be crucial in HPV oncogenesis. " 08/25/2022 - "The Src-homology 2 domain-containing phosphatase 2 (SHP2), which is encoded by PTPN11, participates in many cellular signaling pathways and is closely related to various tumorigenesis. " 07/01/2021 - "The review discusses the properties of SCP phosphatases and their role in oncogenesis. "
5.	Insulin Resistance 06/01/2016 - "In addition, data from the studies addressing the role of PHLPPs in insulin resistance-related disorders and from those investigating the possibility to manipulate these phosphatases for therapeutic purposes are presented. " 12/01/2003 - "Comparing the studies on SHIP2 and other phosphatases suggests how inhibition of SHIP2 leads to increased insulin sensitivity without deleterious effects. " 01/01/2020 - "Therefore, E2 protects NPY/AgRP neurons in females against insulin resistance through, at least in part, attenuating phosphatase activity. " 06/01/2016 - "This observation suggests that PHLPP phosphatases may have a clinically relevant role in the pathogenesis of insulin resistance-related diseases and may thus represent suitable targets for the treatment of these conditions. " 06/01/2016 - "PHLPP phosphatases as a therapeutic target in insulin resistance-related diseases."

Related Drugs and Biologics

1.	Tensins
2.	Phosphotransferases (Kinase)
3.	Tyrosine (L-Tyrosine)
4.	Phosphates (Orthophosphate)
5.	Proteins (Proteins, Gene)
6.	Enzymes
7.	Acids
8.	Biomarkers (Surrogate Marker)
9.	Lipids
10.	Calcineurin

Related Therapies and Procedures

1.	Therapeutics
2.	Adjuvant Chemotherapy
3.	Drug Therapy (Chemotherapy)
4.	Immunotherapy
5.	Renal Dialysis (Hemodialysis)